BRPI0920679A2 - Células construídas expressando múltiplos imunomoduladores e usos das mesmas - Google Patents
Células construídas expressando múltiplos imunomoduladores e usos das mesmasInfo
- Publication number
- BRPI0920679A2 BRPI0920679A2 BRPI0920679A BRPI0920679A BRPI0920679A2 BR PI0920679 A2 BRPI0920679 A2 BR PI0920679A2 BR PI0920679 A BRPI0920679 A BR PI0920679A BR PI0920679 A BRPI0920679 A BR PI0920679A BR PI0920679 A2 BRPI0920679 A2 BR PI0920679A2
- Authority
- BR
- Brazil
- Prior art keywords
- immunomodulators
- expressing multiple
- cells constructed
- constructed expressing
- multiple immunomodulators
- Prior art date
Links
- 239000002955 immunomodulating agent Substances 0.000 title abstract 3
- 229940121354 immunomodulator Drugs 0.000 title abstract 3
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 102000013462 Interleukin-12 Human genes 0.000 abstract 1
- 108010065805 Interleukin-12 Proteins 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000014509 gene expression Effects 0.000 abstract 1
- 210000002865 immune cell Anatomy 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 229940117681 interleukin-12 Drugs 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
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- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Manufacturing & Machinery (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hematology (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10381008P | 2008-10-08 | 2008-10-08 | |
| PCT/US2009/005510 WO2010042189A2 (en) | 2008-10-08 | 2009-10-08 | Engineered cells expressing multiple immunomodulators and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0920679A2 true BRPI0920679A2 (pt) | 2022-05-17 |
Family
ID=42101134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0920679A BRPI0920679A2 (pt) | 2008-10-08 | 2009-10-08 | Células construídas expressando múltiplos imunomoduladores e usos das mesmas |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US9492482B2 (enExample) |
| EP (1) | EP2356219A4 (enExample) |
| JP (3) | JP2012504959A (enExample) |
| KR (2) | KR101361416B1 (enExample) |
| CN (1) | CN102575227A (enExample) |
| AU (3) | AU2009302804B2 (enExample) |
| BR (1) | BRPI0920679A2 (enExample) |
| CA (1) | CA2739902A1 (enExample) |
| IL (3) | IL212184A (enExample) |
| MX (1) | MX340972B (enExample) |
| RU (1) | RU2573912C2 (enExample) |
| WO (1) | WO2010042189A2 (enExample) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009045370A2 (en) | 2007-09-28 | 2009-04-09 | Intrexon Corporation | Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof |
| US20130195800A1 (en) * | 2010-03-23 | 2013-08-01 | Intrexon Corporation | Vectors Conditionally Expressing Therapeutic Proteins, Host Cells Comprising the Vectors, and Uses Thereof |
| US9402919B2 (en) * | 2011-03-04 | 2016-08-02 | Intrexon Corporation | Vectors conditionally expressing protein |
| PH12014500528A1 (en) * | 2011-09-08 | 2014-04-21 | Intrexon Corp | Crystalline diacylhydrazine and the use thereof |
| EP2755487B1 (en) * | 2011-09-16 | 2018-12-19 | Baylor College Of Medicine | Targeting the tumor microenvironment using manipulated nkt cells |
| US11951157B2 (en) | 2011-10-11 | 2024-04-09 | Universitat Zurich | Methods of treating malignant tumour with IL-12 and anti-PD-1 antibody |
| CA2850575C (en) * | 2011-10-11 | 2020-12-15 | Universitat Zurich Prorektorat Mnw | Combination medicament comprising il-12 and an agent for blockade of t-cell inhibitory molecules for tumour therapy |
| CN102631671B (zh) * | 2012-04-05 | 2014-11-26 | 倪国颖 | 提高疫苗诱导的细胞毒性t细胞反应的治疗性疫苗 |
