CN111343963B - 生理清凉活性成分的用途以及包含此类活性成分的组合物 - Google Patents
生理清凉活性成分的用途以及包含此类活性成分的组合物 Download PDFInfo
- Publication number
- CN111343963B CN111343963B CN201880056223.6A CN201880056223A CN111343963B CN 111343963 B CN111343963 B CN 111343963B CN 201880056223 A CN201880056223 A CN 201880056223A CN 111343963 B CN111343963 B CN 111343963B
- Authority
- CN
- China
- Prior art keywords
- composition
- modulator
- cooling effect
- group
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 257
- 238000001816 cooling Methods 0.000 title claims description 104
- 239000004480 active ingredient Substances 0.000 title description 9
- 150000001875 compounds Chemical class 0.000 claims abstract description 109
- 238000000034 method Methods 0.000 claims abstract description 74
- 101150111302 Trpm8 gene Proteins 0.000 claims abstract description 48
- 102000003610 TRPM8 Human genes 0.000 claims abstract description 46
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229940041616 menthol Drugs 0.000 claims abstract description 20
- 102000005962 receptors Human genes 0.000 claims abstract description 18
- 108020003175 receptors Proteins 0.000 claims abstract description 18
- 238000001727 in vivo Methods 0.000 claims abstract description 8
- 238000000338 in vitro Methods 0.000 claims abstract description 6
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract 2
- 230000000694 effects Effects 0.000 claims description 88
- 239000000126 substance Substances 0.000 claims description 64
- 239000004753 textile Substances 0.000 claims description 63
- 238000009472 formulation Methods 0.000 claims description 55
- 239000003795 chemical substances by application Substances 0.000 claims description 48
- 210000004209 hair Anatomy 0.000 claims description 26
- 235000013305 food Nutrition 0.000 claims description 25
- 150000003839 salts Chemical class 0.000 claims description 25
- 239000006071 cream Substances 0.000 claims description 24
- 239000006260 foam Substances 0.000 claims description 21
- 239000000606 toothpaste Substances 0.000 claims description 20
- 230000003750 conditioning effect Effects 0.000 claims description 16
- 241001465754 Metazoa Species 0.000 claims description 15
- 239000002253 acid Substances 0.000 claims description 14
- 210000004400 mucous membrane Anatomy 0.000 claims description 14
- 239000000796 flavoring agent Substances 0.000 claims description 13
- 230000035807 sensation Effects 0.000 claims description 13
- 235000019615 sensations Nutrition 0.000 claims description 13
- 239000002453 shampoo Substances 0.000 claims description 13
- 235000019634 flavors Nutrition 0.000 claims description 12
- 229940034610 toothpaste Drugs 0.000 claims description 11
- QGDQESUNCJQMSA-UHFFFAOYSA-N 2-(4-methylphenoxy)-n-(1h-pyrazol-5-yl)-n-(thiophen-2-ylmethyl)acetamide Chemical compound C1=CC(C)=CC=C1OCC(=O)N(C=1NN=CC=1)CC1=CC=CS1 QGDQESUNCJQMSA-UHFFFAOYSA-N 0.000 claims description 10
- 239000003205 fragrance Substances 0.000 claims description 10
- 241000195940 Bryophyta Species 0.000 claims description 9
- 235000011929 mousse Nutrition 0.000 claims description 9
- 241000282412 Homo Species 0.000 claims description 8
- 239000006210 lotion Substances 0.000 claims description 8
- 235000016709 nutrition Nutrition 0.000 claims description 8
- 239000001182 FEMA 4496 Substances 0.000 claims description 7
- 235000009508 confectionery Nutrition 0.000 claims description 7
- 239000002324 mouth wash Substances 0.000 claims description 7
- 230000002035 prolonged effect Effects 0.000 claims description 7
- 238000002560 therapeutic procedure Methods 0.000 claims description 7
- 150000007513 acids Chemical class 0.000 claims description 6
- 230000001939 inductive effect Effects 0.000 claims description 6
- 101100047459 Homo sapiens TRPM8 gene Proteins 0.000 claims description 5
- 235000015218 chewing gum Nutrition 0.000 claims description 5
- 229940057046 ethyl menthane carboxamide Drugs 0.000 claims description 5
- 230000006698 induction Effects 0.000 claims description 5
- 229940051866 mouthwash Drugs 0.000 claims description 5
- 238000003556 assay Methods 0.000 claims description 4
- 230000001225 therapeutic effect Effects 0.000 claims description 4
- 230000001270 agonistic effect Effects 0.000 claims description 3
- 235000013361 beverage Nutrition 0.000 claims description 3
- 229940112822 chewing gum Drugs 0.000 claims description 3
- 150000002500 ions Chemical class 0.000 claims description 3
- 230000000475 sunscreen effect Effects 0.000 claims description 3
- 239000000516 sunscreening agent Substances 0.000 claims description 3
- 206010042496 Sunburn Diseases 0.000 claims description 2
- 230000001413 cellular effect Effects 0.000 claims description 2
- 235000015243 ice cream Nutrition 0.000 claims description 2
- 230000010220 ion permeability Effects 0.000 claims description 2
- 230000035699 permeability Effects 0.000 claims description 2
- 229940044601 receptor agonist Drugs 0.000 claims description 2
- 239000000018 receptor agonist Substances 0.000 claims description 2
- 150000001491 aromatic compounds Chemical class 0.000 claims 2
- -1 menthane carboxamides Chemical class 0.000 description 279
- 239000013543 active substance Substances 0.000 description 119
- 229920000856 Amylose Polymers 0.000 description 78
- 239000000463 material Substances 0.000 description 66
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 63
- 229920000642 polymer Polymers 0.000 description 56
- 238000002360 preparation method Methods 0.000 description 55
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 52
- 125000000217 alkyl group Chemical group 0.000 description 36
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 35
- 239000002537 cosmetic Substances 0.000 description 35
- 239000003921 oil Substances 0.000 description 34
- 235000019198 oils Nutrition 0.000 description 32
- 239000000243 solution Substances 0.000 description 31
- 229920001577 copolymer Polymers 0.000 description 30
- 239000007788 liquid Substances 0.000 description 29
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 26
- 229920002472 Starch Polymers 0.000 description 26
- 239000000839 emulsion Substances 0.000 description 26
- 235000019698 starch Nutrition 0.000 description 25
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 24
- 239000000047 product Substances 0.000 description 24
- 239000003995 emulsifying agent Substances 0.000 description 23
- 239000000499 gel Substances 0.000 description 23
- 239000011734 sodium Substances 0.000 description 23
- 235000002639 sodium chloride Nutrition 0.000 description 23
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 21
- 235000014113 dietary fatty acids Nutrition 0.000 description 21
- 229930195729 fatty acid Natural products 0.000 description 21
- 239000000194 fatty acid Substances 0.000 description 21
- 238000004519 manufacturing process Methods 0.000 description 21
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 20
- 239000008107 starch Substances 0.000 description 20
- 239000011575 calcium Substances 0.000 description 19
- 230000004048 modification Effects 0.000 description 19
- 238000012986 modification Methods 0.000 description 19
- 229910052757 nitrogen Inorganic materials 0.000 description 18
- 239000012074 organic phase Substances 0.000 description 18
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 17
- 239000002562 thickening agent Substances 0.000 description 17
- 210000004027 cell Anatomy 0.000 description 16
- 229910052760 oxygen Inorganic materials 0.000 description 16
- 239000003755 preservative agent Substances 0.000 description 16
- 239000007787 solid Substances 0.000 description 16
- 239000004094 surface-active agent Substances 0.000 description 16
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 15
- 229920000858 Cyclodextrin Polymers 0.000 description 15
- 125000004432 carbon atom Chemical group C* 0.000 description 15
- 239000000460 chlorine Substances 0.000 description 15
- 229940088594 vitamin Drugs 0.000 description 15
- 229930003231 vitamin Natural products 0.000 description 15
- 235000013343 vitamin Nutrition 0.000 description 15
- 239000011782 vitamin Substances 0.000 description 15
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 14
- 239000011888 foil Substances 0.000 description 14
- 229920001296 polysiloxane Polymers 0.000 description 14
- 229910052717 sulfur Inorganic materials 0.000 description 14
- 238000012360 testing method Methods 0.000 description 14
- 239000011149 active material Substances 0.000 description 13
- 239000000654 additive Substances 0.000 description 13
- 150000001413 amino acids Chemical group 0.000 description 13
- 239000006185 dispersion Substances 0.000 description 13
- 238000001035 drying Methods 0.000 description 13
- 239000004744 fabric Substances 0.000 description 13
- 235000021474 generally recognized As safe (food) Nutrition 0.000 description 13
- 235000021473 generally recognized as safe (food ingredients) Nutrition 0.000 description 13
- 239000004615 ingredient Substances 0.000 description 13
- 239000011541 reaction mixture Substances 0.000 description 13
- 230000002829 reductive effect Effects 0.000 description 13
- 239000007921 spray Substances 0.000 description 13
- 229940024606 amino acid Drugs 0.000 description 12
- 235000001014 amino acid Nutrition 0.000 description 12
- 239000008346 aqueous phase Substances 0.000 description 12
- 125000003118 aryl group Chemical group 0.000 description 12
- 235000010980 cellulose Nutrition 0.000 description 12
- 229920002678 cellulose Polymers 0.000 description 12
- 239000001913 cellulose Substances 0.000 description 12
- 239000000975 dye Substances 0.000 description 12
- 239000003925 fat Substances 0.000 description 12
- 235000019197 fats Nutrition 0.000 description 12
- 150000004665 fatty acids Chemical class 0.000 description 12
- 125000001072 heteroaryl group Chemical group 0.000 description 12
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 12
- 239000003380 propellant Substances 0.000 description 12
- 239000003531 protein hydrolysate Substances 0.000 description 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 11
- 108010009736 Protein Hydrolysates Proteins 0.000 description 11
- 239000000443 aerosol Substances 0.000 description 11
- 239000000556 agonist Substances 0.000 description 11
- 125000002091 cationic group Chemical group 0.000 description 11
- 239000000284 extract Substances 0.000 description 11
- 239000000344 soap Substances 0.000 description 11
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 10
- 239000011230 binding agent Substances 0.000 description 10
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 10
- 239000002270 dispersing agent Substances 0.000 description 10
- 125000000524 functional group Chemical group 0.000 description 10
- 229910052736 halogen Inorganic materials 0.000 description 10
- 150000002367 halogens Chemical class 0.000 description 10
- 239000000077 insect repellent Substances 0.000 description 10
- 239000011777 magnesium Substances 0.000 description 10
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 description 10
- 229920001223 polyethylene glycol Polymers 0.000 description 10
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 9
- VUNOFAIHSALQQH-UHFFFAOYSA-N Ethyl menthane carboxamide Chemical compound CCNC(=O)C1CC(C)CCC1C(C)C VUNOFAIHSALQQH-UHFFFAOYSA-N 0.000 description 9
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 9
- 239000000853 adhesive Substances 0.000 description 9
- 239000002671 adjuvant Substances 0.000 description 9
- 235000001465 calcium Nutrition 0.000 description 9
- 229910052791 calcium Inorganic materials 0.000 description 9
- 239000012043 crude product Substances 0.000 description 9
- 238000000605 extraction Methods 0.000 description 9
- NYPJDWWKZLNGGM-UHFFFAOYSA-N fenvalerate Chemical compound C=1C=C(Cl)C=CC=1C(C(C)C)C(=O)OC(C#N)C(C=1)=CC=CC=1OC1=CC=CC=C1 NYPJDWWKZLNGGM-UHFFFAOYSA-N 0.000 description 9
- 235000018102 proteins Nutrition 0.000 description 9
- 102000004169 proteins and genes Human genes 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
- 125000001424 substituent group Chemical group 0.000 description 9
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 8
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 8
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical class C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 8
- 125000000129 anionic group Chemical group 0.000 description 8
- 229940097362 cyclodextrins Drugs 0.000 description 8
- 150000002148 esters Chemical class 0.000 description 8
- 235000011187 glycerol Nutrition 0.000 description 8
- 125000005842 heteroatom Chemical group 0.000 description 8
- 229910052749 magnesium Inorganic materials 0.000 description 8
- 229920000570 polyether Polymers 0.000 description 8
- 239000000843 powder Substances 0.000 description 8
- 229920006395 saturated elastomer Polymers 0.000 description 8
- 229910052708 sodium Inorganic materials 0.000 description 8
- 239000001993 wax Substances 0.000 description 8
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 7
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 7
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 7
- 229910019142 PO4 Inorganic materials 0.000 description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 7
- 230000001070 adhesive effect Effects 0.000 description 7
- 239000003945 anionic surfactant Substances 0.000 description 7
- 239000003963 antioxidant agent Substances 0.000 description 7
- 235000006708 antioxidants Nutrition 0.000 description 7
- 229910052799 carbon Inorganic materials 0.000 description 7
- 238000000576 coating method Methods 0.000 description 7
- 239000002657 fibrous material Substances 0.000 description 7
- 230000009477 glass transition Effects 0.000 description 7
- 125000000623 heterocyclic group Chemical group 0.000 description 7
- 229910052500 inorganic mineral Inorganic materials 0.000 description 7
- 239000011159 matrix material Substances 0.000 description 7
- 235000010755 mineral Nutrition 0.000 description 7
- 239000011707 mineral Substances 0.000 description 7
- 238000002156 mixing Methods 0.000 description 7
- 239000002736 nonionic surfactant Substances 0.000 description 7
- 239000002674 ointment Substances 0.000 description 7
- 239000002245 particle Substances 0.000 description 7
- 239000000546 pharmaceutical excipient Substances 0.000 description 7
- 235000021317 phosphate Nutrition 0.000 description 7
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 7
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 7
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 7
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 7
- 229940083542 sodium Drugs 0.000 description 7
- 239000002904 solvent Substances 0.000 description 7
- 235000010356 sorbitol Nutrition 0.000 description 7
- 239000000600 sorbitol Substances 0.000 description 7
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 6
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 description 6
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 6
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- 241000238631 Hexapoda Species 0.000 description 6
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 239000002202 Polyethylene glycol Substances 0.000 description 6
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical group CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 229920002125 Sokalan® Polymers 0.000 description 6
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 6
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 6
- 229910052783 alkali metal Inorganic materials 0.000 description 6
- 150000001340 alkali metals Chemical class 0.000 description 6
- 125000003545 alkoxy group Chemical group 0.000 description 6
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 6
- 239000002280 amphoteric surfactant Substances 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 6
- 239000005557 antagonist Substances 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 6
- 239000000969 carrier Substances 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- 238000004132 cross linking Methods 0.000 description 6
- 239000004205 dimethyl polysiloxane Substances 0.000 description 6
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 6
- 235000019439 ethyl acetate Nutrition 0.000 description 6
- 150000002191 fatty alcohols Chemical class 0.000 description 6
- 239000008266 hair spray Substances 0.000 description 6
- 230000036541 health Effects 0.000 description 6
- 239000003906 humectant Substances 0.000 description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 6
- 150000002632 lipids Chemical class 0.000 description 6
- 239000000314 lubricant Substances 0.000 description 6
- HCZKYJDFEPMADG-TXEJJXNPSA-N masoprocol Chemical compound C([C@H](C)[C@H](C)CC=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 HCZKYJDFEPMADG-TXEJJXNPSA-N 0.000 description 6
- 125000004433 nitrogen atom Chemical group N* 0.000 description 6
- 239000000049 pigment Substances 0.000 description 6
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 6
- 230000001953 sensory effect Effects 0.000 description 6
- 239000003381 stabilizer Substances 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- 235000019640 taste Nutrition 0.000 description 6
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 6
- 229920003176 water-insoluble polymer Polymers 0.000 description 6
- 239000011701 zinc Substances 0.000 description 6
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 5
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 5
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 5
- 239000004166 Lanolin Substances 0.000 description 5
- NFLGAXVYCFJBMK-UHFFFAOYSA-N Menthone Chemical compound CC(C)C1CCC(C)CC1=O NFLGAXVYCFJBMK-UHFFFAOYSA-N 0.000 description 5
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 5
- 239000004721 Polyphenylene oxide Substances 0.000 description 5
- 239000004098 Tetracycline Substances 0.000 description 5
- 244000299461 Theobroma cacao Species 0.000 description 5
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 5
- 230000009471 action Effects 0.000 description 5
- 125000002947 alkylene group Chemical group 0.000 description 5
- 229910052782 aluminium Inorganic materials 0.000 description 5
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- 239000002585 base Substances 0.000 description 5
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 5
- 235000019658 bitter taste Nutrition 0.000 description 5
- 239000000872 buffer Substances 0.000 description 5
- 239000003093 cationic surfactant Substances 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 229910052802 copper Inorganic materials 0.000 description 5
- 239000010949 copper Substances 0.000 description 5
- 239000003431 cross linking reagent Substances 0.000 description 5
- 125000000753 cycloalkyl group Chemical group 0.000 description 5
- 235000013325 dietary fiber Nutrition 0.000 description 5
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 239000000417 fungicide Substances 0.000 description 5
- 229920000159 gelatin Polymers 0.000 description 5
- 235000019322 gelatine Nutrition 0.000 description 5
- 239000001257 hydrogen Substances 0.000 description 5
- 229910052739 hydrogen Inorganic materials 0.000 description 5
- 235000019388 lanolin Nutrition 0.000 description 5
- 229940039717 lanolin Drugs 0.000 description 5
- 239000010410 layer Substances 0.000 description 5
- 235000010445 lecithin Nutrition 0.000 description 5
- 239000000787 lecithin Substances 0.000 description 5
- 230000005923 long-lasting effect Effects 0.000 description 5
- 210000004379 membrane Anatomy 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 5
- 229910052751 metal Inorganic materials 0.000 description 5
- 239000002184 metal Substances 0.000 description 5
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 5
- 230000003020 moisturizing effect Effects 0.000 description 5
- 150000002763 monocarboxylic acids Chemical class 0.000 description 5
- 210000002200 mouth mucosa Anatomy 0.000 description 5
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 5
- 239000005022 packaging material Substances 0.000 description 5
- 239000002304 perfume Substances 0.000 description 5
- 239000012071 phase Substances 0.000 description 5
- 239000004014 plasticizer Substances 0.000 description 5
- 229960004063 propylene glycol Drugs 0.000 description 5
- 238000001228 spectrum Methods 0.000 description 5
- 229960002180 tetracycline Drugs 0.000 description 5
- 229930101283 tetracycline Natural products 0.000 description 5
- 235000019364 tetracycline Nutrition 0.000 description 5
- 150000003522 tetracyclines Chemical class 0.000 description 5
- 235000019154 vitamin C Nutrition 0.000 description 5
- 239000011718 vitamin C Substances 0.000 description 5
- 239000011709 vitamin E Substances 0.000 description 5
- 235000019165 vitamin E Nutrition 0.000 description 5
- 229940045997 vitamin a Drugs 0.000 description 5
- 150000003722 vitamin derivatives Chemical class 0.000 description 5
- 229910052725 zinc Inorganic materials 0.000 description 5
- NFLGAXVYCFJBMK-RKDXNWHRSA-N (+)-isomenthone Natural products CC(C)[C@H]1CC[C@@H](C)CC1=O NFLGAXVYCFJBMK-RKDXNWHRSA-N 0.000 description 4
- ZXQYGBMAQZUVMI-RDDWSQKMSA-N (1S)-cis-(alphaR)-cyhalothrin Chemical compound CC1(C)[C@H](\C=C(/Cl)C(F)(F)F)[C@@H]1C(=O)O[C@@H](C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 ZXQYGBMAQZUVMI-RDDWSQKMSA-N 0.000 description 4
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 4
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 4
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 4
- 239000005874 Bifenthrin Substances 0.000 description 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 4
- 239000004971 Cross linker Substances 0.000 description 4
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 4
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 4
- 108010010803 Gelatin Proteins 0.000 description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- 229940124091 Keratolytic Drugs 0.000 description 4
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 4
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 4
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 4
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 4
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
- 229930006000 Sucrose Natural products 0.000 description 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 4
- 102000027545 TRPM Human genes 0.000 description 4
- 108091008847 TRPM Proteins 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- 229930003268 Vitamin C Natural products 0.000 description 4
- 229930003427 Vitamin E Natural products 0.000 description 4
