ES2965283T1 - Tratamiento de pacientes con hemoglobinuria paroxística nocturna mediante un inhibidor del complemento - Google Patents
Tratamiento de pacientes con hemoglobinuria paroxística nocturna mediante un inhibidor del complemento Download PDFInfo
- Publication number
- ES2965283T1 ES2965283T1 ES16195355T ES16195355T ES2965283T1 ES 2965283 T1 ES2965283 T1 ES 2965283T1 ES 16195355 T ES16195355 T ES 16195355T ES 16195355 T ES16195355 T ES 16195355T ES 2965283 T1 ES2965283 T1 ES 2965283T1
- Authority
- ES
- Spain
- Prior art keywords
- eculizumab
- patients
- pnh
- paroxysmal nocturnal
- nocturnal hemoglobinuria
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 208000000733 Paroxysmal Hemoglobinuria Diseases 0.000 title abstract 5
- 102100036050 Phosphatidylinositol N-acetylglucosaminyltransferase subunit A Human genes 0.000 title abstract 5
- 201000003045 paroxysmal nocturnal hemoglobinuria Diseases 0.000 title abstract 5
- 229940124073 Complement inhibitor Drugs 0.000 title 1
- 239000004074 complement inhibitor Substances 0.000 title 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229960002224 eculizumab Drugs 0.000 abstract 4
- 206010018910 Haemolysis Diseases 0.000 abstract 2
- 102000001554 Hemoglobins Human genes 0.000 abstract 2
- 108010054147 Hemoglobins Proteins 0.000 abstract 2
- 206010022822 Intravascular haemolysis Diseases 0.000 abstract 2
- 230000001684 chronic effect Effects 0.000 abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 230000024203 complement activation Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229940068196 placebo Drugs 0.000 abstract 1
- 239000000902 placebo Substances 0.000 abstract 1
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A61K38/00—Medicinal preparations containing peptides
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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Abstract
Eculizumab, un anticuerpo monoclonal humanizado contra C5 que inhibe la activación del complemento terminal, mostró actividad en un ensayo preliminar abierto de 12 semanas en una pequeña cohorte de pacientes con hemoglobinuria paroxística nocturna (HPN). El presente estudio examinó si la terapia crónica con eculizumab podría reducir la hemólisis intravascular, estabilizar los niveles de hemoglobina, reducir los requisitos de transfusión y mejorar la calidad de vida en un ensayo de fase III global, multicéntrico, doble ciego, aleatorizado, controlado con placebo. Se ha descubierto que eculizumab estabilizó los niveles de hemoglobina, disminuyó la necesidad de transfusiones y mejoró la calidad de vida en pacientes con HPN mediante una reducción de la hemólisis intravascular. El tratamiento crónico con eculizumab parece ser una terapia segura y eficaz para la HPN. (Traducción automática con Google Translate, sin valor legal)
Claims (3)
1. Un anticuerpo que se une a C5 que comprende una c
ligera que comprende SEQ ID NOS: 8, 9 y 10.
2. El anticuerpo de la reivindicación 1 que comprende un
3. Una composición farmacéutica que comprende el anticCIONES
na pesada que consiste en SEQ ID NO: 2 y una cadena
adena ligera que consiste en SEQ ID NO: 4.
