ATE294185T1 - Neue pyrazin-derivate oder salze davon, pharmazeutische zusammensetzungen, die die derivate oder deren salze enthalten und intermediäre zur herstellung der derivate - Google Patents

Neue pyrazin-derivate oder salze davon, pharmazeutische zusammensetzungen, die die derivate oder deren salze enthalten und intermediäre zur herstellung der derivate

Info

Publication number
ATE294185T1
ATE294185T1 AT02028152T AT02028152T ATE294185T1 AT E294185 T1 ATE294185 T1 AT E294185T1 AT 02028152 T AT02028152 T AT 02028152T AT 02028152 T AT02028152 T AT 02028152T AT E294185 T1 ATE294185 T1 AT E294185T1
Authority
AT
Austria
Prior art keywords
derivatives
salts
production
intermediaries
pharmaceutical compositions
Prior art date
Application number
AT02028152T
Other languages
English (en)
Inventor
Hiroyuki Egawa
Yousuke Furuta
Jun Sugita
Sayuri Uehara
Shoichi Hamamoto
Kenji Yonezawa
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Application granted granted Critical
Publication of ATE294185T1 publication Critical patent/ATE294185T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT02028152T 2000-02-16 2001-02-14 Neue pyrazin-derivate oder salze davon, pharmazeutische zusammensetzungen, die die derivate oder deren salze enthalten und intermediäre zur herstellung der derivate ATE294185T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000037486 2000-02-16
JP2000040439 2000-02-18
JP2000090071 2000-03-29

Publications (1)

Publication Number Publication Date
ATE294185T1 true ATE294185T1 (de) 2005-05-15

Family

ID=27342371

Family Applications (2)

Application Number Title Priority Date Filing Date
AT01904434T ATE288443T1 (de) 2000-02-16 2001-02-14 Neue pyrazin-derivate oder salze davon, pharmazeutische zusammensetzungen, die die derivate oder deren salze enthalten und intermediate zu beider herstellung
AT02028152T ATE294185T1 (de) 2000-02-16 2001-02-14 Neue pyrazin-derivate oder salze davon, pharmazeutische zusammensetzungen, die die derivate oder deren salze enthalten und intermediäre zur herstellung der derivate

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT01904434T ATE288443T1 (de) 2000-02-16 2001-02-14 Neue pyrazin-derivate oder salze davon, pharmazeutische zusammensetzungen, die die derivate oder deren salze enthalten und intermediate zu beider herstellung

Country Status (15)

