BRPI0108374B8 - derivado de pirazina ou um sal deste e composição farmacêutica - Google Patents

derivado de pirazina ou um sal deste e composição farmacêutica

Info

Publication number
BRPI0108374B8
BRPI0108374B8 BRPI0108374A BRPI0108374B8 BR PI0108374 B8 BRPI0108374 B8 BR PI0108374B8 BR PI0108374 A BRPI0108374 A BR PI0108374A BR PI0108374 B8 BRPI0108374 B8 BR PI0108374B8
Authority
BR
Brazil
Prior art keywords
salt
pharmaceutical composition
general formula
pyrazine derivative
pyrazine
Prior art date
Application number
Other languages
English (en)
Inventor
Egawa Hiroyuki
Sugita Jun
Yonezawa Kenji
Uehara Sayuri
Hamamoto Shoichi
Furuta Yousuke
Original Assignee
Fujifilm Toyama Chemical Co Ltd
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujifilm Toyama Chemical Co Ltd, Toyama Chemical Co Ltd filed Critical Fujifilm Toyama Chemical Co Ltd
Priority to BRPI0116967-0 priority Critical patent/BRPI0116967B8/pt
Publication of BR0108374A publication Critical patent/BR0108374A/pt
Publication of BRPI0108374B1 publication Critical patent/BRPI0108374B1/pt
Publication of BRPI0108374B8 publication Critical patent/BRPI0108374B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

"derivado de pirazina ou um sal deste, composição farmacêutica, e, derivado de fluoropirazina ou um sal deste". derivados de pirazina representados pela fórmula geral [1] em que as variáveis são como definidas no relatório descritivo ou seus sais têm uma atividade antiviral excelente e são úteis como um agente terapêutico para tratar infecções virais. além disso, os derivados de carboxamida da fluoropirazina representados pela fórmula geral [2]: em que as variáveis são como definidas no relatório descritivo ou seus sais são úteis como um intermediário para a produção dos compostos da fórmula geral [1] e como um intermediário para a produção dos derivados de carboxamida da fluoropirazina dos quais um exemplo típico é a 6-fluoro-3-hidróxi-2-pirazinocarboxamida tendo uma atividade antiviral.
BR0108374-0 2000-02-16 2001-02-14 derivado de pirazina ou um sal deste e composição farmacêutica BRPI0108374B8 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BRPI0116967-0 BRPI0116967B8 (pt) 2000-02-16 2001-02-14 derivado de pirazina ou um sal deste, composição farmacêutica, e, derivado de fluoropirazina ou um sal deste

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP2000037486 2000-02-16
JP2000-037486 2000-02-16
JP2000040439 2000-02-18
JP2000-040439 2000-02-18
JP2000-090071 2000-03-29
JP2000090071 2000-03-29
PCT/JP2001/001038 WO2001060834A1 (fr) 2000-02-16 2001-02-14 Nouveaux derives de pyrazine ou leurs sels, compositions pharmaceutiques contenant ces derives ou leurs sels et intermediaires utilises dans leur preparation

Publications (3)

Publication Number Publication Date
BR0108374A BR0108374A (pt) 2003-03-18
BRPI0108374B1 BRPI0108374B1 (pt) 2017-10-10
BRPI0108374B8 true BRPI0108374B8 (pt) 2021-05-25

Family

ID=27342371

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0116967-0 BRPI0116967B8 (pt) 2000-02-16 2001-02-14 derivado de pirazina ou um sal deste, composição farmacêutica, e, derivado de fluoropirazina ou um sal deste
BR0108374-0 BRPI0108374B8 (pt) 2000-02-16 2001-02-14 derivado de pirazina ou um sal deste e composição farmacêutica

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0116967-0 BRPI0116967B8 (pt) 2000-02-16 2001-02-14 derivado de pirazina ou um sal deste, composição farmacêutica, e, derivado de fluoropirazina ou um sal deste

Country Status (15)

Country Link
US (1) US6800629B2 (pt)
EP (2) EP1295890B1 (pt)
JP (2) JP4379767B2 (pt)
KR (3) KR100589935B1 (pt)
CN (1) CN1239511C (pt)
AT (2) ATE294185T1 (pt)
AU (1) AU2001232287A1 (pt)
BR (2) BRPI0116967B8 (pt)
CA (1) CA2398620C (pt)
DE (2) DE60108724T2 (pt)
DK (1) DK1295890T3 (pt)
ES (2) ES2237550T3 (pt)
MX (1) MXPA02007890A (pt)
PT (2) PT1295890E (pt)
WO (1) WO2001060834A1 (pt)

