BR112013011188A2 - compostos úteis como moduladores de trpm8 - Google Patents
compostos úteis como moduladores de trpm8Info
- Publication number
- BR112013011188A2 BR112013011188A2 BR112013011188A BR112013011188A BR112013011188A2 BR 112013011188 A2 BR112013011188 A2 BR 112013011188A2 BR 112013011188 A BR112013011188 A BR 112013011188A BR 112013011188 A BR112013011188 A BR 112013011188A BR 112013011188 A2 BR112013011188 A2 BR 112013011188A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds useful
- compounds
- trpm8 modulators
- trpm8
- modulators
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 238000001816 cooling Methods 0.000 abstract 1
Classifications
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Abstract
compostos úteis como moduladores de trpm8. a presente invenção inclui compostos úteis como moduladores de trpm8, tal como compostos de fórmula (i), e o subgênero e a espécie do mesmo; produtos pessoais contendo esses compostos; e o uso desses compostos e dos produtos pessoais, particularmente o uso para aumentar ou induzir sensações de quimioestasia, tal como sensações de resfriamento ou frio.
Applications Claiming Priority (5)
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US201161443490P | 2011-02-16 | 2011-02-16 | |
US61/443,490 | 2011-02-16 | ||
PCT/US2011/059312 WO2012061698A2 (en) | 2010-11-05 | 2011-11-04 | Compounds useful as modulators of trpm8 |
Publications (2)
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BR112013011188A2 true BR112013011188A2 (pt) | 2016-07-05 |
BR112013011188B1 BR112013011188B1 (pt) | 2022-01-04 |
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BR112013011188-7A BR112013011188B1 (pt) | 2010-11-05 | 2011-11-04 | Método não-médico para modular canal potencial de receptor transiente de melastina 8 (trpm8), método não-médico para modular a sensação de resfriamento de uma composição, método não-médico para induzir uma sensação de resfriamento em um humano ou animal e composto |
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AU (1) | AU2011323245B2 (pt) |
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MY165612A (en) * | 2010-11-05 | 2018-04-18 | Senomyx Inc | Compounds useful as modulators of trpm8 |
EP2481727A1 (en) * | 2011-01-28 | 2012-08-01 | Dompe S.p.A. | TRPM8 receptor antagonists |
CA2839703A1 (en) | 2011-06-24 | 2012-12-27 | Amgen Inc. | Trpm8 antagonists and their use in treatments |
MY157429A (en) | 2011-06-24 | 2016-06-15 | Amgen Inc | Trpm8 antagonists and their use in treatments |
US8952009B2 (en) * | 2012-08-06 | 2015-02-10 | Amgen Inc. | Chroman derivatives as TRPM8 inhibitors |
JP2016508122A (ja) * | 2012-12-12 | 2016-03-17 | シムライズ アーゲー | 調製物 |
JP6882144B6 (ja) * | 2012-12-12 | 2021-06-23 | シムライズ アーゲー | 組成物および化粧品組成物 |
DE202012013357U1 (de) | 2012-12-12 | 2016-07-29 | Symrise Ag | Zubereitungen |
US9840471B2 (en) | 2013-02-19 | 2017-12-12 | Senomyx, Inc. | Compounds useful as modulators of TRPM8 |
WO2014172871A1 (en) * | 2013-04-25 | 2014-10-30 | Syngenta Participations Ag | Dihydrobenzofuran derivatives as insecticidal compounds |
EP2832234A1 (en) * | 2013-07-30 | 2015-02-04 | IMAX Discovery GmbH | Imidazo[1,2-a]pyridine-ylmethyl-derivatives and their use as flavoring agents |
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CA2734682C (en) | 2008-08-26 | 2017-09-26 | Basf Se | Detection and use of low molecular-weight modulators of the cold-menthol receptor trpm8 |
CA2747637A1 (en) | 2008-12-18 | 2010-07-15 | Janssen Pharmaceutica Nv | Sulfamides as trpm8 modulators |
DE102010002558A1 (de) | 2009-11-20 | 2011-06-01 | Symrise Ag | Verwendung physiologischer Kühlwirkstoffe und Mittel enthaltend solche Wirkstoffe |
CA2781888C (en) * | 2009-12-11 | 2019-06-18 | Nono Inc. | Agents and methods for treating ischemic and other diseases |
MY165612A (en) * | 2010-11-05 | 2018-04-18 | Senomyx Inc | Compounds useful as modulators of trpm8 |
EP2481727A1 (en) * | 2011-01-28 | 2012-08-01 | Dompe S.p.A. | TRPM8 receptor antagonists |
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EP3116858B1 (en) | 2014-03-14 | 2020-11-11 | RaQualia Pharma Inc. | Azaspiro derivatives as trpm8 antagonists |
BR112018006471B1 (pt) | 2015-10-01 | 2024-02-27 | Senomyx, Inc | Composto, composição, método de modular o membro de melastina do canal potencial do receptor transitório 8 (trpm8), método de modular a sensação de resfrescância de uma composição e método de induzir uma sensação de refrescância em um ser humano ou animal |
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