AU2001232287A1 - Novel pyrazine derivatives or salts thereof, pharmaceutical compositions containing the derivatives or the salts and intermediates for the preparation of both - Google Patents

Novel pyrazine derivatives or salts thereof, pharmaceutical compositions containing the derivatives or the salts and intermediates for the preparation of both

Info

Publication number
AU2001232287A1
AU2001232287A1 AU2001232287A AU3228701A AU2001232287A1 AU 2001232287 A1 AU2001232287 A1 AU 2001232287A1 AU 2001232287 A AU2001232287 A AU 2001232287A AU 3228701 A AU3228701 A AU 3228701A AU 2001232287 A1 AU2001232287 A1 AU 2001232287A1
Authority
AU
Australia
Prior art keywords
salts
derivatives
intermediates
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001232287A
Other languages
English (en)
Inventor
Hiroyuki Egawa
Yousuke Furuta
Shoichi Hamamoto
Jun Sugita
Sayuri Uehara
Kenji Yonezawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of AU2001232287A1 publication Critical patent/AU2001232287A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
AU2001232287A 2000-02-16 2001-02-14 Novel pyrazine derivatives or salts thereof, pharmaceutical compositions containing the derivatives or the salts and intermediates for the preparation of both Abandoned AU2001232287A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP2000037486 2000-02-16
JP2000-37486 2000-02-16
JP2000-40439 2000-02-18
JP2000040439 2000-02-18
JP2000-90071 2000-03-29
JP2000090071 2000-03-29
PCT/JP2001/001038 WO2001060834A1 (fr) 2000-02-16 2001-02-14 Nouveaux derives de pyrazine ou leurs sels, compositions pharmaceutiques contenant ces derives ou leurs sels et intermediaires utilises dans leur preparation

Publications (1)

Publication Number Publication Date
AU2001232287A1 true AU2001232287A1 (en) 2001-08-27

Family

ID=27342371

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001232287A Abandoned AU2001232287A1 (en) 2000-02-16 2001-02-14 Novel pyrazine derivatives or salts thereof, pharmaceutical compositions containing the derivatives or the salts and intermediates for the preparation of both

Country Status (15)