| US10426794B2 (en) * | 2013-04-11 | 2019-10-01 | The Brigham And Women's Hospital, Inc. | Methods and compositions of treating autoimmune diseases |
| DK3461491T3 (da) * | 2013-04-18 | 2025-02-03 | Tilt Biotherapeutics Oy | Forbedret adoptiv celleterapi |
| US12421502B2 (en) | 2013-04-18 | 2025-09-23 | Tilt Biotherapeutics Oy | Enhanced adoptive cell therapy |
| KR20160137946A (ko) * | 2013-11-22 | 2016-12-02 | 디엔에이트릭스, 인코포레이티드 | 면역 세포 자극성 수용체 작용제(들)를 발현하는 아데노바이러스 |
| DK3597742T3 (da) * | 2014-10-09 | 2022-10-03 | Univ Yamaguchi | Car-udtrykkende vektor og car-udtrykkende t-celler |
| MA41538A (fr) * | 2014-10-17 | 2017-12-26 | Baylor College Medicine | Cellules immunitaires bipartites et tripartites de signalisation |
| JP6755465B2 (ja) * | 2014-12-03 | 2020-09-16 | 株式会社アネロファーマ・サイエンス | 共発現プラスミド |
| EP3808775B1 (en) | 2014-12-09 | 2024-04-17 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized cluster of differentiation 274 gene |
| EP3250682A4 (en) * | 2015-01-26 | 2018-08-01 | Fate Therapeutics, Inc. | Cells with increased immuno-regulatory properties and methods for their use and manufacture |
| EP3804741A3 (en) * | 2015-02-24 | 2021-07-14 | Board of Regents, The University of Texas System | Selection methods for genetically-modified t cells |
| EP3173092B1 (en) | 2015-04-22 | 2019-06-26 | CureVac AG | Rna containing composition for treatment of tumor diseases |
| US20170020922A1 (en) * | 2015-07-16 | 2017-01-26 | Batu Biologics Inc. | Gene editing for immunological destruction of neoplasia |
| AU2016334401A1 (en) | 2015-10-10 | 2018-04-26 | Intrexon Corporation | Improved therapeutic control of proteolytically sensitive, destabilized forms of interleukin-12 |
| SG11201803934YA (en) | 2015-11-11 | 2018-06-28 | Intrexon Corp | Compositions and methods for expression of multiple biologically active polypeptides from a single vector for treatment of cardiac conditions and other pathologies |
| SG11201805162VA (en) * | 2015-12-18 | 2018-07-30 | Oncosec Medical Inc | Plasmid constructs for heterologous protein expression and methods of use |
| WO2017118866A1 (en) | 2016-01-08 | 2017-07-13 | Replimune Limited | Engineered virus |
| AU2017235116B2 (en) * | 2016-03-17 | 2019-11-07 | Yamaguchi University | Immunocompetent cell and expression vector expressing regulatory factors of immune function |
| EP3443001B1 (en) | 2016-04-11 | 2025-04-30 | Obsidian Therapeutics, Inc. | REGULATED BIOCIRCUIT SYSTEMS |
| EP3468994A1 (en) | 2016-06-08 | 2019-04-17 | Intrexon Corporation | Cd33 specific chimeric antigen receptors |
| CN119950689A (zh) * | 2016-07-05 | 2025-05-09 | 北极星药业集团股份有限公司 | 使用精氨酸耗竭剂的组合癌症免疫疗法 |
| UY37343A (es) | 2016-07-25 | 2018-02-28 | Intrexon Corp | Control del fenotipo en plantas |
| JP2018023343A (ja) * | 2016-08-12 | 2018-02-15 | 国立大学法人山口大学 | 細胞培養用培地、及び細胞培養方法 |
| GB201700350D0 (en) | 2017-01-09 | 2017-02-22 | Replimune Ltd | Altered virus |
| CA3049652A1 (en) | 2017-01-10 | 2018-07-19 | Intrexon Corporation | Modulating expression of polypeptides via new gene switch expression systems |
| AU2018228308B2 (en) | 2017-02-28 | 2022-01-27 | Genemedicine Co., Ltd. | Anticancer composition comprising tumor-specific oncolytic adenovirus and immune checkpoint inhibitor |
| JP2020516654A (ja) | 2017-04-13 | 2020-06-11 | センティ バイオサイエンシズ インコーポレイテッド | 組み合わせがん免疫療法 |
| US11344578B2 (en) | 2017-04-19 | 2022-05-31 | Board Of Regents, The University Of Texas System | Immune cells expressing engineered antigen receptors |
| AU2018281316B2 (en) | 2017-06-07 | 2024-05-30 | Precigen, Inc. | Expression of novel cell tags |
