BRPI0708909B8 - uso de um anticorpo que se liga a c5 para tratar um paciente que sofre de hemoglobinúria paroxística noturna - Google Patents
uso de um anticorpo que se liga a c5 para tratar um paciente que sofre de hemoglobinúria paroxística noturnaInfo
- Publication number
- BRPI0708909B8 BRPI0708909B8 BRPI0708909A BRPI0708909A BRPI0708909B8 BR PI0708909 B8 BRPI0708909 B8 BR PI0708909B8 BR PI0708909 A BRPI0708909 A BR PI0708909A BR PI0708909 A BRPI0708909 A BR PI0708909A BR PI0708909 B8 BRPI0708909 B8 BR PI0708909B8
- Authority
- BR
- Brazil
- Prior art keywords
- eculizumab
- paroxysmal nocturnal
- nocturnal hemoglobinuria
- patients
- hpn
- Prior art date
Links
- 208000000733 Paroxysmal Hemoglobinuria Diseases 0.000 title abstract 3
- 102100036050 Phosphatidylinositol N-acetylglucosaminyltransferase subunit A Human genes 0.000 title abstract 3
- 201000003045 paroxysmal nocturnal hemoglobinuria Diseases 0.000 title abstract 3
- 229960002224 eculizumab Drugs 0.000 abstract 4
- 206010018910 Haemolysis Diseases 0.000 abstract 2
- 102000001554 Hemoglobins Human genes 0.000 abstract 2
- 108010054147 Hemoglobins Proteins 0.000 abstract 2
- 206010022822 Intravascular haemolysis Diseases 0.000 abstract 2
- 230000001684 chronic effect Effects 0.000 abstract 2
- 238000012216 screening Methods 0.000 abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 229940124073 Complement inhibitor Drugs 0.000 abstract 1
- 230000024203 complement activation Effects 0.000 abstract 1
- 239000004074 complement inhibitor Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 239000000902 placebo Substances 0.000 abstract 1
- 229940068196 placebo Drugs 0.000 abstract 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Psychiatry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Pain & Pain Management (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR122017024057A BR122017024057B8 (pt) | 2006-03-15 | 2007-03-15 | anticorpo que se liga à c5 e composição farmacêutica compreendendo dito anticorpo e um veículo farmaceuticamente aceitável |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78307006P | 2006-03-15 | 2006-03-15 | |
US60/783,070 | 2006-03-15 | ||
PCT/US2007/006606 WO2007106585A1 (en) | 2006-03-15 | 2007-03-15 | Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0708909A2 BRPI0708909A2 (pt) | 2011-06-14 |
BRPI0708909B1 BRPI0708909B1 (pt) | 2021-02-09 |
BRPI0708909B8 true BRPI0708909B8 (pt) | 2021-05-25 |
Family
ID=38222520
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR122017024057A BR122017024057B8 (pt) | 2006-03-15 | 2007-03-15 | anticorpo que se liga à c5 e composição farmacêutica compreendendo dito anticorpo e um veículo farmaceuticamente aceitável |
BRPI0708909A BRPI0708909B8 (pt) | 2006-03-15 | 2007-03-15 | uso de um anticorpo que se liga a c5 para tratar um paciente que sofre de hemoglobinúria paroxística noturna |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR122017024057A BR122017024057B8 (pt) | 2006-03-15 | 2007-03-15 | anticorpo que se liga à c5 e composição farmacêutica compreendendo dito anticorpo e um veículo farmaceuticamente aceitável |
Country Status (17)
Country | Link |
---|---|
US (8) | US20090220508A1 (pt) |
EP (5) | EP4316465A3 (pt) |
JP (8) | JP2009530299A (pt) |
KR (2) | KR20080110800A (pt) |
AU (1) | AU2007225044C1 (pt) |
BR (2) | BR122017024057B8 (pt) |
CA (2) | CA2645810C (pt) |
DK (1) | DK2359834T5 (pt) |
ES (2) | ES2612118T3 (pt) |
HK (1) | HK1161119A1 (pt) |
HU (1) | HUE030105T2 (pt) |
IL (4) | IL302157A (pt) |
MX (2) | MX340784B (pt) |
PL (1) | PL2359834T3 (pt) |
PT (1) | PT2359834T (pt) |
SI (1) | SI2359834T1 (pt) |
WO (1) | WO2007106585A1 (pt) |
Families Citing this family (116)
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US20050271660A1 (en) | 2002-09-06 | 2005-12-08 | Alexion Pharmaceuticals, Inc. | Nebulization of monoclonal antibodies for treating pulmonary diseases |
EP2845865A1 (en) | 2004-11-12 | 2015-03-11 | Xencor Inc. | Fc variants with altered binding to FcRn |
US20090220508A1 (en) | 2006-03-15 | 2009-09-03 | Alexion Pharmaceuticals, Inc. | Treatment Of Paroxysmal Nocturnal Hemoglobinuria Patients By An Inhibitor Of Complement |
JP5624276B2 (ja) | 2006-03-31 | 2014-11-12 | 中外製薬株式会社 | 抗体の血中動態を制御する方法 |
