CA2229811C - Inverted chimeric and hybrid oligonucleotides - Google Patents

Inverted chimeric and hybrid oligonucleotides Download PDF

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Publication number
CA2229811C
CA2229811C CA2229811A CA2229811A CA2229811C CA 2229811 C CA2229811 C CA 2229811C CA 2229811 A CA2229811 A CA 2229811A CA 2229811 A CA2229811 A CA 2229811A CA 2229811 C CA2229811 C CA 2229811C
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CA
Canada
Prior art keywords
oligonucleotide
oligonucleotides
composition
inverted
gene expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2229811A
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English (en)
French (fr)
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CA2229811A1 (en
Inventor
Sudhir Agrawal
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Aceragen Inc
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Idera Pharmaceuticals Inc
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Publication of CA2229811A1 publication Critical patent/CA2229811A1/en
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Publication of CA2229811C publication Critical patent/CA2229811C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/345—Spatial arrangement of the modifications having at least two different backbone modifications
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA2229811A 1995-08-17 1996-08-16 Inverted chimeric and hybrid oligonucleotides Expired - Lifetime CA2229811C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/516,454 US5652356A (en) 1995-08-17 1995-08-17 Inverted chimeric and hybrid oligonucleotides
US08/516,454 1995-08-17
PCT/US1996/013371 WO1997006662A2 (en) 1995-08-17 1996-08-16 Inverted chimeric and hybrid oligonucleotides

Publications (2)

Publication Number Publication Date
CA2229811A1 CA2229811A1 (en) 1997-02-27
CA2229811C true CA2229811C (en) 2012-01-03

Family

ID=24055671

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2229811A Expired - Lifetime CA2229811C (en) 1995-08-17 1996-08-16 Inverted chimeric and hybrid oligonucleotides

Country Status (11)

Country Link
US (3) US5652356A (cg-RX-API-DMAC7.html)
EP (2) EP1340765B1 (cg-RX-API-DMAC7.html)
JP (1) JP4177455B2 (cg-RX-API-DMAC7.html)
AT (2) ATE411333T1 (cg-RX-API-DMAC7.html)
AU (1) AU6953896A (cg-RX-API-DMAC7.html)
CA (1) CA2229811C (cg-RX-API-DMAC7.html)
DE (2) DE69637718D1 (cg-RX-API-DMAC7.html)
DK (1) DK1019428T3 (cg-RX-API-DMAC7.html)
ES (2) ES2201198T3 (cg-RX-API-DMAC7.html)
PT (1) PT1019428E (cg-RX-API-DMAC7.html)
WO (1) WO1997006662A2 (cg-RX-API-DMAC7.html)

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JPH11512088A (ja) 1999-10-19
EP1340765B1 (en) 2008-10-15
EP1019428A2 (en) 2000-07-19
ATE411333T1 (de) 2008-10-15
WO1997006662A3 (en) 1997-06-19
ES2315442T3 (es) 2009-04-01
ATE243706T1 (de) 2003-07-15
DK1019428T3 (da) 2003-09-22
PT1019428E (pt) 2003-10-31
JP4177455B2 (ja) 2008-11-05
DE69637718D1 (de) 2008-11-27
EP1340765A2 (en) 2003-09-03
AU6953896A (en) 1997-03-12
US5773601A (en) 1998-06-30
US5973136A (en) 1999-10-26
EP1340765A3 (en) 2006-06-21
ES2201198T3 (es) 2004-03-16
DE69628864T2 (de) 2004-05-06
EP1019428B1 (en) 2003-06-25
CA2229811A1 (en) 1997-02-27
WO1997006662A2 (en) 1997-02-27
DE69628864D1 (de) 2003-07-31

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