MX340784B - Inhibidores de complemento para usarse en el tratamiento de pacientes con hemoglobinuria paroxística nocturna. - Google Patents
Inhibidores de complemento para usarse en el tratamiento de pacientes con hemoglobinuria paroxística nocturna.Info
- Publication number
- MX340784B MX340784B MX2008011735A MX2008011735A MX340784B MX 340784 B MX340784 B MX 340784B MX 2008011735 A MX2008011735 A MX 2008011735A MX 2008011735 A MX2008011735 A MX 2008011735A MX 340784 B MX340784 B MX 340784B
- Authority
- MX
- Mexico
- Prior art keywords
- eculizumab
- pnh
- patients
- paroxysmal nocturnal
- nocturnal hemoglobinuria
- Prior art date
Links
- 208000000733 Paroxysmal Hemoglobinuria Diseases 0.000 title abstract 5
- 102100036050 Phosphatidylinositol N-acetylglucosaminyltransferase subunit A Human genes 0.000 title abstract 5
- 201000003045 paroxysmal nocturnal hemoglobinuria Diseases 0.000 title abstract 5
- 230000000295 complement effect Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 229960002224 eculizumab Drugs 0.000 abstract 4
- 206010018910 Haemolysis Diseases 0.000 abstract 2
- 102000001554 Hemoglobins Human genes 0.000 abstract 2
- 108010054147 Hemoglobins Proteins 0.000 abstract 2
- 206010022822 Intravascular haemolysis Diseases 0.000 abstract 2
- 230000001684 chronic effect Effects 0.000 abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 230000024203 complement activation Effects 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229940068196 placebo Drugs 0.000 abstract 1
- 239000000902 placebo Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Abstract
La presente invención se refiere a una composición farmacéutica para usarse en el tratamiento de un paciente afectado con Hemoglobinuria Paroxística Nocturna (PNH), en donde la composición es una forma de dosis de un solo uso de 300 mg de eculizumab que comprende 30 Ml de una solución estéril de 10 mg de eculizumab/ml, libre de conservadores.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78307006P | 2006-03-15 | 2006-03-15 | |
PCT/US2007/006606 WO2007106585A1 (en) | 2006-03-15 | 2007-03-15 | Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2008011735A MX2008011735A (es) | 2009-02-06 |
MX340784B true MX340784B (es) | 2016-07-26 |
Family
ID=38222520
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2008011735A MX340784B (es) | 2006-03-15 | 2007-03-15 | Inhibidores de complemento para usarse en el tratamiento de pacientes con hemoglobinuria paroxística nocturna. |
MX2022002589A MX2022002589A (es) | 2006-03-15 | 2008-09-12 | Inhibidores de complemento para usarse en el tratamiento de pacientes con hemoglobinuria paroxistica nocturna. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022002589A MX2022002589A (es) | 2006-03-15 | 2008-09-12 | Inhibidores de complemento para usarse en el tratamiento de pacientes con hemoglobinuria paroxistica nocturna. |
Country Status (17)
Country | Link |
---|---|
US (8) | US20090220508A1 (es) |
EP (5) | EP4316465A3 (es) |
JP (8) | JP2009530299A (es) |
KR (2) | KR20140057635A (es) |
AU (1) | AU2007225044C1 (es) |
BR (2) | BR122017024057B8 (es) |
CA (2) | CA2645810C (es) |
DK (1) | DK2359834T5 (es) |
ES (2) | ES2965283T1 (es) |
HK (1) | HK1161119A1 (es) |
HU (1) | HUE030105T2 (es) |
IL (4) | IL302157A (es) |
MX (2) | MX340784B (es) |
PL (1) | PL2359834T3 (es) |
PT (1) | PT2359834T (es) |
SI (1) | SI2359834T1 (es) |
WO (1) | WO2007106585A1 (es) |
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