DK1295890T3 - Hidtil ukendte pyrazinderivater eller salte deraf, farmaceutiske præparater, der indeholder derivaterne eller saltene, og mellemprodukter til fremstilling af begge - Google Patents

Hidtil ukendte pyrazinderivater eller salte deraf, farmaceutiske præparater, der indeholder derivaterne eller saltene, og mellemprodukter til fremstilling af begge

Info

Publication number
DK1295890T3
DK1295890T3 DK02028152T DK02028152T DK1295890T3 DK 1295890 T3 DK1295890 T3 DK 1295890T3 DK 02028152 T DK02028152 T DK 02028152T DK 02028152 T DK02028152 T DK 02028152T DK 1295890 T3 DK1295890 T3 DK 1295890T3
Authority
DK
Denmark
Prior art keywords
salts
derivatives
intermediates
preparation
pharmaceutical compositions
Prior art date
Application number
DK02028152T
Other languages
Danish (da)
English (en)
Inventor
Shoichi Hamamoto
Hiroyuki Egawa
Jun Sugita
Sayuri Uehara
Kenji Yonezawa
Yousuke Furuta
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Application granted granted Critical
Publication of DK1295890T3 publication Critical patent/DK1295890T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK02028152T 2000-02-16 2001-02-14 Hidtil ukendte pyrazinderivater eller salte deraf, farmaceutiske præparater, der indeholder derivaterne eller saltene, og mellemprodukter til fremstilling af begge DK1295890T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000037486 2000-02-16
JP2000040439 2000-02-18
JP2000090071 2000-03-29

Publications (1)

Publication Number Publication Date
DK1295890T3 true DK1295890T3 (da) 2005-05-17

Family

ID=27342371

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02028152T DK1295890T3 (da) 2000-02-16 2001-02-14 Hidtil ukendte pyrazinderivater eller salte deraf, farmaceutiske præparater, der indeholder derivaterne eller saltene, og mellemprodukter til fremstilling af begge

Country Status (15)