Country Link
US (1) US6800629B2 (de)
EP (2) EP1256588B1 (de)
JP (2) JP4379767B2 (de)
KR (3) KR100604955B1 (de)
CN (1) CN1239511C (de)
AT (2) ATE288443T1 (de)
AU (1) AU2001232287A1 (de)
BR (2) BRPI0116967B8 (de)
CA (1) CA2398620C (de)
DE (2) DE60108724T2 (de)
DK (1) DK1295890T3 (de)
ES (2) ES2240645T3 (de)
MX (1) MXPA02007890A (de)
PT (2) PT1295890E (de)
WO (1) WO2001060834A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2456292A1 (en) * 2001-08-14 2003-02-27 Toyama Chemical Co., Ltd. Novel virus growth inhibitor and/or virucidal method, and novel pyrazine nucleotide or pirazine nucleoside analog
AU2005289517A1 (en) * 2004-09-24 2006-04-06 Centre National De La Recherche Scientifique Methods and compositions for treating flaviviruses, pestiviruses and hepacivirus
US7989422B2 (en) * 2005-12-22 2011-08-02 Alchemia Limited Antibacterial agents
AU2007268684B2 (en) * 2006-05-31 2012-02-23 Toyama Chemical Co., Ltd. Anti-foot-and-mouth disease virus agent for animal belonging to family Suidae or sheep, and method for prevention or treatment of foot-and-mouth disease in animal belonging to family Suidae or sheep
KR101574567B1 (ko) * 2007-09-27 2015-12-07 토야마 케미칼 컴퍼니 리미티드 6-플루오로-3-히드록시-2-피라진카보니트릴의 유기아민염 및 그 제조법
JP5364327B2 (ja) * 2008-09-26 2013-12-11 富士フイルム株式会社 ハロピラジンカルボキサミド化合物の製造方法
WO2010087117A1 (ja) 2009-01-28 2010-08-05 日本曹達株式会社 ジクロロピラジン誘導体の製造方法
JP5559604B2 (ja) * 2009-05-27 2014-07-23 富山化学工業株式会社 ３，６−ジクロロ−２−ピラジンカルボニトリルの製造法
RS54408B1 (sr) 2010-09-30 2016-04-28 Toyama Chemical Co. Ltd. Natrijumova so 6-fluor-3-hidroksi-2-pirazin karboksamida
US20130217708A1 (en) 2010-09-30 2013-08-22 Toyama Chemical Co., Ltd. Meglumine salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide
SG190772A1 (en) * 2010-11-12 2013-08-30 Fujifilm Corp Pyrazino[2,3-d]isooxazole derivative
CN102850282B (zh) * 2011-07-01 2015-09-16 中国人民解放军军事医学科学院毒物药物研究所 3-取代氧基-2-吡嗪甲酰胺类化合物及其用途
CN102846617B (zh) * 2011-07-01 2016-01-13 中国人民解放军军事医学科学院毒物药物研究所 3－(丁基氧基)－2－吡嗪甲酰氨的制备方法和用途
CN105732748B (zh) * 2014-12-12 2019-01-01 浙江医药股份有限公司新昌制药厂 一种核苷酸类似物及其制备方法、以及含有核苷酸类似物的药物组合物及其应用
WO2016172205A1 (en) * 2015-04-20 2016-10-27 Emory University Managing ebola viral infections
SI3309149T1 (sl) 2015-06-09 2021-09-30 Fujifilm Toyama Chemical Co., Ltd. Kristal 6-bromo-3-hidroksi-2-pirazinkarboksamida in metoda priprave le-tega
CN105017166A (zh) * 2015-07-11 2015-11-04 长沙深橙生物科技有限公司 3-(3-溴苯氧基)吡嗪-2-羧酸的制备方法
CN104961691A (zh) * 2015-07-11 2015-10-07 长沙深橙生物科技有限公司 3-(2-氟苯氧基)吡嗪-2-羧酸的制备方法
CN105037281A (zh) * 2015-07-11 2015-11-11 长沙深橙生物科技有限公司 3-(3-氟苯氧基)吡嗪-2-羧酸的制备方法
CN104961690A (zh) * 2015-07-11 2015-10-07 长沙深橙生物科技有限公司 3-(4-氟苯氧基)吡嗪-2-羧酸的制备方法
CN107641106A (zh) * 2016-07-22 2018-01-30 大连鸿凯化工科技发展有限公司 法匹拉韦中间体以及法匹拉韦的合成方法
JPWO2018199048A1 (ja) * 2017-04-25 2020-05-07 大原薬品工業株式会社 ヌクレオシド系抗がん剤または抗ウィルス剤の５’位モノ燐酸ジベンジルエステル誘導体
CN111265528A (zh) * 2020-01-21 2020-06-12 中国人民解放军军事科学院军事医学研究院 法匹拉韦在治疗冠状病毒感染方面的应用
CN113248450B (zh) * 2020-02-07 2024-04-12 北京四环制药有限公司 一种法匹拉韦的制备方法
CN113735784A (zh) * 2020-05-28 2021-12-03 南京桦冠生物技术有限公司 6-氟-3-羟基吡嗪-2-甲酰胺的制备方法
WO2021255681A1 (en) * 2020-06-17 2021-12-23 Hikal Limited A simple process for the preparation of favipiravir and its intermediates thereof
CN111704582B (zh) * 2020-06-23 2021-06-11 杭州煌森生物科技有限公司 一种法匹拉韦及其衍生物的制备方法
WO2022009036A1 (en) * 2020-07-06 2022-01-13 Optimus Drugs (P) Ltd Synthesis of favipiravir
CN114656412A (zh) * 2020-12-22 2022-06-24 山东特珐曼药业有限公司 一种法匹拉韦的合成方法
CN112552245B (zh) * 2020-12-29 2022-08-02 苏州正济药业有限公司 法匹拉韦的合成方法
CN112851589B (zh) * 2021-01-25 2022-10-11 山东邹平大展新材料有限公司 一种法匹拉韦中间体6-溴-3-羟基吡嗪-2-甲酰胺的制备方法
AU2022422584A1 (en) 2021-12-23 2024-05-30 Subintro Limited Novel antiviral compositions comprising oleic acid
CN114478404A (zh) * 2022-03-17 2022-05-13 浙江海正药业股份有限公司 一种法维拉韦中间体羟基物的纯化方法
CN120607562B (zh) * 2025-08-12 2025-10-10 南京艾镁特生物科技有限公司 一种苯甲酰基修饰核苷的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0394464A4 (en) * 1988-08-22 1991-04-03 Idemitsu Kosan Company Limited Oxirane derivatives and herbicides containing same as active ingredients
DE59209008D1 (de) * 1991-08-17 1997-12-11 Hoechst Ag 2-Fluorpyrazine, Verfahren zu ihrer Herstellung und ihre Verwendung in flüssigkristallinen Mischungen
DK1112743T3 (da) * 1998-08-20 2007-11-26 Toyama Chemical Co Ltd Nitrogenholdige heterocykliske carboxamidderivater eller salte deraf som antivirale midler

