WO2002083641A3 - Amino-aza-cyclohexanes for the treatment of malaria - Google Patents

Amino-aza-cyclohexanes for the treatment of malaria Download PDF

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Publication number
WO2002083641A3
WO2002083641A3 PCT/EP2002/003948 EP0203948W WO02083641A3 WO 2002083641 A3 WO2002083641 A3 WO 2002083641A3 EP 0203948 W EP0203948 W EP 0203948W WO 02083641 A3 WO02083641 A3 WO 02083641A3
Authority
WO
WIPO (PCT)
Prior art keywords
aza
treatment
malaria
amino
cyclohexanes
Prior art date
Application number
PCT/EP2002/003948
Other languages
French (fr)
Other versions
WO2002083641A2 (en
Inventor
Christoph Boss
Christoph Binkert
Walter Fischli
Solange Meyer
Sylvia Richard-Bildstein
Panja Strickner
Thomas Weller
Original Assignee
Actelion Pharmaceuticals Ltd
Christoph Boss
Christoph Binkert
Walter Fischli
Solange Meyer
Sylvia Richard-Bildstein
Panja Strickner
Thomas Weller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd, Christoph Boss, Christoph Binkert, Walter Fischli, Solange Meyer, Sylvia Richard-Bildstein, Panja Strickner, Thomas Weller filed Critical Actelion Pharmaceuticals Ltd
Priority to AU2002304733A priority Critical patent/AU2002304733A1/en
Publication of WO2002083641A2 publication Critical patent/WO2002083641A2/en
Publication of WO2002083641A3 publication Critical patent/WO2002083641A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to novel compounds which are substituted amino-aza-cyclohexane derivatives of the general formula (I). The invention also concerns related aspects including pharmaceutical compositions containing one or more compounds of the general formula I and their use as medicaments for the treatment of protozoal infections, especially malaria.
PCT/EP2002/003948 2001-04-17 2002-04-09 Amino-aza-cyclohexanes for the treatment of malaria WO2002083641A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002304733A AU2002304733A1 (en) 2001-04-17 2002-04-09 Amino-aza-cyclohexanes for the treatment of malaria

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP0104299 2001-04-17
EPPCT/EP01/04299 2001-04-17

Publications (2)

Publication Number Publication Date
WO2002083641A2 WO2002083641A2 (en) 2002-10-24
WO2002083641A3 true WO2002083641A3 (en) 2003-02-27

Family

ID=8164375

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/003948 WO2002083641A2 (en) 2001-04-17 2002-04-09 Amino-aza-cyclohexanes for the treatment of malaria

Country Status (2)

Country Link
AU (1) AU2002304733A1 (en)
WO (1) WO2002083641A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200409637A (en) 2002-06-26 2004-06-16 Glaxo Group Ltd Compounds
US10464896B2 (en) 2015-06-11 2019-11-05 Basilea Pharmaceutica International AG Efflux-pump inhibitors and therapeutic uses thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0395093A1 (en) * 1989-04-28 1990-10-31 Kyowa Hakko Kogyo Co., Ltd. Triphenylmethane derivatives
US5212182A (en) * 1990-10-03 1993-05-18 American Home Products Corpooration Substituted quinolinyl- and naphthalenylbenzamides or benzylamines and related compounds useful as analgesics
US5216165A (en) * 1990-10-03 1993-06-01 American Home Products Corporation N-substituted aminoquinolines as analgesic agents
EP0656353A1 (en) * 1993-10-28 1995-06-07 F. Hoffmann-La Roche Ag Aminochinoline derivates useful in the treatment of malaria
WO2001014331A2 (en) * 1999-08-24 2001-03-01 Regents Of The University Of California Non-quinoline inhibitors of malaria parasites
WO2002024649A1 (en) * 2000-09-25 2002-03-28 Actelion Pharmaceuticals Ltd Substituted amino-aza-cycloalkanes useful against malaria
WO2002031511A2 (en) * 2000-10-12 2002-04-18 Icos Corporation Modulation of ligand binding/enzymatic activity of alpha beta proteins

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0395093A1 (en) * 1989-04-28 1990-10-31 Kyowa Hakko Kogyo Co., Ltd. Triphenylmethane derivatives
US5212182A (en) * 1990-10-03 1993-05-18 American Home Products Corpooration Substituted quinolinyl- and naphthalenylbenzamides or benzylamines and related compounds useful as analgesics
US5216165A (en) * 1990-10-03 1993-06-01 American Home Products Corporation N-substituted aminoquinolines as analgesic agents
EP0656353A1 (en) * 1993-10-28 1995-06-07 F. Hoffmann-La Roche Ag Aminochinoline derivates useful in the treatment of malaria
WO2001014331A2 (en) * 1999-08-24 2001-03-01 Regents Of The University Of California Non-quinoline inhibitors of malaria parasites
WO2002024649A1 (en) * 2000-09-25 2002-03-28 Actelion Pharmaceuticals Ltd Substituted amino-aza-cycloalkanes useful against malaria
WO2002031511A2 (en) * 2000-10-12 2002-04-18 Icos Corporation Modulation of ligand binding/enzymatic activity of alpha beta proteins

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"ComGenex Product List", 16 September 1999, COMGENEX INTERNATIONAL INC:, MONMOUTH JCT., NJ, 08852 USA *
DATABASE CHEMCATS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, USA; XP002219215 *

Also Published As

Publication number Publication date
WO2002083641A2 (en) 2002-10-24
AU2002304733A1 (en) 2002-10-28

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