| CN111133109A (zh) * | 2017-06-13 | 2020-05-08 | 昂科赛克医疗公司 | 用于免疫调节蛋白表达的多基因构建体和其使用方法 |
| WO2019144945A1 (en) | 2018-01-25 | 2019-08-01 | I-Mab | Anti-pd-l1 antibody and il-7 fusions |
| KR102222582B1 (ko) * | 2018-02-02 | 2021-03-04 | 주식회사 에스엘백시젠 | 신규 다가 hpv 백신 조성물 |
| KR102286397B1 (ko) * | 2018-02-02 | 2021-08-05 | 주식회사 에스엘백시젠 | 신규 백신 면역보조제 |
| WO2019165121A1 (en) | 2018-02-21 | 2019-08-29 | Board Of Regents, The University Of Texas System | Methods for activation and expansion of natural killer cells and uses therof |
| IL277128B2 (en) | 2018-03-06 | 2025-11-01 | Precigen Inc | Hepatitis b vaccines and uses of the same |
| US12404306B2 (en) | 2018-03-06 | 2025-09-02 | Precigen, Inc. | Human papillomavirus vaccines and uses of the same |
| JP2021523743A (ja) | 2018-05-15 | 2021-09-09 | カースゲン セラピューティクス カンパニー リミテッドCarsgen Therapeutics Co., Ltd. | 遺伝子操作された細胞及びその応用 |
| WO2019239216A2 (en) * | 2018-06-13 | 2019-12-19 | The Council Of The Queensland Institute Of Medical Research | Viral detection assay |
| CN113226337A (zh) * | 2018-06-27 | 2021-08-06 | 普莱西根股份有限公司 | 治疗癌症的体内受控联合疗法 |
| CN112823011B (zh) * | 2018-07-09 | 2026-05-08 | 加利福尼亚大学董事会 | 基于t细胞的免疫疗法的基因靶标 |
| US11419898B2 (en) | 2018-10-17 | 2022-08-23 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| TW202035685A (zh) | 2018-10-17 | 2020-10-01 | 美商聖堤生物科技股份有限公司 | 組合癌症免疫療法 |
| TWI850282B (zh) * | 2018-11-27 | 2024-08-01 | 香港商弘年發展有限公司 | 用於治療癌症之質體建構體和使用方法 |
| JP2022513639A (ja) * | 2018-11-29 | 2022-02-09 | ヴァイロジン バイオテック カナダ リミテッド | 低神経毒性hsvベクター |
| EP3897700A4 (en) * | 2018-12-17 | 2023-05-10 | Immune Design Corp. | PATHOGEN-ASSOCIATED MOLECULAR SAMPLE AND RNA-IMMUNOGENIC COMPOSITIONS AND METHODS OF USE OF THE COMPOSITIONS TO TREAT CANCER |
| WO2020206056A1 (en) | 2019-04-04 | 2020-10-08 | Greenvenus Llc | Peptides and methods of plant protection |
| EP3999092A4 (en) * | 2019-07-17 | 2023-08-09 | The Regents of the University of California | Combination cancer therapy agents and methods |
| CN110354260B (zh) * | 2019-08-19 | 2020-06-26 | 启辰生生物科技(珠海)有限公司 | 免疫增强剂、药物组合物及其应用 |
| CN110732021B (zh) * | 2019-11-21 | 2020-08-25 | 北京启辰生生物科技有限公司 | 用于解除肿瘤免疫抑制的组合物及其应用 |
| EP4061485A4 (en) * | 2019-11-22 | 2023-12-20 | Alaunos Therapeutics, Inc. | METHOD FOR TREATING GLIOBLASTOMA |
| CN110904050B (zh) * | 2019-12-16 | 2021-02-05 | 启辰生生物科技(珠海)有限公司 | 工程化抗原递呈细胞、免疫调节组合物及应用 |
| CN113005090A (zh) * | 2019-12-20 | 2021-06-22 | 上海细胞治疗集团有限公司 | 共表达趋化因子和共刺激分子的dc细胞及其应用 |
| US12508309B2 (en) * | 2020-02-18 | 2025-12-30 | Vacdiagn Biotechnology Co., Ltd. | Recombinant viral vector, immunogenic composition comprising same, and uses |
| WO2021185824A1 (en) * | 2020-03-16 | 2021-09-23 | Vrije Universiteit Brussel | A mixture of mrna to enhance the potency of dendritic cells |
| CN112029730A (zh) * | 2020-05-20 | 2020-12-04 | 深圳市芥至和生物科技有限公司 | 一种基因修饰的间充质干细胞及其应用 |
| CN115461450A (zh) * | 2020-06-09 | 2022-12-09 | 社会福祉法人三星生命公益财团 | 用于激活和增幅nk细胞的经基因改造的细胞系以及其用途 |
| EP4228610A1 (en) | 2020-10-13 | 2023-08-23 | Kriya Therapeutics, Inc. | Viral vector constructs for delivery of nucleic acids encoding cytokines and uses thereof for treating cancer |
| CN116426483B (zh) * | 2021-12-30 | 2024-02-23 | 南京紫珑生物科技有限公司 | Cd258蛋白在免疫治疗中的应用 |
| CN114426585B (zh) * | 2022-02-15 | 2023-10-03 | 广东香雪干细胞再生医学科技有限公司 | 融合蛋白及其表达细胞株与应用 |
| CN115433734B (zh) * | 2022-06-01 | 2025-03-04 | 北京奇糖科技有限公司 | 核酸片段及其在制备肿瘤疫苗中的应用 |
| CN119470910A (zh) * | 2024-11-01 | 2025-02-18 | 安徽医科大学 | 一种IL-12p70蛋白在认知障碍疾病中的应用 |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4228458A1 (de) | 1992-08-27 | 1994-06-01 | Beiersdorf Ag | Multicistronische Expressionseinheiten und deren Verwendung |