rpo de la reivindicación 1 o 2.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78307006P | 2006-03-15 | 2006-03-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2965283T1 true ES2965283T1 (es) | 2024-04-11 |
ES2965283T3 ES2965283T3 (es) | 2024-05-28 |
Family
ID=38222520
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES11001632.6T Active ES2612118T3 (es) | 2006-03-15 | 2007-03-15 | Tratamiento de pacientes de hemoglobinuria nocturna paroxística mediante un inhibidor del complemento |
ES16195355T Active ES2965283T3 (es) | 2006-03-15 | 2007-03-15 | Tratamiento de pacientes con hemoglobinuria paroxística nocturna mediante un inhibidor del complemento |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES11001632.6T Active ES2612118T3 (es) | 2006-03-15 | 2007-03-15 | Tratamiento de pacientes de hemoglobinuria nocturna paroxística mediante un inhibidor del complemento |
Country Status (17)
Country | Link |
---|---|
US (8) | US20090220508A1 (es) |
EP (5) | EP3124029A1 (es) |
JP (8) | JP2009530299A (es) |
KR (2) | KR20080110800A (es) |
AU (1) | AU2007225044C1 (es) |
BR (2) | BR122017024057B8 (es) |
CA (2) | CA2645810C (es) |
DK (1) | DK2359834T5 (es) |
ES (2) | ES2612118T3 (es) |
HK (1) | HK1161119A1 (es) |
HU (1) | HUE030105T2 (es) |
IL (4) | IL302157A (es) |
MX (2) | MX340784B (es) |
PL (1) | PL2359834T3 (es) |
PT (1) | PT2359834T (es) |
SI (1) | SI2359834T1 (es) |
WO (1) | WO2007106585A1 (es) |
Families Citing this family (116)
Publication number | Priority date | Publication date | Assignee | Title |
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US20050271660A1 (en) | 2002-09-06 | 2005-12-08 | Alexion Pharmaceuticals, Inc. | Nebulization of monoclonal antibodies for treating pulmonary diseases |
KR101027427B1 (ko) | 2004-11-12 | 2011-04-11 | 젠코어 인코포레이티드 | FcRn에 대하여 증가된 결합력을 갖는 Fc 변이체 |
DK2359834T5 (en) | 2006-03-15 | 2017-02-06 | Alexion Pharma Inc | Treatment of paroxysmal nocturnal hemoglobinuria patients with a complement inhibitor |
US11046784B2 (en) | 2006-03-31 | 2021-06-29 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
MX369784B (es) | 2007-09-26 | 2019-11-21 | Chugai Pharmaceutical Co Ltd | Metodo de modificacion del punto isoelectrico de anticuerpos mediante la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr). |
SI2235059T1 (sl) * | 2007-12-26 | 2015-06-30 | Xencor, Inc. | Fc variante s spremenjeno vezjo na fcrn |
DK2708559T3 (en) | 2008-04-11 | 2018-06-14 | Chugai Pharmaceutical Co Ltd | Antigen-binding molecule capable of repeatedly binding two or more antigen molecules |
EP2815766B1 (en) | 2008-08-05 | 2017-07-05 | Novartis AG | Compositions and methods for antibodies targeting complement protein C5 |
PT2894165T (pt) * | 2008-11-10 | 2023-03-17 | Alexion Pharma Inc | Métodos e composições para o tratamento de distúrbios associados ao complemento |
RU2012124090A (ru) * | 2009-11-09 | 2013-12-20 | Алексион Фармасьютикалз, Инк. | Реагенты и способы для определения клеток ii типа при pnh |
WO2012009705A1 (en) | 2010-07-15 | 2012-01-19 | Zyngenia, Inc. | Ang-2 binding complexes and uses thereof |
TW201241008A (en) * | 2010-10-01 | 2012-10-16 | Alexion Pharma Inc | Polypeptides that bind to human complement component C5 |
CN108715614A (zh) | 2010-11-30 | 2018-10-30 | 中外制药株式会社 | 与多分子的抗原重复结合的抗原结合分子 |
CA2827170A1 (en) | 2011-02-11 | 2012-08-16 | David M. Hilbert | Monovalent and multivalent multispecific complexes and uses thereof |
WO2012162561A2 (en) | 2011-05-24 | 2012-11-29 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