- 108010046377 Whey Proteins Proteins 0.000 description 4
- 150000001298 alcohols Chemical class 0.000 description 4
- 125000001931 aliphatic group Chemical group 0.000 description 4
- 150000001408 amides Chemical class 0.000 description 4
- 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 4
- 229960003237 betaine Drugs 0.000 description 4
- 235000010290 biphenyl Nutrition 0.000 description 4
- 239000004305 biphenyl Substances 0.000 description 4
- 239000007844 bleaching agent Substances 0.000 description 4
- 150000001720 carbohydrates Chemical class 0.000 description 4
- 235000014633 carbohydrates Nutrition 0.000 description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 description 4
- 235000010418 carrageenan Nutrition 0.000 description 4
- 229920001525 carrageenan Polymers 0.000 description 4
- 239000000679 carrageenan Substances 0.000 description 4
- 229940113118 carrageenan Drugs 0.000 description 4
- 229920006317 cationic polymer Polymers 0.000 description 4
- 235000019219 chocolate Nutrition 0.000 description 4
- 239000010634 clove oil Substances 0.000 description 4
- 230000035597 cooling sensation Effects 0.000 description 4
- DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 description 4
- 150000001991 dicarboxylic acids Chemical class 0.000 description 4
- UIWXSTHGICQLQT-UHFFFAOYSA-N ethenyl propanoate Chemical compound CCC(=O)OC=C UIWXSTHGICQLQT-UHFFFAOYSA-N 0.000 description 4
- 239000000835 fiber Substances 0.000 description 4
- 238000003818 flash chromatography Methods 0.000 description 4
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 239000008273 gelatin Substances 0.000 description 4
- 229940014259 gelatin Drugs 0.000 description 4
- 235000011852 gelatine desserts Nutrition 0.000 description 4
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 4
- 230000001965 increasing effect Effects 0.000 description 4
- IQPQWNKOIGAROB-UHFFFAOYSA-N isocyanate group Chemical group [N-]=C=O IQPQWNKOIGAROB-UHFFFAOYSA-N 0.000 description 4
- 230000001530 keratinolytic effect Effects 0.000 description 4
- 239000005910 lambda-Cyhalothrin Substances 0.000 description 4
- 229940067606 lecithin Drugs 0.000 description 4
- 229930007503 menthone Natural products 0.000 description 4
- 239000004530 micro-emulsion Substances 0.000 description 4
- 244000005700 microbiome Species 0.000 description 4
- 125000002950 monocyclic group Chemical group 0.000 description 4
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 4
- CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 description 4
- 239000000123 paper Substances 0.000 description 4
- 235000019477 peppermint oil Nutrition 0.000 description 4
- 150000002978 peroxides Chemical class 0.000 description 4
- LCPDWSOZIOUXRV-UHFFFAOYSA-N phenoxyacetic acid Chemical compound OC(=O)COC1=CC=CC=C1 LCPDWSOZIOUXRV-UHFFFAOYSA-N 0.000 description 4
- 229920003023 plastic Polymers 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- 229920000728 polyester Polymers 0.000 description 4
- 239000011591 potassium Substances 0.000 description 4
- 229910052700 potassium Inorganic materials 0.000 description 4
- 230000002335 preservative effect Effects 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 235000013772 propylene glycol Nutrition 0.000 description 4
- 230000000395 remineralizing effect Effects 0.000 description 4
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 4
- 229910052710 silicon Inorganic materials 0.000 description 4
- 239000010703 silicon Substances 0.000 description 4
- 239000002002 slurry Substances 0.000 description 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 4
- 239000012321 sodium triacetoxyborohydride Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 239000005720 sucrose Substances 0.000 description 4
- 239000011593 sulfur Substances 0.000 description 4
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 4
- FPGGTKZVZWFYPV-UHFFFAOYSA-M tetrabutylammonium fluoride Chemical compound [F-].CCCC[N+](CCCC)(CCCC)CCCC FPGGTKZVZWFYPV-UHFFFAOYSA-M 0.000 description 4
- 235000019505 tobacco product Nutrition 0.000 description 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 4
- 235000015112 vegetable and seed oil Nutrition 0.000 description 4
- 239000008158 vegetable oil Substances 0.000 description 4
- 229940046009 vitamin E Drugs 0.000 description 4
- 235000021119 whey protein Nutrition 0.000 description 4
- 229920001285 xanthan gum Polymers 0.000 description 4
- 235000010493 xanthan gum Nutrition 0.000 description 4
- 239000000230 xanthan gum Substances 0.000 description 4
- 229940082509 xanthan gum Drugs 0.000 description 4
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 4
- CXBMCYHAMVGWJQ-CABCVRRESA-N (1,3-dioxo-4,5,6,7-tetrahydroisoindol-2-yl)methyl (1r,3r)-2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxylate Chemical compound CC1(C)[C@H](C=C(C)C)[C@H]1C(=O)OCN1C(=O)C(CCCC2)=C2C1=O CXBMCYHAMVGWJQ-CABCVRRESA-N 0.000 description 3
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 3
- GIQAYFTVFSBMOS-VQHVLOKHSA-N (E)-3-(1,3-benzodioxol-5-yl)-N-(oxolan-3-yl)-N-phenylprop-2-enamide Chemical compound O1COC2=C1C=CC(=C2)/C=C/C(=O)N(C1COCC1)C1=CC=CC=C1 GIQAYFTVFSBMOS-VQHVLOKHSA-N 0.000 description 3
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 3
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical class C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 3
- LMFSGBGORORESR-UHFFFAOYSA-N 1-cyclohexylpyridazin-1-ium Chemical compound C1(CCCCC1)[N+]1=NC=CC=C1 LMFSGBGORORESR-UHFFFAOYSA-N 0.000 description 3
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 description 3
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 3
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 239000005711 Benzoic acid Substances 0.000 description 3
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 3
- 239000004215 Carbon black (E152) Substances 0.000 description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 3
- 108010076119 Caseins Proteins 0.000 description 3
- 102000011632 Caseins Human genes 0.000 description 3
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 3
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 3
- 239000005944 Chlorpyrifos Substances 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 3
- 244000007835 Cyamopsis tetragonoloba Species 0.000 description 3
- 239000005946 Cypermethrin Substances 0.000 description 3
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 3
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- 241000790917 Dioxys <bee> Species 0.000 description 3
- OUVXYXNWSVIOSJ-UHFFFAOYSA-N Fluo-4 Chemical compound CC1=CC=C(N(CC(O)=O)CC(O)=O)C(OCCOC=2C(=CC=C(C=2)C2=C3C=C(F)C(=O)C=C3OC3=CC(O)=C(F)C=C32)N(CC(O)=O)CC(O)=O)=C1 OUVXYXNWSVIOSJ-UHFFFAOYSA-N 0.000 description 3
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 239000012981 Hank's balanced salt solution Substances 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 3
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 3
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 3
- 229920000881 Modified starch Polymers 0.000 description 3
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 description 3
- 239000005642 Oleic acid Substances 0.000 description 3
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 3
- 239000004952 Polyamide Substances 0.000 description 3
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 3
- 240000007651 Rubus glaucus Species 0.000 description 3
- 235000011034 Rubus glaucus Nutrition 0.000 description 3
- 235000009122 Rubus idaeus Nutrition 0.000 description 3
- 108010073771 Soybean Proteins Proteins 0.000 description 3
- 235000019486 Sunflower oil Nutrition 0.000 description 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical class OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 3
- 239000004904 UV filter Substances 0.000 description 3
- 235000009499 Vanilla fragrans Nutrition 0.000 description 3
- 235000012036 Vanilla tahitensis Nutrition 0.000 description 3
- 102000007544 Whey Proteins Human genes 0.000 description 3
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 3
- 230000000895 acaricidal effect Effects 0.000 description 3
- 239000000642 acaricide Substances 0.000 description 3
- 229920006322 acrylamide copolymer Polymers 0.000 description 3
- 229940048053 acrylate Drugs 0.000 description 3
- 125000002252 acyl group Chemical group 0.000 description 3
- 239000002998 adhesive polymer Substances 0.000 description 3
- 230000008484 agonism Effects 0.000 description 3
- 150000001299 aldehydes Chemical class 0.000 description 3
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 3
- 125000005250 alkyl acrylate group Chemical group 0.000 description 3
- 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 description 3
- 150000008052 alkyl sulfonates Chemical class 0.000 description 3
- 150000001412 amines Chemical class 0.000 description 3
- 230000008485 antagonism Effects 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 230000000845 anti-microbial effect Effects 0.000 description 3
- 239000004599 antimicrobial Substances 0.000 description 3
- 125000006615 aromatic heterocyclic group Chemical group 0.000 description 3
- 125000003710 aryl alkyl group Chemical group 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 235000021302 avocado oil Nutrition 0.000 description 3
- 239000008163 avocado oil Substances 0.000 description 3
- 239000003899 bactericide agent Substances 0.000 description 3
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 3
- 235000010233 benzoic acid Nutrition 0.000 description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
- OMFRMAHOUUJSGP-IRHGGOMRSA-N bifenthrin Chemical compound C1=CC=C(C=2C=CC=CC=2)C(C)=C1COC(=O)[C@@H]1[C@H](\C=C(/Cl)C(F)(F)F)C1(C)C OMFRMAHOUUJSGP-IRHGGOMRSA-N 0.000 description 3
- 230000027455 binding Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 235000014121 butter Nutrition 0.000 description 3
- 239000001569 carbon dioxide Substances 0.000 description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 3
- 229940105329 carboxymethylcellulose Drugs 0.000 description 3
- 239000002738 chelating agent Substances 0.000 description 3
- 230000001055 chewing effect Effects 0.000 description 3
- 229960003260 chlorhexidine Drugs 0.000 description 3
- SBPBAQFWLVIOKP-UHFFFAOYSA-N chlorpyrifos Chemical compound CCOP(=S)(OCC)OC1=NC(Cl)=C(Cl)C=C1Cl SBPBAQFWLVIOKP-UHFFFAOYSA-N 0.000 description 3
- 235000019504 cigarettes Nutrition 0.000 description 3
- WBYWAXJHAXSJNI-UHFFFAOYSA-N cinnamic acid Chemical class OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 239000003240 coconut oil Substances 0.000 description 3
- 235000019864 coconut oil Nutrition 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 239000003086 colorant Substances 0.000 description 3
- 230000000295 complement effect Effects 0.000 description 3
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 3
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 3
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 3
- 229960005424 cypermethrin Drugs 0.000 description 3
- 239000002781 deodorant agent Substances 0.000 description 3
- 150000004985 diamines Chemical group 0.000 description 3
- OEBRKCOSUFCWJD-UHFFFAOYSA-N dichlorvos Chemical compound COP(=O)(OC)OC=C(Cl)Cl OEBRKCOSUFCWJD-UHFFFAOYSA-N 0.000 description 3
- 229940008099 dimethicone Drugs 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- HCZKYJDFEPMADG-UHFFFAOYSA-N erythro-nordihydroguaiaretic acid Natural products C=1C=C(O)C(O)=CC=1CC(C)C(C)CC1=CC=C(O)C(O)=C1 HCZKYJDFEPMADG-UHFFFAOYSA-N 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 229940091249 fluoride supplement Drugs 0.000 description 3
- 235000003599 food sweetener Nutrition 0.000 description 3
- BDAGIHXWWSANSR-UHFFFAOYSA-N formic acid Substances OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 3
- 239000003365 glass fiber Substances 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 229930195733 hydrocarbon Natural products 0.000 description 3
- 150000002430 hydrocarbons Chemical group 0.000 description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 239000002917 insecticide Substances 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 3
- 229940119170 jojoba wax Drugs 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 3
- 239000011976 maleic acid Substances 0.000 description 3
- 229960003951 masoprocol Drugs 0.000 description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 3
- 150000002739 metals Chemical class 0.000 description 3
- 229960004452 methionine Drugs 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 235000013336 milk Nutrition 0.000 description 3
- 239000008267 milk Substances 0.000 description 3
- 210000004080 milk Anatomy 0.000 description 3
- 235000019426 modified starch Nutrition 0.000 description 3
- WUVURQVZXKENGN-UHFFFAOYSA-N n-(thiolan-3-yl)pyridin-2-amine Chemical compound C1SCCC1NC1=CC=CC=N1 WUVURQVZXKENGN-UHFFFAOYSA-N 0.000 description 3
- JIKUXBYRTXDNIY-UHFFFAOYSA-N n-methyl-n-phenylformamide Chemical compound O=CN(C)C1=CC=CC=C1 JIKUXBYRTXDNIY-UHFFFAOYSA-N 0.000 description 3
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 3
- 235000010298 natamycin Nutrition 0.000 description 3
- 239000004311 natamycin Substances 0.000 description 3
- NCXMLFZGDNKEPB-FFPOYIOWSA-N natamycin Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C[C@@H](C)OC(=O)/C=C/[C@H]2O[C@@H]2C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 NCXMLFZGDNKEPB-FFPOYIOWSA-N 0.000 description 3
- 239000004745 nonwoven fabric Substances 0.000 description 3
- 239000002773 nucleotide Substances 0.000 description 3
- 125000003729 nucleotide group Chemical group 0.000 description 3
- 235000021313 oleic acid Nutrition 0.000 description 3
- 239000004006 olive oil Substances 0.000 description 3
- 235000008390 olive oil Nutrition 0.000 description 3
- 150000007524 organic acids Chemical class 0.000 description 3
- 235000005985 organic acids Nutrition 0.000 description 3
- 150000002894 organic compounds Chemical class 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 238000004806 packaging method and process Methods 0.000 description 3
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- XQYZDYMELSJDRZ-UHFFFAOYSA-N papaverine Chemical class C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 XQYZDYMELSJDRZ-UHFFFAOYSA-N 0.000 description 3
- 239000010690 paraffinic oil Substances 0.000 description 3
- 239000006072 paste Substances 0.000 description 3
- 239000001814 pectin Substances 0.000 description 3
- 235000010987 pectin Nutrition 0.000 description 3
- 229920001277 pectin Polymers 0.000 description 3
- 229960000490 permethrin Drugs 0.000 description 3
- RLLPVAHGXHCWKJ-UHFFFAOYSA-N permethrin Chemical compound CC1(C)C(C=C(Cl)Cl)C1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 RLLPVAHGXHCWKJ-UHFFFAOYSA-N 0.000 description 3
- 239000000825 pharmaceutical preparation Substances 0.000 description 3
- 229910052698 phosphorus Inorganic materials 0.000 description 3
- 239000011574 phosphorus Substances 0.000 description 3
- ATROHALUCMTWTB-OWBHPGMISA-N phoxim Chemical compound CCOP(=S)(OCC)O\N=C(\C#N)C1=CC=CC=C1 ATROHALUCMTWTB-OWBHPGMISA-N 0.000 description 3
- 229950001664 phoxim Drugs 0.000 description 3
- 229920002647 polyamide Polymers 0.000 description 3
- 229920005596 polymer binder Polymers 0.000 description 3
- 239000002491 polymer binding agent Substances 0.000 description 3
- 229920006254 polymer film Polymers 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 229920003009 polyurethane dispersion Polymers 0.000 description 3
- 229940115476 ppg-1 trideceth-6 Drugs 0.000 description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000000518 rheometry Methods 0.000 description 3
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 3
- 229920002050 silicone resin Polymers 0.000 description 3
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Substances [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 description 3
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulphite Substances [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 3
- ADWNFGORSPBALY-UHFFFAOYSA-M sodium;2-[dodecyl(methyl)amino]acetate Chemical compound [Na+].CCCCCCCCCCCCN(C)CC([O-])=O ADWNFGORSPBALY-UHFFFAOYSA-M 0.000 description 3
- 235000010199 sorbic acid Nutrition 0.000 description 3
- 239000004334 sorbic acid Substances 0.000 description 3
- 229940001941 soy protein Drugs 0.000 description 3
- 235000000346 sugar Nutrition 0.000 description 3
- 239000002600 sunflower oil Substances 0.000 description 3
- 239000003765 sweetening agent Substances 0.000 description 3
- 239000006188 syrup Substances 0.000 description 3
- 235000020357 syrup Nutrition 0.000 description 3
- 229960005199 tetramethrin Drugs 0.000 description 3
- 239000003981 vehicle Substances 0.000 description 3
- 229920001567 vinyl ester resin Polymers 0.000 description 3
- 235000019155 vitamin A Nutrition 0.000 description 3
- 239000011719 vitamin A Substances 0.000 description 3
- 239000000341 volatile oil Substances 0.000 description 3
- 239000007762 w/o emulsion Substances 0.000 description 3
- 239000000080 wetting agent Substances 0.000 description 3
- 235000010447 xylitol Nutrition 0.000 description 3
- 239000000811 xylitol Substances 0.000 description 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 3
- 229960002675 xylitol Drugs 0.000 description 3
- 239000011787 zinc oxide Substances 0.000 description 3
- 239000004711 α-olefin Substances 0.000 description 3
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 description 2
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- XHXUANMFYXWVNG-ADEWGFFLSA-N (-)-Menthyl acetate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(C)=O XHXUANMFYXWVNG-ADEWGFFLSA-N 0.000 description 2
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 2
- SBNFWQZLDJGRLK-RTWAWAEBSA-N (1R)-trans-phenothrin Chemical compound CC1(C)[C@H](C=C(C)C)[C@H]1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 SBNFWQZLDJGRLK-RTWAWAEBSA-N 0.000 description 2
- AGMMRUPNXPWLGF-AATRIKPKSA-N (2,3,5,6-tetrafluoro-4-methylphenyl)methyl 2,2-dimethyl-3-[(e)-prop-1-enyl]cyclopropane-1-carboxylate Chemical compound CC1(C)C(/C=C/C)C1C(=O)OCC1=C(F)C(F)=C(C)C(F)=C1F AGMMRUPNXPWLGF-AATRIKPKSA-N 0.000 description 2
- ZMYFCFLJBGAQRS-IRXDYDNUSA-N (2R,3S)-epoxiconazole Chemical compound C1=CC(F)=CC=C1[C@@]1(CN2N=CN=C2)[C@H](C=2C(=CC=CC=2)Cl)O1 ZMYFCFLJBGAQRS-IRXDYDNUSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- HTFVULUZFGJPTF-CSKARUKUSA-N (E)-3-(1,3-benzodioxol-5-yl)-N-(2-methylsulfanylethyl)-N-phenylprop-2-enamide Chemical compound O1COC2=C1C=CC(=C2)/C=C/C(=O)N(C1=CC=CC=C1)CCSC HTFVULUZFGJPTF-CSKARUKUSA-N 0.000 description 2
- USIFTDYURYPBCZ-FNORWQNLSA-N (E)-3-(1,3-benzodioxol-5-yl)-N-ethyl-N-(2-methylsulfanylethyl)prop-2-enamide Chemical compound CCN(CCSC)C(=O)\C=C\c1ccc2OCOc2c1 USIFTDYURYPBCZ-FNORWQNLSA-N 0.000 description 2
- UTTMZEJETNVTHO-FNORWQNLSA-N (E)-3-(1,3-benzodioxol-5-yl)-N-pyridin-2-yl-N-(thiolan-3-yl)prop-2-enamide Chemical compound O1COC2=C1C=CC(=C2)/C=C/C(=O)N(C1CSCC1)C1=NC=CC=C1 UTTMZEJETNVTHO-FNORWQNLSA-N 0.000 description 2
- JRGIBWXYEQKRBB-JXMROGBWSA-N (E)-3-(4-methoxyphenyl)-N-pyridin-2-yl-N-(thiolan-3-yl)prop-2-enamide Chemical compound COC1=CC=C(C=C1)/C=C/C(=O)N(C1CSCC1)C1=NC=CC=C1 JRGIBWXYEQKRBB-JXMROGBWSA-N 0.000 description 2
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 2
- ZFHGXWPMULPQSE-SZGBIDFHSA-N (Z)-(1S)-cis-tefluthrin Chemical compound FC1=C(F)C(C)=C(F)C(F)=C1COC(=O)[C@@H]1C(C)(C)[C@@H]1\C=C(/Cl)C(F)(F)F ZFHGXWPMULPQSE-SZGBIDFHSA-N 0.000 description 2
- ARGVABDJPRRAQI-VOTSOKGWSA-N (e)-3-(4-methylphenyl)prop-2-enoyl chloride Chemical compound CC1=CC=C(\C=C\C(Cl)=O)C=C1 ARGVABDJPRRAQI-VOTSOKGWSA-N 0.000 description 2
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 2
- DVOAQLUDKIFSNB-UHFFFAOYSA-N 1,1-dimethoxy-2-methylsulfanylethane Chemical compound COC(OC)CSC DVOAQLUDKIFSNB-UHFFFAOYSA-N 0.000 description 2
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 2
- PXMNMQRDXWABCY-UHFFFAOYSA-N 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol Chemical compound C1=NC=NN1CC(O)(C(C)(C)C)CCC1=CC=C(Cl)C=C1 PXMNMQRDXWABCY-UHFFFAOYSA-N 0.000 description 2
- MGNFYQILYYYUBS-UHFFFAOYSA-N 1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine Chemical compound C=1C=C(C(C)(C)C)C=CC=1CC(C)CN1CCCCC1 MGNFYQILYYYUBS-UHFFFAOYSA-N 0.000 description 2
- AFFLGGQVNFXPEV-UHFFFAOYSA-N 1-decene Chemical compound CCCCCCCCC=C AFFLGGQVNFXPEV-UHFFFAOYSA-N 0.000 description 2
- CRSBERNSMYQZNG-UHFFFAOYSA-N 1-dodecene Chemical compound CCCCCCCCCCC=C CRSBERNSMYQZNG-UHFFFAOYSA-N 0.000 description 2
- JWYVGKFDLWWQJX-UHFFFAOYSA-N 1-ethenylazepan-2-one Chemical class C=CN1CCCCCC1=O JWYVGKFDLWWQJX-UHFFFAOYSA-N 0.000 description 2
- KWKAKUADMBZCLK-UHFFFAOYSA-N 1-octene Chemical compound CCCCCCC=C KWKAKUADMBZCLK-UHFFFAOYSA-N 0.000 description 2
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 description 2
- STMIIPIFODONDC-UHFFFAOYSA-N 2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)hexan-2-ol Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(O)(CCCC)CN1C=NC=N1 STMIIPIFODONDC-UHFFFAOYSA-N 0.000 description 2
- JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 description 2
- UFNOUKDBUJZYDE-UHFFFAOYSA-N 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol Chemical compound C1=NC=NN1CC(O)(C=1C=CC(Cl)=CC=1)C(C)C1CC1 UFNOUKDBUJZYDE-UHFFFAOYSA-N 0.000 description 2
- YCCILVSKPBXVIP-UHFFFAOYSA-N 2-(4-hydroxyphenyl)ethanol Chemical compound OCCC1=CC=C(O)C=C1 YCCILVSKPBXVIP-UHFFFAOYSA-N 0.000 description 2
- ZYCSRVUSMNTMPS-UHFFFAOYSA-N 2-(4-methylphenoxy)-N-(2-methylsulfanylethyl)-N-phenylacetamide Chemical compound CC1=CC=C(OCC(=O)N(C2=CC=CC=C2)CCSC)C=C1 ZYCSRVUSMNTMPS-UHFFFAOYSA-N 0.000 description 2
- JKNCOURZONDCGV-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)CCOC(=O)C(C)=C JKNCOURZONDCGV-UHFFFAOYSA-N 0.000 description 2
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
- BTMZHHCFEOXAAN-UHFFFAOYSA-N 2-[bis(2-hydroxyethyl)amino]ethanol;2-dodecylbenzenesulfonic acid Chemical compound OCCN(CCO)CCO.CCCCCCCCCCCCC1=CC=CC=C1S(O)(=O)=O BTMZHHCFEOXAAN-UHFFFAOYSA-N 0.000 description 2
- ICSNLGPSRYBMBD-UHFFFAOYSA-N 2-aminopyridine Chemical compound NC1=CC=CC=N1 ICSNLGPSRYBMBD-UHFFFAOYSA-N 0.000 description 2
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 description 2
- JWAZRIHNYRIHIV-UHFFFAOYSA-N 2-naphthol Chemical compound C1=CC=CC2=CC(O)=CC=C21 JWAZRIHNYRIHIV-UHFFFAOYSA-N 0.000 description 2
- 125000000389 2-pyrrolyl group Chemical group [H]N1C([*])=C([H])C([H])=C1[H] 0.000 description 2
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 description 2
