TR201903267T4 - Büyük ölçekli eculizumab üretim hücre kültürünün replikasyon metotları. - Google Patents

Büyük ölçekli eculizumab üretim hücre kültürünün replikasyon metotları. Download PDF

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Publication number
TR201903267T4
TR201903267T4 TR2019/03267T TR201903267T TR201903267T4 TR 201903267 T4 TR201903267 T4 TR 201903267T4 TR 2019/03267 T TR2019/03267 T TR 2019/03267T TR 201903267 T TR201903267 T TR 201903267T TR 201903267 T4 TR201903267 T4 TR 201903267T4
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TR
Turkey
Prior art keywords
cell culture
scale
production cell
eculizumab production
replication methods
Prior art date
Application number
TR2019/03267T
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English (en)
Inventor
F Malanson Hunter
Jaluria Pratik
Original Assignee
Alexion Pharma Inc
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Publication date
Application filed by Alexion Pharma Inc filed Critical Alexion Pharma Inc
Publication of TR201903267T4 publication Critical patent/TR201903267T4/tr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Mevcut buluş, hiç değilse bir kısmıyla, büyük ölçekli bir eculizumab üretim hücre kültürünün, küçük ölçekli yarı sürekli bir hücre kültürü kullanılarak doğru şekilde replikasyonuna imkan veren bir dizi kültür parametresinin keşfine dayanır. Dolayısıyla mevcut şartname, büyük ölçekli bir eculizumab üretim hücre kültürünü, küçük ölçekli yarı sürekli bir hücre kültürü kullanılarak replike etmeye yönelik metotları içermektedir.
TR2019/03267T 2014-10-15 2015-10-13 Büyük ölçekli eculizumab üretim hücre kültürünün replikasyon metotları. TR201903267T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462064457P 2014-10-15 2014-10-15

Publications (1)

Publication Number Publication Date
TR201903267T4 true TR201903267T4 (tr) 2019-03-21

Family

ID=54542496

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/03267T TR201903267T4 (tr) 2014-10-15 2015-10-13 Büyük ölçekli eculizumab üretim hücre kültürünün replikasyon metotları.

Country Status (6)

Country Link
US (2) US10544209B2 (tr)
EP (1) EP3207121B1 (tr)
JP (1) JP6479974B2 (tr)
ES (1) ES2719876T3 (tr)
TR (1) TR201903267T4 (tr)
WO (1) WO2016061066A1 (tr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR201903267T4 (tr) 2014-10-15 2019-03-21 Alexion Pharma Inc Büyük ölçekli eculizumab üretim hücre kültürünün replikasyon metotları.
WO2018109588A2 (en) * 2016-12-16 2018-06-21 Samsung Bioepis Co., Ltd Stable aqueous anti-c5 antibody composition
MX2019011825A (es) 2017-04-03 2020-12-11 Inflarx Gmbh Tratamiento de enfermedades inflamatorias con inhibidores de actividad de c5a.
US10376595B2 (en) 2017-04-03 2019-08-13 Inflarx Gmbh Treatment of inflammatory diseases with inhibitors of C5a activity
AU2018286754A1 (en) 2017-06-23 2019-12-19 Inflarx Gmbh Treatment of inflammatory diseases with inhibitors of C5A activity
JP2023518884A (ja) 2020-03-27 2023-05-08 インフラルクス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング コロナウイルス感染の処置のためのＣ５ａのインヒビター
WO2023168255A1 (en) * 2022-03-02 2023-09-07 Amgen Inc. Compositions of anti-c5 monoclonal antibody

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6074642A (en) 1994-05-02 2000-06-13 Alexion Pharmaceuticals, Inc. Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis
KR20000065395A (ko) 1999-04-02 2000-11-15 김영환 단전자 트랜지스터의 제조 방법
BR0316882A (pt) 2002-12-23 2005-10-25 Bristol Myers Squibb Co Melhora na qualidade de produtos em processos de cultura de células de mamìferos para a produção de proteìnas
EP1755674B1 (en) * 2004-05-14 2014-11-19 Alexion Pharmaceuticals, Inc. Prolongation of survival of an allograft by inhibiting complement activity
ES2864039T3 (es) 2005-05-20 2021-10-13 Lonza Biologics Plc Expresión de alto nivel de un anticuerpo recombinante en una célula huésped de mamífero
WO2007062218A1 (en) * 2005-11-23 2007-05-31 Bioprocessors Corp. Method for performing fed-batch operations in small volume reactors
BRPI0708909B8 (pt) 2006-03-15 2021-05-25 Alexion Pharma Inc uso de um anticorpo que se liga a c5 para tratar um paciente que sofre de hemoglobinúria paroxística noturna
CA2737642A1 (en) 2008-10-06 2010-04-15 F. Hoffmann-La Roche Ag Small scale shaker flask cultivation
WO2010120514A2 (en) 2009-03-31 2010-10-21 The Trustees Of The University Of Pennsylvania Antigen-binding proteins comprising recombinant protein scaffolds
US8999340B2 (en) 2010-03-01 2015-04-07 Alexion Pharmaceuticals, Inc. Methods for treating multiorgan, systemic degos' disease with a complement inhibitor
CN104402997A (zh) 2010-04-30 2015-03-11 阿雷克森制药公司 在人中具有降低的免疫原性的抗体
CN102391995B (zh) * 2011-11-24 2012-12-12 陈志南 一种杂交瘤细胞无血清高密度悬浮灌流培养工艺
TR201903267T4 (tr) 2014-10-15 2019-03-21 Alexion Pharma Inc Büyük ölçekli eculizumab üretim hücre kültürünün replikasyon metotları.
US20160108357A1 (en) 2014-10-15 2016-04-21 Alexion Pharmaceuticals, Inc. Methods of culturing a cell

Also Published As

Publication number Publication date
US20200172606A1 (en) 2020-06-04
EP3207121A1 (en) 2017-08-23
JP2017534274A (ja) 2017-11-24
WO2016061066A1 (en) 2016-04-21
US20160108112A1 (en) 2016-04-21
US11104726B2 (en) 2021-08-31
EP3207121B1 (en) 2019-02-27
US10544209B2 (en) 2020-01-28
ES2719876T3 (es) 2019-07-16
JP6479974B2 (ja) 2019-03-06

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