DE60108724D1 - Neue pyrazin-derivate oder salze davon, pharmazeutische zusammensetzungen, die die derivate oder deren salze enthalten und intermediate zu beider herstellung - Google Patents

Neue pyrazin-derivate oder salze davon, pharmazeutische zusammensetzungen, die die derivate oder deren salze enthalten und intermediate zu beider herstellung

Info

Publication number
DE60108724D1
DE60108724D1 DE60108724T DE60108724T DE60108724D1 DE 60108724 D1 DE60108724 D1 DE 60108724D1 DE 60108724 T DE60108724 T DE 60108724T DE 60108724 T DE60108724 T DE 60108724T DE 60108724 D1 DE60108724 D1 DE 60108724D1
Authority
DE
Germany
Prior art keywords
salts
derivatives
intermediates
manufacture
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60108724T
Other languages
English (en)
Other versions
DE60108724T2 (de
Inventor
Hiroyuki Egawa
Yousuke Furuta
Jun Sugita
Sayuri Uehara
Shoichi Hamamoto
Kenji Yonezawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of DE60108724D1 publication Critical patent/DE60108724D1/de
Application granted granted Critical
Publication of DE60108724T2 publication Critical patent/DE60108724T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE60108724T 2000-02-16 2001-02-14 Neue pyrazin-derivate oder salze davon, pharmazeutische zusammensetzungen, die die derivate oder deren salze enthalten und intermediate zu beider herstellung Expired - Lifetime DE60108724T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP2000037486 2000-02-16
JP2000037486 2000-02-16
JP2000040439 2000-02-18
JP2000040439 2000-02-18
JP2000090071 2000-03-29
JP2000090071 2000-03-29
PCT/JP2001/001038 WO2001060834A1 (fr) 2000-02-16 2001-02-14 Nouveaux derives de pyrazine ou leurs sels, compositions pharmaceutiques contenant ces derives ou leurs sels et intermediaires utilises dans leur preparation

Publications (2)

Publication Number Publication Date
DE60108724D1 true DE60108724D1 (de) 2005-03-10
DE60108724T2 DE60108724T2 (de) 2005-06-23

Family

ID=27342371

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60108724T Expired - Lifetime DE60108724T2 (de) 2000-02-16 2001-02-14 Neue pyrazin-derivate oder salze davon, pharmazeutische zusammensetzungen, die die derivate oder deren salze enthalten und intermediate zu beider herstellung
DE60110415T Expired - Lifetime DE60110415T2 (de) 2000-02-16 2001-02-14 Neue Pyrazin-Derivate oder Salze davon, pharmazeutische Zusammensetzungen, die die Derivate oder deren Salze enthalten und Intermediate zu beider Herstellung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60110415T Expired - Lifetime DE60110415T2 (de) 2000-02-16 2001-02-14 Neue Pyrazin-Derivate oder Salze davon, pharmazeutische Zusammensetzungen, die die Derivate oder deren Salze enthalten und Intermediate zu beider Herstellung

Country Status (15)

Country Link
US (1) US6800629B2 (de)
EP (2) EP1256588B1 (de)
JP (2) JP4379767B2 (de)
KR (3) KR100589935B1 (de)
CN (1) CN1239511C (de)
AT (2) ATE288443T1 (de)
AU (1) AU2001232287A1 (de)
BR (2) BRPI0116967B8 (de)
CA (1) CA2398620C (de)
DE (2) DE60108724T2 (de)
DK (1) DK1295890T3 (de)
ES (2) ES2240645T3 (de)
MX (1) MXPA02007890A (de)
PT (2) PT1256588E (de)
WO (1) WO2001060834A1 (de)