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MXPA04001361A (es) * 2001-08-14 2004-05-27 Toyama Chemical Co Ltd Metodo novedoso para inhibir el crecimiento de virus y/o metodo virucida, y un analogo novedoso de un nucleotido de pirazina o de un nucleosido de pirazina.
RU2007115419A (ru) * 2004-09-24 2008-10-27 Айденикс (Кайман) Лимитед (Ky) Способы и композиции для лечения флавивирусов, пестивирусов и гепацивируса
EP2545923A1 (en) * 2005-12-22 2013-01-16 Alchemia Limited Antibacterial agents
CA2653933C (en) * 2006-05-31 2013-10-08 Toyama Chemical Co., Ltd. Anti-foot-and-mouth disease virus agent for animal belonging to family suidae or sheep, and method for prevention or treatment of foot-and-mouth disease in animal belonging to family suidae or sheep
RU2470924C2 (ru) * 2007-09-27 2012-12-27 Тояма Кемикал Ко., Лтд. Органическая аминовая соль 6-фтор-3-гидрокси-2-пиразинкарбонитрила и способ ее получения
JP5364327B2 (ja) * 2008-09-26 2013-12-11 富士フイルム株式会社 ハロピラジンカルボキサミド化合物の製造方法
WO2010087117A1 (ja) * 2009-01-28 2010-08-05 日本曹達株式会社 ジクロロピラジン誘導体の製造方法
JP5559604B2 (ja) * 2009-05-27 2014-07-23 富山化学工業株式会社 ３，６−ジクロロ−２−ピラジンカルボニトリルの製造法
JPWO2012043700A1 (ja) 2010-09-30 2014-02-24 富山化学工業株式会社 ６−フルオロ−３−ヒドロキシ−２−ピラジンカルボキサミドのナトリウム塩
EP2623497B1 (en) 2010-09-30 2016-01-20 Toyama Chemical Co., Ltd. Meglumine salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide
WO2012063931A1 (ja) * 2010-11-12 2012-05-18 富士フイルム株式会社 ピラジノ〔２，３－ｄ〕イソオキサゾール誘導体
WO2013004141A1 (zh) * 2011-07-01 2013-01-10 中国人民解放军军事医学科学院毒物药物研究所 3－烷氧基取代－2－吡嗪甲酰氨类化合物及其用途
CN102846617B (zh) * 2011-07-01 2016-01-13 中国人民解放军军事医学科学院毒物药物研究所 3－(丁基氧基)－2－吡嗪甲酰氨的制备方法和用途
CN105732748B (zh) * 2014-12-12 2019-01-01 浙江医药股份有限公司新昌制药厂 一种核苷酸类似物及其制备方法、以及含有核苷酸类似物的药物组合物及其应用
WO2016172205A1 (en) * 2015-04-20 2016-10-27 Emory University Managing ebola viral infections
CN107635976A (zh) 2015-06-09 2018-01-26 富山化学工业株式会社 6‑溴‑3‑羟基‑2‑吡嗪甲酰胺的结晶及其制造方法
CN105017166A (zh) * 2015-07-11 2015-11-04 长沙深橙生物科技有限公司 3-(3-溴苯氧基)吡嗪-2-羧酸的制备方法
CN104961691A (zh) * 2015-07-11 2015-10-07 长沙深橙生物科技有限公司 3-(2-氟苯氧基)吡嗪-2-羧酸的制备方法
CN105037281A (zh) * 2015-07-11 2015-11-11 长沙深橙生物科技有限公司 3-(3-氟苯氧基)吡嗪-2-羧酸的制备方法
CN104961690A (zh) * 2015-07-11 2015-10-07 长沙深橙生物科技有限公司 3-(4-氟苯氧基)吡嗪-2-羧酸的制备方法
CN107641106A (zh) * 2016-07-22 2018-01-30 大连鸿凯化工科技发展有限公司 法匹拉韦中间体以及法匹拉韦的合成方法
JPWO2018199048A1 (ja) * 2017-04-25 2020-05-07 大原薬品工業株式会社 ヌクレオシド系抗がん剤または抗ウィルス剤の５’位モノ燐酸ジベンジルエステル誘導体
CN111265528A (zh) 2020-01-21 2020-06-12 中国人民解放军军事科学院军事医学研究院 法匹拉韦在治疗冠状病毒感染方面的应用
CN113248450B (zh) * 2020-02-07 2024-04-12 北京四环制药有限公司 一种法匹拉韦的制备方法
CN113735784A (zh) * 2020-05-28 2021-12-03 南京桦冠生物技术有限公司 6-氟-3-羟基吡嗪-2-甲酰胺的制备方法
WO2021255681A1 (en) * 2020-06-17 2021-12-23 Hikal Limited A simple process for the preparation of favipiravir and its intermediates thereof
CN111704582B (zh) * 2020-06-23 2021-06-11 杭州煌森生物科技有限公司 一种法匹拉韦及其衍生物的制备方法
KR20230034848A (ko) * 2020-07-06 2023-03-10 옵티머스 드럭스 (피) 엘티디 파비피라비르의 합성
CN114656412A (zh) * 2020-12-22 2022-06-24 山东特珐曼药业有限公司 一种法匹拉韦的合成方法
CN112552245B (zh) * 2020-12-29 2022-08-02 苏州正济药业有限公司 法匹拉韦的合成方法
CN112851589B (zh) * 2021-01-25 2022-10-11 山东邹平大展新材料有限公司 一种法匹拉韦中间体6-溴-3-羟基吡嗪-2-甲酰胺的制备方法
WO2023118896A1 (en) 2021-12-23 2023-06-29 Subintro Limited Novel antiviral compositions comprising oleic acid
CN114478404A (zh) * 2022-03-17 2022-05-13 浙江海正药业股份有限公司 一种法维拉韦中间体羟基物的纯化方法

