BRPI0313155B8 - composto químico derivado ou análogo de carotenóide, composição farmacêutica, e, uso do composto - Google Patents
composto químico derivado ou análogo de carotenóide, composição farmacêutica, e, uso do compostoInfo
- Publication number
- BRPI0313155B8 BRPI0313155B8 BRPI0313155A BR0313155A BRPI0313155B8 BR PI0313155 B8 BRPI0313155 B8 BR PI0313155B8 BR PI0313155 A BRPI0313155 A BR PI0313155A BR 0313155 A BR0313155 A BR 0313155A BR PI0313155 B8 BRPI0313155 B8 BR PI0313155B8
- Authority
- BR
- Brazil
- Prior art keywords
- combination
- analog
- administered
- analogs
- subject
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 235000021466 carotenoid Nutrition 0.000 title abstract 4
- 150000001747 carotenoids Chemical class 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 230000005764 inhibitory process Effects 0.000 abstract 4
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 239000003642 reactive oxygen metabolite Substances 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000007845 reactive nitrogen species Substances 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010063837 Reperfusion injury Diseases 0.000 abstract 1
- 206010049418 Sudden Cardiac Death Diseases 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 150000001514 astaxanthins Chemical class 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 208000012947 ischemia reperfusion injury Diseases 0.000 abstract 1
- 208000019423 liver disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/24—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
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- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
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US47374103P | 2003-05-28 | 2003-05-28 | |
US48530403P | 2003-07-03 | 2003-07-03 | |
PCT/US2003/023706 WO2004011423A2 (en) | 2002-07-29 | 2003-07-29 | Structural carotenoid analogs for the inhibition and amelioration of disease |
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BR0313155A BR0313155A (pt) | 2005-07-12 |
BRPI0313155B1 BRPI0313155B1 (pt) | 2018-11-06 |
BRPI0313155B8 true BRPI0313155B8 (pt) | 2021-05-25 |
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BRPI0313155A BRPI0313155B8 (pt) | 2002-07-29 | 2003-07-29 | composto químico derivado ou análogo de carotenóide, composição farmacêutica, e, uso do composto |
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-
2003
- 2003-07-29 AU AU2003256982A patent/AU2003256982A1/en not_active Abandoned
- 2003-07-29 CN CN2010101657116A patent/CN101845009B/zh not_active Expired - Fee Related
- 2003-07-29 KR KR1020057001714A patent/KR20050069975A/ko not_active Application Discontinuation
- 2003-07-29 BR BRPI0313155A patent/BRPI0313155B8/pt not_active IP Right Cessation
- 2003-07-29 CN CN03823260XA patent/CN1708480B/zh not_active Expired - Fee Related
- 2003-07-29 JP JP2005505633A patent/JP4601549B2/ja not_active Expired - Fee Related
- 2003-07-29 EP EP03772051.3A patent/EP1532108B1/en not_active Expired - Lifetime
- 2003-07-29 CA CA2495167A patent/CA2495167C/en not_active Expired - Fee Related
- 2003-07-29 MX MXPA05001202A patent/MXPA05001202A/es not_active Application Discontinuation
- 2003-07-29 US US10/629,538 patent/US7145025B2/en not_active Expired - Lifetime
- 2003-07-29 EP EP10185924.7A patent/EP2392562B1/en not_active Expired - Lifetime
- 2003-07-29 WO PCT/US2003/023706 patent/WO2004011423A2/en active Search and Examination
-
2004
- 2004-03-04 US US10/793,702 patent/US20050075337A1/en not_active Abandoned
- 2004-03-04 US US10/793,703 patent/US7317008B2/en not_active Expired - Lifetime
- 2004-03-04 US US10/793,696 patent/US20050065097A1/en not_active Abandoned
-
2005
- 2005-02-03 NO NO20050619A patent/NO20050619L/no not_active Application Discontinuation
-
2006
- 2006-02-17 US US11/357,897 patent/US7592449B2/en not_active Expired - Lifetime
- 2006-04-20 HK HK06104731.0A patent/HK1084380A1/xx not_active IP Right Cessation
-
2010
- 2010-07-29 JP JP2010170929A patent/JP5187700B2/ja not_active Expired - Fee Related
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2011
- 2011-03-28 HK HK11103076.8A patent/HK1148997A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP2006517197A (ja) | 2006-07-20 |
US20040162329A1 (en) | 2004-08-19 |
JP4601549B2 (ja) | 2010-12-22 |
BRPI0313155B1 (pt) | 2018-11-06 |
CN101845009A (zh) | 2010-09-29 |
US20050075337A1 (en) | 2005-04-07 |
US7592449B2 (en) | 2009-09-22 |
EP2392562A1 (en) | 2011-12-07 |
EP1532108B1 (en) | 2016-06-29 |
HK1084380A1 (en) | 2006-07-28 |
US7317008B2 (en) | 2008-01-08 |
US20060229446A1 (en) | 2006-10-12 |
US20050037995A1 (en) | 2005-02-17 |
MXPA05001202A (es) | 2005-11-23 |
JP2010248243A (ja) | 2010-11-04 |
NO20050619L (no) | 2005-04-27 |
EP2392562B1 (en) | 2018-03-07 |
WO2004011423A2 (en) | 2004-02-05 |
WO2004011423A3 (en) | 2004-05-06 |
CA2495167A1 (en) | 2004-02-05 |
CN1708480B (zh) | 2010-12-15 |
CA2495167C (en) | 2018-08-21 |
HK1148997A1 (en) | 2011-09-23 |
JP5187700B2 (ja) | 2013-04-24 |
EP1532108A2 (en) | 2005-05-25 |
AU2003256982A1 (en) | 2004-02-16 |
BR0313155A (pt) | 2005-07-12 |
US20050065097A1 (en) | 2005-03-24 |
US7145025B2 (en) | 2006-12-05 |
CN1708480A (zh) | 2005-12-14 |
KR20050069975A (ko) | 2005-07-05 |
CN101845009B (zh) | 2012-10-03 |
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