Country Link
US (1) US6800629B2 (de)
EP (2) EP1295890B1 (de)
JP (2) JP4379767B2 (de)
KR (3) KR100604955B1 (de)
CN (1) CN1239511C (de)
AT (2) ATE288443T1 (de)
AU (1) AU2001232287A1 (de)
BR (2) BRPI0116967B8 (de)
CA (1) CA2398620C (de)
DE (2) DE60108724T2 (de)
DK (1) DK1295890T3 (de)
ES (2) ES2240645T3 (de)
MX (1) MXPA02007890A (de)
PT (2) PT1295890E (de)
WO (1) WO2001060834A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
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KR100894167B1 (ko) * 2001-08-14 2009-04-22 토야마 케미칼 컴퍼니 리미티드 신규의 바이러스 증식저해 ·살바이러스방법 및 신규의피라진뉴클레오티드 ·피라진뉴클레오시드 유사체
AU2005289517A1 (en) * 2004-09-24 2006-04-06 Centre National De La Recherche Scientifique Methods and compositions for treating flaviviruses, pestiviruses and hepacivirus
EP2545923A1 (de) * 2005-12-22 2013-01-16 Alchemia Limited Antibakterielle Wirkstoffe
AU2007268684B2 (en) * 2006-05-31 2012-02-23 Toyama Chemical Co., Ltd. Anti-foot-and-mouth disease virus agent for animal belonging to family Suidae or sheep, and method for prevention or treatment of foot-and-mouth disease in animal belonging to family Suidae or sheep
PL2192117T3 (pl) * 2007-09-27 2014-10-31 Toyama Chemical Co Ltd Sól 6-fluoro-3-hydroksy-2-pirazynokarbonitrylu z organiczną aminą i sposób jej wytwarzania
JP5364327B2 (ja) * 2008-09-26 2013-12-11 富士フイルム株式会社 ハロピラジンカルボキサミド化合物の製造方法
CN102307865B (zh) 2009-01-28 2015-04-01 日本曹达株式会社 二氯吡嗪衍生物的制备方法
JP5559604B2 (ja) * 2009-05-27 2014-07-23 富山化学工業株式会社 ３，６−ジクロロ−２−ピラジンカルボニトリルの製造法
SI2623498T1 (sl) 2010-09-30 2016-03-31 Toyama Chemical Co., Ltd. Natrijeva sol 6-fluoro-3-hidroksi-2-pirazinkarboksamida
JP5936546B2 (ja) 2010-09-30 2016-06-22 富山化学工業株式会社 ６−フルオロ−３−ヒドロキシ−２−ピラジンカルボキサミドのメグルミン塩
AU2011327111B2 (en) * 2010-11-12 2015-04-23 Fujifilm Toyama Chemical Co., Ltd. Pyrazino[2,3-d]isoxazole Derivative
CN102846617B (zh) * 2011-07-01 2016-01-13 中国人民解放军军事医学科学院毒物药物研究所 3－(丁基氧基)－2－吡嗪甲酰氨的制备方法和用途
WO2013004141A1 (zh) * 2011-07-01 2013-01-10 中国人民解放军军事医学科学院毒物药物研究所 3－烷氧基取代－2－吡嗪甲酰氨类化合物及其用途
CN105732748B (zh) * 2014-12-12 2019-01-01 浙江医药股份有限公司新昌制药厂 一种核苷酸类似物及其制备方法、以及含有核苷酸类似物的药物组合物及其应用
WO2016172205A1 (en) * 2015-04-20 2016-10-27 Emory University Managing ebola viral infections
WO2016199824A1 (ja) 2015-06-09 2016-12-15 富山化学工業株式会社 ６－ブロモ－３－ヒドロキシ－２－ピラジンカルボキサミドの結晶およびその製造方法
CN104961691A (zh) * 2015-07-11 2015-10-07 长沙深橙生物科技有限公司 3-(2-氟苯氧基)吡嗪-2-羧酸的制备方法
CN105017166A (zh) * 2015-07-11 2015-11-04 长沙深橙生物科技有限公司 3-(3-溴苯氧基)吡嗪-2-羧酸的制备方法
CN105037281A (zh) * 2015-07-11 2015-11-11 长沙深橙生物科技有限公司 3-(3-氟苯氧基)吡嗪-2-羧酸的制备方法
CN104961690A (zh) * 2015-07-11 2015-10-07 长沙深橙生物科技有限公司 3-(4-氟苯氧基)吡嗪-2-羧酸的制备方法
CN107641106A (zh) * 2016-07-22 2018-01-30 大连鸿凯化工科技发展有限公司 法匹拉韦中间体以及法匹拉韦的合成方法
WO2018199048A1 (ja) * 2017-04-25 2018-11-01 大原薬品工業株式会社 ヌクレオシド系抗がん剤または抗ウィルス剤の５'位モノ燐酸ジベンジルエステル誘導体
CN111265528A (zh) * 2020-01-21 2020-06-12 中国人民解放军军事科学院军事医学研究院 法匹拉韦在治疗冠状病毒感染方面的应用
CN113248450B (zh) * 2020-02-07 2024-04-12 北京四环制药有限公司 一种法匹拉韦的制备方法
CN113735784A (zh) * 2020-05-28 2021-12-03 南京桦冠生物技术有限公司 6-氟-3-羟基吡嗪-2-甲酰胺的制备方法
WO2021255681A1 (en) * 2020-06-17 2021-12-23 Hikal Limited A simple process for the preparation of favipiravir and its intermediates thereof
CN111704582B (zh) * 2020-06-23 2021-06-11 杭州煌森生物科技有限公司 一种法匹拉韦及其衍生物的制备方法
WO2022009036A1 (en) * 2020-07-06 2022-01-13 Optimus Drugs (P) Ltd Synthesis of favipiravir
CN114656412A (zh) * 2020-12-22 2022-06-24 山东特珐曼药业有限公司 一种法匹拉韦的合成方法
CN112552245B (zh) * 2020-12-29 2022-08-02 苏州正济药业有限公司 法匹拉韦的合成方法
CN112851589B (zh) * 2021-01-25 2022-10-11 山东邹平大展新材料有限公司 一种法匹拉韦中间体6-溴-3-羟基吡嗪-2-甲酰胺的制备方法
WO2023118896A1 (en) 2021-12-23 2023-06-29 Subintro Limited Novel antiviral compositions comprising oleic acid
CN114478404A (zh) * 2022-03-17 2022-05-13 浙江海正药业股份有限公司 一种法维拉韦中间体羟基物的纯化方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990002125A1 (en) * 1988-08-22 1990-03-08 Idemitsu Kosan Co. Ltd. Oxirane derivatives and herbicides containing same as active ingredients
DE59209008D1 (de) * 1991-08-17 1997-12-11 Hoechst Ag 2-Fluorpyrazine, Verfahren zu ihrer Herstellung und ihre Verwendung in flüssigkristallinen Mischungen
CZ301763B6 (cs) * 1998-08-20 2010-06-16 Toyama Chemical Co., Ltd. Protivirový prostredek a derivát dusíkatého heterocyklického karboxamidu

Also Published As

Publication number Publication date
BRPI0116967A2 (pt) 2009-07-14
KR20030032918A (ko) 2003-04-26
PT1295890E (pt) 2005-06-30
CN1418220A (zh) 2003-05-14
PT1256588E (pt) 2005-05-31
ES2240645T3 (es) 2005-10-16
CA2398620A1 (en) 2001-08-23
JP4379767B2 (ja) 2009-12-09
DE60108724T2 (de) 2005-06-23
EP1256588A1 (de) 2002-11-13
BR0108374A (pt) 2003-03-18
DK1295890T3 (da) 2005-05-17
KR20030048108A (ko) 2003-06-18
BRPI0108374B1 (pt) 2017-10-10
EP1295890A1 (de) 2003-03-26
EP1295890B1 (de) 2005-04-27
KR100589935B1 (ko) 2006-06-15
DE60110415D1 (de) 2005-06-02
BRPI0116967B8 (pt) 2021-05-25
BRPI0116967B1 (pt) 2018-05-22
DE60108724D1 (de) 2005-03-10
JP2009161553A (ja) 2009-07-23
ATE288443T1 (de) 2005-02-15
US20030130213A1 (en) 2003-07-10
KR20030034120A (ko) 2003-05-01
ATE294185T1 (de) 2005-05-15
KR100604955B1 (ko) 2006-07-26
EP1256588A4 (de) 2003-03-26
BRPI0108374B8 (pt) 2021-05-25
JP5038345B2 (ja) 2012-10-03
ES2237550T3 (es) 2005-08-01
EP1256588B1 (de) 2005-02-02
DE60110415T2 (de) 2005-09-29
CA2398620C (en) 2009-06-23
CN1239511C (zh) 2006-02-01
US6800629B2 (en) 2004-10-05
WO2001060834A1 (fr) 2001-08-23
MXPA02007890A (es) 2002-10-31

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