WO2002102793A3 - Quinazolinediones as antibacterial agents - Google Patents
Quinazolinediones as antibacterial agents Download PDFInfo
- Publication number
- WO2002102793A3 WO2002102793A3 PCT/IB2002/001768 IB0201768W WO02102793A3 WO 2002102793 A3 WO2002102793 A3 WO 2002102793A3 IB 0201768 W IB0201768 W IB 0201768W WO 02102793 A3 WO02102793 A3 WO 02102793A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- formula
- antibacterial agents
- quinazolinediones
- compounds
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02730582A EP1401830A2 (en) | 2001-06-19 | 2002-05-13 | Quinazolinediones as antibacterial agents |
MXPA03009894A MXPA03009894A (en) | 2001-06-19 | 2002-05-13 | Quinazolinediones as antibacterial agents. |
CA002446963A CA2446963A1 (en) | 2001-06-19 | 2002-05-13 | Quinazolinediones as antibacterial agents |
AU2002302894A AU2002302894A1 (en) | 2001-06-19 | 2002-05-13 | Quinazolinediones as antibacterial agents |
BR0210028-2A BR0210028A (en) | 2001-06-19 | 2002-05-13 | Antibacterial agents |
JP2003506266A JP2005501021A (en) | 2001-06-19 | 2002-05-13 | Antibacterial agent |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29924901P | 2001-06-19 | 2001-06-19 | |
US60/299,249 | 2001-06-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002102793A2 WO2002102793A2 (en) | 2002-12-27 |
WO2002102793A3 true WO2002102793A3 (en) | 2003-04-10 |
Family
ID=23153973
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2002/001768 WO2002102793A2 (en) | 2001-06-19 | 2002-05-13 | Quinazolinediones as antibacterial agents |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1401830A2 (en) |
JP (1) | JP2005501021A (en) |
AU (1) | AU2002302894A1 (en) |
BR (1) | BR0210028A (en) |
CA (1) | CA2446963A1 (en) |
DO (1) | DOP2002000422A (en) |
GT (1) | GT200200104A (en) |
HN (1) | HN2002000150A (en) |
MX (1) | MXPA03009894A (en) |
PA (1) | PA8548401A1 (en) |
PE (1) | PE20030272A1 (en) |
SV (1) | SV2003001089A (en) |
WO (1) | WO2002102793A2 (en) |
Cited By (7)
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---|---|---|---|---|
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
US9533954B2 (en) | 2010-12-22 | 2017-01-03 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
US9533984B2 (en) | 2013-04-19 | 2017-01-03 | Incyte Holdings Corporation | Bicyclic heterocycles as FGFR inhibitors |
US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005026154A1 (en) * | 2003-09-12 | 2005-03-24 | Warner-Lambert Company Llc | Quinolone antibacterial agents |
MXPA06005550A (en) * | 2003-11-18 | 2006-08-17 | Warner Lambert Co | Antibacterial aminoquinazolidinedione derivatives. |
US9090568B2 (en) | 2011-03-14 | 2015-07-28 | Impact Therapeutics, Inc. | Quinazolinediones and their use |
TWI527800B (en) | 2011-04-01 | 2016-04-01 | 南京英派藥業有限公司 | 1-(arylmethyl)quinazoline-2,4(1h,3h)-diones as parp inhibitors and the use thereof |
LT3495367T (en) | 2012-06-13 | 2021-02-25 | Incyte Holdings Corporation | Substituted tricyclic compounds as fgfr inhibitors |
US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
WO2016134320A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
MA41551A (en) | 2015-02-20 | 2017-12-26 | Incyte Corp | BICYCLIC HETEROCYCLES USED AS FGFR4 INHIBITORS |
CL2015003780A1 (en) | 2015-12-30 | 2016-09-16 | Univ Chile | Pyrimido-isoquinolin-quinone derivative compounds, their salts, isomers, acceptable pharmaceutical tautomers; farm compositions; preparation procedure; and its use in the treatment of multiresistant bacterial and bacterial diseases. |