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JP4370164B2 (ja) * 2001-08-14 2009-11-25 富山化学工業株式会社 新規なウイルス増殖阻害・殺ウイルス方法および新規なピラジンヌクレオチド・ピラジンヌクレオシド類似体
EP1804811A4 (de) * 2004-09-24 2011-04-27 Idenix Cayman Ltd Verfahren und zusammensetzung zur behandlung von flavivren, pestiviren und hepaciviren
WO2007070947A1 (en) * 2005-12-22 2007-06-28 Alchemia Ltd Antibacterial agents
SI2022786T1 (sl) * 2006-05-31 2012-04-30 Toyama Chemical Co Ltd Sredstvo proti virusu slinavke in parkljevke za ĺ˝ival, pripadajoäśo druĺ˝ini suidae, ali ovco in postopek za prepreäśevanje ali zdravljenje slinavke in parkljevke pri ĺ˝ivali, pripadajoäśi druĺ˝ini suidae, ali ovci
KR101574567B1 (ko) * 2007-09-27 2015-12-07 토야마 케미칼 컴퍼니 리미티드 6-플루오로-3-히드록시-2-피라진카보니트릴의 유기아민염 및 그 제조법
JP5364327B2 (ja) * 2008-09-26 2013-12-11 富士フイルム株式会社 ハロピラジンカルボキサミド化合物の製造方法
JP5385309B2 (ja) * 2009-01-28 2014-01-08 日本曹達株式会社 ジクロロピラジン誘導体の製造方法
JP5559604B2 (ja) * 2009-05-27 2014-07-23 富山化学工業株式会社 ３，６−ジクロロ−２−ピラジンカルボニトリルの製造法
ES2554630T3 (es) 2010-09-30 2015-12-22 Toyama Chemical Co., Ltd. Sal sódica de 6-fluoro-3-hidroxi-2-pirazinocarboxamida
ES2561878T3 (es) 2010-09-30 2016-03-01 Toyama Chemical Co., Ltd. Sal de meglumina de 6-fluoro-3-hidroxi-2-pirazinacarboxamida
ES2535341T3 (es) 2010-11-12 2015-05-08 Fujifilm Corporation Derivado de pirazino[2,3-d]isoxazol
CN102846617B (zh) * 2011-07-01 2016-01-13 中国人民解放军军事医学科学院毒物药物研究所 3－(丁基氧基)－2－吡嗪甲酰氨的制备方法和用途
CN102850282B (zh) * 2011-07-01 2015-09-16 中国人民解放军军事医学科学院毒物药物研究所 3-取代氧基-2-吡嗪甲酰胺类化合物及其用途
CN105732748B (zh) * 2014-12-12 2019-01-01 浙江医药股份有限公司新昌制药厂 一种核苷酸类似物及其制备方法、以及含有核苷酸类似物的药物组合物及其应用
WO2016172205A1 (en) * 2015-04-20 2016-10-27 Emory University Managing ebola viral infections
DK3309149T3 (da) 2015-06-09 2021-05-31 Fujifilm Toyama Chemical Co Ltd 6-Brom-3-hydroxy-2-pyrazincarboxamid-krystal og fremgangsmåde til fremstilling af dette
CN104961690A (zh) * 2015-07-11 2015-10-07 长沙深橙生物科技有限公司 3-(4-氟苯氧基)吡嗪-2-羧酸的制备方法
CN105017166A (zh) * 2015-07-11 2015-11-04 长沙深橙生物科技有限公司 3-(3-溴苯氧基)吡嗪-2-羧酸的制备方法
CN104961691A (zh) * 2015-07-11 2015-10-07 长沙深橙生物科技有限公司 3-(2-氟苯氧基)吡嗪-2-羧酸的制备方法
CN105037281A (zh) * 2015-07-11 2015-11-11 长沙深橙生物科技有限公司 3-(3-氟苯氧基)吡嗪-2-羧酸的制备方法
CN107641106A (zh) * 2016-07-22 2018-01-30 大连鸿凯化工科技发展有限公司 法匹拉韦中间体以及法匹拉韦的合成方法
WO2018199048A1 (ja) * 2017-04-25 2018-11-01 大原薬品工業株式会社 ヌクレオシド系抗がん剤または抗ウィルス剤の５'位モノ燐酸ジベンジルエステル誘導体
CN111265528A (zh) * 2020-01-21 2020-06-12 中国人民解放军军事科学院军事医学研究院 法匹拉韦在治疗冠状病毒感染方面的应用
CN113248450B (zh) * 2020-02-07 2024-04-12 北京四环制药有限公司 一种法匹拉韦的制备方法
CN113735784A (zh) * 2020-05-28 2021-12-03 南京桦冠生物技术有限公司 6-氟-3-羟基吡嗪-2-甲酰胺的制备方法
WO2021255681A1 (en) * 2020-06-17 2021-12-23 Hikal Limited A simple process for the preparation of favipiravir and its intermediates thereof
CN111704582B (zh) * 2020-06-23 2021-06-11 杭州煌森生物科技有限公司 一种法匹拉韦及其衍生物的制备方法
KR20230034848A (ko) * 2020-07-06 2023-03-10 옵티머스 드럭스 (피) 엘티디 파비피라비르의 합성
CN114656412A (zh) * 2020-12-22 2022-06-24 山东特珐曼药业有限公司 一种法匹拉韦的合成方法
CN112552245B (zh) * 2020-12-29 2022-08-02 苏州正济药业有限公司 法匹拉韦的合成方法
CN112851589B (zh) * 2021-01-25 2022-10-11 山东邹平大展新材料有限公司 一种法匹拉韦中间体6-溴-3-羟基吡嗪-2-甲酰胺的制备方法
WO2023118896A1 (en) 2021-12-23 2023-06-29 Subintro Limited Novel antiviral compositions comprising oleic acid
CN114478404A (zh) * 2022-03-17 2022-05-13 浙江海正药业股份有限公司 一种法维拉韦中间体羟基物的纯化方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990002125A1 (en) * 1988-08-22 1990-03-08 Idemitsu Kosan Co. Ltd. Oxirane derivatives and herbicides containing same as active ingredients
EP0532916B1 (de) * 1991-08-17 1997-11-05 Hoechst Aktiengesellschaft 2-Fluorpyrazine, Verfahren zu ihrer Herstellung und ihre Verwendung in flüssigkristallinen Mischungen
DE69937405T2 (de) * 1998-08-20 2008-02-14 Toyama Chemical Co. Ltd. Stickstoffheterocyclische Carboxamidverbindungen oder deren Salze als antivirale Mittel