Also Published As

Publication number Publication date
CN1418220A (zh) 2003-05-14
PT1295890E (pt) 2005-06-30
US20030130213A1 (en) 2003-07-10
PT1256588E (pt) 2005-05-31
DE60108724T2 (de) 2005-06-23
KR100589935B1 (ko) 2006-06-15
MXPA02007890A (es) 2002-10-31
BRPI0108374B1 (pt) 2017-10-10
DE60110415T2 (de) 2005-09-29
BRPI0116967B8 (pt) 2021-05-25
ES2237550T3 (es) 2005-08-01
BRPI0116967B1 (pt) 2018-05-22
BRPI0116967A2 (pt) 2009-07-14
ATE288443T1 (de) 2005-02-15
JP2009161553A (ja) 2009-07-23
AU2001232287A1 (en) 2001-08-27
KR100604955B1 (ko) 2006-07-26
EP1295890B1 (de) 2005-04-27
WO2001060834A1 (en) 2001-08-23
BRPI0108374B8 (pt) 2021-05-25
US6800629B2 (en) 2004-10-05
CA2398620A1 (en) 2001-08-23
CA2398620C (en) 2009-06-23
ES2240645T3 (es) 2005-10-16
KR20030048108A (ko) 2003-06-18
EP1256588A4 (de) 2003-03-26
DK1295890T3 (da) 2005-05-17
DE60110415D1 (de) 2005-06-02
JP4379767B2 (ja) 2009-12-09
KR20030032918A (ko) 2003-04-26
BR0108374A (pt) 2003-03-18
CN1239511C (zh) 2006-02-01
DE60108724D1 (de) 2005-03-10
EP1256588A1 (de) 2002-11-13
JP5038345B2 (ja) 2012-10-03
EP1295890A1 (de) 2003-03-26
EP1256588B1 (de) 2005-02-02
KR20030034120A (ko) 2003-05-01

Similar Documents

Publication Publication Date Title
DE60110415D1 (de) Neue Pyrazin-Derivate oder Salze davon, pharmazeutische Zusammensetzungen, die die Derivate oder deren Salze enthalten und Intermediäre zur Herstellung der Derivate
ATE361287T1 (de) Neue indol-2-on derivate
DK1353911T3 (da) Antivirale midler
EA200301216A1 (ru) Замещенные хинуклидинами мультициклические гетероарилы для лечения заболевания
DE3587777D1 (de) Heterozyklische Verbindungen, deren Herstellung und Medikamente diese enthaltend.
DK0992509T3 (da) Nye makrolid-derivater
BR0215067A (pt) Piridoquinoxalinas antivirais
PT947513E (pt) Derivados de amina triciclicos
ATE141605T1 (de) Thienotriazoldiazepinverbindungen und deren pharmazeutische anwendungen
ATE114154T1 (de) Thienotriazolodiazepine und ihre pharmazeutische verwendung.
FI911138A0 (fi) Ny substituerad aminfoerening och foerfarande foer dess framstaellning.
BRPI0411208A (pt) uso de derivados 2-amino-1,3-propanodiol para a fabricação de um medicamento para o tratamento de vários tipos de dor
DE60119514D1 (de) Amidderivate der 2-amino-3-hydroxy-4-tert-leucyl-amino-5-phenyl-pentansäure
DE69917668D1 (de) Substanz gm-95, verfahren zu ihrer herstellung und ihre verwendung
DE60119378T8 (de) Benzofuranderivate und pharmazeutische zusammensetzungen, die diese enthalten
DE69400352D1 (de) 3- oder 4-Glykosyloxybenzopyranderivat und dieses enthaltende antiallergisches Mittel
ATE334977T1 (de) Discodermolid-analoga und ihre pharmazeutische verwendung
DE69819002D1 (de) Polyhydroxyalkylpyrazine derivate,deren herstellung und diese enthaltende arzneimitteln
BR0109252A (pt) Composto, processo para produzir um composto, composição farmacêutica, e, uso de um composto ou de uma composição
BR9902049A (pt) Derivados 9a,11b-desidro de 9-oxima-3-ceto-6-o-metileritromicina.
DE69222438D1 (de) Aids-virus-infektion hemmende zusammensetzung
ATE241604T1 (de) Polyhydroxyalkylpyrazine derivate und deren herstellung und diese enthaltende arzneimittel
TH13944A (th) สารประกอบเฮเทโรไซคลิค

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1295890

Country of ref document: EP