Country Link
US (1) US6800629B2 (pt)
EP (2) EP1256588B1 (pt)
JP (2) JP4379767B2 (pt)
KR (3) KR100604955B1 (pt)
CN (1) CN1239511C (pt)
AT (2) ATE288443T1 (pt)
AU (1) AU2001232287A1 (pt)
BR (2) BRPI0108374B8 (pt)
CA (1) CA2398620C (pt)
DE (2) DE60108724T2 (pt)
DK (1) DK1295890T3 (pt)
ES (2) ES2237550T3 (pt)
MX (1) MXPA02007890A (pt)
PT (2) PT1256588E (pt)
WO (1) WO2001060834A1 (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1417967A4 (en) * 2001-08-14 2007-03-28 Toyama Chemical Co Ltd NEW VIRUS PROTECTION INHIBITION, VIRCIDIDIC PROCEDURE AND NEW PYRADIN NUCLEOTIDE / PYRADIN NUCLEOSIDE ANALOGON
JP2008514639A (ja) * 2004-09-24 2008-05-08 イデニクス（ケイマン）リミテツド フラビウイルス、ペスチウイルス及びヘパシウイルスの感染症を治療するための方法及び組成物
WO2007070947A1 (en) * 2005-12-22 2007-06-28 Alchemia Ltd Antibacterial agents
EP2022786B1 (en) * 2006-05-31 2011-10-26 Toyama Chemical Co., Ltd. Anti-foot-and-mouth disease virus agent for animal belonging to family suidae or sheep, and method for prevention or treatment of foot-and-mouth disease in animal belonging to family suidae or sheep
NZ584157A (en) 2007-09-27 2012-04-27 Toyama Chemical Co Ltd Organic amine salt of 6-fluoro-3-hydroxy-2-pyrazinecarbonitrile and method for producing the same
JP5364327B2 (ja) * 2008-09-26 2013-12-11 富士フイルム株式会社 ハロピラジンカルボキサミド化合物の製造方法
JP5385309B2 (ja) * 2009-01-28 2014-01-08 日本曹達株式会社 ジクロロピラジン誘導体の製造方法
JP5559604B2 (ja) * 2009-05-27 2014-07-23 富山化学工業株式会社 ３，６−ジクロロ−２−ピラジンカルボニトリルの製造法
HUE026872T2 (en) 2010-09-30 2016-07-28 Toyama Chemical Co Ltd Sodium salt of 6-fluoro-3-hydroxy-2-pyrazinecarboxamide
TWI507397B (zh) 2010-09-30 2015-11-11 Toyama Chemical Co Ltd ６－氟－３－羥－２－吡羧醯胺之美洛明鹽
CA2816687C (en) 2010-11-12 2018-11-27 Fujifilm Corporation Pyrazino[2,3-d]isoxazole derivative
CN102850282B (zh) * 2011-07-01 2015-09-16 中国人民解放军军事医学科学院毒物药物研究所 3-取代氧基-2-吡嗪甲酰胺类化合物及其用途
CN102846617B (zh) * 2011-07-01 2016-01-13 中国人民解放军军事医学科学院毒物药物研究所 3－(丁基氧基)－2－吡嗪甲酰氨的制备方法和用途
CN105732748B (zh) * 2014-12-12 2019-01-01 浙江医药股份有限公司新昌制药厂 一种核苷酸类似物及其制备方法、以及含有核苷酸类似物的药物组合物及其应用
WO2016172205A1 (en) * 2015-04-20 2016-10-27 Emory University Managing ebola viral infections
LT3309149T (lt) * 2015-06-09 2021-06-25 Fujifilm Toyama Chemical Co., Ltd. 6-brom-3-hidroksi-2-pirazinkarboksamido kristalas ir jo gamybos būdas
CN104961691A (zh) * 2015-07-11 2015-10-07 长沙深橙生物科技有限公司 3-(2-氟苯氧基)吡嗪-2-羧酸的制备方法
CN105037281A (zh) * 2015-07-11 2015-11-11 长沙深橙生物科技有限公司 3-(3-氟苯氧基)吡嗪-2-羧酸的制备方法
CN104961690A (zh) * 2015-07-11 2015-10-07 长沙深橙生物科技有限公司 3-(4-氟苯氧基)吡嗪-2-羧酸的制备方法
CN105017166A (zh) * 2015-07-11 2015-11-04 长沙深橙生物科技有限公司 3-(3-溴苯氧基)吡嗪-2-羧酸的制备方法
CN107641106A (zh) * 2016-07-22 2018-01-30 大连鸿凯化工科技发展有限公司 法匹拉韦中间体以及法匹拉韦的合成方法
US20200123190A1 (en) * 2017-04-25 2020-04-23 Ohara Pharmaceutical Co., Ltd. 5'-position dibenzyl monophosphate derivative of nucleoside-based anticancer agent or antivirus agent
CN111265528A (zh) * 2020-01-21 2020-06-12 中国人民解放军军事科学院军事医学研究院 法匹拉韦在治疗冠状病毒感染方面的应用
CN113248450B (zh) * 2020-02-07 2024-04-12 北京四环制药有限公司 一种法匹拉韦的制备方法
CN113735784A (zh) * 2020-05-28 2021-12-03 南京桦冠生物技术有限公司 6-氟-3-羟基吡嗪-2-甲酰胺的制备方法
WO2021255681A1 (en) * 2020-06-17 2021-12-23 Hikal Limited A simple process for the preparation of favipiravir and its intermediates thereof
CN111704582B (zh) * 2020-06-23 2021-06-11 杭州煌森生物科技有限公司 一种法匹拉韦及其衍生物的制备方法
WO2022009036A1 (en) * 2020-07-06 2022-01-13 Optimus Drugs (P) Ltd Synthesis of favipiravir
CN114656412A (zh) * 2020-12-22 2022-06-24 山东特珐曼药业有限公司 一种法匹拉韦的合成方法
CN112552245B (zh) * 2020-12-29 2022-08-02 苏州正济药业有限公司 法匹拉韦的合成方法
CN112851589B (zh) * 2021-01-25 2022-10-11 山东邹平大展新材料有限公司 一种法匹拉韦中间体6-溴-3-羟基吡嗪-2-甲酰胺的制备方法
CN118488831A (zh) 2021-12-23 2024-08-13 苏宾特罗有限公司 包含油酸的新抗病毒组合物
CN114478404A (zh) * 2022-03-17 2022-05-13 浙江海正药业股份有限公司 一种法维拉韦中间体羟基物的纯化方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990002125A1 (en) * 1988-08-22 1990-03-08 Idemitsu Kosan Co. Ltd. Oxirane derivatives and herbicides containing same as active ingredients
DE59209008D1 (de) * 1991-08-17 1997-12-11 Hoechst Ag 2-Fluorpyrazine, Verfahren zu ihrer Herstellung und ihre Verwendung in flüssigkristallinen Mischungen
PL200955B1 (pl) * 1998-08-20 2009-02-27 Toyama Chemical Co Ltd Przeciwwirusowa kompozycja farmaceutyczna i jej zastosowanie oraz zawierająca azot heterocykliczna pochodna karboksamidu

Also Published As

Publication number Publication date
BRPI0108374B1 (pt) 2017-10-10
ATE288443T1 (de) 2005-02-15
KR100604955B1 (ko) 2006-07-26
KR20030048108A (ko) 2003-06-18
BRPI0116967B1 (pt) 2018-05-22
AU2001232287A1 (en) 2001-08-27
CA2398620A1 (en) 2001-08-23
EP1256588A1 (en) 2002-11-13
DE60110415D1 (de) 2005-06-02
US20030130213A1 (en) 2003-07-10
KR20030034120A (ko) 2003-05-01
DE60108724T2 (de) 2005-06-23
BR0108374A (pt) 2003-03-18
CA2398620C (en) 2009-06-23
BRPI0116967A2 (pt) 2009-07-14
EP1295890A1 (en) 2003-03-26
DE60108724D1 (de) 2005-03-10
MXPA02007890A (es) 2002-10-31
CN1418220A (zh) 2003-05-14
PT1256588E (pt) 2005-05-31
BRPI0108374B8 (pt) 2021-05-25
PT1295890E (pt) 2005-06-30
JP4379767B2 (ja) 2009-12-09
JP5038345B2 (ja) 2012-10-03
KR20030032918A (ko) 2003-04-26
KR100589935B1 (ko) 2006-06-15
ES2237550T3 (es) 2005-08-01
EP1256588B1 (en) 2005-02-02
US6800629B2 (en) 2004-10-05
ATE294185T1 (de) 2005-05-15
WO2001060834A1 (fr) 2001-08-23
CN1239511C (zh) 2006-02-01
EP1295890B1 (en) 2005-04-27
EP1256588A4 (en) 2003-03-26
BRPI0116967B8 (pt) 2021-05-25
ES2240645T3 (es) 2005-10-16
JP2009161553A (ja) 2009-07-23
DE60110415T2 (de) 2005-09-29

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