- QFQYZMGOKIROEC-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yl)prop-2-enoic acid Chemical compound OC(=O)C=CC1=CC=C2OCOC2=C1 QFQYZMGOKIROEC-UHFFFAOYSA-N 0.000 description 2
- RCEFMOGVOYEGJN-UHFFFAOYSA-N 3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-1,4-dihydropyrimidin-2-one Chemical compound OC1=CC=CC=C1N1C(=O)NC(C=2C=C(C=CC=2)[N+]([O-])=O)=CC1 RCEFMOGVOYEGJN-UHFFFAOYSA-N 0.000 description 2
- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 description 2
- WYVVKGNFXHOCQV-UHFFFAOYSA-N 3-iodoprop-2-yn-1-yl butylcarbamate Chemical compound CCCCNC(=O)OCC#CI WYVVKGNFXHOCQV-UHFFFAOYSA-N 0.000 description 2
- RQDJADAKIFFEKQ-UHFFFAOYSA-N 4-(4-chlorophenyl)-2-phenyl-2-(1,2,4-triazol-1-ylmethyl)butanenitrile Chemical compound C1=CC(Cl)=CC=C1CCC(C=1C=CC=CC=1)(C#N)CN1N=CN=C1 RQDJADAKIFFEKQ-UHFFFAOYSA-N 0.000 description 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 2
- KDDQRKBRJSGMQE-UHFFFAOYSA-N 4-thiazolyl Chemical group [C]1=CSC=N1 KDDQRKBRJSGMQE-UHFFFAOYSA-N 0.000 description 2
- ZOCSXAVNDGMNBV-UHFFFAOYSA-N 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile Chemical compound NC1=C(S(=O)C(F)(F)F)C(C#N)=NN1C1=C(Cl)C=C(C(F)(F)F)C=C1Cl ZOCSXAVNDGMNBV-UHFFFAOYSA-N 0.000 description 2
- CWDWFSXUQODZGW-UHFFFAOYSA-N 5-thiazolyl Chemical group [C]1=CN=CS1 CWDWFSXUQODZGW-UHFFFAOYSA-N 0.000 description 2
- 241000238876 Acari Species 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- 244000198134 Agave sisalana Species 0.000 description 2
- 229920001450 Alpha-Cyclodextrin Polymers 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 2
- 241000416162 Astragalus gummifer Species 0.000 description 2
- 239000005884 Beta-Cyfluthrin Substances 0.000 description 2
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
- 240000008564 Boehmeria nivea Species 0.000 description 2
- 235000004936 Bromus mango Nutrition 0.000 description 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 2
- 235000012766 Cannabis sativa ssp. sativa var. sativa Nutrition 0.000 description 2
- 235000012765 Cannabis sativa ssp. sativa var. spontanea Nutrition 0.000 description 2
- 108010087806 Carnosine Proteins 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 2
- 241000723346 Cinnamomum camphora Species 0.000 description 2
- 235000013162 Cocos nucifera Nutrition 0.000 description 2
- 244000060011 Cocos nucifera Species 0.000 description 2
- OMFXVFTZEKFJBZ-UHFFFAOYSA-N Corticosterone Natural products O=C1CCC2(C)C3C(O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 OMFXVFTZEKFJBZ-UHFFFAOYSA-N 0.000 description 2
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 description 2
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 description 2
- UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 2
- 239000005757 Cyproconazole Substances 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- 208000001840 Dandruff Diseases 0.000 description 2
- 239000005892 Deltamethrin Substances 0.000 description 2
- 208000006558 Dental Calculus Diseases 0.000 description 2
- 108010082495 Dietary Plant Proteins Proteins 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 239000005760 Difenoconazole Substances 0.000 description 2
- 239000005947 Dimethoate Substances 0.000 description 2
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 2
- NIQCNGHVCWTJSM-UHFFFAOYSA-N Dimethyl phthalate Chemical compound COC(=O)C1=CC=CC=C1C(=O)OC NIQCNGHVCWTJSM-UHFFFAOYSA-N 0.000 description 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 239000005767 Epoxiconazole Substances 0.000 description 2
- FNELVJVBIYMIMC-UHFFFAOYSA-N Ethiprole Chemical compound N1=C(C#N)C(S(=O)CC)=C(N)N1C1=C(Cl)C=C(C(F)(F)F)C=C1Cl FNELVJVBIYMIMC-UHFFFAOYSA-N 0.000 description 2
- 244000166124 Eucalyptus globulus Species 0.000 description 2
- 239000005775 Fenbuconazole Substances 0.000 description 2
- 239000005777 Fenpropidin Substances 0.000 description 2
- 239000005899 Fipronil Substances 0.000 description 2
- 239000005785 Fluquinconazole Substances 0.000 description 2
- 235000016623 Fragaria vesca Nutrition 0.000 description 2
- 240000009088 Fragaria x ananassa Species 0.000 description 2
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- 239000005903 Gamma-cyhalothrin Substances 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 2
- 229920002907 Guar gum Polymers 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 2
- GRRNUXAQVGOGFE-UHFFFAOYSA-N Hygromycin-B Natural products OC1C(NC)CC(N)C(O)C1OC1C2OC3(C(C(O)C(O)C(C(N)CO)O3)O)OC2C(O)C(CO)O1 GRRNUXAQVGOGFE-UHFFFAOYSA-N 0.000 description 2
- 102000004310 Ion Channels Human genes 0.000 description 2
- 108090000862 Ion Channels Proteins 0.000 description 2
- 108010076876 Keratins Proteins 0.000 description 2
- 102000011782 Keratins Human genes 0.000 description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 2
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 2
- 229930182816 L-glutamine Natural products 0.000 description 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 2
- 235000004431 Linum usitatissimum Nutrition 0.000 description 2
- 240000006240 Linum usitatissimum Species 0.000 description 2
- 235000014826 Mangifera indica Nutrition 0.000 description 2
- 240000007228 Mangifera indica Species 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- 229920000877 Melamine resin Polymers 0.000 description 2
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 2
- FQISKWAFAHGMGT-SGJOWKDISA-M Methylprednisolone sodium succinate Chemical compound [Na+].C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(=O)CCC([O-])=O)CC[C@H]21 FQISKWAFAHGMGT-SGJOWKDISA-M 0.000 description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 2
- 102000014171 Milk Proteins Human genes 0.000 description 2
- 108010011756 Milk Proteins Proteins 0.000 description 2
- GOEZDDBZVRISTL-UHFFFAOYSA-N N-(thiolan-2-ylmethyl)-1-(2-trimethylsilylethoxymethyl)pyrazol-3-amine Chemical compound S1C(CCC1)CNC1=NN(C=C1)COCC[Si](C)(C)C GOEZDDBZVRISTL-UHFFFAOYSA-N 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- 235000021314 Palmitic acid Nutrition 0.000 description 2
- 229920000289 Polyquaternium Polymers 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000005822 Propiconazole Substances 0.000 description 2
- 108010029485 Protein Isoforms Proteins 0.000 description 2
- 102000001708 Protein Isoforms Human genes 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 2
- 229920000297 Rayon Polymers 0.000 description 2
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- 235000019485 Safflower oil Nutrition 0.000 description 2
- 108010077895 Sarcosine Proteins 0.000 description 2
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000004280 Sodium formate Substances 0.000 description 2
- 235000009184 Spondias indica Nutrition 0.000 description 2
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 description 2
- 239000005839 Tebuconazole Substances 0.000 description 2
- 239000005658 Tebufenpyrad Substances 0.000 description 2
- 239000005939 Tefluthrin Substances 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 2
- 229920001615 Tragacanth Polymers 0.000 description 2
- 102100034030 Transient receptor potential cation channel subfamily M member 8 Human genes 0.000 description 2
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 2
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 2
- 239000005857 Trifloxystrobin Substances 0.000 description 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 2
- 244000263375 Vanilla tahitensis Species 0.000 description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 2
- 229930003571 Vitamin B5 Natural products 0.000 description 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 2
- 235000019742 Vitamins premix Nutrition 0.000 description 2
- 229920004482 WACKER® Polymers 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 2
- UJNOLBSYLSYIBM-WISYIIOYSA-N [(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl] (2r)-2-hydroxypropanoate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)[C@@H](C)O UJNOLBSYLSYIBM-WISYIIOYSA-N 0.000 description 2
- QQODLKZGRKWIFG-RUTXASTPSA-N [(R)-cyano-(4-fluoro-3-phenoxyphenyl)methyl] (1S)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate Chemical compound CC1(C)C(C=C(Cl)Cl)[C@@H]1C(=O)O[C@@H](C#N)C1=CC=C(F)C(OC=2C=CC=CC=2)=C1 QQODLKZGRKWIFG-RUTXASTPSA-N 0.000 description 2
- INISTDXBRIBGOC-CGAIIQECSA-N [cyano-(3-phenoxyphenyl)methyl] (2s)-2-[2-chloro-4-(trifluoromethyl)anilino]-3-methylbutanoate Chemical compound N([C@@H](C(C)C)C(=O)OC(C#N)C=1C=C(OC=2C=CC=CC=2)C=CC=1)C1=CC=C(C(F)(F)F)C=C1Cl INISTDXBRIBGOC-CGAIIQECSA-N 0.000 description 2
- YASYVMFAVPKPKE-UHFFFAOYSA-N acephate Chemical compound COP(=O)(SC)NC(C)=O YASYVMFAVPKPKE-UHFFFAOYSA-N 0.000 description 2
- DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical compound C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 description 2
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 239000012790 adhesive layer Substances 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 description 2
- 150000003973 alkyl amines Chemical class 0.000 description 2
- 150000008055 alkyl aryl sulfonates Chemical class 0.000 description 2
- 150000008051 alkyl sulfates Chemical class 0.000 description 2
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 description 2
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- 239000008168 almond oil Substances 0.000 description 2
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 description 2
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 2
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 2
- BTBJBAZGXNKLQC-UHFFFAOYSA-N ammonium lauryl sulfate Chemical compound [NH4+].CCCCCCCCCCCCOS([O-])(=O)=O BTBJBAZGXNKLQC-UHFFFAOYSA-N 0.000 description 2
- 229940063953 ammonium lauryl sulfate Drugs 0.000 description 2
- 150000003863 ammonium salts Chemical class 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 150000008064 anhydrides Chemical group 0.000 description 2
- 239000010775 animal oil Substances 0.000 description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 description 2
- 239000002260 anti-inflammatory agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
- 239000004760 aramid Substances 0.000 description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
- 235000009697 arginine Nutrition 0.000 description 2
- 229920003235 aromatic polyamide Polymers 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- AKNQMEBLVAMSNZ-UHFFFAOYSA-N azaconazole Chemical compound ClC1=CC(Cl)=CC=C1C1(CN2N=CN=C2)OCCO1 AKNQMEBLVAMSNZ-UHFFFAOYSA-N 0.000 description 2
- 229950000294 azaconazole Drugs 0.000 description 2
- OPVLOHUACNWTQT-UHFFFAOYSA-N azane;2-dodecoxyethyl hydrogen sulfate Chemical compound N.CCCCCCCCCCCCOCCOS(O)(=O)=O OPVLOHUACNWTQT-UHFFFAOYSA-N 0.000 description 2
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 2
- 239000003788 bath preparation Substances 0.000 description 2
- 235000013871 bee wax Nutrition 0.000 description 2
- 239000012166 beeswax Substances 0.000 description 2
- 229940092738 beeswax Drugs 0.000 description 2
- 229960000686 benzalkonium chloride Drugs 0.000 description 2
- ISAOCJYIOMOJEB-UHFFFAOYSA-N benzoin Chemical compound C=1C=CC=CC=1C(O)C(=O)C1=CC=CC=C1 ISAOCJYIOMOJEB-UHFFFAOYSA-N 0.000 description 2
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 2
- 235000013734 beta-carotene Nutrition 0.000 description 2
- 239000011648 beta-carotene Substances 0.000 description 2
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 2
- 229960002747 betacarotene Drugs 0.000 description 2
- LLEMOWNGBBNAJR-UHFFFAOYSA-N biphenyl-2-ol Chemical compound OC1=CC=CC=C1C1=CC=CC=C1 LLEMOWNGBBNAJR-UHFFFAOYSA-N 0.000 description 2
- 229940036350 bisabolol Drugs 0.000 description 2
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 description 2
- 235000015895 biscuits Nutrition 0.000 description 2
- 229930189065 blasticidin Natural products 0.000 description 2
- 229920001400 block copolymer Polymers 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 2
- 235000019255 calcium formate Nutrition 0.000 description 2
- 239000004281 calcium formate Substances 0.000 description 2
- 229960002079 calcium pantothenate Drugs 0.000 description 2
- 235000010331 calcium propionate Nutrition 0.000 description 2
- 239000004330 calcium propionate Substances 0.000 description 2
- 235000010261 calcium sulphite Nutrition 0.000 description 2
- 235000009120 camo Nutrition 0.000 description 2
- 229930008380 camphor Natural products 0.000 description 2
- 229960000846 camphor Drugs 0.000 description 2
- 239000004204 candelilla wax Substances 0.000 description 2
- 235000013868 candelilla wax Nutrition 0.000 description 2
- 229940073532 candelilla wax Drugs 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 150000001735 carboxylic acids Chemical class 0.000 description 2
- MRUAUOIMASANKQ-UHFFFAOYSA-O carboxymethyl-[3-(dodecanoylamino)propyl]-dimethylazanium Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC(O)=O MRUAUOIMASANKQ-UHFFFAOYSA-O 0.000 description 2
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 description 2
- 229940044199 carnosine Drugs 0.000 description 2
- 239000005018 casein Substances 0.000 description 2
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 2
- 235000021240 caseins Nutrition 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- WOWHHFRSBJGXCM-UHFFFAOYSA-M cetyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)C WOWHHFRSBJGXCM-UHFFFAOYSA-M 0.000 description 2
- 235000005607 chanvre indien Nutrition 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- CWFOCCVIPCEQCK-UHFFFAOYSA-N chlorfenapyr Chemical compound BrC1=C(C(F)(F)F)N(COCC)C(C=2C=CC(Cl)=CC=2)=C1C#N CWFOCCVIPCEQCK-UHFFFAOYSA-N 0.000 description 2
- DHNRXBZYEKSXIM-UHFFFAOYSA-N chloromethylisothiazolinone Chemical compound CN1SC(Cl)=CC1=O DHNRXBZYEKSXIM-UHFFFAOYSA-N 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 235000013985 cinnamic acid Nutrition 0.000 description 2
- 229930016911 cinnamic acid Natural products 0.000 description 2
- 235000015165 citric acid Nutrition 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000010367 cloning Methods 0.000 description 2
- 238000004040 coloring Methods 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 239000003246 corticosteroid Substances 0.000 description 2
- 229960001334 corticosteroids Drugs 0.000 description 2
- OMFXVFTZEKFJBZ-HJTSIMOOSA-N corticosterone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OMFXVFTZEKFJBZ-HJTSIMOOSA-N 0.000 description 2
- 229960004544 cortisone Drugs 0.000 description 2
- 239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 description 2
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 2
- 125000004850 cyclobutylmethyl group Chemical group C1(CCC1)C* 0.000 description 2
- YPHMISFOHDHNIV-FSZOTQKASA-N cycloheximide Chemical compound C1[C@@H](C)C[C@H](C)C(=O)[C@@H]1[C@H](O)CC1CC(=O)NC(=O)C1 YPHMISFOHDHNIV-FSZOTQKASA-N 0.000 description 2
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 2
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 description 2
- LSFUGNKKPMBOMG-UHFFFAOYSA-N cycloprothrin Chemical compound ClC1(Cl)CC1(C=1C=CC=CC=1)C(=O)OC(C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 LSFUGNKKPMBOMG-UHFFFAOYSA-N 0.000 description 2
- 229960001591 cyfluthrin Drugs 0.000 description 2
- QQODLKZGRKWIFG-QSFXBCCZSA-N cyfluthrin Chemical compound CC1(C)[C@@H](C=C(Cl)Cl)[C@H]1C(=O)O[C@@H](C#N)C1=CC=C(F)C(OC=2C=CC=CC=2)=C1 QQODLKZGRKWIFG-QSFXBCCZSA-N 0.000 description 2
- ZXQYGBMAQZUVMI-UNOMPAQXSA-N cyhalothrin Chemical compound CC1(C)C(\C=C(/Cl)C(F)(F)F)C1C(=O)OC(C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 ZXQYGBMAQZUVMI-UNOMPAQXSA-N 0.000 description 2
- KAATUXNTWXVJKI-UHFFFAOYSA-N cypermethrin Chemical compound CC1(C)C(C=C(Cl)Cl)C1C(=O)OC(C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 KAATUXNTWXVJKI-UHFFFAOYSA-N 0.000 description 2
- 229960003067 cystine Drugs 0.000 description 2
- 229960002483 decamethrin Drugs 0.000 description 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 2
- OWZREIFADZCYQD-NSHGMRRFSA-N deltamethrin Chemical compound CC1(C)[C@@H](C=C(Br)Br)[C@H]1C(=O)O[C@H](C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 OWZREIFADZCYQD-NSHGMRRFSA-N 0.000 description 2
- 238000010511 deprotection reaction Methods 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 2
- 229960003957 dexamethasone Drugs 0.000 description 2
- FHIVAFMUCKRCQO-UHFFFAOYSA-N diazinon Chemical compound CCOP(=S)(OCC)OC1=CC(C)=NC(C(C)C)=N1 FHIVAFMUCKRCQO-UHFFFAOYSA-N 0.000 description 2
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 description 2
- 229950001327 dichlorvos Drugs 0.000 description 2
- DENRZWYUOJLTMF-UHFFFAOYSA-N diethyl sulfate Chemical compound CCOS(=O)(=O)OCC DENRZWYUOJLTMF-UHFFFAOYSA-N 0.000 description 2
- 229940008406 diethyl sulfate Drugs 0.000 description 2
- BQYJATMQXGBDHF-UHFFFAOYSA-N difenoconazole Chemical compound O1C(C)COC1(C=1C(=CC(OC=2C=CC(Cl)=CC=2)=CC=1)Cl)CN1N=CN=C1 BQYJATMQXGBDHF-UHFFFAOYSA-N 0.000 description 2
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- MCWXGJITAZMZEV-UHFFFAOYSA-N dimethoate Chemical compound CNC(=O)CSP(=S)(OC)OC MCWXGJITAZMZEV-UHFFFAOYSA-N 0.000 description 2
- FBOUIAKEJMZPQG-BLXFFLACSA-N diniconazole-M Chemical compound C1=NC=NN1/C([C@H](O)C(C)(C)C)=C/C1=CC=C(Cl)C=C1Cl FBOUIAKEJMZPQG-BLXFFLACSA-N 0.000 description 2
- SMVRDGHCVNAOIN-UHFFFAOYSA-L disodium;1-dodecoxydodecane;sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O.CCCCCCCCCCCCOCCCCCCCCCCCC SMVRDGHCVNAOIN-UHFFFAOYSA-L 0.000 description 2
- 239000004815 dispersion polymer Substances 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 2
- 239000006196 drop Substances 0.000 description 2
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 2
- RIZMRRKBZQXFOY-UHFFFAOYSA-N ethion Chemical compound CCOP(=S)(OCC)SCSP(=S)(OCC)OCC RIZMRRKBZQXFOY-UHFFFAOYSA-N 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- XIRNKXNNONJFQO-UHFFFAOYSA-N ethyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC XIRNKXNNONJFQO-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- ZNOLGFHPUIJIMJ-UHFFFAOYSA-N fenitrothion Chemical compound COP(=S)(OC)OC1=CC=C([N+]([O-])=O)C(C)=C1 ZNOLGFHPUIJIMJ-UHFFFAOYSA-N 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 239000012065 filter cake Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 229940013764 fipronil Drugs 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- IJJVMEJXYNJXOJ-UHFFFAOYSA-N fluquinconazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1C(=O)C2=CC(F)=CC=C2N=C1N1C=NC=N1 IJJVMEJXYNJXOJ-UHFFFAOYSA-N 0.000 description 2
- FQKUGOMFVDPBIZ-UHFFFAOYSA-N flusilazole Chemical compound C=1C=C(F)C=CC=1[Si](C=1C=CC(F)=CC=1)(C)CN1C=NC=N1 FQKUGOMFVDPBIZ-UHFFFAOYSA-N 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 235000011194 food seasoning agent Nutrition 0.000 description 2
- 235000019253 formic acid Nutrition 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000000855 fungicidal effect Effects 0.000 description 2
- HYBBIBNJHNGZAN-UHFFFAOYSA-N furfural Chemical compound O=CC1=CC=CO1 HYBBIBNJHNGZAN-UHFFFAOYSA-N 0.000 description 2
- ZXQYGBMAQZUVMI-GCMPRSNUSA-N gamma-cyhalothrin Chemical compound CC1(C)[C@@H](\C=C(/Cl)C(F)(F)F)[C@H]1C(=O)O[C@H](C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 ZXQYGBMAQZUVMI-GCMPRSNUSA-N 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- LEQAOMBKQFMDFZ-UHFFFAOYSA-N glyoxal Chemical compound O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 235000010417 guar gum Nutrition 0.000 description 2
- 239000000665 guar gum Substances 0.000 description 2
- 229960002154 guar gum Drugs 0.000 description 2
- 239000000118 hair dye Substances 0.000 description 2
- 239000011487 hemp Substances 0.000 description 2
- IUJAMGNYPWYUPM-UHFFFAOYSA-N hentriacontane Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC IUJAMGNYPWYUPM-UHFFFAOYSA-N 0.000 description 2
- 235000010299 hexamethylene tetramine Nutrition 0.000 description 2
- 239000004312 hexamethylene tetramine Substances 0.000 description 2
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 description 2
- NAQMVNRVTILPCV-UHFFFAOYSA-N hexane-1,6-diamine Chemical compound NCCCCCCN NAQMVNRVTILPCV-UHFFFAOYSA-N 0.000 description 2
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 2
- 229920001519 homopolymer Polymers 0.000 description 2
- 239000000416 hydrocolloid Substances 0.000 description 2
- 239000000017 hydrogel Substances 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- GRRNUXAQVGOGFE-NZSRVPFOSA-N hygromycin B Chemical compound O[C@@H]1[C@@H](NC)C[C@@H](N)[C@H](O)[C@H]1O[C@H]1[C@H]2O[C@@]3([C@@H]([C@@H](O)[C@@H](O)[C@@H](C(N)CO)O3)O)O[C@H]2[C@@H](O)[C@@H](CO)O1 GRRNUXAQVGOGFE-NZSRVPFOSA-N 0.000 description 2
- 229940097277 hygromycin b Drugs 0.000 description 2
- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 description 2
- 230000003100 immobilizing effect Effects 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
- 239000001023 inorganic pigment Substances 0.000 description 2
- 230000000749 insecticidal effect Effects 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 239000002085 irritant Substances 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 150000003903 lactic acid esters Chemical class 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 239000004816 latex Substances 0.000 description 2
- 229920000126 latex Polymers 0.000 description 2
- 229940094506 lauryl betaine Drugs 0.000 description 2
- 239000004611 light stabiliser Substances 0.000 description 2
- 229960004488 linolenic acid Drugs 0.000 description 2
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 2
- 239000011344 liquid material Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 230000000873 masking effect Effects 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 229940057917 medium chain triglycerides Drugs 0.000 description 2
- 239000001683 mentha spicata herb oil Substances 0.000 description 2
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 2
- 229930182817 methionine Natural products 0.000 description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 2
- GEPDYQSQVLXLEU-AATRIKPKSA-N methyl (e)-3-dimethoxyphosphoryloxybut-2-enoate Chemical compound COC(=O)\C=C(/C)OP(=O)(OC)OC GEPDYQSQVLXLEU-AATRIKPKSA-N 0.000 description 2
- LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 description 2
- 229960004584 methylprednisolone Drugs 0.000 description 2
- 229960001952 metrifonate Drugs 0.000 description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 2
- 239000008108 microcrystalline cellulose Substances 0.000 description 2
- 239000004200 microcrystalline wax Substances 0.000 description 2
- 235000019808 microcrystalline wax Nutrition 0.000 description 2
- 239000002480 mineral oil Substances 0.000 description 2
- 239000003750 molluscacide Substances 0.000 description 2
