BRPI0818119A2 - Uma nova classe de produtos terapêuticos que melhoram difusão de molécula pequena - Google Patents
Uma nova classe de produtos terapêuticos que melhoram difusão de molécula pequenaInfo
- Publication number
- BRPI0818119A2 BRPI0818119A2 BRPI0818119-5A BRPI0818119A BRPI0818119A2 BR PI0818119 A2 BRPI0818119 A2 BR PI0818119A2 BR PI0818119 A BRPI0818119 A BR PI0818119A BR PI0818119 A2 BRPI0818119 A2 BR PI0818119A2
- Authority
- BR
- Brazil
- Prior art keywords
- small molecule
- new class
- therapeutic products
- molecule diffusion
- improve small
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US109507P | 2007-10-31 | 2007-10-31 | |
PCT/US2008/012440 WO2009058399A1 (en) | 2007-10-31 | 2008-10-31 | A new class of therapeutics that enhance small molecule diffusion |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0818119A2 true BRPI0818119A2 (pt) | 2015-08-04 |
Family
ID=40583148
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0818119-5A BRPI0818119A2 (pt) | 2007-10-31 | 2008-10-31 | Uma nova classe de produtos terapêuticos que melhoram difusão de molécula pequena |
Country Status (13)
Country | Link |
---|---|
US (2) | US8206751B2 (pt) |
EP (1) | EP2214714A4 (pt) |
JP (2) | JP2011502125A (pt) |
KR (1) | KR20100083820A (pt) |
CN (1) | CN101878040A (pt) |
AU (1) | AU2008319225B2 (pt) |
BR (1) | BRPI0818119A2 (pt) |
CA (1) | CA2703946A1 (pt) |
EA (1) | EA201070544A1 (pt) |
IL (1) | IL205417A0 (pt) |
MX (1) | MX2010004803A (pt) |
WO (1) | WO2009058399A1 (pt) |
ZA (1) | ZA201003475B (pt) |
Families Citing this family (32)
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EA200401111A1 (ru) * | 2002-02-25 | 2005-02-24 | Диффьюжн Фармасьютикалз Ллс | Биполярные соли транс-каротиноидов и их применение |
US7759506B2 (en) | 2002-02-25 | 2010-07-20 | Diffusion Pharmaceuticals Llc | Bipolar trans carotenoid salts and their uses |
MX2007010359A (es) * | 2005-02-24 | 2008-04-04 | Diffusion Pharmaceuticals Llc | Trans carotenoides, su sintesis, formulacion y usos. |
EP2198869B1 (en) * | 2007-02-23 | 2015-09-16 | Next 21 K.K. | Trehalose for the treatment or prevention of vasospasm |
EP2146948A4 (en) | 2007-04-13 | 2010-08-04 | Diffusion Pharmaceuticals Llc | USE OF BIPOLAR TRANS-CAROTINOIDES AS PRE-TREATMENT AND TREATMENT OF PERIPHERAL VASCULAR DISEASE |
BRPI0818119A2 (pt) | 2007-10-31 | 2015-08-04 | Diffusion Pharmaceuticals Llc | Uma nova classe de produtos terapêuticos que melhoram difusão de molécula pequena |
ES2562798T3 (es) * | 2008-08-09 | 2016-03-08 | Merck Patent Gmbh | Uso de compuestos de indol como cosmético |
EP2445339B1 (en) | 2009-06-22 | 2019-08-07 | Diffusion Pharmaceuticals LLC | Diffusion enhancing compound and its use with a thrombolytic |
EP2575487B1 (en) | 2010-06-02 | 2017-10-18 | Diffusion Pharmaceuticals Llc | Oral formulations of bipolar trans carotenoids |
CN102372623A (zh) * | 2010-08-27 | 2012-03-14 | 江苏天晟药业有限公司 | 藏红花酸二铵盐 |
US20130323166A1 (en) * | 2010-09-10 | 2013-12-05 | William Beaumont Hospital | Radiation Therapy for Treating Alzheimer's Disease |
US20120171184A1 (en) * | 2010-12-31 | 2012-07-05 | Lajos Szente | Cellular hydration compositions |
WO2012090018A1 (en) | 2010-12-31 | 2012-07-05 | Eastpond Laboratories Limited | Cellular hydration compositions containing cyclodextrins |
CN102210685B (zh) * | 2011-04-29 | 2013-01-30 | 济南环肽医药科技有限公司 | 四氢嘧啶及其衍生物在制备预防和治疗化疗药物引发的口腔粘膜炎药物中的应用 |
CN102210868A (zh) * | 2011-04-29 | 2011-10-12 | 济南环肽医药科技有限公司 | 四氢嘧啶及其衍生物在制备口服吸收促进剂中的应用 |
CN102210869B (zh) * | 2011-04-29 | 2012-07-25 | 山东弘立医学动物实验研究有限公司 | 四氢嘧啶及其衍生物在制备透皮吸收促进剂中的应用 |
