WO2002102793A3 - Quinazolinediones as antibacterial agents - Google Patents

Quinazolinediones as antibacterial agents

Info

Publication number
WO2002102793A3
WO2002102793A3 PCT/IB2002/001768 IB0201768W WO2002102793A3 WO 2002102793 A3 WO2002102793 A3 WO 2002102793A3 IB 0201768 W IB0201768 W IB 0201768W WO 2002102793 A3 WO2002102793 A3 WO 2002102793A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
formula
compounds
preparing
antibacterial
agents
Prior art date
Application number
PCT/IB2002/001768
Other languages
French (fr)
Other versions
WO2002102793A2 (en )
Inventor
Edmund Lee Ellsworth
James Alan Kerschen
Sharon Anne Powell
Joseph Peter Sanchez
Howard Daniel Hollis Showalter
Michael Andrew Stier
Tuan Phong Tran
Original Assignee
Edmund Lee Ellsworth
James Alan Kerschen
Sharon Anne Powell
Joseph Peter Sanchez
Howard Daniel Hollis Showalter
Michael Andrew Stier
Tuan Phong Tran
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06Peri-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Abstract

The present invention provides compounds of formula (I): wherein R1-R6 and J and K have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful as antibacterial agents. Also disclosed are pharmaceutical compositions comprising one or more compounds of formula I, processes for preparing compounds of formula I, and intermediates useful for preparing compounds of formula I.
PCT/IB2002/001768 2001-06-19 2002-05-13 Quinazolinediones as antibacterial agents WO2002102793A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US29924901 true 2001-06-19 2001-06-19
US60/299,249 2001-06-19

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003506266A JP2005501021A (en) 2001-06-19 2002-05-13 Anti-bacterial agents
CA 2446963 CA2446963A1 (en) 2001-06-19 2002-05-13 Quinazolinediones as antibacterial agents
EP20020730582 EP1401830A2 (en) 2001-06-19 2002-05-13 Quinazolinediones as antibacterial agents

Publications (2)

Publication Number Publication Date
WO2002102793A2 true WO2002102793A2 (en) 2002-12-27
WO2002102793A3 true true WO2002102793A3 (en) 2003-04-10

Family

ID=23153973

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2002/001768 WO2002102793A3 (en) 2001-06-19 2002-05-13 Quinazolinediones as antibacterial agents

Country Status (4)

Country Link
EP (1) EP1401830A2 (en)
JP (1) JP2005501021A (en)
CA (1) CA2446963A1 (en)
WO (1) WO2002102793A3 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9533984B2 (en) 2013-04-19 2017-01-03 Incyte Holdings Corporation Bicyclic heterocycles as FGFR inhibitors
US9533954B2 (en) 2010-12-22 2017-01-03 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005026154A1 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinolone antibacterial agents
JP2007511597A (en) * 2003-11-18 2007-05-10 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー Antimicrobial amino quinazolinylmethoxy Ding diethylene one derivative
CN103443085B (en) 2011-03-14 2016-03-23 南京英派药业有限公司 Its Application quinazolinedione
US9290460B2 (en) * 2011-04-01 2016-03-22 Impact Therapeutics, Inc. 1-(Arylmethyl)quinazoline-2,4(1H,3H)-diones as PARP inhibitors and the use thereof
EP2861595B9 (en) 2012-06-13 2017-06-21 Incyte Holdings Corporation Substituted tricyclic compounds as fgfr inhibitors
EP3259269A1 (en) 2015-02-20 2017-12-27 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
EP3259270A1 (en) 2015-02-20 2017-12-27 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors

Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2120663A1 (en) * 1970-04-27 1971-11-11
DE2334266A1 (en) * 1972-07-07 1974-01-31 Hisamitsu Pharmaceutical Co Pyrido square bracket 2,3-d bracket to pyrimidine-2,4 (1H, 3H) -dione
JPS50142596A (en) * 1974-04-03 1975-11-17
JPS50148368A (en) * 1974-04-25 1975-11-27
DE2446543A1 (en) * 1974-09-28 1976-04-15 Hoechst Ag Monoazomethine pigments - from 3-hydroxy 4-formylnaphthalic acid or derivs.
DE2614148A1 (en) * 1976-04-02 1977-10-20 Henkel & Cie Gmbh Oxidation, bleaches and detergents with a content of bleach activators
EP0382687A2 (en) * 1989-02-06 1990-08-16 BOEHRINGER INGELHEIM ITALIA S.p.A. Benzofused-N-containing heterocycle derivatives
WO1994014809A1 (en) * 1992-12-23 1994-07-07 Byk Gulden Lomberg Chemische Fabrik Gmbh Anellated uracil derivates
WO1997024335A1 (en) * 1995-12-28 1997-07-10 Fuji Chemical Industry Co., Ltd. Process for the preparation of 3-dihalobenzyl-2,4-quinazolinedione derivatives
JPH09208543A (en) * 1995-11-29 1997-08-12 Ono Pharmaceut Co Ltd Production of isocyanate derivative and its related compound
EP0789020A1 (en) * 1996-02-01 1997-08-13 Sumitomo Chemical Company, Limited Process for producing dioxoquinazolines
JPH09295977A (en) * 1996-04-30 1997-11-18 Terumo Corp Pyridopyrimidine derivative and medicinal composition containing the same
WO1998018781A2 (en) * 1996-10-28 1998-05-07 Versicor, Inc. Fused 2,4-pyrimidinedione combinatorial libraries, their preparation and the use of fused 2,4-pyrimidinediones derivatives as antimicrobial agents
WO1999021840A1 (en) * 1997-10-28 1999-05-06 Warner-Lambert Company Novel 7-substituted quinazolin-2,4-diones useful as antibacterial agents
WO2001053273A1 (en) * 2000-01-24 2001-07-26 Warner-Lambert Company 3-aminoquinazolin-2,4-dione antibacterial agents
WO2001079206A1 (en) * 2000-04-18 2001-10-25 Sumitomo Pharmaceuticals Company, Limited Tricyclic quinazolinediones
JP2002284699A (en) * 2001-03-28 2002-10-03 Sumitomo Pharmaceut Co Ltd Curative for visual cell degenerative disease

Patent Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2120663A1 (en) * 1970-04-27 1971-11-11
DE2334266A1 (en) * 1972-07-07 1974-01-31 Hisamitsu Pharmaceutical Co Pyrido square bracket 2,3-d bracket to pyrimidine-2,4 (1H, 3H) -dione
JPS50142596A (en) * 1974-04-03 1975-11-17
JPS50148368A (en) * 1974-04-25 1975-11-27
DE2446543A1 (en) * 1974-09-28 1976-04-15 Hoechst Ag Monoazomethine pigments - from 3-hydroxy 4-formylnaphthalic acid or derivs.
DE2614148A1 (en) * 1976-04-02 1977-10-20 Henkel & Cie Gmbh Oxidation, bleaches and detergents with a content of bleach activators
EP0382687A2 (en) * 1989-02-06 1990-08-16 BOEHRINGER INGELHEIM ITALIA S.p.A. Benzofused-N-containing heterocycle derivatives
WO1994014809A1 (en) * 1992-12-23 1994-07-07 Byk Gulden Lomberg Chemische Fabrik Gmbh Anellated uracil derivates
JPH09208543A (en) * 1995-11-29 1997-08-12 Ono Pharmaceut Co Ltd Production of isocyanate derivative and its related compound
WO1997024335A1 (en) * 1995-12-28 1997-07-10 Fuji Chemical Industry Co., Ltd. Process for the preparation of 3-dihalobenzyl-2,4-quinazolinedione derivatives
EP0789020A1 (en) * 1996-02-01 1997-08-13 Sumitomo Chemical Company, Limited Process for producing dioxoquinazolines
JPH09295977A (en) * 1996-04-30 1997-11-18 Terumo Corp Pyridopyrimidine derivative and medicinal composition containing the same
WO1998018781A2 (en) * 1996-10-28 1998-05-07 Versicor, Inc. Fused 2,4-pyrimidinedione combinatorial libraries, their preparation and the use of fused 2,4-pyrimidinediones derivatives as antimicrobial agents
WO1999021840A1 (en) * 1997-10-28 1999-05-06 Warner-Lambert Company Novel 7-substituted quinazolin-2,4-diones useful as antibacterial agents
WO2001053273A1 (en) * 2000-01-24 2001-07-26 Warner-Lambert Company 3-aminoquinazolin-2,4-dione antibacterial agents
WO2001079206A1 (en) * 2000-04-18 2001-10-25 Sumitomo Pharmaceuticals Company, Limited Tricyclic quinazolinediones
JP2002284699A (en) * 2001-03-28 2002-10-03 Sumitomo Pharmaceut Co Ltd Curative for visual cell degenerative disease

Non-Patent Citations (34)