- 230000002013 molluscicidal effect Effects 0.000 description 2
- KRTSDMXIXPKRQR-AATRIKPKSA-N monocrotophos Chemical compound CNC(=O)\C=C(/C)OP(=O)(OC)OC KRTSDMXIXPKRQR-AATRIKPKSA-N 0.000 description 2
- 150000002772 monosaccharides Chemical class 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- AJDUTMFFZHIJEM-UHFFFAOYSA-N n-(9,10-dioxoanthracen-1-yl)-4-[4-[[4-[4-[(9,10-dioxoanthracen-1-yl)carbamoyl]phenyl]phenyl]diazenyl]phenyl]benzamide Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C=CC=C2NC(=O)C(C=C1)=CC=C1C(C=C1)=CC=C1N=NC(C=C1)=CC=C1C(C=C1)=CC=C1C(=O)NC1=CC=CC2=C1C(=O)C1=CC=CC=C1C2=O AJDUTMFFZHIJEM-UHFFFAOYSA-N 0.000 description 2
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 2
- DVEKCXOJTLDBFE-UHFFFAOYSA-N n-dodecyl-n,n-dimethylglycinate Chemical compound CCCCCCCCCCCC[N+](C)(C)CC([O-])=O DVEKCXOJTLDBFE-UHFFFAOYSA-N 0.000 description 2
- GZZHJTKDOXFXBW-UHFFFAOYSA-N n-phenylthiolan-3-amine Chemical compound C1SCCC1NC1=CC=CC=C1 GZZHJTKDOXFXBW-UHFFFAOYSA-N 0.000 description 2
- 229960003255 natamycin Drugs 0.000 description 2
- 239000005645 nematicide Substances 0.000 description 2
- 210000002569 neuron Anatomy 0.000 description 2
- 230000003472 neutralizing effect Effects 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 229920001542 oligosaccharide Polymers 0.000 description 2
- 239000003605 opacifier Substances 0.000 description 2
- 235000010292 orthophenyl phenol Nutrition 0.000 description 2
- 229940098695 palmitic acid Drugs 0.000 description 2
- SSZBUIDZHHWXNJ-UHFFFAOYSA-N palmityl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCC SSZBUIDZHHWXNJ-UHFFFAOYSA-N 0.000 description 2
- 229940101267 panthenol Drugs 0.000 description 2
- 239000011619 pantothenol Substances 0.000 description 2
- 235000020957 pantothenol Nutrition 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- 230000003071 parasitic effect Effects 0.000 description 2
- LCCNCVORNKJIRZ-UHFFFAOYSA-N parathion Chemical compound CCOP(=S)(OCC)OC1=CC=C([N+]([O-])=O)C=C1 LCCNCVORNKJIRZ-UHFFFAOYSA-N 0.000 description 2
- RLBIQVVOMOPOHC-UHFFFAOYSA-N parathion-methyl Chemical compound COP(=S)(OC)OC1=CC=C([N+]([O-])=O)C=C1 RLBIQVVOMOPOHC-UHFFFAOYSA-N 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 229940127557 pharmaceutical product Drugs 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 229960003536 phenothrin Drugs 0.000 description 2
- 239000013612 plasmid Substances 0.000 description 2
- 229920002553 poly(2-methacrylolyloxyethyltrimethylammonium chloride) polymer Polymers 0.000 description 2
- 229920002239 polyacrylonitrile Polymers 0.000 description 2
- 229920000223 polyglycerol Polymers 0.000 description 2
- 229920005862 polyol Polymers 0.000 description 2
- 150000003077 polyols Chemical class 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 229920002689 polyvinyl acetate Polymers 0.000 description 2
- 239000011118 polyvinyl acetate Substances 0.000 description 2
- 235000010259 potassium hydrogen sulphite Nutrition 0.000 description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
- 235000010333 potassium nitrate Nutrition 0.000 description 2
- 239000004323 potassium nitrate Substances 0.000 description 2
- 235000010289 potassium nitrite Nutrition 0.000 description 2
- 239000004304 potassium nitrite Substances 0.000 description 2
- 235000010332 potassium propionate Nutrition 0.000 description 2
- 239000004331 potassium propionate Substances 0.000 description 2
- 235000010241 potassium sorbate Nutrition 0.000 description 2
- 239000004302 potassium sorbate Substances 0.000 description 2
- 229960005205 prednisolone Drugs 0.000 description 2
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 2
- QYMMJNLHFKGANY-UHFFFAOYSA-N profenofos Chemical compound CCCSP(=O)(OCC)OC1=CC=C(Br)C=C1Cl QYMMJNLHFKGANY-UHFFFAOYSA-N 0.000 description 2
- 229960003387 progesterone Drugs 0.000 description 2
- 239000000186 progesterone Substances 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- STJLVHWMYQXCPB-UHFFFAOYSA-N propiconazole Chemical compound O1C(CCC)COC1(C=1C(=CC(Cl)=CC=1)Cl)CN1N=CN=C1 STJLVHWMYQXCPB-UHFFFAOYSA-N 0.000 description 2
- 235000019260 propionic acid Nutrition 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229940108410 resmethrin Drugs 0.000 description 2
- VEMKTZHHVJILDY-FIWHBWSRSA-N resmethrin Chemical compound CC1(C)[C@H](C=C(C)C)C1C(=O)OCC1=COC(CC=2C=CC=CC=2)=C1 VEMKTZHHVJILDY-FIWHBWSRSA-N 0.000 description 2
- 229960003471 retinol Drugs 0.000 description 2
- 235000020944 retinol Nutrition 0.000 description 2
- 239000011607 retinol Substances 0.000 description 2
- 235000020748 rosemary extract Nutrition 0.000 description 2
- 229940092258 rosemary extract Drugs 0.000 description 2
- 239000001233 rosmarinus officinalis l. extract Substances 0.000 description 2
- 238000002390 rotary evaporation Methods 0.000 description 2
- 229960004555 rutoside Drugs 0.000 description 2
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 2
- 239000003813 safflower oil Substances 0.000 description 2
- 235000005713 safflower oil Nutrition 0.000 description 2
- 229960004889 salicylic acid Drugs 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 229910052711 selenium Inorganic materials 0.000 description 2
- 239000011669 selenium Substances 0.000 description 2
- 239000012056 semi-solid material Substances 0.000 description 2
- 238000007493 shaping process Methods 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 229920002545 silicone oil Polymers 0.000 description 2
- 235000020183 skimmed milk Nutrition 0.000 description 2
- 239000002884 skin cream Substances 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 229940047670 sodium acrylate Drugs 0.000 description 2
- 235000010234 sodium benzoate Nutrition 0.000 description 2
- 239000004299 sodium benzoate Substances 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- 235000019254 sodium formate Nutrition 0.000 description 2
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 2
- 229940079862 sodium lauryl sarcosinate Drugs 0.000 description 2
- 235000010262 sodium metabisulphite Nutrition 0.000 description 2
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 2
- 235000010344 sodium nitrate Nutrition 0.000 description 2
- 239000004317 sodium nitrate Substances 0.000 description 2
- 235000010288 sodium nitrite Nutrition 0.000 description 2
- 235000010334 sodium propionate Nutrition 0.000 description 2
- 239000004324 sodium propionate Substances 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- LROWVYNUWKVTCU-STWYSWDKSA-M sodium sorbate Chemical compound [Na+].C\C=C\C=C\C([O-])=O LROWVYNUWKVTCU-STWYSWDKSA-M 0.000 description 2
- 235000010265 sodium sulphite Nutrition 0.000 description 2
- SLBXZQMMERXQAL-UHFFFAOYSA-M sodium;1-dodecoxy-4-hydroxy-1,4-dioxobutane-2-sulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)C(S(O)(=O)=O)CC([O-])=O SLBXZQMMERXQAL-UHFFFAOYSA-M 0.000 description 2
- 239000011343 solid material Substances 0.000 description 2
- 229940075582 sorbic acid Drugs 0.000 description 2
- 235000012424 soybean oil Nutrition 0.000 description 2
- 239000003549 soybean oil Substances 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 150000003871 sulfonates Chemical class 0.000 description 2
- 125000005555 sulfoximide group Chemical group 0.000 description 2
- 125000004434 sulfur atom Chemical group 0.000 description 2
- 235000010269 sulphur dioxide Nutrition 0.000 description 2
- 239000000375 suspending agent Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 229920002994 synthetic fiber Polymers 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 229960003080 taurine Drugs 0.000 description 2
- 229940105956 tea-dodecylbenzenesulfonate Drugs 0.000 description 2
- ZZYSLNWGKKDOML-UHFFFAOYSA-N tebufenpyrad Chemical compound CCC1=NN(C)C(C(=O)NCC=2C=CC(=CC=2)C(C)(C)C)=C1Cl ZZYSLNWGKKDOML-UHFFFAOYSA-N 0.000 description 2
- 238000009988 textile finishing Methods 0.000 description 2
- YAPQBXQYLJRXSA-UHFFFAOYSA-N theobromine Chemical compound CN1C(=O)NC(=O)C2=C1N=CN2C YAPQBXQYLJRXSA-UHFFFAOYSA-N 0.000 description 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 2
- 235000010296 thiabendazole Nutrition 0.000 description 2
- 239000004308 thiabendazole Substances 0.000 description 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 2
- 239000010678 thyme oil Substances 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- 239000011135 tin Substances 0.000 description 2
- 229910052718 tin Inorganic materials 0.000 description 2
- 239000004408 titanium dioxide Substances 0.000 description 2
- 235000010384 tocopherol Nutrition 0.000 description 2
- 229930003799 tocopherol Natural products 0.000 description 2
- 239000011732 tocopherol Substances 0.000 description 2
- 229960001295 tocopherol Drugs 0.000 description 2
- WPALTCMYPARVNV-UHFFFAOYSA-N tolfenpyrad Chemical compound CCC1=NN(C)C(C(=O)NCC=2C=CC(OC=3C=CC(C)=CC=3)=CC=2)=C1Cl WPALTCMYPARVNV-UHFFFAOYSA-N 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 239000012049 topical pharmaceutical composition Substances 0.000 description 2
- 235000010487 tragacanth Nutrition 0.000 description 2
- 239000000196 tragacanth Substances 0.000 description 2
- 229940116362 tragacanth Drugs 0.000 description 2
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 description 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 2
- 229960005294 triamcinolone Drugs 0.000 description 2
- AMFGTOFWMRQMEM-UHFFFAOYSA-N triazophos Chemical compound N1=C(OP(=S)(OCC)OCC)N=CN1C1=CC=CC=C1 AMFGTOFWMRQMEM-UHFFFAOYSA-N 0.000 description 2
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 2
- NFACJZMKEDPNKN-UHFFFAOYSA-N trichlorfon Chemical compound COP(=O)(OC)C(O)C(Cl)(Cl)Cl NFACJZMKEDPNKN-UHFFFAOYSA-N 0.000 description 2
- 239000001069 triethyl citrate Substances 0.000 description 2
- 235000013769 triethyl citrate Nutrition 0.000 description 2
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 2
- ONCZDRURRATYFI-TVJDWZFNSA-N trifloxystrobin Chemical compound CO\N=C(\C(=O)OC)C1=CC=CC=C1CO\N=C(/C)C1=CC=CC(C(F)(F)F)=C1 ONCZDRURRATYFI-TVJDWZFNSA-N 0.000 description 2
- 229960004799 tryptophan Drugs 0.000 description 2
- 229910052721 tungsten Inorganic materials 0.000 description 2
- 229960004441 tyrosine Drugs 0.000 description 2
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 2
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- 239000011675 vitamin B5 Substances 0.000 description 2
- 235000009492 vitamin B5 Nutrition 0.000 description 2
- 210000002268 wool Anatomy 0.000 description 2
- 239000002759 woven fabric Substances 0.000 description 2
- 239000001043 yellow dye Substances 0.000 description 2
- 229910052726 zirconium Inorganic materials 0.000 description 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 2
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 2
- ZCVAOQKBXKSDMS-PVAVHDDUSA-N (+)-trans-(S)-allethrin Chemical compound CC1(C)[C@H](C=C(C)C)[C@H]1C(=O)O[C@@H]1C(C)=C(CC=C)C(=O)C1 ZCVAOQKBXKSDMS-PVAVHDDUSA-N 0.000 description 1
- ZCVAOQKBXKSDMS-AQYZNVCMSA-N (+)-trans-allethrin Chemical compound CC1(C)[C@H](C=C(C)C)[C@H]1C(=O)OC1C(C)=C(CC=C)C(=O)C1 ZCVAOQKBXKSDMS-AQYZNVCMSA-N 0.000 description 1
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- NFLGAXVYCFJBMK-IUCAKERBSA-N (-)-isomenthone Chemical compound CC(C)[C@@H]1CC[C@H](C)CC1=O NFLGAXVYCFJBMK-IUCAKERBSA-N 0.000 description 1
- 125000001755 (-)-menthol group Chemical group 0.000 description 1
- AKNNEGZIBPJZJG-MSOLQXFVSA-N (-)-noscapine Chemical compound CN1CCC2=CC=3OCOC=3C(OC)=C2[C@@H]1[C@@H]1C2=CC=C(OC)C(OC)=C2C(=O)O1 AKNNEGZIBPJZJG-MSOLQXFVSA-N 0.000 description 1
- KAATUXNTWXVJKI-NSHGMRRFSA-N (1R)-cis-(alphaS)-cypermethrin Chemical compound CC1(C)[C@@H](C=C(Cl)Cl)[C@H]1C(=O)O[C@H](C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 KAATUXNTWXVJKI-NSHGMRRFSA-N 0.000 description 1
- FJDPATXIBIBRIM-QFMSAKRMSA-N (1R)-trans-cyphenothrin Chemical compound CC1(C)[C@H](C=C(C)C)[C@H]1C(=O)OC(C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 FJDPATXIBIBRIM-QFMSAKRMSA-N 0.000 description 1
- XERJKGMBORTKEO-VZUCSPMQSA-N (1e)-2-(ethylcarbamoylamino)-n-methoxy-2-oxoethanimidoyl cyanide Chemical compound CCNC(=O)NC(=O)C(\C#N)=N\OC XERJKGMBORTKEO-VZUCSPMQSA-N 0.000 description 1
- YATDSXRLIUJOQN-SVRRBLITSA-N (2,3,4,5,6-pentafluorophenyl)methyl (1r,3s)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate Chemical compound CC1(C)[C@H](C=C(Cl)Cl)[C@H]1C(=O)OCC1=C(F)C(F)=C(F)C(F)=C1F YATDSXRLIUJOQN-SVRRBLITSA-N 0.000 description 1
- FHNKBSDJERHDHZ-UHFFFAOYSA-N (2,4-dimethylphenyl)methyl 2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxylate Chemical compound CC1(C)C(C=C(C)C)C1C(=O)OCC1=CC=C(C)C=C1C FHNKBSDJERHDHZ-UHFFFAOYSA-N 0.000 description 1
- CRDAMVZIKSXKFV-FBXUGWQNSA-N (2-cis,6-cis)-farnesol Chemical compound CC(C)=CCC\C(C)=C/CC\C(C)=C/CO CRDAMVZIKSXKFV-FBXUGWQNSA-N 0.000 description 1
- MIZYPRIEDMSCAC-UHFFFAOYSA-N (2-methyl-4-oxo-3-prop-2-enylcyclopent-2-en-1-yl) 2,2,3,3-tetramethylcyclopropane-1-carboxylate Chemical compound CC1=C(CC=C)C(=O)CC1OC(=O)C1C(C)(C)C1(C)C MIZYPRIEDMSCAC-UHFFFAOYSA-N 0.000 description 1
- WXBHKHTWAPLUSQ-UHFFFAOYSA-N (2-methyl-5-prop-2-ynylfuran-3-yl)methyl 2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxylate Chemical compound CC1(C)C(C=C(C)C)C1C(=O)OCC1=C(C)OC(CC#C)=C1 WXBHKHTWAPLUSQ-UHFFFAOYSA-N 0.000 description 1
- 239000000260 (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol Substances 0.000 description 1
- RYAUSSKQMZRMAI-ALOPSCKCSA-N (2S,6R)-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine Chemical compound C=1C=C(C(C)(C)C)C=CC=1CC(C)CN1C[C@H](C)O[C@H](C)C1 RYAUSSKQMZRMAI-ALOPSCKCSA-N 0.000 description 1
- URDNHJIVMYZFRT-KGLIPLIRSA-N (2r,3r)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)pentan-3-ol Chemical compound C([C@H]([C@H](O)C(C)(C)C)N1N=CN=C1)C1=CC=C(Cl)C=C1Cl URDNHJIVMYZFRT-KGLIPLIRSA-N 0.000 description 1
- DNISEZBAYYIQFB-PHDIDXHHSA-N (2r,3r)-2,3-diacetyloxybutanedioic acid Chemical class CC(=O)O[C@@H](C(O)=O)[C@H](C(O)=O)OC(C)=O DNISEZBAYYIQFB-PHDIDXHHSA-N 0.000 description 1
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 1
- RLLPVAHGXHCWKJ-MJGOQNOKSA-N (3-phenoxyphenyl)methyl (1r,3s)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate Chemical compound CC1(C)[C@H](C=C(Cl)Cl)[C@H]1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 RLLPVAHGXHCWKJ-MJGOQNOKSA-N 0.000 description 1
- MGRRXBWTLBJEMS-YADHBBJMSA-N (5-benzylfuran-3-yl)methyl (1r,3r)-3-(cyclopentylidenemethyl)-2,2-dimethylcyclopropane-1-carboxylate Chemical compound C([C@H]1C([C@@H]1C(=O)OCC=1C=C(CC=2C=CC=CC=2)OC=1)(C)C)=C1CCCC1 MGRRXBWTLBJEMS-YADHBBJMSA-N 0.000 description 1
- XHTIJBPVFRWDPT-UHFFFAOYSA-N (5-hydroxy-3-methylpentan-2-yl) piperidine-1-carboxylate Chemical compound OCCC(C)C(C)OC(=O)N1CCCCC1 XHTIJBPVFRWDPT-UHFFFAOYSA-N 0.000 description 1
- RBCOYOYDYNXAFA-UHFFFAOYSA-L (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate Chemical compound CC1=NC=C(COP([O-])([O-])=O)C(C)=C1O RBCOYOYDYNXAFA-UHFFFAOYSA-L 0.000 description 1
- 239000001605 (5-methyl-2-propan-2-ylcyclohexyl) acetate Substances 0.000 description 1
- PPDBOQMNKNNODG-NTEUORMPSA-N (5E)-5-(4-chlorobenzylidene)-2,2-dimethyl-1-(1,2,4-triazol-1-ylmethyl)cyclopentanol Chemical compound C1=NC=NN1CC1(O)C(C)(C)CC\C1=C/C1=CC=C(Cl)C=C1 PPDBOQMNKNNODG-NTEUORMPSA-N 0.000 description 1
- KPMWGGRSOPMANK-UHFFFAOYSA-N (6-chloro-1,3-benzodioxol-5-yl)methyl 2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxylate Chemical compound CC1(C)C(C=C(C)C)C1C(=O)OCC(C(=C1)Cl)=CC2=C1OCO2 KPMWGGRSOPMANK-UHFFFAOYSA-N 0.000 description 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 description 1
- JLPAYWSRTYTKQZ-CSKARUKUSA-N (E)-3-(1,3-benzodioxol-5-yl)-N-(2-methoxyethyl)-N-phenylprop-2-enamide Chemical compound O1COC2=C1C=CC(=C2)/C=C/C(=O)N(C1=CC=CC=C1)CCOC JLPAYWSRTYTKQZ-CSKARUKUSA-N 0.000 description 1
- DIHDDVOUALSHIH-PKNBQFBNSA-N (E)-3-(1,3-benzodioxol-5-yl)-N-(3-methylsulfanylpropyl)-N-phenylprop-2-enamide Chemical compound CSCCCN(C(=O)\C=C\c1ccc2OCOc2c1)c1ccccc1 DIHDDVOUALSHIH-PKNBQFBNSA-N 0.000 description 1
- HUNYXVQRUAFLMM-PKNBQFBNSA-N (E)-3-(1,3-benzodioxol-5-yl)-N-(oxolan-2-ylmethyl)-N-phenylprop-2-enamide Chemical compound O1COC2=C1C=CC(=C2)/C=C/C(=O)N(CC1OCCC1)C1=CC=CC=C1 HUNYXVQRUAFLMM-PKNBQFBNSA-N 0.000 description 1
- QSZRWTRVOJHUPS-SOFGYWHQSA-N (E)-3-(1,3-benzodioxol-5-yl)-N-ethyl-N-(3-methylsulfanylpropyl)prop-2-enamide Chemical compound O1COC2=C1C=CC(=C2)/C=C/C(=O)N(CCCSC)CC QSZRWTRVOJHUPS-SOFGYWHQSA-N 0.000 description 1
- CPDGQVACSWHGIR-QPJJXVBHSA-N (E)-3-(4-methoxyphenyl)-N-(1H-pyrazol-5-yl)-N-(thiolan-3-yl)prop-2-enamide Chemical compound COC1=CC=C(C=C1)/C=C/C(=O)N(C1CSCC1)C1=NNC=C1 CPDGQVACSWHGIR-QPJJXVBHSA-N 0.000 description 1
- MYSHEVZBQCPQMN-JLHYYAGUSA-N (E)-3-(4-methoxyphenyl)-N-(2-methylsulfanylethyl)-N-phenylprop-2-enamide Chemical compound COC1=CC=C(C=C1)/C=C/C(=O)N(C1=CC=CC=C1)CCSC MYSHEVZBQCPQMN-JLHYYAGUSA-N 0.000 description 1
- KKQWAANKCVITOE-FMIVXFBMSA-N (E)-3-(4-methoxyphenyl)-N-(oxolan-3-yl)-N-phenylprop-2-enamide Chemical compound COC1=CC=C(C=C1)/C=C/C(=O)N(C1COCC1)C1=CC=CC=C1 KKQWAANKCVITOE-FMIVXFBMSA-N 0.000 description 1
- JVZHTYMQFIAWOS-VOTSOKGWSA-N (E)-3-(4-methylphenyl)-N-(1H-pyrazol-5-yl)-N-(thiolan-3-yl)prop-2-enamide Chemical compound C1(=CC=C(C=C1)/C=C/C(=O)N(C1CSCC1)C1=NNC=C1)C JVZHTYMQFIAWOS-VOTSOKGWSA-N 0.000 description 1
- WKKPYAKOMYKTCO-VAWYXSNFSA-N (E)-3-(4-methylphenyl)-N-(oxolan-3-yl)-N-phenylprop-2-enamide Chemical compound C1(=CC=CC=C1)N(C(\C=C\C1=CC=C(C=C1)C)=O)C1COCC1 WKKPYAKOMYKTCO-VAWYXSNFSA-N 0.000 description 1
- IHBSTEOKHRHAET-MDZDMXLPSA-N (E)-3-(4-methylphenyl)-N-pyridin-2-yl-N-(thiolan-3-yl)prop-2-enamide Chemical compound C1(=CC=C(C=C1)/C=C/C(=O)N(C1CSCC1)C1=NC=CC=C1)C IHBSTEOKHRHAET-MDZDMXLPSA-N 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 1
- MIYICGBMUWSIIZ-JXMROGBWSA-N (E)-N-ethyl-3-(4-methoxyphenyl)-N-(2-methylsulfanylethyl)prop-2-enamide Chemical compound C(C)N(C(\C=C\C1=CC=C(C=C1)OC)=O)CCSC MIYICGBMUWSIIZ-JXMROGBWSA-N 0.000 description 1
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 description 1
- IZFHEQBZOYJLPK-SSDOTTSWSA-N (R)-dihydrolipoic acid Chemical compound OC(=O)CCCC[C@@H](S)CCS IZFHEQBZOYJLPK-SSDOTTSWSA-N 0.000 description 1
- BGRJTUBHPOOWDU-NSHDSACASA-N (S)-(-)-sulpiride Chemical compound CCN1CCC[C@H]1CNC(=O)C1=CC(S(N)(=O)=O)=CC=C1OC BGRJTUBHPOOWDU-NSHDSACASA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- WBJQTHIVYWAEDD-DUXPYHPUSA-N (e)-3-(1,3-benzodioxol-5-yl)prop-2-enoyl chloride Chemical compound ClC(=O)\C=C\C1=CC=C2OCOC2=C1 WBJQTHIVYWAEDD-DUXPYHPUSA-N 0.000 description 1
- CGOJOQBYEAVATL-QPJJXVBHSA-N (e)-3-(4-methoxyphenyl)prop-2-enoyl chloride Chemical compound COC1=CC=C(\C=C\C(Cl)=O)C=C1 CGOJOQBYEAVATL-QPJJXVBHSA-N 0.000 description 1
- WOGITNXCNOTRLK-VOTSOKGWSA-N (e)-3-phenylprop-2-enoyl chloride Chemical compound ClC(=O)\C=C\C1=CC=CC=C1 WOGITNXCNOTRLK-VOTSOKGWSA-N 0.000 description 1
- WHIVNJATOVLWBW-PLNGDYQASA-N (nz)-n-butan-2-ylidenehydroxylamine Chemical compound CC\C(C)=N/O WHIVNJATOVLWBW-PLNGDYQASA-N 0.000 description 1
- DYOZNCVZPFIXLU-UHFFFAOYSA-N 1,1,2-trimethoxyethane Chemical compound COCC(OC)OC DYOZNCVZPFIXLU-UHFFFAOYSA-N 0.000 description 1
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
- 125000001766 1,2,4-oxadiazol-3-yl group Chemical group [H]C1=NC(*)=NO1 0.000 description 1
- 125000004505 1,2,4-oxadiazol-5-yl group Chemical group O1N=CN=C1* 0.000 description 1
- 125000004515 1,2,4-thiadiazol-3-yl group Chemical group S1N=C(N=C1)* 0.000 description 1
- 125000004516 1,2,4-thiadiazol-5-yl group Chemical group S1N=CN=C1* 0.000 description 1
- AHFMSNDOYCFEPH-UHFFFAOYSA-N 1,2-difluoroethane Chemical compound FCCF AHFMSNDOYCFEPH-UHFFFAOYSA-N 0.000 description 1
- 125000005918 1,2-dimethylbutyl group Chemical group 0.000 description 1
- VUWCWMOCWKCZTA-UHFFFAOYSA-N 1,2-thiazol-4-one Chemical class O=C1CSN=C1 VUWCWMOCWKCZTA-UHFFFAOYSA-N 0.000 description 1
- 125000004509 1,3,4-oxadiazol-2-yl group Chemical group O1C(=NN=C1)* 0.000 description 1
- 125000004521 1,3,4-thiadiazol-2-yl group Chemical group S1C(=NN=C1)* 0.000 description 1
- 125000004317 1,3,5-triazin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=N1 0.000 description 1
- PNHUHPSIWGBXDF-UHFFFAOYSA-N 1,3,5-trichloro-2,4-dihydrotriazine Chemical compound ClN1CC(Cl)=CN(Cl)N1 PNHUHPSIWGBXDF-UHFFFAOYSA-N 0.000 description 1
- XKALZGSIEJZJCZ-UHFFFAOYSA-N 1,3-bis(methoxymethyl)urea Chemical compound COCNC(=O)NCOC XKALZGSIEJZJCZ-UHFFFAOYSA-N 0.000 description 1
- OVBFMUAFNIIQAL-UHFFFAOYSA-N 1,4-diisocyanatobutane Chemical compound O=C=NCCCCN=C=O OVBFMUAFNIIQAL-UHFFFAOYSA-N 0.000 description 1
- RSWGJHLUYNHPMX-UHFFFAOYSA-N 1,4a-dimethyl-7-propan-2-yl-2,3,4,4b,5,6,10,10a-octahydrophenanthrene-1-carboxylic acid Chemical compound C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 1
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 1
- JWUCHKBSVLQQCO-UHFFFAOYSA-N 1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol Chemical compound C=1C=C(F)C=CC=1C(C=1C(=CC=CC=1)F)(O)CN1C=NC=N1 JWUCHKBSVLQQCO-UHFFFAOYSA-N 0.000 description 1
- RURQAJURNPMSSK-UHFFFAOYSA-N 1-(4-chlorophenoxy)-3-{[2-(4-ethoxyphenyl)-3,3,3-trifluoropropoxy]methyl}benzene Chemical compound C1=CC(OCC)=CC=C1C(C(F)(F)F)COCC1=CC=CC(OC=2C=CC(Cl)=CC=2)=C1 RURQAJURNPMSSK-UHFFFAOYSA-N 0.000 description 1
- HMLSBRLVTDLLOI-UHFFFAOYSA-N 1-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)C(C)OC(=O)C(C)=C HMLSBRLVTDLLOI-UHFFFAOYSA-N 0.000 description 1
- XQCHHZHVJHXGCM-UHFFFAOYSA-N 1-(hydroxymethyl)imidazolidin-2-one Chemical compound OCN1CCNC1=O XQCHHZHVJHXGCM-UHFFFAOYSA-N 0.000 description 1
- IAUGBVWVWDTCJV-UHFFFAOYSA-N 1-(prop-2-enoylamino)propane-1-sulfonic acid Chemical compound CCC(S(O)(=O)=O)NC(=O)C=C IAUGBVWVWDTCJV-UHFFFAOYSA-N 0.000 description 1
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 description 1
- ZOWYFYXTIWQBEP-UHFFFAOYSA-N 1-[(3,4-diethoxyphenyl)methyl]-6,7-diethoxyisoquinoline Chemical compound C1=C(OCC)C(OCC)=CC=C1CC1=NC=CC2=CC(OCC)=C(OCC)C=C12 ZOWYFYXTIWQBEP-UHFFFAOYSA-N 0.000 description 1
- LWWDYSLFWMWORA-BEJOPBHTSA-N 1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5-[(E)-(4-hydroxy-3-methoxyphenyl)methylideneamino]-4-(trifluoromethylsulfanyl)pyrazole-3-carbonitrile Chemical compound c1cc(O)c(OC)cc1\C=N\c1c(SC(F)(F)F)c(C#N)nn1-c1c(Cl)cc(C(F)(F)F)cc1Cl LWWDYSLFWMWORA-BEJOPBHTSA-N 0.000 description 1
- LQDARGUHUSPFNL-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)-3-(1,1,2,2-tetrafluoroethoxy)propyl]1,2,4-triazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(COC(F)(F)C(F)F)CN1C=NC=N1 LQDARGUHUSPFNL-UHFFFAOYSA-N 0.000 description 1
- LDMOEFOXLIZJOW-UHFFFAOYSA-N 1-dodecanesulfonic acid Chemical compound CCCCCCCCCCCCS(O)(=O)=O LDMOEFOXLIZJOW-UHFFFAOYSA-N 0.000 description 1