AU2012356170B2 (en) | 2011-12-21 | 2016-06-16 | Novartis Ag | Compositions and methods for antibodies targeting Factor P |
WO2013126006A1 (en) | 2012-02-20 | 2013-08-29 | Swedish Orphan Biovitrum Ab (Publ) | Polypeptides binding to human complement c5 |
EA201400950A1 (ru) * | 2012-03-16 | 2014-12-30 | Алексион Фармасьютикалс, Инк. | Способы распространения комплемент-ингибирующих лекарственных средств среди пациентов, получающих ингибитор комплемента |
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WO2014144600A2 (en) | 2013-03-15 | 2014-09-18 | Viktor Roschke | Multivalent and monovalent multispecific complexes and their uses |
ES2768648T3 (es) * | 2013-03-29 | 2020-06-23 | Alexion Pharma Inc | Composiciones y métodos para aumentar la semivida en suero de un agente terapéutico dirigido a C5 del complemento |
WO2015028558A1 (en) | 2013-08-28 | 2015-03-05 | Swedish Orphan Biovitrum Ab (Publ) | Stable polypeptides binding to human complement c5 |
JP7138411B2 (ja) | 2013-08-28 | 2022-09-16 | アフィボディ・アーベー | 変異した骨格を有する結合ポリペプチド |
US20150104445A1 (en) | 2013-10-10 | 2015-04-16 | Viropharma Holdings Limited | Methods of inhibiting the alternative pathway of complement immune system activation and compositions used therein |
NZ631007A (en) * | 2014-03-07 | 2015-10-30 | Alexion Pharma Inc | Anti-c5 antibodies having improved pharmacokinetics |
TWI701042B (zh) | 2014-03-19 | 2020-08-11 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
EP4223317A3 (en) | 2014-06-12 | 2023-09-27 | RA Pharmaceuticals, Inc. | Modulation of complement activity |
MX2017001531A (es) | 2014-08-08 | 2017-05-15 | Alector Llc | Anticuerpos anti-trem2 y metodos de uso de los mismos. |
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US20160108357A1 (en) * | 2014-10-15 | 2016-04-21 | Alexion Pharmaceuticals, Inc. | Methods of culturing a cell |
WO2016061066A1 (en) | 2014-10-15 | 2016-04-21 | Alexion Pharmaceuticals, Inc. | Methods of replicating a large scale eculizumab production cell culture |
PL3221359T3 (pl) | 2014-11-17 | 2020-11-16 | Regeneron Pharmaceuticals, Inc. | Sposoby leczenia nowotworów przy użyciu dwuswoistego przeciwciała CD3XCD20 |
WO2016094834A2 (en) | 2014-12-12 | 2016-06-16 | Alexion Pharmaceuticals, Inc. | A method for treating a complement mediated disorder caused by an infectious agent in a patient |
LT3233921T (lt) | 2014-12-19 | 2021-12-10 | Chugai Seiyaku Kabushiki Kaisha | Anti-c5 antikūnai ir panaudojimo būdai |
EP3247723A1 (en) | 2015-01-22 | 2017-11-29 | Chugai Seiyaku Kabushiki Kaisha | A combination of two or more anti-c5 antibodies and methods of use |
EP3988110A1 (en) | 2015-01-28 | 2022-04-27 | RA Pharmaceuticals, Inc. | Modulators of complement activity |
WO2016154290A1 (en) | 2015-03-23 | 2016-09-29 | Alexion Pharmaceuticals, Inc. | Virus filtration |
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EP3277715A2 (en) * | 2015-03-31 | 2018-02-07 | Alexion Pharmaceuticals, Inc. | Identifying and treating subpopulations of paroxysmal nocturnal hemoglobinuria (pnh) patients |
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PT3280441T (pt) | 2015-04-07 | 2021-11-30 | Alector Llc | Anticorpos anti-sortilina e métodos para a sua utilização |
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2021
- 2021-02-17 JP JP2021023314A patent/JP2021073319A/ja not_active Withdrawn
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2022
- 2022-12-28 JP JP2022211659A patent/JP2023026536A/ja active Pending
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