AR111960A1 (en) | 2017-05-26 | 2019-09-04 | Incyte Corp | CRYSTALLINE FORMS OF A FGFR INHIBITOR AND PROCESSES FOR ITS PREPARATION |
MA52494A (en) | 2018-05-04 | 2021-03-10 | Incyte Corp | SOLID FORMS OF FGFR INHIBITOR AND THEIR PREPARATION PROCEDURES |
EP3788046A1 (en) | 2018-05-04 | 2021-03-10 | Incyte Corporation | Salts of an fgfr inhibitor |
CN111620866A (en) * | 2019-02-27 | 2020-09-04 | 南京药石科技股份有限公司 | Cis-7, 7-difluoro-hexahydro-1H pyrrolo [3,4-c ] pyridine derivative and preparation method thereof |
US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
EP4045151A1 (en) | 2019-10-14 | 2022-08-24 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
WO2021113479A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
CA3162010A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Derivatives of an fgfr inhibitor |
US11738002B2 (en) | 2020-04-14 | 2023-08-29 | Sunovion Pharmaceuticals Inc. | Methods of treating neurological and psychiatric disorders |
TW202313611A (en) | 2021-06-09 | 2023-04-01 | 美商英塞特公司 | Tricyclic heterocycles as fgfr inhibitors |
Citations (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2120663A1 (en) * | 1970-04-27 | 1971-11-11 | Hisamitsu Pharmaceutical Co., Inc., Tosu, Saga (Japan) | Quinazolinedione derivatives and process for their preparation |
DE2334266A1 (en) * | 1972-07-07 | 1974-01-31 | Hisamitsu Pharmaceutical Co | PYRIDO SQUARE BRACKET ON 2.3-D SQUARE BRACKET FOR PYRIMIDINE-2,4 (1H, 3H) -DIONE |
JPS50142596A (en) * | 1974-04-03 | 1975-11-17 | ||
JPS50148368A (en) * | 1974-04-25 | 1975-11-27 | ||
DE2446543A1 (en) * | 1974-09-28 | 1976-04-15 | Hoechst Ag | Monoazomethine pigments - from 3-hydroxy 4-formylnaphthalic acid or derivs. |
DE2614148A1 (en) * | 1976-04-02 | 1977-10-20 | Henkel & Cie Gmbh | OXIDIZING AGENTS, BLEACHING AGENTS AND DETERGENTS WITH A BLEACH ACTIVATOR CONTENT |
EP0382687A2 (en) * | 1989-02-06 | 1990-08-16 | BOEHRINGER INGELHEIM ITALIA S.p.A. | Benzofused-N-containing heterocycle derivatives |
WO1994014809A1 (en) * | 1992-12-23 | 1994-07-07 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Anellated uracil derivates |
WO1997024335A1 (en) * | 1995-12-28 | 1997-07-10 | Fuji Chemical Industry Co., Ltd. | Process for the preparation of 3-dihalobenzyl-2,4-quinazolinedione derivatives |
JPH09208543A (en) * | 1995-11-29 | 1997-08-12 | Ono Pharmaceut Co Ltd | Production of isocyanate derivative and its related compound |
EP0789020A1 (en) * | 1996-02-01 | 1997-08-13 | Sumitomo Chemical Company, Limited | Process for producing dioxoquinazolines |
JPH09295977A (en) * | 1996-04-30 | 1997-11-18 | Terumo Corp | Pyridopyrimidine derivative and medicinal composition containing the same |
WO1998018781A2 (en) * | 1996-10-28 | 1998-05-07 | Versicor, Inc. | Fused 2,4-pyrimidinedione combinatorial libraries, their preparation and the use of fused 2,4-pyrimidinediones derivatives as antimicrobial agents |
WO1999021840A1 (en) * | 1997-10-28 | 1999-05-06 | Warner-Lambert Company | Novel 7-substituted quinazolin-2,4-diones useful as antibacterial agents |
WO2001053273A1 (en) * | 2000-01-24 | 2001-07-26 | Warner-Lambert Company | 3-aminoquinazolin-2,4-dione antibacterial agents |
WO2001079206A1 (en) * | 2000-04-18 | 2001-10-25 | Sumitomo Pharmaceuticals Company, Limited | Tricyclic quinazolinediones |
JP2002284699A (en) * | 2001-03-28 | 2002-10-03 | Sumitomo Pharmaceut Co Ltd | Curative for visual cell degenerative disease |