- YIKWKLYQRFRGPM-UHFFFAOYSA-N 1-dodecylguanidine acetate Chemical compound CC(O)=O.CCCCCCCCCCCCN=C(N)N YIKWKLYQRFRGPM-UHFFFAOYSA-N 0.000 description 1
- 125000006218 1-ethylbutyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])[H] 0.000 description 1
- FDCJDKXCCYFOCV-UHFFFAOYSA-N 1-hexadecoxyhexadecane Chemical compound CCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCC FDCJDKXCCYFOCV-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 description 1
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000001462 1-pyrrolyl group Chemical group [*]N1C([H])=C([H])C([H])=C1[H] 0.000 description 1
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- FMTFEIJHMMQUJI-NJAFHUGGSA-N 102130-98-3 Natural products CC=CCC1=C(C)[C@H](CC1=O)OC(=O)[C@@H]1[C@@H](C=C(C)C)C1(C)C FMTFEIJHMMQUJI-NJAFHUGGSA-N 0.000 description 1
- GCKMFJBGXUYNAG-UHFFFAOYSA-N 17alpha-methyltestosterone Natural products C1CC2=CC(=O)CCC2(C)C2C1C1CCC(C)(O)C1(C)CC2 GCKMFJBGXUYNAG-UHFFFAOYSA-N 0.000 description 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- ZEKJLTJKOQGNQK-UHFFFAOYSA-N 18-methyldocosanoic acid Chemical compound CCCCC(C)CCCCCCCCCCCCCCCCC(=O)O ZEKJLTJKOQGNQK-UHFFFAOYSA-N 0.000 description 1
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 description 1
- VILCJCGEZXAXTO-UHFFFAOYSA-N 2,2,2-tetramine Chemical compound NCCNCCNCCN VILCJCGEZXAXTO-UHFFFAOYSA-N 0.000 description 1
- OVSKIKFHRZPJSS-UHFFFAOYSA-N 2,4-D Chemical compound OC(=O)COC1=CC=C(Cl)C=C1Cl OVSKIKFHRZPJSS-UHFFFAOYSA-N 0.000 description 1
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- YTOPFCCWCSOHFV-UHFFFAOYSA-N 2,6-dimethyl-4-tridecylmorpholine Chemical compound CCCCCCCCCCCCCN1CC(C)OC(C)C1 YTOPFCCWCSOHFV-UHFFFAOYSA-N 0.000 description 1
- CLWHPYNDTLMBJU-UHFFFAOYSA-N 2-(2-ethoxyethoxy)ethane-1,1-diamine Chemical compound CCOCCOCC(N)N CLWHPYNDTLMBJU-UHFFFAOYSA-N 0.000 description 1
- KHICUSAUSRBPJT-UHFFFAOYSA-N 2-(2-octadecanoyloxypropanoyloxy)propanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)C(=O)OC(C)C(O)=O KHICUSAUSRBPJT-UHFFFAOYSA-N 0.000 description 1
- AASMKGUQGIZWHA-UHFFFAOYSA-N 2-(3-ethoxypropoxy)ethane-1,1-diamine Chemical compound CCOCCCOCC(N)N AASMKGUQGIZWHA-UHFFFAOYSA-N 0.000 description 1
- HTYFFCPFVMJTKM-UHFFFAOYSA-N 2-(4-chlorophenyl)-1-(diaminomethylidene)guanidine Chemical compound NC(N)=NC(N)=NC1=CC=C(Cl)C=C1 HTYFFCPFVMJTKM-UHFFFAOYSA-N 0.000 description 1
- DXVZRQBQNXNAQP-UHFFFAOYSA-N 2-(4-methoxyphenoxy)-N-(1H-pyrazol-5-yl)-N-(thiolan-3-yl)acetamide Chemical compound COC1=CC=C(OCC(=O)N(C2CSCC2)C2=NNC=C2)C=C1 DXVZRQBQNXNAQP-UHFFFAOYSA-N 0.000 description 1
- CLTKCTAZWZBJCD-UHFFFAOYSA-N 2-(4-methoxyphenoxy)-N-(2-methylsulfanylethyl)-N-phenylacetamide Chemical compound COC1=CC=C(OCC(=O)N(C2=CC=CC=C2)CCSC)C=C1 CLTKCTAZWZBJCD-UHFFFAOYSA-N 0.000 description 1
- ANYWBAJLLFPHKL-UHFFFAOYSA-N 2-(4-methylphenoxy)-N-(oxolan-3-yl)-N-phenylacetamide Chemical compound CC1=CC=C(OCC(=O)N(C2COCC2)C2=CC=CC=C2)C=C1 ANYWBAJLLFPHKL-UHFFFAOYSA-N 0.000 description 1
- ZADLAUHVKOVXBJ-UHFFFAOYSA-N 2-(4-methylphenoxy)-N-phenyl-N-(thiolan-3-yl)acetamide Chemical compound CC1=CC=C(OCC(=O)N(C2CSCC2)C2=CC=CC=C2)C=C1 ZADLAUHVKOVXBJ-UHFFFAOYSA-N 0.000 description 1
- FALRKNHUBBKYCC-UHFFFAOYSA-N 2-(chloromethyl)pyridine-3-carbonitrile Chemical compound ClCC1=NC=CC=C1C#N FALRKNHUBBKYCC-UHFFFAOYSA-N 0.000 description 1
- ZZKQDGKMUQGSIO-UHFFFAOYSA-N 2-(dimethylamino)-1h-pyridine-2-carboxylic acid Chemical compound CN(C)C1(C(O)=O)NC=CC=C1 ZZKQDGKMUQGSIO-UHFFFAOYSA-N 0.000 description 1
- ALRKUEBABWXDOS-UHFFFAOYSA-N 2-(oxolan-2-ylmethyl)aniline Chemical compound NC1=CC=CC=C1CC1OCCC1 ALRKUEBABWXDOS-UHFFFAOYSA-N 0.000 description 1
- BEWCNXNIQCLWHP-UHFFFAOYSA-N 2-(tert-butylamino)ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCNC(C)(C)C BEWCNXNIQCLWHP-UHFFFAOYSA-N 0.000 description 1
- RWLALWYNXFYRGW-UHFFFAOYSA-N 2-Ethyl-1,3-hexanediol Chemical compound CCCC(O)C(CC)CO RWLALWYNXFYRGW-UHFFFAOYSA-N 0.000 description 1
- GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 description 1
- KRHJHPAXCIEMOX-UHFFFAOYSA-N 2-[2-(2-ethoxyethoxy)ethoxy]ethane-1,1-diamine Chemical compound CCOCCOCCOCC(N)N KRHJHPAXCIEMOX-UHFFFAOYSA-N 0.000 description 1
- NLMKTBGFQGKQEV-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hexadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO NLMKTBGFQGKQEV-UHFFFAOYSA-N 0.000 description 1
- OVUDIKNHEYJSMX-UHFFFAOYSA-N 2-bromo-2-(bromomethyl)pentanedinitrile 2,3-dibromo-2,3-dimethylbutanedinitrile Chemical compound BrC(C#N)(CCC#N)CBr.BrC(C(C)(C#N)Br)(C)C#N OVUDIKNHEYJSMX-UHFFFAOYSA-N 0.000 description 1
- SUPFNMXTAGSTIP-UHFFFAOYSA-N 2-chloro-4,6-difluoropyrimidine Chemical compound FC1=CC(F)=NC(Cl)=N1 SUPFNMXTAGSTIP-UHFFFAOYSA-N 0.000 description 1
- JIVPVXMEBJLZRO-CQSZACIVSA-N 2-chloro-5-[(1r)-1-hydroxy-3-oxo-2h-isoindol-1-yl]benzenesulfonamide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC([C@@]2(O)C3=CC=CC=C3C(=O)N2)=C1 JIVPVXMEBJLZRO-CQSZACIVSA-N 0.000 description 1
- 125000006176 2-ethylbutyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(C([H])([H])*)C([H])([H])C([H])([H])[H] 0.000 description 1
- XYOSFLPUWVWHOA-UHFFFAOYSA-N 2-ethylidenepropane-1,3-diol;urea Chemical compound NC(N)=O.CC=C(CO)CO XYOSFLPUWVWHOA-UHFFFAOYSA-N 0.000 description 1
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 description 1
- SJXPQSRCFCPWQQ-UHFFFAOYSA-N 2-methyl-1,2-thiazol-2-ium-3-ol;chloride Chemical compound Cl.CN1SC=CC1=O SJXPQSRCFCPWQQ-UHFFFAOYSA-N 0.000 description 1
- GJJVAFUKOBZPCB-UHFFFAOYSA-N 2-methyl-2-(4,8,12-trimethyltrideca-3,7,11-trienyl)-3,4-dihydrochromen-6-ol Chemical compound OC1=CC=C2OC(CCC=C(C)CCC=C(C)CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-UHFFFAOYSA-N 0.000 description 1
- 125000004493 2-methylbut-1-yl group Chemical group CC(C*)CC 0.000 description 1
- ZKYCLDTVJCJYIB-UHFFFAOYSA-N 2-methylidenedecanamide Chemical compound CCCCCCCCC(=C)C(N)=O ZKYCLDTVJCJYIB-UHFFFAOYSA-N 0.000 description 1
- MPBLPZLNKKGCGP-UHFFFAOYSA-N 2-methyloctane-2-thiol Chemical compound CCCCCCC(C)(C)S MPBLPZLNKKGCGP-UHFFFAOYSA-N 0.000 description 1
- 125000005916 2-methylpentyl group Chemical group 0.000 description 1
- DNOUKPGPAUUCPC-UHFFFAOYSA-N 2-methylsulfanylpropanal Chemical compound CSC(C)C=O DNOUKPGPAUUCPC-UHFFFAOYSA-N 0.000 description 1
- HFOCAQPWSXBFFN-UHFFFAOYSA-N 2-methylsulfonylbenzaldehyde Chemical compound CS(=O)(=O)C1=CC=CC=C1C=O HFOCAQPWSXBFFN-UHFFFAOYSA-N 0.000 description 1
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 description 1
- AVGVFDSUDIUXEU-UHFFFAOYSA-N 2-octyl-1,2-thiazolidin-3-one Chemical compound CCCCCCCCN1SCCC1=O AVGVFDSUDIUXEU-UHFFFAOYSA-N 0.000 description 1
- AOPRXJXHLWYPQR-UHFFFAOYSA-N 2-phenoxyacetamide Chemical class NC(=O)COC1=CC=CC=C1 AOPRXJXHLWYPQR-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- AGBXYHCHUYARJY-UHFFFAOYSA-N 2-phenylethenesulfonic acid Chemical compound OS(=O)(=O)C=CC1=CC=CC=C1 AGBXYHCHUYARJY-UHFFFAOYSA-N 0.000 description 1
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004485 2-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])C1([H])* 0.000 description 1
- ODJQKYXPKWQWNK-UHFFFAOYSA-L 3-(2-carboxylatoethylsulfanyl)propanoate Chemical compound [O-]C(=O)CCSCCC([O-])=O ODJQKYXPKWQWNK-UHFFFAOYSA-L 0.000 description 1
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
- 229940099451 3-iodo-2-propynylbutylcarbamate Drugs 0.000 description 1
- MLLCKJUPWCAWQD-UHFFFAOYSA-N 3-iodoprop-2-ynyl n-hexylcarbamate Chemical compound CCCCCCNC(=O)OCC#CI MLLCKJUPWCAWQD-UHFFFAOYSA-N 0.000 description 1
- WNGHJMKXNAZRCS-UHFFFAOYSA-N 3-iodoprop-2-ynyl n-phenylcarbamate Chemical compound IC#CCOC(=O)NC1=CC=CC=C1 WNGHJMKXNAZRCS-UHFFFAOYSA-N 0.000 description 1
- 125000003542 3-methylbutan-2-yl group Chemical group [H]C([H])([H])C([H])(*)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000005917 3-methylpentyl group Chemical group 0.000 description 1
- QJZYHAIUNVAGQP-UHFFFAOYSA-N 3-nitrobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid Chemical compound C1C2C=CC1C(C(=O)O)C2(C(O)=O)[N+]([O-])=O QJZYHAIUNVAGQP-UHFFFAOYSA-N 0.000 description 1
- ATVJXMYDOSMEPO-UHFFFAOYSA-N 3-prop-2-enoxyprop-1-ene Chemical compound C=CCOCC=C ATVJXMYDOSMEPO-UHFFFAOYSA-N 0.000 description 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 description 1
- 125000001397 3-pyrrolyl group Chemical group [H]N1C([H])=C([*])C([H])=C1[H] 0.000 description 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 description 1
- CXIVKQSIEXBSRQ-UHFFFAOYSA-N 4,5-dichloro-2-octyl-1,2-thiazolidin-3-one Chemical compound CCCCCCCCN1SC(Cl)C(Cl)C1=O CXIVKQSIEXBSRQ-UHFFFAOYSA-N 0.000 description 1
- SYPNXFTUXUIACQ-UHFFFAOYSA-N 4,5-dihydroxy-1-(hydroxymethyl)imidazolidin-2-one Chemical compound OCN1C(O)C(O)NC1=O SYPNXFTUXUIACQ-UHFFFAOYSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- DZIHTWJGPDVSGE-UHFFFAOYSA-N 4-[(4-aminocyclohexyl)methyl]cyclohexan-1-amine Chemical compound C1CC(N)CCC1CC1CCC(N)CC1 DZIHTWJGPDVSGE-UHFFFAOYSA-N 0.000 description 1
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical class NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 1
- KFZXVMNBUMVKLN-UHFFFAOYSA-N 4-chloro-5-methyl-2-propan-2-ylphenol Chemical compound CC(C)C1=CC(Cl)=C(C)C=C1O KFZXVMNBUMVKLN-UHFFFAOYSA-N 0.000 description 1
- WFJIVOKAWHGMBH-UHFFFAOYSA-N 4-hexylbenzene-1,3-diol Chemical compound CCCCCCC1=CC=C(O)C=C1O WFJIVOKAWHGMBH-UHFFFAOYSA-N 0.000 description 1
- JHWGFJBTMHEZME-UHFFFAOYSA-N 4-prop-2-enoyloxybutyl prop-2-enoate Chemical compound C=CC(=O)OCCCCOC(=O)C=C JHWGFJBTMHEZME-UHFFFAOYSA-N 0.000 description 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 description 1
- 125000004487 4-tetrahydropyranyl group Chemical group [H]C1([H])OC([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- CTMTYSVTTGVYAW-FRRDWIJNSA-N 5-[(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl]oxy-5-oxopentanoic acid Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)CCCC(O)=O CTMTYSVTTGVYAW-FRRDWIJNSA-N 0.000 description 1
- XJFIKRXIJXAJGH-UHFFFAOYSA-N 5-chloro-1,3-dihydroimidazo[4,5-b]pyridin-2-one Chemical group ClC1=CC=C2NC(=O)NC2=N1 XJFIKRXIJXAJGH-UHFFFAOYSA-N 0.000 description 1
- 229940100484 5-chloro-2-methyl-4-isothiazolin-3-one Drugs 0.000 description 1
- FINKDHKJINNQQW-UHFFFAOYSA-N 5-methyl-2-propan-2-ylcyclohexane-1-carboxamide Chemical compound CC(C)C1CCC(C)CC1C(N)=O FINKDHKJINNQQW-UHFFFAOYSA-N 0.000 description 1
- MNVSUVYRIVXDBK-UHFFFAOYSA-N 5-methyl-2-propan-2-ylcyclohexane-1-carboxylic acid Chemical class CC(C)C1CCC(C)CC1C(O)=O MNVSUVYRIVXDBK-UHFFFAOYSA-N 0.000 description 1
- BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 description 1
- 229930008281 A03AD01 - Papaverine Natural products 0.000 description 1
- 229920005789 ACRONAL® acrylic binder Polymers 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 1
- LPMXVESGRSUGHW-UHFFFAOYSA-N Acolongiflorosid K Natural products OC1C(O)C(O)C(C)OC1OC1CC2(O)CCC3C4(O)CCC(C=5COC(=O)C=5)C4(C)CC(O)C3C2(CO)C(O)C1 LPMXVESGRSUGHW-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 229920002126 Acrylic acid copolymer Polymers 0.000 description 1
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- 235000019489 Almond oil Nutrition 0.000 description 1
- 239000005877 Alpha-Cypermethrin Substances 0.000 description 1
- 241001237961 Amanita rubescens Species 0.000 description 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-M Aminoacetate Chemical compound NCC([O-])=O DHMQDGOQFOQNFH-UHFFFAOYSA-M 0.000 description 1
- 244000144725 Amygdalus communis Species 0.000 description 1
- 235000011437 Amygdalus communis Nutrition 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 108010085443 Anserine Proteins 0.000 description 1
- 101100350964 Arabidopsis thaliana PANS1 gene Proteins 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- XHVAWZZCDCWGBK-WYRLRVFGSA-M Aurothioglucose Chemical compound OC[C@H]1O[C@H](S[Au])[C@H](O)[C@@H](O)[C@@H]1O XHVAWZZCDCWGBK-WYRLRVFGSA-M 0.000 description 1
- 229920005716 BUTOFAN® Polymers 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- 235000018185 Betula X alpestris Nutrition 0.000 description 1
- 235000018212 Betula X uliginosa Nutrition 0.000 description 1
- GWZYPXHJIZCRAJ-UHFFFAOYSA-N Biliverdin Natural products CC1=C(C=C)C(=C/C2=NC(=Cc3[nH]c(C=C/4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)C(=C2C)CCC(=O)O)NC1=O GWZYPXHJIZCRAJ-UHFFFAOYSA-N 0.000 description 1
- RCNSAJSGRJSBKK-NSQVQWHSSA-N Biliverdin IX Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(\C=C/2C(=C(C)C(=C/C=3C(=C(C=C)C(=O)N=3)C)/N\2)CCC(O)=O)N1 RCNSAJSGRJSBKK-NSQVQWHSSA-N 0.000 description 1
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- 208000035985 Body Odor Diseases 0.000 description 1
- 241000167854 Bourreria succulenta Species 0.000 description 1
- SGHZXLIDFTYFHQ-UHFFFAOYSA-L Brilliant Blue Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 SGHZXLIDFTYFHQ-UHFFFAOYSA-L 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- LVDKZNITIUWNER-UHFFFAOYSA-N Bronopol Chemical compound OCC(Br)(CO)[N+]([O-])=O LVDKZNITIUWNER-UHFFFAOYSA-N 0.000 description 1
- VAFFPZJGZFNXFD-UHFFFAOYSA-N C(O)NC(=O)NCO.C(O)NC(=O)NCO Chemical compound C(O)NC(=O)NCO.C(O)NC(=O)NCO VAFFPZJGZFNXFD-UHFFFAOYSA-N 0.000 description 1
- 101150076566 CMR1 gene Proteins 0.000 description 1
- CBOCVOKPQGJKKJ-UHFFFAOYSA-L Calcium formate Chemical compound [Ca+2].[O-]C=O.[O-]C=O CBOCVOKPQGJKKJ-UHFFFAOYSA-L 0.000 description 1
- BCZXFFBUYPCTSJ-UHFFFAOYSA-L Calcium propionate Chemical compound [Ca+2].CCC([O-])=O.CCC([O-])=O BCZXFFBUYPCTSJ-UHFFFAOYSA-L 0.000 description 1
- 241001246270 Calophyllum Species 0.000 description 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 1
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 description 1
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 description 1
- 241001070941 Castanea Species 0.000 description 1
- 235000014036 Castanea Nutrition 0.000 description 1
- 229910052684 Cerium Inorganic materials 0.000 description 1
- 108091006146 Channels Proteins 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 239000005945 Chlorpyrifos-methyl Substances 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 241001340526 Chrysoclista linneella Species 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 1
- 241000911175 Citharexylum caudatum Species 0.000 description 1
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 1
- LAAPRQODJPXAHC-UHFFFAOYSA-N Coniferyl benzoate Natural products C1=C(O)C(OC)=CC(C=CCOC(=O)C=2C=CC=CC=2)=C1 LAAPRQODJPXAHC-UHFFFAOYSA-N 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 229920000089 Cyclic olefin copolymer Polymers 0.000 description 1
- 239000005756 Cymoxanil Substances 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 description 1
- XHXUANMFYXWVNG-UHFFFAOYSA-N D-menthyl acetate Natural products CC(C)C1CCC(C)CC1OC(C)=O XHXUANMFYXWVNG-UHFFFAOYSA-N 0.000 description 1
- 235000004866 D-panthenol Nutrition 0.000 description 1
- 239000011703 D-panthenol Substances 0.000 description 1
- 102000015781 Dietary Proteins Human genes 0.000 description 1
- 108010010256 Dietary Proteins Proteins 0.000 description 1
- RPNUMPOLZDHAAY-UHFFFAOYSA-N Diethylenetriamine Chemical compound NCCNCCN RPNUMPOLZDHAAY-UHFFFAOYSA-N 0.000 description 1
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 description 1
- IIUZTXTZRGLYTI-UHFFFAOYSA-N Dihydrogriseofulvin Natural products COC1CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 IIUZTXTZRGLYTI-UHFFFAOYSA-N 0.000 description 1
- 239000005762 Dimoxystrobin Substances 0.000 description 1
- 241000255925 Diptera Species 0.000 description 1
- 239000002656 Distearyl thiodipropionate Substances 0.000 description 1
- 239000005765 Dodemorph Substances 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- YUGWDVYLFSETPE-JLHYYAGUSA-N Empenthrin Chemical compound CC\C=C(/C)C(C#C)OC(=O)C1C(C=C(C)C)C1(C)C YUGWDVYLFSETPE-JLHYYAGUSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 239000005895 Esfenvalerate Substances 0.000 description 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 description 1
- 235000004692 Eucalyptus globulus Nutrition 0.000 description 1
- 239000001116 FEMA 4028 Substances 0.000 description 1
- 239000005778 Fenpropimorph Substances 0.000 description 1
- PNVJTZOFSHSLTO-UHFFFAOYSA-N Fenthion Chemical compound COP(=S)(OC)OC1=CC=C(SC)C(C)=C1 PNVJTZOFSHSLTO-UHFFFAOYSA-N 0.000 description 1
- 239000005784 Fluoxastrobin Substances 0.000 description 1
- PLDUPXSUYLZYBN-UHFFFAOYSA-N Fluphenazine Chemical compound C1CN(CCO)CCN1CCCN1C2=CC(C(F)(F)F)=CC=C2SC2=CC=CC=C21 PLDUPXSUYLZYBN-UHFFFAOYSA-N 0.000 description 1
- 239000005787 Flutriafol Substances 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000237858 Gastropoda Species 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- UXWOXTQWVMFRSE-UHFFFAOYSA-N Griseoviridin Natural products O=C1OC(C)CC=C(C(NCC=CC=CC(O)CC(O)C2)=O)SCC1NC(=O)C1=COC2=N1 UXWOXTQWVMFRSE-UHFFFAOYSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- 239000005057 Hexamethylene diisocyanate Substances 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 208000004454 Hyperalgesia Diseases 0.000 description 1
- 208000035154 Hyperesthesia Diseases 0.000 description 1
- 206010020853 Hypertonic bladder Diseases 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 206010065390 Inflammatory pain Diseases 0.000 description 1
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 1
- 229920001202 Inulin Polymers 0.000 description 1
- 239000005058 Isophorone diisocyanate Substances 0.000 description 1
- 240000007049 Juglans regia Species 0.000 description 1
- 235000009496 Juglans regia Nutrition 0.000 description 1
- 229930194542 Keto Natural products 0.000 description 1
- 229920000271 Kevlar® Polymers 0.000 description 1
- 239000005800 Kresoxim-methyl Substances 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
- FFEARJCKVFRZRR-UHFFFAOYSA-N L-Methionine Natural products CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 description 1
- SLRNWACWRVGMKD-UHFFFAOYSA-N L-anserine Natural products CN1C=NC(CC(NC(=O)CCN)C(O)=O)=C1 SLRNWACWRVGMKD-UHFFFAOYSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
- 229930064664 L-arginine Natural products 0.000 description 1
- 235000014852 L-arginine Nutrition 0.000 description 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 1
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 1
- 239000004158 L-cystine Substances 0.000 description 1
- 235000019393 L-cystine Nutrition 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- 229930195722 L-methionine Natural products 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
- DBLDQZASZZMNSL-QMMMGPOBSA-N L-tyrosinol Natural products OC[C@@H](N)CC1=CC=C(O)C=C1 DBLDQZASZZMNSL-QMMMGPOBSA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- 102000010445 Lactoferrin Human genes 0.000 description 1
- 108010063045 Lactoferrin Proteins 0.000 description 1
- 229920002884 Laureth 4 Polymers 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- 241000514697 Lepidothamnus laxifolius Species 0.000 description 1
- 240000007472 Leucaena leucocephala Species 0.000 description 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 229920001732 Lignosulfonate Polymers 0.000 description 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 229920002774 Maltodextrin Polymers 0.000 description 1
- 239000005913 Maltodextrin Substances 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 1
- 235000010804 Maranta arundinacea Nutrition 0.000 description 1
- 235000010654 Melissa officinalis Nutrition 0.000 description 1
- 244000062730 Melissa officinalis Species 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- JFKCVAZSEWPOIX-UHFFFAOYSA-N Menthyl ethylene glycol carbonate Chemical compound CC(C)C1CCC(C)CC1OC(=O)OCCO JFKCVAZSEWPOIX-UHFFFAOYSA-N 0.000 description 1
- 239000005868 Metconazole Substances 0.000 description 1
- GCKMFJBGXUYNAG-HLXURNFRSA-N Methyltestosterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@](C)(O)[C@@]1(C)CC2 GCKMFJBGXUYNAG-HLXURNFRSA-N 0.000 description 1
- 239000004368 Modified starch Substances 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- BLILOGGUTRWFNI-UHFFFAOYSA-N Monomenthyl succinate Chemical compound CC(C)C1CCC(C)CC1OC(=O)CCC(O)=O BLILOGGUTRWFNI-UHFFFAOYSA-N 0.000 description 1
- 235000009421 Myristica fragrans Nutrition 0.000 description 1
- 244000270834 Myristica fragrans Species 0.000 description 1
- MMOXZBCLCQITDF-UHFFFAOYSA-N N,N-diethyl-m-toluamide Chemical compound CCN(CC)C(=O)C1=CC=CC(C)=C1 MMOXZBCLCQITDF-UHFFFAOYSA-N 0.000 description 1
- LKXLXBRRRILMJL-UHFFFAOYSA-N N-(2-methylsulfanylethyl)-1H-pyrazol-5-amine Chemical compound CSCCNC=1C=CNN=1 LKXLXBRRRILMJL-UHFFFAOYSA-N 0.000 description 1
- DAOANAATJZWTSJ-UHFFFAOYSA-N N-Decanoylmorpholine Chemical compound CCCCCCCCCC(=O)N1CCOCC1 DAOANAATJZWTSJ-UHFFFAOYSA-N 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- 125000003047 N-acetyl group Chemical group 0.000 description 1
- DDUHZTYCFQRHIY-UHFFFAOYSA-N Negwer: 6874 Natural products COC1=CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 1
- 239000000006 Nitroglycerin Substances 0.000 description 1
- LPMXVESGRSUGHW-GHYGWZAOSA-N Ouabain Natural products O([C@@H]1[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O1)[C@H]1C[C@@H](O)[C@@]2(CO)[C@@](O)(C1)CC[C@H]1[C@]3(O)[C@@](C)([C@H](C4=CC(=O)OC4)CC3)C[C@@H](O)[C@H]21 LPMXVESGRSUGHW-GHYGWZAOSA-N 0.000 description 1
- 208000009722 Overactive Urinary Bladder Diseases 0.000 description 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 241000282372 Panthera onca Species 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 108010033276 Peptide Fragments Proteins 0.000 description 1
- 102000007079 Peptide Fragments Human genes 0.000 description 1
- 229920001774 Perfluoroether Polymers 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 description 1
- 241001674048 Phthiraptera Species 0.000 description 1
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 1
- 239000005818 Picoxystrobin Substances 0.000 description 1
- 235000010450 Pino mugo Nutrition 0.000 description 1
- 239000005924 Pirimiphos-methyl Substances 0.000 description 1
- 229920002873 Polyethylenimine Polymers 0.000 description 1
- 229920002367 Polyisobutene Polymers 0.000 description 1
- 229930182764 Polyoxin Natural products 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 241000210053 Potentilla elegans Species 0.000 description 1
- 239000004146 Propane-1,2-diol Substances 0.000 description 1
- KNAHARQHSZJURB-UHFFFAOYSA-N Propylthiouracile Chemical compound CCCC1=CC(=O)NC(=S)N1 KNAHARQHSZJURB-UHFFFAOYSA-N 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 239000005869 Pyraclostrobin Substances 0.000 description 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 description 1