| JP3509100B2 (ja) | 1993-01-21 | 2004-03-22 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 哺乳動物のストレスプロモーターを利用する化合物の毒性測定方法および診断用キット |
| US5698413A (en) | 1993-05-05 | 1997-12-16 | The United States Of America As Represented By The Department Of Health And Human Services | Method of evaluating chemotherapeutic agents in vivo |
| US20040265288A1 (en) * | 1995-03-08 | 2004-12-30 | Gilman Michael Z. | New applications of gene therapy technology |
| US5744304A (en) | 1995-05-30 | 1998-04-28 | Board Of Regents, The University Of Texas System | Inflammation-induced expression of a recombinant gene |
| US6306649B1 (en) | 1995-06-27 | 2001-10-23 | Ariad Gene Therapeutics, Inc. | Heterologous transcription factors |
| US5922685A (en) | 1996-06-05 | 1999-07-13 | Powderject Vaccines, Inc. | IL-12 gene therapy of tumors |
| US20040086494A1 (en) | 1996-10-07 | 2004-05-06 | John Constance Mary | Immune privileged cells for delivery of proteins and peptides |
| DE69738072T2 (de) | 1996-10-29 | 2008-05-21 | Baylor College Of Medicine, Houston | Modifizierte steroid-hormon rezeptoren |
| US20040103448A1 (en) | 1997-09-05 | 2004-05-27 | Anders Bjorklund | Methods for inducing in vivo proliferation and migration of transplanted progenitor cells in the brain |
| CA2309766C (en) | 1997-11-20 | 2008-09-30 | Vical Incorporated | Treatment of cancer using cytokine-expressing polynucleotides and compositions therefor |
| US6617171B2 (en) | 1998-02-27 | 2003-09-09 | The General Hospital Corporation | Methods for diagnosing and treating autoimmune disease |
| US6866842B1 (en) | 1998-05-01 | 2005-03-15 | University Of Pittsburgh | Muscle-derived cells (MDCs) for treating muscle-or bone-related injury or dysfunction |
| US7279565B2 (en) | 1998-05-05 | 2007-10-09 | Richard Voellmy | Molecular regulatory circuits to achieve sustained activation of genes of interest by a single stress |
| CN1330557A (zh) | 1998-09-15 | 2002-01-09 | 匹兹堡大学联邦系统高等教育 | 原位注射具有基因上增进细胞因子表达的抗原呈递细胞 |
| AU1523900A (en) * | 1998-11-20 | 2000-06-13 | Valentis, Inc. | Adenoviral vector-mediated delivery of modified steroid hormone receptors and related products and methods |
| US6365385B1 (en) | 1999-03-22 | 2002-04-02 | Duke University | Methods of culturing and encapsulating pancreatic islet cells |
| US6696272B1 (en) | 1999-06-02 | 2004-02-24 | Hsc Research & Development Limited Partnership | Products and methods for gaucher disease therapy |
| CN1304578C (zh) | 2000-03-22 | 2007-03-14 | 罗姆和哈斯公司 | 新的基于蜕皮激素受体的可诱导的基因表达系统 |
| WO2002024899A2 (en) * | 2000-09-25 | 2002-03-28 | Valentis, Inc. | Improved system for regulation of transgene expression |
| US20030180719A1 (en) | 2001-04-13 | 2003-09-25 | Thomas Herget | Human cellular protein gastrointestinal glutathione peroxidase as target for medical intervention against hepatitis C virus infections |
| US20040235169A1 (en) | 2001-04-20 | 2004-11-25 | Evans Ronald M. | Inducible expression of transfected genes |
| US20030221203A1 (en) * | 2001-10-03 | 2003-11-27 | Agha-Mohammadi Siamak | High efficiency regulatable gene expression system |
| DK1448229T3 (da) * | 2001-11-29 | 2010-03-08 | Dandrit Biotech As | Farmaceutisk sammensætning til at inducere et immunrespons hos et menneske eller et dyr |
| GB0216286D0 (en) | 2002-07-15 | 2002-08-21 | Univ Leeds | Network |
| CA2502312A1 (en) * | 2002-10-14 | 2004-04-29 | F. Hoffmann-La Roche Ag | Transplantable cell with immune modulator |