-
2002
- 2002-05-13 EP EP02730582A patent/EP1401830A2/en not_active Withdrawn
- 2002-05-13 MX MXPA03009894A patent/MXPA03009894A/en unknown
- 2002-05-13 WO PCT/IB2002/001768 patent/WO2002102793A2/en not_active Application Discontinuation
- 2002-05-13 CA CA002446963A patent/CA2446963A1/en not_active Abandoned
- 2002-05-13 JP JP2003506266A patent/JP2005501021A/en not_active Withdrawn
- 2002-05-13 AU AU2002302894A patent/AU2002302894A1/en not_active Abandoned
- 2002-05-13 BR BR0210028-2A patent/BR0210028A/en not_active IP Right Cessation
- 2002-05-31 GT GT200200104A patent/GT200200104A/en unknown
- 2002-06-18 PE PE2002000523A patent/PE20030272A1/en not_active Application Discontinuation
- 2002-06-18 HN HN2002000150A patent/HN2002000150A/en unknown
- 2002-06-18 SV SV2002001089A patent/SV2003001089A/en unknown
- 2002-06-19 PA PA20028548401A patent/PA8548401A1/en unknown
- 2002-06-19 DO DO2002000422A patent/DOP2002000422A/en unknown
Patent Citations (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2120663A1 (en) * | 1970-04-27 | 1971-11-11 | Hisamitsu Pharmaceutical Co., Inc., Tosu, Saga (Japan) | Quinazolinedione derivatives and process for their preparation |
DE2334266A1 (en) * | 1972-07-07 | 1974-01-31 | Hisamitsu Pharmaceutical Co | PYRIDO SQUARE BRACKET ON 2.3-D SQUARE BRACKET FOR PYRIMIDINE-2,4 (1H, 3H) -DIONE |
JPS50142596A (en) * | 1974-04-03 | 1975-11-17 | ||
JPS50148368A (en) * | 1974-04-25 | 1975-11-27 | ||
DE2446543A1 (en) * | 1974-09-28 | 1976-04-15 | Hoechst Ag | Monoazomethine pigments - from 3-hydroxy 4-formylnaphthalic acid or derivs. |
DE2614148A1 (en) * | 1976-04-02 | 1977-10-20 | Henkel & Cie Gmbh | OXIDIZING AGENTS, BLEACHING AGENTS AND DETERGENTS WITH A BLEACH ACTIVATOR CONTENT |
EP0382687A2 (en) * | 1989-02-06 | 1990-08-16 | BOEHRINGER INGELHEIM ITALIA S.p.A. | Benzofused-N-containing heterocycle derivatives |
WO1994014809A1 (en) * | 1992-12-23 | 1994-07-07 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Anellated uracil derivates |
JPH09208543A (en) * | 1995-11-29 | 1997-08-12 | Ono Pharmaceut Co Ltd | Production of isocyanate derivative and its related compound |
WO1997024335A1 (en) * | 1995-12-28 | 1997-07-10 | Fuji Chemical Industry Co., Ltd. | Process for the preparation of 3-dihalobenzyl-2,4-quinazolinedione derivatives |
EP0789020A1 (en) * | 1996-02-01 | 1997-08-13 | Sumitomo Chemical Company, Limited | Process for producing dioxoquinazolines |
JPH09295977A (en) * | 1996-04-30 | 1997-11-18 | Terumo Corp | Pyridopyrimidine derivative and medicinal composition containing the same |
WO1998018781A2 (en) * | 1996-10-28 | 1998-05-07 | Versicor, Inc. | Fused 2,4-pyrimidinedione combinatorial libraries, their preparation and the use of fused 2,4-pyrimidinediones derivatives as antimicrobial agents |
WO1999021840A1 (en) * | 1997-10-28 | 1999-05-06 | Warner-Lambert Company | Novel 7-substituted quinazolin-2,4-diones useful as antibacterial agents |
WO2001053273A1 (en) * | 2000-01-24 | 2001-07-26 | Warner-Lambert Company | 3-aminoquinazolin-2,4-dione antibacterial agents |
WO2001079206A1 (en) * | 2000-04-18 | 2001-10-25 | Sumitomo Pharmaceuticals Company, Limited | Tricyclic quinazolinediones |
JP2002284699A (en) * | 2001-03-28 | 2002-10-03 | Sumitomo Pharmaceut Co Ltd | Curative for visual cell degenerative disease |
Non-Patent Citations (34)
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