CN102847161A (zh) * | 2011-06-30 | 2013-01-02 | 山东弘立医学动物实验研究有限公司 | 四氢嘧啶及其衍生物在制备药物肺部收促进剂中的应用 |
CN102274238B (zh) * | 2011-06-30 | 2012-10-03 | 山东弘立医学动物实验研究有限公司 | 一种治疗胰腺癌的药物组合物 |
CN102302498B (zh) * | 2011-08-22 | 2012-10-03 | 济南环肽医药科技有限公司 | 一种治疗肾炎的药物 |
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EP2994145B1 (en) | 2013-05-07 | 2023-01-04 | Bio Blast Pharma Ltd. | Treatment of oculopharyngeal muscular dystrophy by intravenous administration of trehalose |
US20150345882A1 (en) * | 2014-06-03 | 2015-12-03 | Magpul Industries Corp | Compact anti-tilt follower for an ammunition magazine |
CN104069110A (zh) * | 2014-07-14 | 2014-10-01 | 济南环肽医药科技有限公司 | 四氢嘧啶及其衍生物在制备血容量扩充药物中的应用 |
JP7032320B2 (ja) * | 2016-03-24 | 2022-03-08 | ディフュージョン・ファーマシューティカルズ・エルエルシー | 癌を処置するための、化学療法及び放射線療法を伴う二極性トランスカロテノイドの使用 |
EP3600337A4 (en) | 2017-03-31 | 2020-12-30 | The Florey Institute Of Neuroscience And Mental Health | PROPHYLAXIS AND TREATMENT OF COGNITIVE DYSFUNCTION AND DECLINE |
JP2017155046A (ja) * | 2017-04-05 | 2017-09-07 | イーストポンド・ラボラトリーズ・リミテッド | シクロデキストリンを含有する細胞水和組成物 |
CA3140941C (en) * | 2017-11-16 | 2024-01-02 | Aivita Biomedical, Inc. | Use of cell membrane-bound signaling factors |
JP2019178154A (ja) * | 2019-06-18 | 2019-10-17 | イーストポンド・ラボラトリーズ・リミテッド | シクロデキストリンを含有する細胞水和組成物 |
EP4132294A1 (en) | 2020-04-06 | 2023-02-15 | Eastpond Laboratories Limited | Compositions for promoting cellular hydration |
KR102453320B1 (ko) | 2022-04-29 | 2022-10-11 | 장세진 | 유속 증가 기능을 갖는 수류터빈 및 이를 활용한 수류발전 시스템 |
WO2024006901A1 (en) * | 2022-06-29 | 2024-01-04 | Diffusion Pharmaceuticals Llc | Uses of bipolar trans carotenoids in the treatment of cancer |
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-
2008
- 2008-10-31 BR BRPI0818119-5A patent/BRPI0818119A2/pt not_active IP Right Cessation
- 2008-10-31 EP EP08844993A patent/EP2214714A4/en not_active Withdrawn
- 2008-10-31 US US12/289,713 patent/US8206751B2/en active Active
- 2008-10-31 KR KR1020107010445A patent/KR20100083820A/ko active IP Right Grant
- 2008-10-31 JP JP2010531078A patent/JP2011502125A/ja not_active Ceased
- 2008-10-31 WO PCT/US2008/012440 patent/WO2009058399A1/en active Application Filing
- 2008-10-31 MX MX2010004803A patent/MX2010004803A/es not_active Application Discontinuation
- 2008-10-31 EA EA201070544A patent/EA201070544A1/ru unknown
- 2008-10-31 AU AU2008319225A patent/AU2008319225B2/en not_active Expired - Fee Related
- 2008-10-31 CN CN2008801143109A patent/CN101878040A/zh active Pending
- 2008-10-31 CA CA2703946A patent/CA2703946A1/en not_active Abandoned
-
2010
- 2010-04-28 IL IL205417A patent/IL205417A0/en unknown
- 2010-05-17 ZA ZA2010/03475A patent/ZA201003475B/en unknown
-
2012
- 2012-06-22 US US13/507,365 patent/US20130018014A1/en not_active Abandoned
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2015
- 2015-08-13 JP JP2015159872A patent/JP2016026156A/ja active Pending
Also Published As
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---|---|
WO2009058399A1 (en) | 2009-05-07 |
EP2214714A4 (en) | 2011-01-12 |
CA2703946A1 (en) | 2009-05-07 |
MX2010004803A (es) | 2010-09-09 |
IL205417A0 (en) | 2010-12-30 |
AU2008319225B2 (en) | 2016-09-29 |
ZA201003475B (en) | 2011-10-26 |
JP2011502125A (ja) | 2011-01-20 |
US20130018014A1 (en) | 2013-01-17 |
US20090110746A1 (en) | 2009-04-30 |
AU2008319225A1 (en) | 2009-05-07 |
JP2016026156A (ja) | 2016-02-12 |
KR20100083820A (ko) | 2010-07-22 |
US8206751B2 (en) | 2012-06-26 |
EP2214714A1 (en) | 2010-08-11 |
EA201070544A1 (ru) | 2010-12-30 |
CN101878040A (zh) | 2010-11-03 |
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