- VQXSOUPNOZTNAI-UHFFFAOYSA-N Pyrethrin I Natural products CC(=CC1CC1C(=O)OC2CC(=O)C(=C2C)CC=C/C=C)C VQXSOUPNOZTNAI-UHFFFAOYSA-N 0.000 description 1
- 101100047461 Rattus norvegicus Trpm8 gene Proteins 0.000 description 1
- 229920000294 Resistant starch Polymers 0.000 description 1
- VYGQUTWHTHXGQB-UHFFFAOYSA-N Retinol hexadecanoate Natural products CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-UHFFFAOYSA-N 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- ARCJQKUWGAZPFX-KBPBESRZSA-N S-trans-stilbene oxide Chemical compound C1([C@H]2[C@@H](O2)C=2C=CC=CC=2)=CC=CC=C1 ARCJQKUWGAZPFX-KBPBESRZSA-N 0.000 description 1
- 229920005740 STYROFAN® Polymers 0.000 description 1
- RJFAYQIBOAGBLC-BYPYZUCNSA-N Selenium-L-methionine Chemical compound C[Se]CC[C@H](N)C(O)=O RJFAYQIBOAGBLC-BYPYZUCNSA-N 0.000 description 1
- RJFAYQIBOAGBLC-UHFFFAOYSA-N Selenomethionine Natural products C[Se]CCC(N)C(O)=O RJFAYQIBOAGBLC-UHFFFAOYSA-N 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 241000258242 Siphonaptera Species 0.000 description 1
- 241000907663 Siproeta stelenes Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 206010040904 Skin odour abnormal Diseases 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
- KSQXVLVXUFHGJQ-UHFFFAOYSA-M Sodium ortho-phenylphenate Chemical compound [Na+].[O-]C1=CC=CC=C1C1=CC=CC=C1 KSQXVLVXUFHGJQ-UHFFFAOYSA-M 0.000 description 1
- 239000004283 Sodium sorbate Substances 0.000 description 1
- 239000004902 Softening Agent Substances 0.000 description 1
- 240000003829 Sorghum propinquum Species 0.000 description 1
- 235000011684 Sorghum saccharatum Nutrition 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 description 1
- 229930182692 Strobilurin Natural products 0.000 description 1
- 244000166550 Strophanthus gratus Species 0.000 description 1
- 244000028419 Styrax benzoin Species 0.000 description 1
- 235000000126 Styrax benzoin Nutrition 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 239000001833 Succinylated monoglyceride Substances 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical class OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 description 1
- 235000008411 Sumatra benzointree Nutrition 0.000 description 1
- 102000003563 TRPV Human genes 0.000 description 1
- 108060008564 TRPV Proteins 0.000 description 1
- 240000004460 Tanacetum coccineum Species 0.000 description 1
- 239000005840 Tetraconazole Substances 0.000 description 1
- BOTDANWDWHJENH-UHFFFAOYSA-N Tetraethyl orthosilicate Chemical compound CCO[Si](OCC)(OCC)OCC BOTDANWDWHJENH-UHFFFAOYSA-N 0.000 description 1
- 244000145580 Thalia geniculata Species 0.000 description 1
- 235000012419 Thalia geniculata Nutrition 0.000 description 1
- 235000009470 Theobroma cacao Nutrition 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- 102000002933 Thioredoxin Human genes 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 239000005844 Thymol Substances 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- APQHKWPGGHMYKJ-UHFFFAOYSA-N Tributyltin oxide Chemical compound CCCC[Sn](CCCC)(CCCC)O[Sn](CCCC)(CCCC)CCCC APQHKWPGGHMYKJ-UHFFFAOYSA-N 0.000 description 1
- 239000005859 Triticonazole Substances 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
- 239000004930 VINNOL Substances 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 244000290333 Vanilla fragrans Species 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- 229930003448 Vitamin K Natural products 0.000 description 1
- 235000018936 Vitellaria paradoxa Nutrition 0.000 description 1
- 241001135917 Vitellaria paradoxa Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 239000004164 Wax ester Substances 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- AZFNGPAYDKGCRB-XCPIVNJJSA-M [(1s,2s)-2-amino-1,2-diphenylethyl]-(4-methylphenyl)sulfonylazanide;chlororuthenium(1+);1-methyl-4-propan-2-ylbenzene Chemical compound [Ru+]Cl.CC(C)C1=CC=C(C)C=C1.C1=CC(C)=CC=C1S(=O)(=O)[N-][C@@H](C=1C=CC=CC=1)[C@@H](N)C1=CC=CC=C1 AZFNGPAYDKGCRB-XCPIVNJJSA-M 0.000 description 1
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 1
- OOWCJRMYMAMSOH-UHFFFAOYSA-N [2,3,5,6-tetrafluoro-4-(methoxymethyl)phenyl]methyl 2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxylate Chemical compound FC1=C(F)C(COC)=C(F)C(F)=C1COC(=O)C1C(C)(C)C1C=C(C)C OOWCJRMYMAMSOH-UHFFFAOYSA-N 0.000 description 1
- ROVGZAWFACYCSP-MQBLHHJJSA-N [2-methyl-4-oxo-3-[(2z)-penta-2,4-dienyl]cyclopent-2-en-1-yl] (1r,3r)-2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxylate Chemical compound CC1(C)[C@H](C=C(C)C)[C@H]1C(=O)OC1C(C)=C(C\C=C/C=C)C(=O)C1 ROVGZAWFACYCSP-MQBLHHJJSA-N 0.000 description 1
- ZXQYGBMAQZUVMI-UHFFFAOYSA-N [cyano-(3-phenoxyphenyl)methyl] 3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropane-1-carboxylate Chemical compound CC1(C)C(C=C(Cl)C(F)(F)F)C1C(=O)OC(C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 ZXQYGBMAQZUVMI-UHFFFAOYSA-N 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010358 acesulfame potassium Nutrition 0.000 description 1
- 239000000619 acesulfame-K Substances 0.000 description 1
- 159000000021 acetate salts Chemical class 0.000 description 1
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- GDZNYEZGJAFIKA-UHFFFAOYSA-N acetoprole Chemical compound NC1=C(S(C)=O)C(C(=O)C)=NN1C1=C(Cl)C=C(C(F)(F)F)C=C1Cl GDZNYEZGJAFIKA-UHFFFAOYSA-N 0.000 description 1
- QOMNQGZXFYNBNG-UHFFFAOYSA-N acetyloxymethyl 2-[2-[2-[5-[3-(acetyloxymethoxy)-2,7-difluoro-6-oxoxanthen-9-yl]-2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]-n-[2-(acetyloxymethoxy)-2-oxoethyl]-4-methylanilino]acetate Chemical compound CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)C1=CC=C(C)C=C1OCCOC1=CC(C2=C3C=C(F)C(=O)C=C3OC3=CC(OCOC(C)=O)=C(F)C=C32)=CC=C1N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O QOMNQGZXFYNBNG-UHFFFAOYSA-N 0.000 description 1
- 229920000800 acrylic rubber Polymers 0.000 description 1
- 239000002313 adhesive film Substances 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- IBVAQQYNSHJXBV-UHFFFAOYSA-N adipic acid dihydrazide Chemical compound NNC(=O)CCCCC(=O)NN IBVAQQYNSHJXBV-UHFFFAOYSA-N 0.000 description 1
- 230000000274 adsorptive effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 1
- 229910000318 alkali metal phosphate Inorganic materials 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 125000004450 alkenylene group Chemical group 0.000 description 1
- 125000005083 alkoxyalkoxy group Chemical group 0.000 description 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 1
- 125000003282 alkyl amino group Chemical group 0.000 description 1
- 125000004414 alkyl thio group Chemical group 0.000 description 1
- 125000005263 alkylenediamine group Chemical group 0.000 description 1
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 description 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- 229940024113 allethrin Drugs 0.000 description 1
- 229940061720 alpha hydroxy acid Drugs 0.000 description 1
- 150000001280 alpha hydroxy acids Chemical class 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 description 1
- 229940043377 alpha-cyclodextrin Drugs 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- AKNNEGZIBPJZJG-UHFFFAOYSA-N alpha-noscapine Natural products CN1CCC2=CC=3OCOC=3C(OC)=C2C1C1C2=CC=C(OC)C(OC)=C2C(=O)O1 AKNNEGZIBPJZJG-UHFFFAOYSA-N 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical class [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 description 1
- 229940103272 aluminum potassium sulfate Drugs 0.000 description 1
- DNEHKUCSURWDGO-UHFFFAOYSA-N aluminum sodium Chemical compound [Na].[Al] DNEHKUCSURWDGO-UHFFFAOYSA-N 0.000 description 1
- NNCOOIBIVIODKO-UHFFFAOYSA-N aluminum;hypochlorous acid Chemical compound [Al].ClO NNCOOIBIVIODKO-UHFFFAOYSA-N 0.000 description 1
- HSMXEPWDIJUMSS-UHFFFAOYSA-K aluminum;tetradecanoate Chemical class [Al+3].CCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCC([O-])=O HSMXEPWDIJUMSS-UHFFFAOYSA-K 0.000 description 1
- 150000001414 amino alcohols Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- 229940011037 anethole Drugs 0.000 description 1
- 235000021120 animal protein Nutrition 0.000 description 1
- 229920006318 anionic polymer Polymers 0.000 description 1
- MYYIAHXIVFADCU-QMMMGPOBSA-N anserine Chemical compound CN1C=NC=C1C[C@H](NC(=O)CC[NH3+])C([O-])=O MYYIAHXIVFADCU-QMMMGPOBSA-N 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 description 1
- 150000004056 anthraquinones Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003255 anti-acne Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000001760 anti-analgesic effect Effects 0.000 description 1
- 230000001166 anti-perspirative effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000001153 anti-wrinkle effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 239000003213 antiperspirant Substances 0.000 description 1
- 239000002216 antistatic agent Substances 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- VMWNQDUVQKEIOC-CYBMUJFWSA-N apomorphine Chemical compound C([C@H]1N(C)CC2)C3=CC=C(O)C(O)=C3C3=C1C2=CC=C3 VMWNQDUVQKEIOC-CYBMUJFWSA-N 0.000 description 1
- 229960004046 apomorphine Drugs 0.000 description 1
- 229940114079 arachidonic acid Drugs 0.000 description 1
- 235000021342 arachidonic acid Nutrition 0.000 description 1
- 150000005840 aryl radicals Chemical class 0.000 description 1
- 235000010385 ascorbyl palmitate Nutrition 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- CJJOSEISRRTUQB-UHFFFAOYSA-N azinphos-methyl Chemical group C1=CC=C2C(=O)N(CSP(=S)(OC)OC)N=NC2=C1 CJJOSEISRRTUQB-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000037358 bacterial metabolism Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229960004365 benzoic acid Drugs 0.000 description 1
- 150000001558 benzoic acid derivatives Chemical class 0.000 description 1
- 229960002130 benzoin Drugs 0.000 description 1
- 239000012965 benzophenone Substances 0.000 description 1
- 150000008366 benzophenones Chemical class 0.000 description 1
- 235000019400 benzoyl peroxide Nutrition 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 description 1
- 229940093265 berberine Drugs 0.000 description 1
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 description 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 1
- 235000011175 beta-cyclodextrine Nutrition 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 229960004853 betadex Drugs 0.000 description 1
- 229950011260 betanaphthol Drugs 0.000 description 1
- 125000002619 bicyclic group Chemical group 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 239000003613 bile acid Substances 0.000 description 1
- QBUVFDKTZJNUPP-UHFFFAOYSA-N biliverdin-IXalpha Natural products N1C(=O)C(C)=C(C=C)C1=CC1=C(C)C(CCC(O)=O)=C(C=C2C(=C(C)C(C=C3C(=C(C=C)C(=O)N3)C)=N2)CCC(O)=O)N1 QBUVFDKTZJNUPP-UHFFFAOYSA-N 0.000 description 1
- 229960001901 bioallethrin Drugs 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 125000006267 biphenyl group Chemical group 0.000 description 1
- 238000004061 bleaching Methods 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- 239000004161 brilliant blue FCF Substances 0.000 description 1
- 235000012745 brilliant blue FCF Nutrition 0.000 description 1
- 229940055580 brilliant blue fcf Drugs 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 239000001273 butane Substances 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- HBVUDJVVVFGZMB-UHFFFAOYSA-N butyl 3-methylquinoline-4-carboxylate Chemical group C1=CC=C2C(C(=O)OCCCC)=C(C)C=NC2=C1 HBVUDJVVVFGZMB-UHFFFAOYSA-N 0.000 description 1
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 description 1
- DHAZIUXMHRHVMP-UHFFFAOYSA-N butyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCCCC DHAZIUXMHRHVMP-UHFFFAOYSA-N 0.000 description 1
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 1
- 229960005069 calcium Drugs 0.000 description 1
- 239000004301 calcium benzoate Substances 0.000 description 1
- NSQPPSOSXWOZNH-UHFFFAOYSA-L calcium benzoate Chemical compound [Ca+2].[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1 NSQPPSOSXWOZNH-UHFFFAOYSA-L 0.000 description 1
- 235000010237 calcium benzoate Nutrition 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- 108010033929 calcium caseinate Proteins 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- 229940044172 calcium formate Drugs 0.000 description 1
- 239000004294 calcium hydrogen sulphite Substances 0.000 description 1
- 235000010260 calcium hydrogen sulphite Nutrition 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 229940043256 calcium pyrophosphate Drugs 0.000 description 1
- 239000000378 calcium silicate Substances 0.000 description 1
- 229910052918 calcium silicate Inorganic materials 0.000 description 1
- 229960003340 calcium silicate Drugs 0.000 description 1
- 235000012241 calcium silicate Nutrition 0.000 description 1
- 239000004303 calcium sorbate Substances 0.000 description 1
- 235000010244 calcium sorbate Nutrition 0.000 description 1
- GBAOBIBJACZTNA-UHFFFAOYSA-L calcium sulfite Chemical compound [Ca+2].[O-]S([O-])=O GBAOBIBJACZTNA-UHFFFAOYSA-L 0.000 description 1
- 239000004295 calcium sulphite Substances 0.000 description 1
- CNYFJCCVJNARLE-UHFFFAOYSA-L calcium;2-sulfanylacetic acid;2-sulfidoacetate Chemical compound [Ca+2].[O-]C(=O)CS.[O-]C(=O)CS CNYFJCCVJNARLE-UHFFFAOYSA-L 0.000 description 1
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 description 1
- YAECNLICDQSIKA-UHFFFAOYSA-L calcium;sulfanide Chemical compound [SH-].[SH-].[Ca+2] YAECNLICDQSIKA-UHFFFAOYSA-L 0.000 description 1
- 239000000828 canola oil Substances 0.000 description 1
- 235000019519 canola oil Nutrition 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 125000004452 carbocyclyl group Chemical group 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 150000003857 carboxamides Chemical class 0.000 description 1
- 150000007942 carboxylates Chemical group 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 150000001746 carotenes Chemical class 0.000 description 1
- 235000005473 carotenes Nutrition 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
- IRUJZVNXZWPBMU-UHFFFAOYSA-N cartap Chemical compound NC(=O)SCC(N(C)C)CSC(N)=O IRUJZVNXZWPBMU-UHFFFAOYSA-N 0.000 description 1
- 108010079058 casein hydrolysate Proteins 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 229920003086 cellulose ether Polymers 0.000 description 1
- GWXLDORMOJMVQZ-UHFFFAOYSA-N cerium Chemical compound [Ce] GWXLDORMOJMVQZ-UHFFFAOYSA-N 0.000 description 1
- 229940048851 cetyl ricinoleate Drugs 0.000 description 1
- 235000020221 chamomile extract Nutrition 0.000 description 1
- 229940119217 chamomile extract Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000013351 cheese Nutrition 0.000 description 1
- 235000019693 cherries Nutrition 0.000 description 1
- 150000001805 chlorine compounds Chemical class 0.000 description 1
- VXIVSQZSERGHQP-UHFFFAOYSA-N chloroacetamide Chemical compound NC(=O)CCl VXIVSQZSERGHQP-UHFFFAOYSA-N 0.000 description 1
- 235000001368 chlorogenic acid Nutrition 0.000 description 1
- 229940031956 chlorothymol Drugs 0.000 description 1
- HRBKVYFZANMGRE-UHFFFAOYSA-N chlorpyrifos-methyl Chemical compound COP(=S)(OC)OC1=NC(Cl)=C(Cl)C=C1Cl HRBKVYFZANMGRE-UHFFFAOYSA-N 0.000 description 1
- 229960001523 chlortalidone Drugs 0.000 description 1
- NZNRRXXETLSZRO-UHFFFAOYSA-N chlorthion Chemical compound COP(=S)(OC)OC1=CC=C([N+]([O-])=O)C(Cl)=C1 NZNRRXXETLSZRO-UHFFFAOYSA-N 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 235000019506 cigar Nutrition 0.000 description 1
- 229960005233 cineole Drugs 0.000 description 1
- APEJMQOBVMLION-UHFFFAOYSA-N cinnamamide Chemical class NC(=O)C=CC1=CC=CC=C1 APEJMQOBVMLION-UHFFFAOYSA-N 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 239000010630 cinnamon oil Substances 0.000 description 1
- 239000001926 citrus aurantium l. subsp. bergamia wright et arn. oil Substances 0.000 description 1
- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 description 1
- 239000007957 coemulsifier Substances 0.000 description 1
- 235000017471 coenzyme Q10 Nutrition 0.000 description 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 229940125904 compound 1 Drugs 0.000 description 1
- 229940125782 compound 2 Drugs 0.000 description 1
- 229940126214 compound 3 Drugs 0.000 description 1
- 229940125898 compound 5 Drugs 0.000 description 1
- 235000008504 concentrate Nutrition 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000007859 condensation product Substances 0.000 description 1
- 235000013409 condiments Nutrition 0.000 description 1
- 229920013750 conditioning polymer Polymers 0.000 description 1
- LAAPRQODJPXAHC-AATRIKPKSA-N coniferyl benzoate Chemical compound C1=C(O)C(OC)=CC(\C=C\COC(=O)C=2C=CC=CC=2)=C1 LAAPRQODJPXAHC-AATRIKPKSA-N 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 229940120693 copper naphthenate Drugs 0.000 description 1
- SEVNKWFHTNVOLD-UHFFFAOYSA-L copper;3-(4-ethylcyclohexyl)propanoate;3-(3-ethylcyclopentyl)propanoate Chemical compound [Cu+2].CCC1CCC(CCC([O-])=O)C1.CCC1CCC(CCC([O-])=O)CC1 SEVNKWFHTNVOLD-UHFFFAOYSA-L 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 239000008271 cosmetic emulsion Substances 0.000 description 1
- 239000008406 cosmetic ingredient Substances 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 229940109275 cyclamate Drugs 0.000 description 1
- HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 description 1
- 125000006547 cyclononyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000000640 cyclooctyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000004851 cyclopentylmethyl group Chemical group C1(CCCC1)C* 0.000 description 1
- OOTFVKOQINZBBF-UHFFFAOYSA-N cystamine Chemical compound CCSSCCN OOTFVKOQINZBBF-UHFFFAOYSA-N 0.000 description 1
- 229940099500 cystamine Drugs 0.000 description 1
- 229960002433 cysteine Drugs 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- PWEOPMBMTXREGV-UHFFFAOYSA-N decanoic acid;octanoic acid;propane-1,2-diol Chemical compound CC(O)CO.CCCCCCCC(O)=O.CCCCCCCC(O)=O.CCCCCCCCCC(O)=O.CCCCCCCCCC(O)=O PWEOPMBMTXREGV-UHFFFAOYSA-N 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000001877 deodorizing effect Effects 0.000 description 1
- 230000002951 depilatory effect Effects 0.000 description 1
- 239000002274 desiccant Substances 0.000 description 1
- 229960003949 dexpanthenol Drugs 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 125000004386 diacrylate group Chemical group 0.000 description 1
- 125000004663 dialkyl amino group Chemical group 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- WURGXGVFSMYFCG-UHFFFAOYSA-N dichlofluanid Chemical compound CN(C)S(=O)(=O)N(SC(F)(Cl)Cl)C1=CC=CC=C1 WURGXGVFSMYFCG-UHFFFAOYSA-N 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 description 1
- 229960005156 digoxin Drugs 0.000 description 1
- LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 description 1
- SGZVXLFVBKDMJH-UHFFFAOYSA-M dihydrogen phosphate;hexadecyl-(2-hydroxyethyl)-dimethylazanium Chemical compound OP(O)([O-])=O.CCCCCCCCCCCCCCCC[N+](C)(C)CCO SGZVXLFVBKDMJH-UHFFFAOYSA-M 0.000 description 1
- 229940120503 dihydroxyacetone Drugs 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000006471 dimerization reaction Methods 0.000 description 1
- JJQZDUKDJDQPMQ-UHFFFAOYSA-N dimethoxy(dimethyl)silane Chemical compound CO[Si](C)(C)OC JJQZDUKDJDQPMQ-UHFFFAOYSA-N 0.000 description 1
- IEJIGPNLZYLLBP-UHFFFAOYSA-N dimethyl carbonate Chemical compound COC(=O)OC IEJIGPNLZYLLBP-UHFFFAOYSA-N 0.000 description 1
- FBSAITBEAPNWJG-UHFFFAOYSA-N dimethyl phthalate Natural products CC(=O)OC1=CC=CC=C1OC(C)=O FBSAITBEAPNWJG-UHFFFAOYSA-N 0.000 description 1
- GQOKIYDTHHZSCJ-UHFFFAOYSA-M dimethyl-bis(prop-2-enyl)azanium;chloride Chemical compound [Cl-].C=CC[N+](C)(C)CC=C GQOKIYDTHHZSCJ-UHFFFAOYSA-M 0.000 description 1
- YYLGKUPAFFKGRQ-UHFFFAOYSA-N dimethyldiethoxysilane Chemical compound CCO[Si](C)(C)OCC YYLGKUPAFFKGRQ-UHFFFAOYSA-N 0.000 description 1
- 229960001826 dimethylphthalate Drugs 0.000 description 1
- WXUZAHCNPWONDH-DYTRJAOYSA-N dimoxystrobin Chemical compound CNC(=O)C(=N\OC)\C1=CC=CC=C1COC1=CC(C)=CC=C1C WXUZAHCNPWONDH-DYTRJAOYSA-N 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- PWWSSIYVTQUJQQ-UHFFFAOYSA-N distearyl thiodipropionate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)CCSCCC(=O)OCCCCCCCCCCCCCCCCCC PWWSSIYVTQUJQQ-UHFFFAOYSA-N 0.000 description 1
- 235000019305 distearyl thiodipropionate Nutrition 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940090949 docosahexaenoic acid Drugs 0.000 description 1
- 235000020669 docosahexaenoic acid Nutrition 0.000 description 1
- 229940069096 dodecene Drugs 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- JMXKCYUTURMERF-UHFFFAOYSA-N dodemorph Chemical compound C1C(C)OC(C)CN1C1CCCCCCCCCCC1 JMXKCYUTURMERF-UHFFFAOYSA-N 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000010981 drying operation Methods 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 239000003221 ear drop Substances 0.000 description 1
- 229940047652 ear drops Drugs 0.000 description 1
- 230000001999 effect on insects Effects 0.000 description 1
- 235000013345 egg yolk Nutrition 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 229960005135 eicosapentaenoic acid Drugs 0.000 description 1
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 description 1
- 235000020673 eicosapentaenoic acid Nutrition 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 230000007515 enzymatic degradation Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 1
- NYPJDWWKZLNGGM-RPWUZVMVSA-N esfenvalerate Chemical compound C=1C([C@@H](C#N)OC(=O)[C@@H](C(C)C)C=2C=CC(Cl)=CC=2)=CC=CC=1OC1=CC=CC=C1 NYPJDWWKZLNGGM-RPWUZVMVSA-N 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 229960005269 ethaverine Drugs 0.000 description 1
- MEGHWIAOTJPCHQ-UHFFFAOYSA-N ethenyl butanoate Chemical compound CCCC(=O)OC=C MEGHWIAOTJPCHQ-UHFFFAOYSA-N 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 description 1
- 238000007046 ethoxylation reaction Methods 0.000 description 1
- NTNZTEQNFHNYBC-UHFFFAOYSA-N ethyl 2-aminoacetate Chemical compound CCOC(=O)CN NTNZTEQNFHNYBC-UHFFFAOYSA-N 0.000 description 1
- 229940093499 ethyl acetate Drugs 0.000 description 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229940067592 ethyl palmitate Drugs 0.000 description 1
- 229920001038 ethylene copolymer Polymers 0.000 description 1
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- 239000010642 eucalyptus oil Substances 0.000 description 1
- 229940044949 eucalyptus oil Drugs 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 235000008524 evening primrose extract Nutrition 0.000 description 1
- 239000010475 evening primrose oil Substances 0.000 description 1
- 229940089020 evening primrose oil Drugs 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 210000004709 eyebrow Anatomy 0.000 description 1