| WO2004073641A2 (en) * | 2003-02-18 | 2004-09-02 | Kevin Slawin | Induced activation in dendritic cells |
| US7304162B2 (en) | 2003-02-21 | 2007-12-04 | Intrexon Corporation | Oxadiazoline ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
| CA2517245C (en) | 2003-02-28 | 2009-01-20 | Mcgill University | Cell and enzyme compositions for modulating bile acids, cholesterol and triglycerides |
| US7456315B2 (en) * | 2003-02-28 | 2008-11-25 | Intrexon Corporation | Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
| CA2519680A1 (en) * | 2003-03-28 | 2004-11-18 | The Scripps Research Institute | Adenovirus particles with enhanced infectivity of dendritic cells and particles with decreased infectivity of hepatocytes |
| DK1651161T3 (da) | 2003-08-07 | 2012-01-30 | Healor Ltd | Farmaceutiske præparater og fremgangsmåder til at fremme sårheling |
| WO2005033297A1 (en) | 2003-09-19 | 2005-04-14 | The Rockefeller University | Compositions, methods and kits relating to reprogramming adult differentiated cells and production of embryonic stem cell-like cells |
| US20070053845A1 (en) | 2004-03-02 | 2007-03-08 | Shiladitya Sengupta | Nanocell drug delivery system |
| US20050267027A1 (en) | 2004-04-05 | 2005-12-01 | Lounsbury Karen M | Use of erythropoietin for treatment of cancer |
| US7704714B2 (en) | 2004-07-26 | 2010-04-27 | Agency For Science, Technology & Research | Encapsulation of cells in biologic compatible scaffolds by coacervation of charged polymers |
| US20060067942A1 (en) | 2004-09-24 | 2006-03-30 | Salama Zoser B | Pharmaceutical agent comprising amino acids, peptides, proteins and/or fractions and fragments thereof and the use of same in the prophylaxis and treatment of immune system deficiency in humans and animals |
| CN101238214A (zh) | 2005-05-19 | 2008-08-06 | 拜尔先灵制药股份公司 | 使用改进的调节表达系统治疗疾病 |
| US7868159B2 (en) | 2005-06-23 | 2011-01-11 | Baylor College Of Medicine | Modulation of negative immune regulators and applications for immunotherapy |
| US20070036770A1 (en) | 2005-08-12 | 2007-02-15 | Wagner Darrell O | Biologic device for regulation of gene expression and method therefor |
| JP2009515933A (ja) | 2005-11-18 | 2009-04-16 | アレス トレーディング ソシエテ アノニム | インフルエンザにおけるインターフェロン |
| AU2006332971B2 (en) | 2005-12-30 | 2013-03-07 | Neurotech Usa, Inc. | Micronized device for the delivery of biologically active molecules and methods of use thereof |
| US20080181874A1 (en) * | 2007-01-29 | 2008-07-31 | Alexander Kharazi | Cell composition and method for treating cancer |
| US20080241100A1 (en) | 2007-03-27 | 2008-10-02 | Stefan Strobl | Pharmaceutical composition comprising a cytokine |
| MX2009012834A (es) * | 2007-05-29 | 2010-05-17 | Intrexon Corp | Ligandos quirales de diacilhidrazina para modular la expresion de genes exogenos por medio de un complejo receptor de ecdisona. |
| WO2009009115A2 (en) | 2007-07-11 | 2009-01-15 | Nevsky Pharmaceutical Development | Liposome compositions for treatment of hepatitis c |
| AU2008289461A1 (en) | 2007-08-23 | 2009-02-26 | Intrexon Corporation | Methods and compositions for diagnosing disease |
| WO2009045370A2 (en) | 2007-09-28 | 2009-04-09 | Intrexon Corporation | Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof |
| RU2484132C2 (ru) * | 2007-10-08 | 2013-06-10 | Интрексон Корпорейшн | Модифицированные дендритные клетки и их применение в лечении злокачественных опухолей |
| US20130195800A1 (en) | 2010-03-23 | 2013-08-01 | Intrexon Corporation | Vectors Conditionally Expressing Therapeutic Proteins, Host Cells Comprising the Vectors, and Uses Thereof |
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