* Cited by examiner, † Cited by third party
Title
A. N. OSMAN ET AL.: "Synthesis and biological activity of certain derivatives of 2,4-dioxo-1,2,3,4-tetrahydroquinazoline. I", EGYPT. J. CHEM., vol. 25, no. 2, 1982, pages 159 - 164, XP009001225 *
A. N. OSMAN ET AL.: "Synthesis and biological activity of certain derivatives of 2,4-dioxo-1,2,3,4-tetrahydroquinazoline. I", REV. ROUM. CHIM., vol. 27, no. 7, 1982, pages 859 - 864, XP009001179 *
CHATTERJEE, ANAND, J. SCI. IND. RES., vol. 17B, 1958, pages 63 *
CHEMICAL ABSTRACTS, vol. 118, no. 23, 7 June 1993, Columbus, Ohio, US; abstract no. 233993w, H. A. ABDEL-HAMID ET AL.: "Synthesis of some biologically active heterocycles. Reactions of the hydrazide of 2'-thienoylanthranilic acid and its 3,5-dibromo derivative" page 996; XP002210829 *
CHEMICAL ABSTRACTS, vol. 123, no. 25, 18 December 1995, Columbus, Ohio, US; abstract no. 339967j, A. K. SHARMA ET AL.: "Synthesis of some new pyrimidine bases as precursors of potential anticancer nucleosides" page 1164; XP002210830 *
CHEMICAL ABSTRACTS, vol. 127, no. 2, 14 July 1997, Columbus, Ohio, US; abstract no. 17901h, A. K. YADAV ET AL.: "Synthesis of some novel nucleosides of dioxo pyrido[2,3-d]pyrimidines" page 586; XP002210831 *
CHEMICAL ABSTRACTS, vol. 128, no. 4, 26 January 1998, Columbus, Ohio, US; abstract no. 34737x, E. H. EL-TAMANY ET AL.: "Synthesis and antimicrobial activities of some quinazolinone derivatives" page 565; XP002210832 *
CHEMICAL ABSTRACTS, vol. 133, no. 17, 23 October 2000, Columbus, Ohio, US; abstract no. 237941k, S. E. S. BARAKAT: "Synthesis, reactions and antimicrobial activity of 3-aryl-2-pyridiniummethyl-4(3H)-quinazolinone bromides" page 715; XP002210833 *
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002210834, Database accession no. 8138 *
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002210835, Database accession no. 157768 *
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002210836, Database accession no. 383776 *
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002210837, Database accession no. 1198342 & 1174334 *
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002222384, Database accession no. 329145, 233007 *
EGYPT. J. CHEM., vol. 40, no. 5, 1997, pages 339 - 351 *
EGYPT. J. PHARM. SCI., vol. 39, no. 4-6, 1998, pages 497 - 509 *
F. ISHIKAWA ET AL.: "Cyclic Guanidines. 17. Novel (N-Substituted amino)imidazo[2,1-b]quinazolin-2-ones: Water-Soluble Platelet Aggregation Inhibitors", J. MED. CHEM., vol. 28, no. 10, 1985, pages 1387 - 1393, XP009000843 *
H. G. GARCIA-QUINTANA ET AL.: "Essai de benzotriazepines et quinazolines obtenues par synthèse sur des populations bactériennes", J. VET. MED. B, vol. 34, 1987, pages 341 - 346, XP000985582 *
H. M. S. AHMED: "Antiinflammatory, analgesic and antipyretic activities of certain 1,3 and 1,6 disubstituted and 1,3,6 trisubstituted quinazoline 2,6-dione derivatives", BULL. FAC. PHARM. (CAIRO UNIV.), vol. 19, no. 1, 1980, pages 1 - 9, XP002222379 *
HELLER, J. PRAKT. CHEM. <2>, vol. 111, 1925, pages 19 *
INDIAN J. CHEM. SECT. B: ORG. CHEM. INCL. MED. CHEM., vol. 34B, no. 8, 1995, pages 740 - 742 *
INDIAN J. HETEROCYCL. CHEM., vol. 6, no. 3, 1997, pages 237 - 238 *
J. BOMPART ET AL.: "1H,3H-Quinazoline-2,4-diones: synthesis, physicochemical characterization and study of the stabilization of bovine serum albumin against denaturation", ANNALES PHARMACEUTIQUES FRANCAISES, vol. 46, no. 6, 1989, pages 361 - 370, XP009001198 *
J. BOMPART ET AL.: "Determination of the hydrophobic constants of 1H,3H-quinazoline-2,4-diones", ANNALES PHARMACEUTIQUES FRANCAISES, vol. 46, no. 5, 1988, pages 301 - 308, XP009001200 *
JACINI, GAZZ. CHIM. ITAL., vol. 73, 1943, pages 85 *
K. GROHE, H. HEITZER, JUSTUS LIEBIGS ANN. CHEM., 1974, pages 2066 - 2073 *
M. GÜTSCHOW: "Novel Heterocycles Derived from Substituted Aroylthioureas: Synthesis of 3,1-Benzothiazin-4-ones, Thieno[3,2-d][1,3]thiazin-4-ones and 1,2,4-Thiadiazolo[2,3-a][3,1]benzothiazin-5-ones", J. HETEROCYCL. CHEM., vol. 33, no. 2, 1996, pages 355 - 360, XP002222380 *
M. KHALIFA ET AL.: "Synthesis and Biological Activity of Certain Derivatives of 2,4-Dioxo-1,2,3,4-tetrahydroquinazoline Part 2", EGYPT. J. CHEM., vol. 25, no. 3, 1982, pages 285 - 291, XP000978530 *
M. KHALIFA ET AL.: "Synthesis and Biological Activity of Certain Derivatives of 2,4-Dioxo-1,2,3,4-tetrahydroquinazoline", PHARMAZIE, vol. 37, no. 2, 1982, pages 115 - 117, XP002157063 *
PATENT ABSTRACTS OF JAPAN vol. 1997, no. 12 25 December 1997 (1997-12-25) *
PATENT ABSTRACTS OF JAPAN vol. 1998, no. 03 27 February 1998 (1998-02-27) *
PHOSPHORUS, SULFUR SILICON RELAT. ELEM., vol. 72, no. 1-4, 1992, pages 237 - 247 *
R. BARONNET ET AL.: "Synthèse et pharmacodynamie de dialkylamino-3 1H,3H quinazolinediones-2,4 et de dérivés", EUR. J. MED. CHEM., vol. 18, no. 3, 1983, pages 241 - 247, XP000985490 *
ROBINS, HITCHINGS, J. AMER. CHEM. SOC., vol. 77, 1955, pages 2256 *
Z. BUDESINSKY ET AL.: "Alkoxy-2,4-quinazolinediamines", COLLECT. CZECH. CHEM. COMMUN., vol. 41, no. 11, 1976, pages 3405 - 3414, XP002222381 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9533954B2 (en) 2010-12-22 2017-01-03 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
US9533984B2 (en) 2013-04-19 2017-01-03 Incyte Holdings Corporation Bicyclic heterocycles as FGFR inhibitors
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors

Also Published As

Publication number Publication date Type
WO2002102793A2 (en) 2002-12-27 application
CA2446963A1 (en) 2002-12-27 application
EP1401830A2 (en) 2004-03-31 application
JP2005501021A (en) 2005-01-13 application

Similar Documents

Publication Publication Date Title
WO2001019829A3 (en) Pyrazolopyrimidines as therapeutic agents
WO2003000187A3 (en) Novel pyrazolo-and pyrrolo-pyrimidines and uses thereof
CA2463989A1 (en) Pyrimidine derivatives, pharmaceutical compositions containing these compounds, the use thereof and process for the preparation thereof
WO2003047577A3 (en) Pharmaceutical compositions comprising dihydropyridinone compounds and an immunoregulatory or an antiinflammatory agent and their uses
WO2006063841A3 (en) Trycyclic heterocycles, their manufacture and use as pharmaceutical agents
WO2004060882A8 (en) Cb 1/cb 2 receptor ligands and their use in the treatment of pain
CA2559699A1 (en) Pharmaceutical combinations containing benzoxazine for treating respiratory diseases
WO2004005286A3 (en) Viral inhibitors
WO2004108715A8 (en) 3-aryloxy and 3-heteroaryloxy substituted benzo(b) thiophenes as therapeutic agents with pi3k activity
WO2004074244A3 (en) Pyrimidine compounds
WO2004037176A3 (en) Quinazolinones and derivatives thereof as factor xa inhibitors
CA2446461A1 (en) Substituted cyclohexane-1,4-diamine derivatives
WO2002070438A3 (en) Compositions for delivering bisphosphonates
WO2005002626A8 (en) Therapeutic phosphonate compounds
WO2003051838A3 (en) Protein kinase inhibitors
WO2006024486A3 (en) Amide derivatives of 3-phenyl dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents
WO2003045330A3 (en) Materials and methods for making improved micelle compositions
WO2003051276B1 (en) Therapeutic heterocycles
WO2001068633A1 (en) 2-phenylpyran-4-one derivatives
WO2004112718A3 (en) Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases
WO2003045912A8 (en) Inhibitors of factor xa and other serine proteases involved in the coagulation cascade
WO2006068826A3 (en) 2-pyrimidinyl pyrazolopyridine erbb kinase inhibitors
WO2004026836A3 (en) 1-pyridin-4-yl-urea derivatives
WO2004071426A3 (en) Compounds for the treatment of viral infection
WO2002080846A3 (en) Epothilone derivatives and methods for making and using the same

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: PA/a/2003/009894

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 2446963

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2002730582

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2003506266

Country of ref document: JP

WWP Wipo information: published in national office

Ref document number: 2002730582

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 2002730582

Country of ref document: EP