EP3689912A1 (en) | 2007-09-26 | 2020-08-05 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in cdr |
EP3575317A1 (en) * | 2007-12-26 | 2019-12-04 | Xencor, Inc. | Fc variants with altered binding to fcrn |
TWI564021B (zh) | 2008-04-11 | 2017-01-01 | Chugai Pharmaceutical Co Ltd | Repeated binding of antigen to antigen binding molecules |
MX356218B (es) | 2008-08-05 | 2018-05-18 | Novartis Ag | Composiciones y métodos para anticuerpos que se dirigen a la proteína de complemento c5. |
ES2940466T3 (es) * | 2008-11-10 | 2023-05-08 | Alexion Pharma Inc | Métodos y composiciones para tratar trastornos asociados al complemento |
WO2011057250A1 (en) * | 2009-11-09 | 2011-05-12 | Alexion Pharmaceuticals, Inc. | Reagents and methods for detecting pnh type ii white blood cells and their identification as risk factors for thrombotic disorders |
US20120100166A1 (en) | 2010-07-15 | 2012-04-26 | Zyngenia, Inc. | Ang-2 Binding Complexes and Uses Thereof |
TW201241008A (en) * | 2010-10-01 | 2012-10-16 | Alexion Pharma Inc | Polypeptides that bind to human complement component C5 |
MX365235B (es) | 2010-11-30 | 2019-05-28 | Chugai Pharmaceutical Co Ltd | Molécula de unión a antígeno capaz de unir repetidamente a la pluralidad de moléculas de antígeno. |
US20140088019A1 (en) | 2011-02-11 | 2014-03-27 | Zyngenia, Inc. | Monovalent and Multivalent Multispecific Complexes and Uses Thereof |
CN106432506A (zh) | 2011-05-24 | 2017-02-22 | 泽恩格尼亚股份有限公司 | 多价和单价多特异性复合物及其用途 |
CN106831985A (zh) | 2011-12-21 | 2017-06-13 | 诺华股份有限公司 | 用于抗体靶定p因子的组合物和方法 |
KR102336895B1 (ko) | 2012-02-20 | 2021-12-08 | 스위디쉬 오르펀 바이오비트럼 에이비 (피유비엘) | 인간 보체 c5에 결합하는 폴리펩티드 |
CN104205155A (zh) * | 2012-03-16 | 2014-12-10 | 亚力克恩制药公司 | 给接受补体抑制剂的患者分配补体抑制药物的方法 |
TWI635098B (zh) | 2013-02-01 | 2018-09-11 | 再生元醫藥公司 | 含嵌合恆定區之抗體 |
EA201890895A1 (ru) | 2013-03-15 | 2019-02-28 | Зинджения, Инк. | Мультивалентные и моновалентные мультиспецифические комплексы и их применение |
US20160051673A1 (en) * | 2013-03-29 | 2016-02-25 | Alexion Pharmaceuticals, Inc. | Compositions and methods for increasing the serum half-life of a therapeutic agent targeting complement c5 |
DK3039033T3 (da) | 2013-08-28 | 2019-08-26 | Affibody Ab | Bindende polypeptider, der har et muteret skelet |
RU2733897C2 (ru) * | 2013-08-28 | 2020-10-09 | Сведиш Орфан Биовитрум Аб (Пабл) | Стабильные полипептиды, связывающиеся с с5 комплемента человека |
US20150104445A1 (en) | 2013-10-10 | 2015-04-16 | Viropharma Holdings Limited | Methods of inhibiting the alternative pathway of complement immune system activation and compositions used therein |
NZ711451A (en) | 2014-03-07 | 2016-05-27 | Alexion Pharma Inc | Anti-c5 antibodies having improved pharmacokinetics |
TWI701042B (zh) | 2014-03-19 | 2020-08-11 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
NZ727420A (en) | 2014-06-12 | 2018-06-29 | Ra Pharmaceuticals Inc | Modulation of complement activity |
IL279606B (en) | 2014-08-08 | 2022-08-01 | Alector Llc | Anti-trem2 antibodies and methods of using them |
DK3200791T3 (da) | 2014-09-29 | 2020-05-25 | Chemocentryx Inc | Fremgangsmåder og mellemprodukter i fremstilling af C5AR- antagonister |
JP6948942B2 (ja) | 2014-10-15 | 2021-10-13 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | タンパク質産物の等電性プロファイルをシフトさせる方法およびその使用 |
JP6778185B2 (ja) * | 2014-10-15 | 2020-10-28 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 細胞を培養する方法 |
TR201903267T4 (tr) | 2014-10-15 | 2019-03-21 | Alexion Pharma Inc | Büyük ölçekli eculizumab üretim hücre kültürünün replikasyon metotları. |
KR102614189B1 (ko) | 2014-11-17 | 2023-12-18 | 리제너론 파아마슈티컬스, 인크. | Cd3xcd20 이특이적 항체를 이용한 종양의 치료 방법 |
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CN107428823B (zh) | 2015-01-22 | 2021-10-26 | 中外制药株式会社 | 两种以上抗-c5抗体的组合与使用方法 |
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PL3280441T3 (pl) | 2015-04-07 | 2022-02-21 | Alector Llc | Przeciwciała przeciwko sortilinie i sposoby ich stosowania |
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2018
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2019
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2020
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2021
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