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EP0394464A4 (en) * 1988-08-22 1991-04-03 Idemitsu Kosan Company Limited Oxirane derivatives and herbicides containing same as active ingredients
DE59209008D1 (de) * 1991-08-17 1997-12-11 Hoechst Ag 2-Fluorpyrazine, Verfahren zu ihrer Herstellung und ihre Verwendung in flüssigkristallinen Mischungen
CZ301763B6 (cs) * 1998-08-20 2010-06-16 Toyama Chemical Co., Ltd. Protivirový prostredek a derivát dusíkatého heterocyklického karboxamidu

Also Published As

Publication number Publication date
KR20030034120A (ko) 2003-05-01
US6800629B2 (en) 2004-10-05
KR20030048108A (ko) 2003-06-18
MXPA02007890A (es) 2002-10-31
CN1418220A (zh) 2003-05-14
ES2240645T3 (es) 2005-10-16
EP1256588A4 (en) 2003-03-26
JP5038345B2 (ja) 2012-10-03
EP1295890A1 (en) 2003-03-26
DE60108724T2 (de) 2005-06-23
CN1239511C (zh) 2006-02-01
BRPI0108374B1 (pt) 2017-10-10
ATE294185T1 (de) 2005-05-15
BRPI0116967B8 (pt) 2021-05-25
US20030130213A1 (en) 2003-07-10
BR0108374A (pt) 2003-03-18
ES2237550T3 (es) 2005-08-01
EP1256588B1 (en) 2005-02-02
WO2001060834A1 (fr) 2001-08-23
JP2009161553A (ja) 2009-07-23
BRPI0116967B1 (pt) 2018-05-22
EP1295890B1 (en) 2005-04-27
KR20030032918A (ko) 2003-04-26
CA2398620A1 (en) 2001-08-23
PT1256588E (pt) 2005-05-31
DE60110415T2 (de) 2005-09-29
JP4379767B2 (ja) 2009-12-09
ATE288443T1 (de) 2005-02-15
EP1256588A1 (en) 2002-11-13
DE60110415D1 (de) 2005-06-02
PT1295890E (pt) 2005-06-30
KR100589935B1 (ko) 2006-06-15
BRPI0116967A2 (pt) 2009-07-14
DE60108724D1 (de) 2005-03-10
KR100604955B1 (ko) 2006-07-26
DK1295890T3 (da) 2005-05-17
CA2398620C (en) 2009-06-23
AU2001232287A1 (en) 2001-08-27

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B25A Requested transfer of rights approved
B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/02/2001 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 14/02/2021