- 229940043259 farnesol Drugs 0.000 description 1
- 229930002886 farnesol Natural products 0.000 description 1
- 235000013861 fat-free Nutrition 0.000 description 1
- 229950006668 fenfluthrin Drugs 0.000 description 1
- XQUXKZZNEFRCAW-UHFFFAOYSA-N fenpropathrin Chemical compound CC1(C)C(C)(C)C1C(=O)OC(C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 XQUXKZZNEFRCAW-UHFFFAOYSA-N 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 1
- 235000001785 ferulic acid Nutrition 0.000 description 1
- 229940114124 ferulic acid Drugs 0.000 description 1
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 description 1
- 235000021323 fish oil Nutrition 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- GBIHOLCMZGAKNG-CGAIIQECSA-N flucythrinate Chemical compound O=C([C@@H](C(C)C)C=1C=CC(OC(F)F)=CC=1)OC(C#N)C(C=1)=CC=CC=1OC1=CC=CC=C1 GBIHOLCMZGAKNG-CGAIIQECSA-N 0.000 description 1
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- UFEODZBUAFNAEU-NLRVBDNBSA-N fluoxastrobin Chemical compound C=1C=CC=C(OC=2C(=C(OC=3C(=CC=CC=3)Cl)N=CN=2)F)C=1C(=N/OC)\C1=NOCCO1 UFEODZBUAFNAEU-NLRVBDNBSA-N 0.000 description 1
- 229960002390 flurbiprofen Drugs 0.000 description 1
- SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 150000002224 folic acids Chemical class 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000005417 food ingredient Substances 0.000 description 1
- QJAUKMLCDVOYNX-UHFFFAOYSA-N formaldehyde;2-hydroxybenzenesulfonic acid Chemical compound O=C.OC1=CC=CC=C1S(O)(=O)=O QJAUKMLCDVOYNX-UHFFFAOYSA-N 0.000 description 1
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 229960003883 furosemide Drugs 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 description 1
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 description 1
- 229940080345 gamma-cyclodextrin Drugs 0.000 description 1
- VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 description 1
- 235000020664 gamma-linolenic acid Nutrition 0.000 description 1
- 229960002733 gamolenic acid Drugs 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
- 235000019717 geranium oil Nutrition 0.000 description 1
- 239000010648 geranium oil Substances 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 150000002314 glycerols Chemical class 0.000 description 1
- 125000005908 glyceryl ester group Chemical group 0.000 description 1
- 239000001087 glyceryl triacetate Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- 229960003711 glyceryl trinitrate Drugs 0.000 description 1
- 229960002449 glycine Drugs 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 125000003147 glycosyl group Chemical group 0.000 description 1
- 229940015043 glyoxal Drugs 0.000 description 1
- HHLFWLYXYJOTON-UHFFFAOYSA-N glyoxylic acid Chemical compound OC(=O)C=O HHLFWLYXYJOTON-UHFFFAOYSA-N 0.000 description 1
- 229920000578 graft copolymer Polymers 0.000 description 1
- DDUHZTYCFQRHIY-RBHXEPJQSA-N griseofulvin Chemical compound COC1=CC(=O)C[C@@H](C)[C@@]11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-RBHXEPJQSA-N 0.000 description 1
- 229960002867 griseofulvin Drugs 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 229920000591 gum Polymers 0.000 description 1
- 235000019382 gum benzoic Nutrition 0.000 description 1
- 230000003793 hair pigmentation Effects 0.000 description 1
- 239000003676 hair preparation Substances 0.000 description 1
- WIFXJBMOTMKRMM-UHFFFAOYSA-N halfenprox Chemical compound C=1C=C(OC(F)(F)Br)C=CC=1C(C)(C)COCC(C=1)=CC=CC=1OC1=CC=CC=C1 WIFXJBMOTMKRMM-UHFFFAOYSA-N 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000008821 health effect Effects 0.000 description 1
- 239000004009 herbicide Substances 0.000 description 1
- XAMHKORMKJIEFW-AYTKPMRMSA-N hexadecyl (z,12r)-12-hydroxyoctadec-9-enoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)CCCCCCC\C=C/C[C@H](O)CCCCCC XAMHKORMKJIEFW-AYTKPMRMSA-N 0.000 description 1
- QAKXLTNAJLFSQC-UHFFFAOYSA-N hexadecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC QAKXLTNAJLFSQC-UHFFFAOYSA-N 0.000 description 1
- RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 description 1
- ALBYIUDWACNRRB-UHFFFAOYSA-N hexanamide Chemical compound CCCCCC(N)=O ALBYIUDWACNRRB-UHFFFAOYSA-N 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 229960003258 hexylresorcinol Drugs 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 229960002885 histidine Drugs 0.000 description 1
- 235000020721 horse chestnut extract Nutrition 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 102000045979 human TRPM8 Human genes 0.000 description 1
- 239000004021 humic acid Substances 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 229940079826 hydrogen sulfite Drugs 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 230000000544 hyperemic effect Effects 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 150000002460 imidazoles Chemical class 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- 230000037456 inflammatory mechanism Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 1
- 229940029339 inulin Drugs 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 150000002497 iodine compounds Chemical class 0.000 description 1
- 239000002563 ionic surfactant Substances 0.000 description 1
- PGHMRUGBZOYCAA-ADZNBVRBSA-N ionomycin Chemical compound O1[C@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C[C@@H](C)C[C@@H](C)C(/O)=C/C(=O)[C@@H](C)C[C@@H](C)C[C@@H](CCC(O)=O)C)CC[C@@]1(C)[C@@H]1O[C@](C)([C@@H](C)O)CC1 PGHMRUGBZOYCAA-ADZNBVRBSA-N 0.000 description 1
- PGHMRUGBZOYCAA-UHFFFAOYSA-N ionomycin Natural products O1C(CC(O)C(C)C(O)C(C)C=CCC(C)CC(C)C(O)=CC(=O)C(C)CC(C)CC(CCC(O)=O)C)CCC1(C)C1OC(C)(C(C)O)CC1 PGHMRUGBZOYCAA-UHFFFAOYSA-N 0.000 description 1
- OEXHQOGQTVQTAT-JRNQLAHRSA-N ipratropium Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 OEXHQOGQTVQTAT-JRNQLAHRSA-N 0.000 description 1
- 229960001888 ipratropium Drugs 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 239000012948 isocyanate Substances 0.000 description 1
- 150000002513 isocyanates Chemical class 0.000 description 1
- 125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
- NIMLQBUJDJZYEJ-UHFFFAOYSA-N isophorone diisocyanate Chemical compound CC1(C)CC(N=C=O)CC(C)(CN=C=O)C1 NIMLQBUJDJZYEJ-UHFFFAOYSA-N 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 239000000177 juniperus communis l. berry Substances 0.000 description 1
- PVTHJAPFENJVNC-MHRBZPPQSA-N kasugamycin Chemical compound N[C@H]1C[C@H](NC(=N)C(O)=O)[C@@H](C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H]1O PVTHJAPFENJVNC-MHRBZPPQSA-N 0.000 description 1
- 125000000468 ketone group Chemical group 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000004761 kevlar Substances 0.000 description 1
- 235000020061 kirsch Nutrition 0.000 description 1
- ZOTBXTZVPHCKPN-HTXNQAPBSA-N kresoxim-methyl Chemical compound CO\N=C(\C(=O)OC)C1=CC=CC=C1COC1=CC=CC=C1C ZOTBXTZVPHCKPN-HTXNQAPBSA-N 0.000 description 1
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 229940078795 lactoferrin Drugs 0.000 description 1
- 235000021242 lactoferrin Nutrition 0.000 description 1
- 229940061515 laureth-4 Drugs 0.000 description 1
- 229940033355 lauric acid Drugs 0.000 description 1
- 229940083980 lavender extract Drugs 0.000 description 1
- 235000020723 lavender extract Nutrition 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 150000004668 long chain fatty acids Chemical class 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 235000012661 lycopene Nutrition 0.000 description 1
- 229960004999 lycopene Drugs 0.000 description 1
- 239000001751 lycopene Substances 0.000 description 1
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 229940078752 magnesium ascorbyl phosphate Drugs 0.000 description 1
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 1
- 239000004137 magnesium phosphate Substances 0.000 description 1
- 229910000157 magnesium phosphate Inorganic materials 0.000 description 1
- 229960002261 magnesium phosphate Drugs 0.000 description 1
- 235000010994 magnesium phosphates Nutrition 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 239000011572 manganese Substances 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 150000007974 melamines Chemical class 0.000 description 1
- 102000006240 membrane receptors Human genes 0.000 description 1
- 108020004084 membrane receptors Proteins 0.000 description 1
- JSEFYOBABBXEJJ-UHFFFAOYSA-N menthol propylene glycol carbonate Chemical compound CC(O)COC(=O)OC1CC(C)CCC1C(C)C.CC(C)C1CCC(C)CC1OC(=O)OC(C)CO JSEFYOBABBXEJJ-UHFFFAOYSA-N 0.000 description 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- 150000002736 metal compounds Chemical class 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- XWPZUHJBOLQNMN-UHFFFAOYSA-N metconazole Chemical compound C1=NC=NN1CC1(O)C(C)(C)CCC1CC1=CC=C(Cl)C=C1 XWPZUHJBOLQNMN-UHFFFAOYSA-N 0.000 description 1
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 description 1
- 229960001252 methamphetamine Drugs 0.000 description 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 229960004011 methenamine Drugs 0.000 description 1
- MEBQXILRKZHVCX-UHFFFAOYSA-N methidathion Chemical compound COC1=NN(CSP(=S)(OC)OC)C(=O)S1 MEBQXILRKZHVCX-UHFFFAOYSA-N 0.000 description 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
- KRCMKUNIILUXPF-UHFFFAOYSA-N methyl 4-hydroxybenzoate;sodium Chemical compound [Na].COC(=O)C1=CC=C(O)C=C1 KRCMKUNIILUXPF-UHFFFAOYSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 229940044591 methyl glucose dioleate Drugs 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 235000021239 milk protein Nutrition 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- DEDOPGXGGQYYMW-UHFFFAOYSA-N molinate Chemical compound CCSC(=O)N1CCCCCC1 DEDOPGXGGQYYMW-UHFFFAOYSA-N 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 231100000017 mucous membrane irritation Toxicity 0.000 description 1
- NPGPTUUNZYOKIM-UHFFFAOYSA-N n,7,7-trimethyloctanamide Chemical compound CNC(=O)CCCCCC(C)(C)C NPGPTUUNZYOKIM-UHFFFAOYSA-N 0.000 description 1
- XTTMNDFFWSZHCZ-UHFFFAOYSA-N n-(2-methoxyethyl)aniline Chemical compound COCCNC1=CC=CC=C1 XTTMNDFFWSZHCZ-UHFFFAOYSA-N 0.000 description 1
- RJJIVFLXJQOMCG-UHFFFAOYSA-N n-(2-methylsulfanylethyl)aniline Chemical compound CSCCNC1=CC=CC=C1 RJJIVFLXJQOMCG-UHFFFAOYSA-N 0.000 description 1
- NTMYWKWDHRKIPZ-UHFFFAOYSA-N n-(2-methylsulfanylethyl)pyridin-2-amine Chemical compound CSCCNC1=CC=CC=N1 NTMYWKWDHRKIPZ-UHFFFAOYSA-N 0.000 description 1
- HCYZEVXWZFESIN-UHFFFAOYSA-N n-(furan-2-ylmethyl)aniline Chemical compound C=1C=COC=1CNC1=CC=CC=C1 HCYZEVXWZFESIN-UHFFFAOYSA-N 0.000 description 1
- MWKUECPGLXXAGM-UHFFFAOYSA-N n-(oxolan-2-ylmethyl)aniline Chemical compound C1CCOC1CNC1=CC=CC=C1 MWKUECPGLXXAGM-UHFFFAOYSA-N 0.000 description 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N n-Octanol Natural products CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- ZEHZHWJORJLVPH-UHFFFAOYSA-N n-ethyl-1-methyl-4-propan-2-ylcyclohexane-1-carboxamide Chemical compound CCNC(=O)C1(C)CCC(C(C)C)CC1 ZEHZHWJORJLVPH-UHFFFAOYSA-N 0.000 description 1
- GEFMUUGSTDXPSY-UHFFFAOYSA-N n-ethyl-2-methylsulfanylethanamine Chemical compound CCNCCSC GEFMUUGSTDXPSY-UHFFFAOYSA-N 0.000 description 1
- WDEVKSOFGCDCKV-UHFFFAOYSA-N n-ethyl-3-methylsulfanylpropan-1-amine Chemical compound CCNCCCSC WDEVKSOFGCDCKV-UHFFFAOYSA-N 0.000 description 1
- QBTUBLBTJXFCCB-UHFFFAOYSA-N n-pentan-3-ylaniline Chemical compound CCC(CC)NC1=CC=CC=C1 QBTUBLBTJXFCCB-UHFFFAOYSA-N 0.000 description 1
- IAHIMTVWPDQJOM-UHFFFAOYSA-N n-phenyloxolan-3-amine Chemical compound C1OCCC1NC1=CC=CC=C1 IAHIMTVWPDQJOM-UHFFFAOYSA-N 0.000 description 1
- ZUKUBTGXSHTDHA-UHFFFAOYSA-N n-pyridin-2-ylprop-2-enamide Chemical compound C=CC(=O)NC1=CC=CC=N1 ZUKUBTGXSHTDHA-UHFFFAOYSA-N 0.000 description 1
- 125000005609 naphthenate group Chemical group 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- PLPRGLOFPNJOTN-UHFFFAOYSA-N narcotine Natural products COc1ccc2C(OC(=O)c2c1OC)C3Cc4c(CN3C)cc5OCOc5c4OC PLPRGLOFPNJOTN-UHFFFAOYSA-N 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 239000000978 natural dye Substances 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 239000000820 nonprescription drug Substances 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 229940053934 norethindrone Drugs 0.000 description 1
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 125000003835 nucleoside group Chemical group 0.000 description 1
- 239000001702 nutmeg Substances 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- 235000019895 oat fiber Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229960002446 octanoic acid Drugs 0.000 description 1
- 239000003883 ointment base Substances 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- 229960002969 oleic acid Drugs 0.000 description 1
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 235000020665 omega-6 fatty acid Nutrition 0.000 description 1
- 229940033080 omega-6 fatty acid Drugs 0.000 description 1
- 150000004045 organic chlorine compounds Chemical class 0.000 description 1
- 150000001451 organic peroxides Chemical class 0.000 description 1
- 239000004306 orthophenyl phenol Substances 0.000 description 1
- JHIPUJPTQJYEQK-ZLHHXESBSA-N orysastrobin Chemical compound CNC(=O)C(=N\OC)\C1=CC=CC=C1CO\N=C(/C)\C(=N\OC)\C(\C)=N\OC JHIPUJPTQJYEQK-ZLHHXESBSA-N 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- LPMXVESGRSUGHW-HBYQJFLCSA-N ouabain Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3[C@@]4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)C[C@@H](O)[C@@H]3[C@@]2(CO)[C@H](O)C1 LPMXVESGRSUGHW-HBYQJFLCSA-N 0.000 description 1
- 229960003343 ouabain Drugs 0.000 description 1
- 208000020629 overactive bladder Diseases 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 150000004880 oxines Chemical class 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- 239000003346 palm kernel oil Substances 0.000 description 1
- 235000019865 palm kernel oil Nutrition 0.000 description 1
- 150000002942 palmitic acid derivatives Chemical class 0.000 description 1
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 229960001789 papaverine Drugs 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 229960005489 paracetamol Drugs 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 229960004623 paraoxon Drugs 0.000 description 1
- WYMSBXTXOHUIGT-UHFFFAOYSA-N paraoxon Chemical compound CCOP(=O)(OCC)OC1=CC=C([N+]([O-])=O)C=C1 WYMSBXTXOHUIGT-UHFFFAOYSA-N 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000003961 penetration enhancing agent Substances 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 125000003538 pentan-3-yl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 125000002081 peroxide group Chemical group 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 125000005561 phenanthryl group Chemical group 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- XAMUDJHXFNRLCY-UHFFFAOYSA-N phenthoate Chemical compound CCOC(=O)C(SP(=S)(OC)OC)C1=CC=CC=C1 XAMUDJHXFNRLCY-UHFFFAOYSA-N 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 229960002036 phenytoin Drugs 0.000 description 1
- BULVZWIRKLYCBC-UHFFFAOYSA-N phorate Chemical compound CCOP(=S)(OCC)SCSCC BULVZWIRKLYCBC-UHFFFAOYSA-N 0.000 description 1
- IOUNQDKNJZEDEP-UHFFFAOYSA-N phosalone Chemical compound C1=C(Cl)C=C2OC(=O)N(CSP(=S)(OCC)OCC)C2=C1 IOUNQDKNJZEDEP-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- CGIHFIDULQUVJG-VNTMZGSJSA-N phytantriol Natural products CC(C)CCC[C@H](C)CCC[C@H](C)CCC[C@@](C)(O)[C@H](O)CO CGIHFIDULQUVJG-VNTMZGSJSA-N 0.000 description 1
- CGIHFIDULQUVJG-UHFFFAOYSA-N phytantriol Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)(O)C(O)CO CGIHFIDULQUVJG-UHFFFAOYSA-N 0.000 description 1
- 235000002949 phytic acid Nutrition 0.000 description 1
- 239000000467 phytic acid Substances 0.000 description 1
- 229940068041 phytic acid Drugs 0.000 description 1
- IBSNKSODLGJUMQ-SDNWHVSQSA-N picoxystrobin Chemical compound CO\C=C(\C(=O)OC)C1=CC=CC=C1COC1=CC=CC(C(F)(F)F)=N1 IBSNKSODLGJUMQ-SDNWHVSQSA-N 0.000 description 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000004483 piperidin-3-yl group Chemical group N1CC(CCC1)* 0.000 description 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 description 1
- QHOQHJPRIBSPCY-UHFFFAOYSA-N pirimiphos-methyl Chemical group CCN(CC)C1=NC(C)=CC(OP(=S)(OC)OC)=N1 QHOQHJPRIBSPCY-UHFFFAOYSA-N 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 108010064470 polyaspartate Proteins 0.000 description 1
- 125000003367 polycyclic group Chemical group 0.000 description 1
- 229920000867 polyelectrolyte Polymers 0.000 description 1
- 229920006267 polyester film Polymers 0.000 description 1
- 229920001228 polyisocyanate Polymers 0.000 description 1
- 239000005056 polyisocyanate Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- YEBIHIICWDDQOL-YBHNRIQQSA-N polyoxin Polymers O[C@@H]1[C@H](O)[C@@H](C(C=O)N)O[C@H]1N1C(=O)NC(=O)C(C(O)=O)=C1 YEBIHIICWDDQOL-YBHNRIQQSA-N 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000011527 polyurethane coating Substances 0.000 description 1
- 229920005749 polyurethane resin Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 229920001290 polyvinyl ester Polymers 0.000 description 1
- 229920001289 polyvinyl ether Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- GRLPQNLYRHEGIJ-UHFFFAOYSA-J potassium aluminium sulfate Chemical compound [Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GRLPQNLYRHEGIJ-UHFFFAOYSA-J 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000004300 potassium benzoate Substances 0.000 description 1
- 235000010235 potassium benzoate Nutrition 0.000 description 1
- DJEHXEMURTVAOE-UHFFFAOYSA-M potassium bisulfite Chemical compound [K+].OS([O-])=O DJEHXEMURTVAOE-UHFFFAOYSA-M 0.000 description 1
- 239000004293 potassium hydrogen sulphite Substances 0.000 description 1
- 229910001414 potassium ion Inorganic materials 0.000 description 1
- RWPGFSMJFRPDDP-UHFFFAOYSA-L potassium metabisulfite Chemical compound [K+].[K+].[O-]S(=O)S([O-])(=O)=O RWPGFSMJFRPDDP-UHFFFAOYSA-L 0.000 description 1
- 239000004297 potassium metabisulphite Substances 0.000 description 1
- 235000010263 potassium metabisulphite Nutrition 0.000 description 1
- BWILYWWHXDGKQA-UHFFFAOYSA-M potassium propanoate Chemical compound [K+].CCC([O-])=O BWILYWWHXDGKQA-UHFFFAOYSA-M 0.000 description 1
- CHHHXKFHOYLYRE-STWYSWDKSA-M potassium sorbate Chemical compound [K+].C\C=C\C=C\C([O-])=O CHHHXKFHOYLYRE-STWYSWDKSA-M 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- SMKRKQBMYOFFMU-UHFFFAOYSA-N prallethrin Chemical compound CC1(C)C(C=C(C)C)C1C(=O)OC1C(C)=C(CC#C)C(=O)C1 SMKRKQBMYOFFMU-UHFFFAOYSA-N 0.000 description 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
- 229960004618 prednisone Drugs 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000583 progesterone congener Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- HXHCOXPZCUFAJI-UHFFFAOYSA-N prop-2-enoic acid;styrene Chemical class OC(=O)C=C.C=CC1=CC=CC=C1 HXHCOXPZCUFAJI-UHFFFAOYSA-N 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 229960002662 propylthiouracil Drugs 0.000 description 1
- 208000023958 prostate neoplasm Diseases 0.000 description 1
- ROSDSFDQCJNGOL-UHFFFAOYSA-N protonated dimethyl amine Natural products CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- HZRSNVGNWUDEFX-UHFFFAOYSA-N pyraclostrobin Chemical compound COC(=O)N(OC)C1=CC=CC=C1COC1=NN(C=2C=CC(Cl)=CC=2)C=C1 HZRSNVGNWUDEFX-UHFFFAOYSA-N 0.000 description 1
- 125000004307 pyrazin-2-yl group Chemical group [H]C1=C([H])N=C(*)C([H])=N1 0.000 description 1
- HYJYGLGUBUDSLJ-UHFFFAOYSA-N pyrethrin Natural products CCC(=O)OC1CC(=C)C2CC3OC3(C)C2C2OC(=O)C(=C)C12 HYJYGLGUBUDSLJ-UHFFFAOYSA-N 0.000 description 1
- VJFUPGQZSXIULQ-XIGJTORUSA-N pyrethrin II Chemical compound CC1(C)[C@H](/C=C(\C)C(=O)OC)[C@H]1C(=O)O[C@@H]1C(C)=C(C\C=C/C=C)C(=O)C1 VJFUPGQZSXIULQ-XIGJTORUSA-N 0.000 description 1
- 239000002728 pyrethroid Substances 0.000 description 1
- 229940015367 pyrethrum Drugs 0.000 description 1
- 125000002206 pyridazin-3-yl group Chemical group [H]C1=C([H])C([H])=C(*)N=N1 0.000 description 1
- 125000004940 pyridazin-4-yl group Chemical group N1=NC=C(C=C1)* 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 description 1
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 description 1
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 description 1
- YBBJKCMMCRQZMA-UHFFFAOYSA-N pyrithione Chemical compound ON1C=CC=CC1=S YBBJKCMMCRQZMA-UHFFFAOYSA-N 0.000 description 1
- 229960002026 pyrithione Drugs 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 229940075993 receptor modulator Drugs 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 235000021254 resistant starch Nutrition 0.000 description 1
- 229930002330 retinoic acid Natural products 0.000 description 1
- 229940108325 retinyl palmitate Drugs 0.000 description 1
- 235000019172 retinyl palmitate Nutrition 0.000 description 1
- 239000011769 retinyl palmitate Substances 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 229940100486 rice starch Drugs 0.000 description 1
- 239000003128 rodenticide Substances 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 239000003229 sclerosing agent Substances 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000003548 sec-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 229960002718 selenomethionine Drugs 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 229940057910 shea butter Drugs 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229960004029 silicic acid Drugs 0.000 description 1
- 229960001866 silicon dioxide Drugs 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 235000020374 simple syrup Nutrition 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- IFGCUJZIWBUILZ-UHFFFAOYSA-N sodium 2-[[2-[[hydroxy-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid Chemical compound [Na+].C=1NC2=CC=CC=C2C=1CC(C(O)=O)NC(=O)C(CC(C)C)NP(O)(=O)OC1OC(C)C(O)C(O)C1O IFGCUJZIWBUILZ-UHFFFAOYSA-N 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000010378 sodium ascorbate Nutrition 0.000 description 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
- 229960005055 sodium ascorbate Drugs 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 229940080237 sodium caseinate Drugs 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 1
- 229960001462 sodium cyclamate Drugs 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 239000004402 sodium ethyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010226 sodium ethyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- HLBBKKJFGFRGMU-UHFFFAOYSA-M sodium formate Chemical compound [Na+].[O-]C=O HLBBKKJFGFRGMU-UHFFFAOYSA-M 0.000 description 1
- 239000004289 sodium hydrogen sulphite Substances 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940075560 sodium lauryl sulfoacetate Drugs 0.000 description 1