Also Published As

Publication number Publication date
JP2009161553A (ja) 2009-07-23
KR100589935B1 (ko) 2006-06-15
WO2001060834A1 (fr) 2001-08-23
DK1295890T3 (da) 2005-05-17
BRPI0116967B1 (pt) 2018-05-22
BRPI0108374B8 (pt) 2021-05-25
ES2240645T3 (es) 2005-10-16
CN1239511C (zh) 2006-02-01
BRPI0116967A2 (pt) 2009-07-14
CA2398620C (en) 2009-06-23
JP5038345B2 (ja) 2012-10-03
US20030130213A1 (en) 2003-07-10
KR100604955B1 (ko) 2006-07-26
EP1256588A4 (de) 2003-03-26
EP1256588B1 (de) 2005-02-02
ES2237550T3 (es) 2005-08-01
MXPA02007890A (es) 2002-10-31
BRPI0108374B1 (pt) 2017-10-10
DE60108724T2 (de) 2005-06-23
BR0108374A (pt) 2003-03-18
EP1256588A1 (de) 2002-11-13
EP1295890A1 (de) 2003-03-26
KR20030034120A (ko) 2003-05-01
DE60110415D1 (de) 2005-06-02
CA2398620A1 (en) 2001-08-23
KR20030032918A (ko) 2003-04-26
ATE294185T1 (de) 2005-05-15
KR20030048108A (ko) 2003-06-18
DE60110415T2 (de) 2005-09-29
PT1256588E (pt) 2005-05-31
AU2001232287A1 (en) 2001-08-27
BRPI0116967B8 (pt) 2021-05-25
PT1295890E (pt) 2005-06-30
CN1418220A (zh) 2003-05-14
EP1295890B1 (de) 2005-04-27
JP4379767B2 (ja) 2009-12-09
US6800629B2 (en) 2004-10-05
ATE288443T1 (de) 2005-02-15

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