JP4177455B2 - 逆キメラおよびハイブリッドオリゴヌクレオチド - Google Patents
逆キメラおよびハイブリッドオリゴヌクレオチド Download PDFInfo
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- JP4177455B2 JP4177455B2 JP50953597A JP50953597A JP4177455B2 JP 4177455 B2 JP4177455 B2 JP 4177455B2 JP 50953597 A JP50953597 A JP 50953597A JP 50953597 A JP50953597 A JP 50953597A JP 4177455 B2 JP4177455 B2 JP 4177455B2
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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| US08/516,454 | 1995-08-17 | ||
| PCT/US1996/013371 WO1997006662A2 (en) | 1995-08-17 | 1996-08-16 | Inverted chimeric and hybrid oligonucleotides |
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| IL107150A0 (en) * | 1992-09-29 | 1993-12-28 | Isis Pharmaceuticals Inc | Oligonucleotides having a conserved g4 core sequence |
| DE69433036T2 (de) | 1993-09-03 | 2004-05-27 | Isis Pharmaceuticals, Inc., Carlsbad | Aminoderivatisierte nukleoside und oligonukleoside |
| US6420549B1 (en) | 1995-06-06 | 2002-07-16 | Isis Pharmaceuticals, Inc. | Oligonucleotide analogs having modified dimers |
| US5898031A (en) | 1996-06-06 | 1999-04-27 | Isis Pharmaceuticals, Inc. | Oligoribonucleotides for cleaving RNA |
| US9096636B2 (en) * | 1996-06-06 | 2015-08-04 | Isis Pharmaceuticals, Inc. | Chimeric oligomeric compounds and their use in gene modulation |
| US7875733B2 (en) | 2003-09-18 | 2011-01-25 | Isis Pharmaceuticals, Inc. | Oligomeric compounds comprising 4′-thionucleosides for use in gene modulation |
| US20030044941A1 (en) | 1996-06-06 | 2003-03-06 | Crooke Stanley T. | Human RNase III and compositions and uses thereof |
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| US5849902A (en) * | 1996-09-26 | 1998-12-15 | Oligos Etc. Inc. | Three component chimeric antisense oligonucleotides |
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| US20020165174A1 (en) * | 1997-01-31 | 2002-11-07 | Gill Parkash S. | Methods and compositions for antisense VEGF oligonucleotides |
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| ES2315442T3 (es) | 2009-04-01 |
| ATE243706T1 (de) | 2003-07-15 |
| DK1019428T3 (da) | 2003-09-22 |
| PT1019428E (pt) | 2003-10-31 |
| DE69637718D1 (de) | 2008-11-27 |
| EP1340765A2 (en) | 2003-09-03 |
| AU6953896A (en) | 1997-03-12 |
| US5773601A (en) | 1998-06-30 |
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| EP1340765A3 (en) | 2006-06-21 |
| ES2201198T3 (es) | 2004-03-16 |
| DE69628864T2 (de) | 2004-05-06 |
| EP1019428B1 (en) | 2003-06-25 |
| CA2229811A1 (en) | 1997-02-27 |
| WO1997006662A2 (en) | 1997-02-27 |
| DE69628864D1 (de) | 2003-07-31 |
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