BR9911163A - Formulação de vacina, formulação farmacêutica, vìrus atenuado de influenza, processos para vacinar um indivìduo, para prevenir uma doença infecciosa em um indivìduo, e, para tratar ou prevenir tumores em um indivìduo - Google Patents
Formulação de vacina, formulação farmacêutica, vìrus atenuado de influenza, processos para vacinar um indivìduo, para prevenir uma doença infecciosa em um indivìduo, e, para tratar ou prevenir tumores em um indivìduoInfo
- Publication number
- BR9911163A BR9911163A BR9911163-2A BR9911163A BR9911163A BR 9911163 A BR9911163 A BR 9911163A BR 9911163 A BR9911163 A BR 9911163A BR 9911163 A BR9911163 A BR 9911163A
- Authority
- BR
- Brazil
- Prior art keywords
- individual
- prevent
- attenuated
- viruses
- vaccine
- Prior art date
Links
- 230000002238 attenuated effect Effects 0.000 title abstract 6
- 229960005486 vaccine Drugs 0.000 title abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- 208000035473 Communicable disease Diseases 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 title abstract 2
- 208000015181 infectious disease Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 241000712461 unidentified influenza virus Species 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 abstract 5
- 102000014150 Interferons Human genes 0.000 abstract 4
- 108010050904 Interferons Proteins 0.000 abstract 4
- 229940079322 interferon Drugs 0.000 abstract 4
- 101150033828 NS1 gene Proteins 0.000 abstract 2
- 230000001413 cellular effect Effects 0.000 abstract 2
- 230000002950 deficient Effects 0.000 abstract 1
- 241001493065 dsRNA viruses Species 0.000 abstract 1
- 230000001771 impaired effect Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 230000007918 pathogenicity Effects 0.000 abstract 1
Classifications
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Abstract
"FORMULAçãO DE VACINA, FORMULAçãO FARMACêUTICA, VìRUS ATENUADO DE INFLUENZA, PROCESSOS PARA VACINAR UM INDIVìDUO, PARA PREVENIR UMA DOENçA INFECCIOSA EM UM INDIVìDUO, E, PARA TRATAR OU PREVENIR TUMORES EM UM INDIVìDUO". A presente invenção refere-se, geralmente, a vírus de RNA de filamento negativo, atenuados, tendo uma capacidade prejudicada para antagonizar a resposta a interferon celular (IFN), e o uso destes vírus atenuados em formulações de vacina e farmacêuticas. A invenção também se refere ao desenvolvimento e uso de sistemas deficientes em IFN para seleção destes vírus atenuados. Em particular, a invenção refere-se a vírus atenuados de influenza tendo modificações para o gene NS1 que diminuem ou eliminam a capacidade do produto de gene NS1 de antagonizar a resposta a IFN celular. Os vírus mutantes replicam in vivo mas demonstram reduzida patogenicidade e, assim, são bem apropriados para vacinas de vírus, e formulações farmacêuticas.
Applications Claiming Priority (4)
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US8910398P | 1998-06-12 | 1998-06-12 | |
US10883298P | 1998-11-18 | 1998-11-18 | |
US11768399P | 1999-01-29 | 1999-01-29 | |
PCT/US1999/013144 WO1999064068A1 (en) | 1998-06-12 | 1999-06-11 | Attenuated negative strand viruses with altered interferon antagonist activity for use as vaccines and pharmaceuticals |
Publications (1)
Publication Number | Publication Date |
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BR9911163A true BR9911163A (pt) | 2002-01-15 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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BR9911163-2A BR9911163A (pt) | 1998-06-12 | 1999-06-11 | Formulação de vacina, formulação farmacêutica, vìrus atenuado de influenza, processos para vacinar um indivìduo, para prevenir uma doença infecciosa em um indivìduo, e, para tratar ou prevenir tumores em um indivìduo |
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JP (7) | JP4837827B2 (pt) |
KR (2) | KR20060080249A (pt) |
CN (1) | CN1312725A (pt) |
AT (1) | ATE351901T1 (pt) |
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BR (1) | BR9911163A (pt) |
CA (2) | CA2334850C (pt) |
CY (1) | CY1113689T1 (pt) |
CZ (2) | CZ302601B6 (pt) |
DE (1) | DE69934885T2 (pt) |
DK (4) | DK2316923T3 (pt) |
ES (4) | ES2281177T3 (pt) |
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NO (1) | NO20006328L (pt) |
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PL (3) | PL212316B1 (pt) |
PT (1) | PT1085904E (pt) |
RU (1) | RU2236252C2 (pt) |
SK (3) | SK288567B6 (pt) |
WO (2) | WO1999064068A1 (pt) |
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