- 239000004296 sodium metabisulphite Substances 0.000 description 1
- 239000004290 sodium methyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010268 sodium methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- 235000010294 sodium orthophenyl phenol Nutrition 0.000 description 1
- 239000004307 sodium orthophenyl phenol Substances 0.000 description 1
- JXKPEJDQGNYQSM-UHFFFAOYSA-M sodium propionate Chemical compound [Na+].CCC([O-])=O JXKPEJDQGNYQSM-UHFFFAOYSA-M 0.000 description 1
- 229960003212 sodium propionate Drugs 0.000 description 1
- 239000004404 sodium propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010230 sodium propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 235000019250 sodium sorbate Nutrition 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000019721 spearmint oil Nutrition 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 1
- 229960002256 spironolactone Drugs 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 239000012192 staining solution Substances 0.000 description 1
- 239000010676 star anise oil Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229960004274 stearic acid Drugs 0.000 description 1
- 229940071209 stearoyl lactylate Drugs 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical compound C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 description 1
- ARCJQKUWGAZPFX-UHFFFAOYSA-N stilbene oxide Chemical compound O1C(C=2C=CC=CC=2)C1C1=CC=CC=C1 ARCJQKUWGAZPFX-UHFFFAOYSA-N 0.000 description 1
- 235000021286 stilbenes Nutrition 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 229920003048 styrene butadiene rubber Polymers 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 229940014800 succinic anhydride Drugs 0.000 description 1
- 235000019327 succinylated monoglyceride Nutrition 0.000 description 1
- 235000010965 sucrose esters of fatty acids Nutrition 0.000 description 1
- 239000001959 sucrose esters of fatty acids Substances 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 description 1
- 150000003457 sulfones Chemical class 0.000 description 1
- 125000000542 sulfonic acid group Chemical group 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 239000004291 sulphur dioxide Substances 0.000 description 1
- 229960004940 sulpiride Drugs 0.000 description 1
- 230000037072 sun protection Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000002511 suppository base Substances 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000000271 synthetic detergent Substances 0.000 description 1
- 239000000979 synthetic dye Substances 0.000 description 1
- 239000012209 synthetic fiber Substances 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 239000002700 tablet coating Substances 0.000 description 1
- 238000009492 tablet coating Methods 0.000 description 1
- 230000003655 tactile properties Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 238000010345 tape casting Methods 0.000 description 1
- 239000010677 tea tree oil Substances 0.000 description 1
- 229940111630 tea tree oil Drugs 0.000 description 1
- 229920001897 terpolymer Polymers 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- FAGUFWYHJQFNRV-UHFFFAOYSA-N tetraethylenepentamine Chemical compound NCCNCCNCCNCCN FAGUFWYHJQFNRV-UHFFFAOYSA-N 0.000 description 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 229960004559 theobromine Drugs 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- 230000008646 thermal stress Effects 0.000 description 1
- WJCNZQLZVWNLKY-UHFFFAOYSA-N thiabendazole Chemical compound S1C=NC(C=2NC3=CC=CC=C3N=2)=C1 WJCNZQLZVWNLKY-UHFFFAOYSA-N 0.000 description 1
- 229960004546 thiabendazole Drugs 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 description 1
- DSXFPRKPFJRPIB-UHFFFAOYSA-N thiolan-3-one Chemical compound O=C1CCSC1 DSXFPRKPFJRPIB-UHFFFAOYSA-N 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 229940094937 thioredoxin Drugs 0.000 description 1
- 108060008226 thioredoxin Proteins 0.000 description 1
- 230000009974 thixotropic effect Effects 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 229930003802 tocotrienol Natural products 0.000 description 1
- 239000011731 tocotrienol Substances 0.000 description 1
- 235000019148 tocotrienols Nutrition 0.000 description 1
- DVKJHBMWWAPEIU-UHFFFAOYSA-N toluene 2,4-diisocyanate Chemical compound CC1=CC=C(N=C=O)C=C1N=C=O DVKJHBMWWAPEIU-UHFFFAOYSA-N 0.000 description 1
- HYVWIQDYBVKITD-UHFFFAOYSA-N tolylfluanid Chemical compound CN(C)S(=O)(=O)N(SC(F)(Cl)Cl)C1=CC=C(C)C=C1 HYVWIQDYBVKITD-UHFFFAOYSA-N 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- YWSCPYYRJXKUDB-KAKFPZCNSA-N tralomethrin Chemical compound CC1(C)[C@@H](C(Br)C(Br)(Br)Br)[C@H]1C(=O)O[C@H](C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 YWSCPYYRJXKUDB-KAKFPZCNSA-N 0.000 description 1
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- DDVNRFNDOPPVQJ-HQJQHLMTSA-N transfluthrin Chemical compound CC1(C)[C@H](C=C(Cl)Cl)[C@H]1C(=O)OCC1=C(F)C(F)=CC(F)=C1F DDVNRFNDOPPVQJ-HQJQHLMTSA-N 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 102000042565 transient receptor (TC 1.A.4) family Human genes 0.000 description 1
- 108091053409 transient receptor (TC 1.A.4) family Proteins 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- PIILXFBHQILWPS-UHFFFAOYSA-N tributyltin Chemical compound CCCC[Sn](CCCC)CCCC PIILXFBHQILWPS-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- JCVQKRGIASEUKR-UHFFFAOYSA-N triethoxy(phenyl)silane Chemical compound CCO[Si](OCC)(OCC)C1=CC=CC=C1 JCVQKRGIASEUKR-UHFFFAOYSA-N 0.000 description 1
- 235000019649 trigeminal effects Nutrition 0.000 description 1
- HTJNEBVCZXHBNJ-XCTPRCOBSA-H trimagnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;diphosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O HTJNEBVCZXHBNJ-XCTPRCOBSA-H 0.000 description 1
- 238000005829 trimerization reaction Methods 0.000 description 1
- OEIXGLMQZVLOQX-UHFFFAOYSA-N trimethyl-[3-(prop-2-enoylamino)propyl]azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CCCNC(=O)C=C OEIXGLMQZVLOQX-UHFFFAOYSA-N 0.000 description 1
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
- VXYADVIJALMOEQ-UHFFFAOYSA-K tris(lactato)aluminium Chemical compound CC(O)C(=O)O[Al](OC(=O)C(C)O)OC(=O)C(C)O VXYADVIJALMOEQ-UHFFFAOYSA-K 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 235000004330 tyrosol Nutrition 0.000 description 1
- 229940040064 ubiquinol Drugs 0.000 description 1
- QNTNKSLOFHEFPK-UPTCCGCDSA-N ubiquinol-10 Chemical compound COC1=C(O)C(C)=C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)C(O)=C1OC QNTNKSLOFHEFPK-UPTCCGCDSA-N 0.000 description 1
- 229940035936 ubiquinone Drugs 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 150000003673 urethanes Chemical class 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 239000008371 vanilla flavor Substances 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 229940021056 vitamin d3 Drugs 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 235000020234 walnut Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 235000019386 wax ester Nutrition 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 239000011746 zinc citrate Substances 0.000 description 1
- 235000006076 zinc citrate Nutrition 0.000 description 1
- 229940068475 zinc citrate Drugs 0.000 description 1
- 229940043810 zinc pyrithione Drugs 0.000 description 1
- GAWWVVGZMLGEIW-GNNYBVKZSA-L zinc ricinoleate Chemical compound [Zn+2].CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O.CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O GAWWVVGZMLGEIW-GNNYBVKZSA-L 0.000 description 1
- 229940100530 zinc ricinoleate Drugs 0.000 description 1
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 1
- 239000002888 zwitterionic surfactant Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/88—Taste or flavour enhancing agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
- A23L29/035—Organic compounds containing oxygen as heteroatom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
- A23L29/045—Organic compounds containing nitrogen as heteroatom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
- A23L29/055—Organic compounds containing sulfur as heteroatom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4986—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with sulfur as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/22—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
本发明主要涉及调节优选体外和/或体内调节冷薄荷醇受体TRPM8的方法,其中使该受体与选自文中所述的结构类型1的化合物的至少一种调节剂接触。本发明进一步涉及相应用途和包含此类化合物的组合物。
Description
本发明主要涉及冷薄荷醇受体TRPM8的新调节剂,使用这些调节剂调节TRPM8受体的方法,所述调节剂用于诱导冷感的用途,以及使用这些调节剂制备的组合物。
在一个特定方面,本发明涉及一种组合物,其包含至少一种这样的调节剂,其用于实现对皮肤或粘膜的清凉效果,与已知的清凉活性成分(活性物质)(例如N-乙基薄荷烷-3-甲酰胺(WS3))相比,有利地具有更长时间的清凉效果,和/或与已知的清凉活性物质例如FEMA 4809或FEMA 4496)相比,清凉效果更早发生。
此外,本发明的一个特定方面涉及包含此类选择的TRPM8受体调节剂的组合物,其中所述组合物用于特定目的。
另外,本发明还涉及在皮肤或粘膜上实现生理清凉效果的方法,其中使用了所述组合物。
通过以下说明书、实施例尤其是所附权利要求书,本发明的其他方面将变得显而易见。
定期使用生理清凉活性物质,以便在皮肤或粘膜(例如口腔、鼻腔和/或咽腔的粘膜)上产生清凉的感官印象,即使没有例如在溶剂蒸发中实际上发生的物理冷却。所用的生理清凉活性剂可以是单独的组分或混合物。在此应该考虑的是,并不是所有在体外(invitro)影响受体并且(也)参与赋予生理清凉作用的化合物实际上都在体内(in vivo)对皮肤或粘膜产生这种作用。更具体地,这种效果将不会总是具有相同的进展。这意味着,例如,所传递的生理性清凉作用的强度和清凉作用强度随时间的发展不能仅仅根据以下事实得出结论:特定的化合物是参与赋予清凉效果的受体的激动剂。
最广为人知的生理活性清凉活性物质是L-薄荷醇,但它具有一些缺点,例如强烈的气味感、高挥发性以及相对高的浓度、苦味和/或强烈的内在味道,或对皮肤的刺激作用。
因此,先前已经在寻找不具有L-薄荷醇的不利性质的强清凉活性物质。例如,在DE2 608 226中描述了薄荷醇的乳酸酯,在DE 4 226 043中描述了薄荷醇和多元醇的混合碳酸酯,并且在EP 0 507 190中描述了薄荷酮缩酮。
根据US 5,725,865和US 5,843,466的二酸薄荷基单酯是天然产生的令人关注的替代物,但是在感官测试中不能达到上述清凉活性物质的强度。
J.Soc.Cosmet.Chem.1978,29,185-200介绍了大约1200种化合物的研究结果,其中化合物N-乙基-L-薄荷烷甲酰胺(“WS3”),尤其是Nα-(L-薄荷烷羰基)甘氨酸乙酯(“WS5”)被发现是最强的清凉活性物质。但是,后者虽然具有很强的作用,但缺点是对水解敏感,并形成相应的游离酸Nα-(L-薄荷烷羰基)甘氨酸,其本身仅具有非常小的清凉作用。尽管描述了详细的研究,但仍无法系统地预测潜在的清凉活性物质的性质,尤其是关于其苦味和/或其他三叉神经作用的性质,也没有进行描述。例如,薄荷烷甲酰胺类中的许多分子也具有很强的清凉作用,但经常同时具有明显的苦味(例如,根据JP 2004059474的N-(烷氧基烷基)薄荷烷甲酰胺)或另外具有强烈的刺激作用(WS5:N-[[5-甲基-2-(1-甲基乙基)环己基]羰基]甘氨酸乙酯,US 2005/0222256)。
JP 2004059474中描述了Nα-(薄荷烷羰基)烷氧基烷基酰胺。尽管具有强的清凉效果和高的水解稳定性,但是它们具有很高的苦味的缺点,因此它们不能用于食品以及用于面部护理目的的美容化妆品中。
另外,在JP 2005343795中将乙醛酸薄荷酯及其水合物描述为清凉物质。
迄今为止生产和使用的清凉活性物质的概述可参见M.Erman,Perfumer&Flavorist 32(10),20-35(2007)和M.L.Dewis in D.J.Rowe,Chemistry and Tech-nologyof Flavors and Fragrances,Blackwell Publishing Ltd,Oxford 2005,p.212-222。
冷薄荷醇受体TRPM8(也称为冷膜受体(CMR)1)属于瞬时受体电位离子通道家族,在特定的神经元组中特异性表达,并在细胞膜中形成孔(每种情况4个单位结合形成四聚体),选择性地允许Ca2+离子通过。该蛋白质具有6个跨膜结构域以及一个胞质C和N末端。低温(最好是10-25℃)会刺激该受体,从而导致信号转导,这被神经系统解释为冷感觉。该受体于2002年在多种出版物中首次被描述为冷受体(Peier AM等人,A TRP channel thatsenses cold stimuli and menthol.Cell.2002Mar 8;108(5):705-15;McKemy DD等人.Identification of a cold receptor reveals a general role for TRP channels inthermosensation Nature 2002Mar 7;416(6876):52-8;Zuker CS.Neurobiology:A coolion channel Nature 2002Mar 7;416(6876):27-8)。
长期以来,清凉化合物(例如薄荷醇)在调味品和增香剂行业中一直发挥着重要作用,以建立与新鲜和清新的联系。对于化合物薄荷醇,已显示其充当TRPM8受体的天然调节剂(McKemy D.D.,Molecular Pain 1,2005,16;McKemy D.D.,Nature 416,2002,52-58;Peier A.M.,Cell 108,2002,705-715;Dhaka A.,Annu.Rev.Neurosci.29,2006,135-161)。薄荷醇的应用激活TRPM8,从而导致Ca2+流入冷敏感神经元。产生的电信号最终被感知为冷感觉。薄荷醇浓度过高会引起刺激和麻醉作用。此外,各种出版物描述了具有类似作用的薄荷醇衍生物(英国专利1971#1315761Watson H.R.,J.Soc.Cosmet.Chem.29,1978,185-200;Furrer S.M.,Chem.Percept.1,2008,119-126)。还存在与薄荷醇在结构上不相关的个体化合物,其引起显著的TRPM8调节,例如icilin(Wei E.T.,J.Pharm.Pharmacol.35,1983,110-112;WO 2004/026840)、WS-23或专利申请WO 2007/019719中详述的化合物。
调节TRPM8受体或其昆虫类似物的物质的进一步作用是对昆虫的排斥作用(WO2002/015692;WO 2004/000023、US 2004/0028714),以及抗肿瘤治疗的活性(例如对前列腺肿瘤的影响),在治疗炎性疼痛/痛觉过敏中的活性以及作为TRPM8拮抗剂在治疗膀胱综合征或膀胱过度活动症中的作用(Beck B.Cell Calcium,41,2007,285-294;LevineJ.D.Biochim.Biophys.Acta,Mol.Basis Dis.1772,2007,989-1003;Mukerji G.,BMCUrology 6,2006,6;US 2003/0207904;US 2005/6893626,Behrendt HJ的论文2004,波鸿大学;Lashinger E.S.R.Am.J.Physiol.Renal Physiol.Am J Physiol RenalPhysiol.2008Jun 18.[印刷前的电子出版];PMID:18562636)。
然而,迄今为止发现的许多TRPM8调节剂在作用强度、作用时间、皮肤/粘膜刺激性、气味、味道、溶解度和/或挥发性方面存在缺点。
申请人在先的国际专利申请PCT/EP2009/061019提出了用于调节TRPM8受体的个体化合物。例如,已公开以下化合物:
这些化合物也可以通过商业途径获得:
CAS号为99602-94-5的化合物1(3R-顺式形式)
CAS号为165753-08-2的化合物2
CAS号为338771-57-6的化合物3
CAS号为878942-21-3的化合物4
CAS号为748783-13-3的化合物5(无立体化学)
在这一点上另外参考申请人的国际专利申请PCT/EP2010/067936,其中同样提出了用于调节TRPM8受体的化合物。
本发明的主要目的是鉴定具有超常的生理清凉作用的新物质,优选导致调节TRPM8受体的那些物质,其可以用作迄今为止已知的调节剂的替代物,优选作为比已知的调节剂更合适的物质。这些化合物还应该特别适用于美容化妆品领域(例如护发、护肤、口腔护理)、食品和饲料、纺织品、非处方药产品(例如烧伤药膏)、药品(例如肿瘤治疗、膀胱无力)或包装。所指定的化合物或化合物的混合物应优选表现出最小的固有味道,并且特别是仅具有轻微的苦味(如果有的话),并且引起最小的刺激。
为了实现本发明的目的,特别是寻找具有可以赋予特别长效的清凉感的活性物质的组合物。这些组合物优选另外还能够赋予特别强烈和/或迅速开始的清凉感。
在口腔粘膜上,现有技术中已知的许多上述常规清凉物质都显示出或多或少相同的清凉特性。它们赋予的清凉新鲜感大约在0.5分钟后就会出现,但在3至5分钟达到峰值后又相对快地平稳下来,在整个最长30分钟的时间内可清晰感觉到清凉,而且经验表明,其强度和持续时间只能受剂量变化的较小影响。然而,在消费者方面,希望与使用者相关的特别持久的清凉效果,并具有相应的新鲜感和健康感。
令人惊奇地发现,根据本发明使用的化合物具有在体内对皮肤或粘膜具有特别长的清凉作用的共同的特性。对于本申请中提到的TRPM8激动剂,这是不可预测的,其也不适用于所有这些激动剂。
迄今为止,在现有技术中没有指示特别是根据本发明使用的化合物能够赋予特别合适的清凉效果。为了量化持久的清凉效果,可以使用N-乙基薄荷烷-3-甲酰胺进行比较测试。对于这些比较测试,本领域技术人员交换根据本发明使用的化合物或N-乙基薄荷烷-3-甲酰胺化合物(也为WS3),优选以相同的浓度。然后将各个组合物的清凉效果相互比较。如果根据本发明使用的化合物以高于100ppm的浓度存在于待检查的组合物中,则优选的是评价与WS3相比清凉效果是否延长,被测试的组合物应该被稀释,使得所使用的本发明化合物以100ppm的浓度存在。对于包含WS3的对比组合物,当然也应该实施相同的稀释步骤。
就此而言,优选的是,在相应的比较中,包含根据本发明使用的化合物的组合物的清凉效果与对比测试相比优选延长至少10分钟,更优选延长至少15分钟,进一步优选延长至少20分钟,并特别优选至少30分钟。
根据本发明,本发明的主要目的是通过调节优选在体外和/或体内调节冷薄荷醇受体TRPM8的非治疗性方法实现的,其中该受体与至少一种调节剂接触,所述调节剂选自以下结构类型1的化合物:
结构类型1:
其中
R1由下列结构构成:
其中
Z选自O和S;
n=0或1;
m
-=1且Y是氢且R8是直链或支链的C1至C5烷烃,优选C5烷烃,或Y是NR9或CR9且R9与R8一起形成部分或完全饱和的5-或6-元环,或
-=0、2或3且Y是氢且R8是直链或支链的C1至C5烷烃,优选C5烷烃,或Y是NR9或CR9且R9与R8一起形成芳香的、部分或完全饱和的5-或6-元环;
R2是直链或支链的C1至C5烷基基团、5-或6-元环烷基基团或5-或6-元芳基基团,其中所述烷基基团、环烷基基团或芳基基团任选包含一个或两个(环)杂原子;
R3、R4、R5、R6和R7是相同或不同的且选自
氢;
卤素;
直链或支链的C1-至C6-烷基基团,其任选载有1、2、3或4个相同或不同的选自以下的取代基:NH2、OH、SH、卤素和直链或支链的C1-至C6-烷基基团;
直链或支链的C1-至C6-烷氧基基团,其任选载有1、2、3或4个相同或不同的选自以下的取代基:NH2、OH、SH、卤素和C1-至C6-烷氧基基团;
单环或多环芳基、芳基烷基和杂芳基基团,其任选载有1、2、3或4个相同或不同的选自以下的取代基:NH2、OH、SH、卤素、直链或支链的C1-至C6-烷基基团;其中所述杂芳基基团含有1、2、3或4个相同或不同的且选自O、N和S的环杂原子,或
两个相邻的R3、R4、R5、R6和R7基团与它们所键合的碳原子一起形成4-、5-、6-或7-元单-或多不饱和的杂环,其任选载有1、2、3、4或5个相同或不同的选自直链或支链的C1-至C6-烷基基团的取代基,且含有1、2或3个相同或不同的且选自O、N和S的环杂原子;
X
-选自
-C1-至C4-亚烷基基团;-C2-至C4-亚烯基基团,和-A-C1-至C4-或-C1-至C4-A-亚烷基基团或–A-C2-至C4-或-C2-至C4-A-亚烯基基团,其中A是O、S或NH;或
-是化学单键;
和这些化合物的盐,尤其是与无机或特别是有机、一元羧酸和尤其多元羧酸的酸加成盐;
和任选的立体异构纯形式的这些化合物或其立体异构体的混合物。
在文献中对于“TRPM8”有各种同义词:TRPP8、LTRPC6、CMR1、MGC2849、瞬时受体电位阳离子通道亚家族M成员8。本发明的范围包括所有名称。还包括所述受体的所有功能修饰,例如,更具体地,剪接变体、同工型,例如TRPM8 CRA_a、TRPM8 CRA_b,以及来自不同生物体(例如人、小鼠、大鼠)的所有类似受体。各种受体的核苷酸或氨基酸序列本身是已知的,并记录在序列数据库中。例如,hTRPM8的序列信息注册在编号NM_024080下。
在本发明的上下文中,“调节剂”是可以在体内和/或体外特别是在体内充当TRPM8受体的激动剂和/或拮抗剂的化合物。
合适的调节剂在此可以单独地充当拮抗剂或激动剂,尤其是单独地充当激动剂,或者既充当拮抗剂又充当激动剂。在此特别有可能作为所选的特定调节剂浓度的函数来确立激动作用或拮抗作用。
此处的“激动剂”是赋予TRPM8受体活化作用即诱导Ca2+流入冷敏感神经元并因此产生冷感觉的化合物。
相反,“拮抗剂”是可以抵消TRPM8受体活化的化合物。
本发明的调节剂可以通过与TRPM8受体分子可逆或不可逆地、特异性或非特异性结合而发挥作用。通常,结合通过与受体分子的离子和/或非离子的例如疏水的相互作用而是非共价的。这里的“特异性的”包括与一种或多种不同的TRPM8受体分子(例如不同来源或不同同工型的TRPM8分子)的排他性相互作用。相比之下,“非特异性”是调节剂与具有不同功能和/或序列的多种不同受体分子的相互作用,但其结果是TRPM8受体的期望的激动和/或拮抗调节(如上所述)可以被检测到。
本发明的调节剂特别用于诱导人和/或动物的冷感。当本文所述的细胞活性测试中的化合物显示出对hTRPM8的激动作用时,优选存在“诱导冷感”。
本发明的组合物包括有效量的至少一种本发明的调节剂,以及对于各组合物常规的组分。在本文中,“有效的”是指一旦组合物应用(例如,应用至皮肤)足以赋予期望的作用例如药理作用或感觉作用例如嗅觉冷作用的调节剂的浓度。
除非另有说明,否则以下一般定义适用于本发明的上下文:
卤素:F、Cl、Br或I
烷基和由其衍生的基团例如烷氧基、烷硫基、烷氧基烷基、烷氧基烷氧基、烷基氨基和二烷基氨基中的所有烷基部分:具有1-4、1至6、1至8或1至10个碳原子的饱和、直链或支链的烃基,例如
-C1-至C6-烷基例如甲基、乙基、丙基、1-甲基乙基、丁基、1-甲基丙基、2-甲基丙基、1,1-二甲基乙基、戊基、1-甲基丁基、2-甲基丁基、3-甲基丁基、2,2-二甲基丙基、1-乙基丙基、己基、1,1-二甲基丙基、1,2-二甲基丙基、1-甲基戊基、2-甲基戊基、3-甲基戊基、4-甲基戊基、1,1-二甲基丁基、1,2-二甲基丁基、1,3-二甲基丁基、2,2-二甲基丁基、2,3-二甲基丁基、3,3-二甲基丁基、1-乙基丁基、2-乙基丁基、1,1,2-三甲基丙基、1,2,2-三甲基丙基、1-乙基-1-甲基丙基和1-乙基-2-甲基丙基。
-C1-至C6-烷氧基,包括C1-至C4-烷氧基,例如甲氧基、乙氧基、正丙氧基、1-甲基乙氧基、丁氧基、1-甲基丙氧基、2-甲基丙氧基或1,1-二甲基乙氧基;
和例如戊氧基、1-甲基丁氧基、2-甲基丁氧基、3-甲基丁氧基、1,1-二甲基丙氧基、1,2-二甲基丙氧基、2,2-二甲基丙氧基、1-乙基丙氧基、己氧基、1-甲基戊氧基、2-甲基戊氧基、3-甲基戊氧基、4-甲基戊氧基、1,1-二甲基丁氧基、1,2-二甲基丁氧基、1,3-二甲基丁氧基、2,2-二甲基丁氧基、2,3-二甲基丁氧基、3,3-二甲基丁氧基、1-乙基丁氧基、2-乙基丁氧基、1,1,2-三甲基丙氧基、1,2,2-三甲基丙氧基、1-乙基-1-甲基丙氧基或1-乙基-2-甲基丙氧基;
环烷基(环):具有3至20个碳原子的碳环基,例如
C3-至C12-环烷基,例如环丙基、环丁基、环戊基、环己基、环庚基、环辛基、环壬基、环癸基、环十一烷基和环十二烷基;优选环戊基、环己基、环庚基,以及环丙基甲基、环丙基乙基、环丁基甲基、环丁基乙基、环戊基甲基、环戊基乙基、环己基甲基或
C3-至C7-环烷基,例如环丙基、环丁基、环戊基、环己基、环庚基、环丙基甲基、环丙基乙基、环丁基甲基、环戊基乙基、环己基甲基,
其中所述基团可以通过任何合适的碳原子连接到分子的其余部分。
亚烷基:具有1至20个碳原子的直链或单支链或多支链的烃桥基,例如
-C1-至C7-亚烷基基团,其选自-CH2-、-(CH2)2-、-(CH2)3-、-(CH2)4-、-(CH2)2-CH(CH3)-、-CH2-CH(CH3)-CH2-、(CH2)4-、-(CH2)5-、-(CH2)6、-(CH2)7-、-CH(CH3)-CH2-CH2-CH(CH3)-或–CH(CH3)-CH2-CH2-CH2-CH(CH3)-或
-C1-至C4-亚烷基基团,其选自-CH2-、-(CH2)2-、-(CH2)3-、-(CH2)4-、-(CH2)2-CH(CH3)-、-CH2-CH(CH3)-CH2-。
亚烯基:具有2至20个碳原子的上述亚烷基的单或多不饱和、特别是单不饱和的类似物,尤其是C2-至C7-亚烯基或C2-至C4-亚烯基,例如-CH=CH-、-CH=CH-CH2-、-CH2-CH=CH-、-CH=CH-CH2-CH2-、-CH2-CH=CH-CH2-、-CH2-CH2-CH=CH-、-CH(CH3)-CH=CH-、-CH2-C(CH3)=CH-。
芳基:具有6至20个、尤其是6至10个环碳原子的单环或多环(优选单环或双环)、任选取代的芳族基团,例如苯基、联苯基、萘基、例如1-或2-萘基、四氢萘基、芴基、茚基和菲基。这些芳基可以任选地带有1、2、3、4、5或6个相同或不同的取代基。
芳基烷基:上述烷基的芳基取代的类似物,其中芳基同样具有上述定义,例如选自苯甲基或苯乙基的苯基-C1-至C4-烷基基团。
杂环基(杂环):五至七元饱和、部分不饱和或芳族杂环或杂环基,其含有一个、两个、三个或四个选自O,N和S的杂原子,例如
-包含1至2个氮原子和/或氧或硫原子或1或2个氧和/或硫原子作为环成员的5或6元饱和或单不饱和杂环基,例如2-四氢呋喃基、3-四氢呋喃基、2-四氢噻吩基、3-四氢噻吩基、1-吡咯烷基、2-吡咯烷基、3-吡咯烷基、3-异噁唑烷基、4-异噁唑烷基、5-异噁唑烷基、3-异噻唑烷基、4-异噻唑烷基、5-异噻唑烷基、3-吡唑烷基、4-吡唑烷基、5-吡唑烷基、2-噁唑烷基、4-噁唑烷基、5-噁唑烷基、2-噻唑烷基、4-噻唑烷基、5-噻唑烷基、2-咪唑烷基、4-咪唑烷基、2-吡咯啉-2-基、2-吡咯啉-3-基、3-吡咯啉-2-基、3-吡咯啉-3-基、1-哌啶基、2-哌啶基、3-哌啶基、4-哌啶基、1,3-二噁烷-5-基、2-四氢吡喃基、4-四氢吡喃基、2-四氢噻吩基、3-六氢哒嗪基、4-六氢哒嗪基、2-六氢嘧啶基、4-六氢嘧啶基、5-六氢嘧啶基和2-哌嗪基;
5元芳族杂环基(=杂芳基或杂芳基基团),除碳原子外,其还包含1、2或3个氮原子或者1或2个氮原子和1个硫或氧原子作为环成员,例如2-呋喃基、3-呋喃基、2-噻吩基、3-噻吩基、2-吡咯基、3-吡咯基、3-吡唑基、4-吡唑基、5-吡唑基、2-噁唑基、4-噁唑基、5-噁唑基、2-噻唑基、4-噻唑基、5-噻唑基、2-咪唑基、4-咪唑基和1,3,4-三唑-2-基;
-具有作为环成员的1、2、3或4个氮原子的5元芳族杂环基(=杂芳基或杂芳基基团),例如1-、2-或3-吡咯基、1-、3-或4-吡唑基、1-、2-或4-咪唑基、1,2,3-[1H]-三唑基-1-基、1,2,3-[2H]-三唑基-2-基、1,2,3-[1H]-三唑基-4-基、1,2,3-[1H]-三唑基-5-基、1,2,3-[2H]-三唑基-4-基、1,2,4-[1H]-三唑基-1-基、1,2,4-[1H]-三唑基-3-基、1,2,4-[1H]-三唑基-5-基、1,2,4-[4H]-三唑基-4-基、1,2,4-[4H]-三唑基-3-基、[1H]-四唑-1-基、[1H]-四唑-5-基、[2H]-四唑-2-基和[2H]-四唑-5-基;
-具有1个选自氧和硫的杂原子和任选的1、2或3个氮原子作为环成员的5元芳族杂环基(=杂芳基或杂芳基基团),例如2-呋喃基、3-呋喃基、2-噻吩基、3-噻吩基、3-或4-异噁唑基、3-或4-异噻唑基、2-、4-或5-噁唑基、2-、4-或5-噻唑基、1,2,4-噻二唑-3-基、1,2,4-噻二唑-5-基、1,3,4-噻二唑-2-基、1,2,4-噁二唑-3-基、1,2,4-噁二唑-5-基和1,3,4-噁二唑-2-基;
-6元杂环基(=杂芳基或杂芳基基团),除碳原子外,其还包含一个或两个或者一个、两个或三个氮原子作为环成员,例如2-吡啶基、3-吡啶基、4-吡啶基、3-哒嗪基、4-哒嗪基、2-嘧啶基、4-嘧啶基、5-嘧啶基、2-吡嗪基、1,2,4-三嗪-3-基;1,2,4-三嗪-5-基、1,2,4-三嗪-6-基和1,3,5-三嗪-2-基;
特别是对于上述基团而言,取代基尤其选自酮基、-COOH、-COO-烷基、-OH、-SH、-CN、氨基、-NO2、烷基,或其中烷基基团中的一个或多个氢原子的可以被卤素替换。
在本发明方法的一个优选实施方案中,结构类型1的化合物选自由以下化合物组成的A组:
/>
/>
如果给定的名称与相应的结构式图像之间存在差异,则以结构式图像为准。
在此特别优选A组化合物,其选自由以下化合物组成的B组:
/>
/>
进一步优选来自A组和B组的化合物:其选自由以下化合物组成的C组:
在本发明的一种构型中,结构类型1的化合物不选自WO2011/061330中描述的化合物。
因此,在本发明的一个优选实施方案中,结构类型1的化合物不选自由以下化合物组成的D组:
结构类型1:
其中
R1由下列结构构成:
其中
Z选自O和S;
n=0或1;
m=0且Y是NR9或CR9且R9与R8一起形成芳香的或完全饱和的5-或6-元环;
且
其中R2是直链或支链的C1至C5烷基基团、5-或6-元环烷基基团或5-或6-元芳基基团,其中所述环烷基基团和芳基基团任选包含一个或两个(环)杂原子,所述杂原子是相同或不同的且选自O、N和S;
R3、R4、R5、R6和R7是相同或不同的且选自
氢;
卤素;
直链或支链的C1-至C6-烷基基团,其任选载有1、2、3或4个相同或不同的选自以下的取代基:NH2、OH、SH、卤素和直链或支链的C1-至C6-烷基基团;
直链或支链的C1-至C6-烷氧基基团,其任选载有1、2、3或4个相同或不同的选自以下的取代基:NH2、OH、SH、卤素和C1-至C6-烷氧基基团;
单环或多环芳基、芳基烷基和杂芳基基团,其任选载有1、2、3或4个相同或不同的选自以下的取代基:NH2、OH、SH、卤素、直链或支链的C1-至C6-烷基基团;其中所述杂芳基基团含有1、2、3或4个相同或不同的且选自O、N和S的环杂原子,或
两个相邻的R3、R4、R5、R6和R7基团与它们所键合的碳原子一起形成4-、5-、6-或7-元单-或多不饱和的杂环,其任选载有1、2、3、4或5个相同或不同的选自直链或支链的C1-至C6-烷基基团的取代基,且含有1、2或3个相同或不同的且选自O、N和S的环杂原子;
X
-选自
-C1-至C4-亚烷基基团;-C2-至C4-亚烯基基团和-A-C1-至C4-或-C1-至C4-A-亚烷基基团或–A-C2-至C4-或-C2-至C4-A-亚烯基基团,其中A是O、S或NH;或
-是化学单键;
和这些化合物的盐、尤其是与无机或特别是有机、一元和尤其多元羧酸的酸加成盐;
和任选的立体异构纯形式的这些化合物或其立体异构体的混合物。
在本发明的另一个优选实施方案中,结构类型1的化合物不选自由以下化合物组成的E组:
/>
/>
/>
/>
/>
/>
/>
/>
/>
/>
/>
/>
/>
/>
在本发明的一个可供选择的实施方案中,如上所述,D组化合物是在本发明范围内优选使用的化合物。
在另一个可供选择的实施方案中,如上所述的E组化合物是在本发明范围内优选使用的化合物。
在本发明的方法中,特别是在其优选的配置中,优选使受体与至少一种调节剂接触,所述调节剂在使用重组表达人TRPM8受体的细胞的细胞活性测试中调节这些细胞对Ca2+离子的渗透性。
在本发明的方法中,优选在上述优选的实施方案中,调节剂对细胞Ca2+离子渗透性具有激动或拮抗作用。
特别优选实施本发明的方法,特别是优选的配置,其中调节剂是TRPM8受体激动剂。
本发明的另一方面包括本发明的调节剂(特别是在一种或多种优选方法中)用于非治疗性诱导人和/或动物的冷感的用途。
优选地,上述用途中的本发明的这种调节剂优选用于通过包含该调节剂的包装(packing)或纺织品来非治疗性地诱导冷感。
在本发明用途的一种供选择方案中,优选使用包含至少一种、两种、三种或更多种本发明调节剂的组合物,尤其是优选配置的调节剂,优选以组合物的总重量计,(总)量为0.1ppm至10重量%,与其中仅仅调节剂被替换为N-乙基薄荷烷甲酰胺的相同组成的组合物的清凉效果相比,优选在相同的浓度下,在皮肤或粘膜上实现优选延长的清凉效果,优选延长至少10分钟,和/或与其中仅仅调节剂被替换为FEMA 4809或FEMA 4496的相同组成的组合物的清凉效果相比,优选在相同的浓度下,更早出现清凉效果。
为了量化根据本发明使用的化合物的持久的清凉效果,优选使用N-乙基薄荷烷-3-甲酰胺(如上所述)进行对比实验。
优选地,对于优选的用途之一,本发明的一种或多种调节剂分别选自已经描述的A组、B组或C组,或在另一个实施方案中选自D组或E组。
本发明的另一方面涉及如上所述的调节剂,其用作TRPM8受体的调节剂,优选用于调节TRPM8受体的治疗方法。
本发明另外涉及结构类型1的新化合物本身。更特别地,本发明涉及本文分别描述的选自A组、B组或C组、或D组或E组的化合物,或此类化合物的盐,特别是选自与无机酸或尤其与有机、一元或尤其是多元羧酸形成的酸加成盐。
不管本文所述的用途如何,本发明还涉及包含结构类型1的新型化合物特别是选自本文分别所述的A组、B组或C组、或D组或E组的化合物的组合物。
本发明的另一方面涉及包含至少一种如上所述的调节剂的组合物,其用作TRPM8受体的调节剂,优选用于调节TRPM8受体的治疗方法。
在一个优选的实施方案中,本发明的这种组合物用作TRPM8受体的调节剂,优选用于调节TRPM8受体的治疗方法,其选自:
a)食品,优选冰淇淋、慕斯、奶油、饮料和糖果,
b)口腔护理产品,优选牙膏、漱口水和口香糖,
c)个人护理产品,优选护肤或护发产品,例如防晒霜、晒斑霜、乳液和洗发剂以及贴剂,
d)泡沫和凝胶。
在一个特别优选的实施方案中,本发明的组合物用作TRPM8受体的调节剂,优选用于调节TRPM8受体的治疗方法,特别是在上述优选的实施方案中,其选自:用于营养、口腔卫生或娱乐目的的芳香混合物和制剂或美容化妆品制剂,其包含一种、两种、三种或更多种上述调节剂,其中以香料混合物或制剂的总重量为基准计,所述一种或多种调节剂的(总)量为0.05ppm-10重量%,优选0.1ppm-10重量%。
优选地,用作TRPM8受体调节剂优选用于调节TRPM8受体的治疗方法的本发明组合物,还包含:
(1)具有生理清凉作用的一种或多种其他物质,其中该其他物质或一种、多于一种或全部所述其他物质(i)引起调味作用,或(ii)不会引起调味作用,
和/或
(2)一种或多种没有生理清凉作用的芳香物
和/或
(3)一种或多种具有三叉神经或令人垂涎作用而没有生理清凉作用的物质
和/或
(4)(iii)一种化合物或(iv)两种或更多种化合物,其(在情况(iv)中独立地或共同地)另外引起风味调节作用和/或三叉神经和/或令人垂涎的刺激。
具有生理清凉作用的其他物质包括例如WO 2014/090293 A1中所述的那些,优选薄荷醇、薄荷醇化合物、Optamint或薄荷油。
薄荷醇化合物优选选自薄荷醇、薄荷基甲基醚、薄荷酮甘油缩醛(MGA、FEMA GRAS 3807)、薄荷酮甘油缩酮(FEMA GRAS 3808)、乳酸薄荷酯/>ML,FEMAGRAS 3748),薄荷醇乙二醇碳酸酯(/>MGC,FEMA GRAS 3805)、薄荷醇丙二醇碳酸酯(/>MPC,FEMA GRAS 3806)、N-乙基草酸薄荷酯/>琥珀酸单薄荷酯(FEMA GRAS 3810)、戊二酸单薄荷酯(FEMA GRAS 4006),薄荷醇基-1,2-丙二醇(FEMA GRAS3784)、薄荷醇基-2-甲基-1,2-丙二醇(FEMA GRAS 3849)和薄荷烷羧酸酯和羧酰胺,例如WS-3(FEMA GRAS 3455)、WS-5(FEMA GRAS 4309)、WS-12(/>SC-1,FEMA GRAS4681)和WS-23(FEMA GRAS 3804)及其混合物。
Optamint是50多种不同的天然精油和天然或与自然相同的芳香物的混合物。Optamint具有多种(部分分馏)的油的可变组成,这些油优选是例如不同的薄荷油和留兰香油、桉树(Eucalyptus globulus)油、八角茴香油、薄荷醇、薄荷酮、异薄荷酮、乙酸薄荷酯、茴香脑、桉油精等的混合物。因此,不能确切说明Optamint的组成。产品系列可从Symrise AG商购获得。
在本发明的调节剂的应用特别是在一种或多种优选方法中的一个优选实施方案中,用于非治疗性地诱导人和/或动物的冷感,以实现对皮肤和/或粘膜的生理清凉效果,与其中仅仅调节剂被替换为N-乙基薄荷烷甲酰胺的相同组成的组合物的清凉效果相比,优选在相同的浓度下,清凉效果被延长至少10分钟,和/或与其中仅仅调节剂被替换为FEMA4809或FEMA 4496的相同组成的组合物的清凉效果相比,优选在相同的浓度下,更早出现清凉效果,其包括以下步骤:
施用一定量的如上所述的组合物,尤其是在一个或多个优选的实施方案中,其足以对皮肤和/或粘膜实现生理清凉效果。
更优选地,在本发明的这种用途中的一种或多种调节剂选自上述A组。
本发明的活性物质在人类美容化妆品和护理特别是在护肤和护发中具有广泛的用途,但也可在药理学、食品和纺织品中使用,还可以用作驱虫剂和杀虫组合物的成分。
本发明的组合物尤其可以是皮肤美容化妆品,头发美容化妆品,皮肤病学、卫生或药物产品。更特别地,特别是具有清凉作用的本发明的活性物质被用于皮肤美容化妆品和/或头发美容化妆品或作为口腔护理组合物。
本发明的护发或护肤组合物或制剂特别是乳剂、分散体、混悬液的形式,含水(aqueous)表面活性剂制剂、乳、乳液、乳膏、香脂、软膏、凝胶、颗粒、粉末、棒制剂例如口红、泡沫、气雾剂或喷雾剂的形式。这样的制剂高度适合于局部制剂。合适的乳剂是水包油乳剂和油包水乳剂或微乳剂。
通常,头发或皮肤美容化妆品制剂用于施用于皮肤(局部)或头发。在本文中,“局部制剂”应理解为是指适合例如以可通过皮肤吸收的形式精细分布地将活性物质施用于皮肤的那些制剂。为此目的的合适实例是水溶液和含水醇溶液、喷雾剂、泡沫、泡沫气雾剂、软膏、含水凝胶、O/W或W/O型乳剂、微乳剂或美容化妆品棒制剂。
在本发明的美容化妆品组合物的一个实施方案中,其包含载体。优选的载体是水、气体、水基液体、油、凝胶、乳剂或微乳剂、分散体或其混合物。指定的载体表现出良好的皮肤相容性。含水凝胶、乳剂或微乳剂对于局部制剂特别有利。
本发明的教导还包括本文所述的活性物质在药物产品中的用途,所述药物产品用于治疗个体优选哺乳动物,尤其是人、农场动物或家养动物。为此目的,活性物质以药物组合物的形式施用,所述药物组合物包含药学上相容的赋形剂以及至少一种本发明的活性物质和任选的其他活性物质。这些组合物可以例如通过口服、直肠、透皮、皮下、静脉内、肌内或鼻内途径施用。
合适的药物制剂或组合物的实例是固体药物形式,例如散剂、颗粒剂、片剂、锭剂、香囊剂、扁囊剂、糖衣片、胶囊例如硬和软明胶胶囊、栓剂或阴道药物形式,半固体药物形式例如软膏、乳膏、水凝胶、糊剂或贴剂,以及液体药物形式例如溶液剂、乳剂尤其是水包油乳剂、混悬液,例如洗剂、注射和输注制剂、滴眼剂和滴耳剂。植入的释放装置也可用于施用本发明的抑制剂。另外,也可以使用脂质体、微球或聚合物基质。
在生产本发明的产品或制剂或组合物中,通常将本发明的活性物质与赋形剂混合或用赋形剂稀释。赋形剂可以是固体、半固体或液体材料,它们用作活性物质的溶媒、载体或介质。(同时存在的本发明的一种或多种活性物质的)活性成分含量可以在很宽的范围内变化,例如,在每种情况下,基于组合物的总重量,在约0.05ppm至10重量%,优选0.1ppm至10重量%的ppm范围。
合适的赋形剂包括例如乳糖、右旋糖、蔗糖、山梨醇、甘露醇、淀粉、阿拉伯胶、磷酸钙、藻酸盐、黄蓍胶、明胶、硅酸钙、微晶纤维素、聚乙烯吡咯烷酮、纤维素、水、糖浆和甲基纤维素。另外,所述制剂可以包含药学上可接受的载体或常规助剂,例如润滑剂,例如牛脂、硬脂酸镁和矿物油;润湿剂;乳化剂和助悬剂;防腐剂,例如羟基苯甲酸甲酯和羟基苯甲酸丙酯;抗氧化剂;抗刺激剂;螯合剂;包衣助剂;乳液稳定剂;成膜剂;凝胶形成剂;气味掩蔽剂;味道矫正剂;树脂;水胶体;溶剂;增溶剂;中和剂;渗透促进剂;颜料;季铵化合物;加脂剂和超脂剂;软膏、乳膏或油性基质;硅酮衍生物;散布助剂;稳定剂;消毒剂;栓剂基质;压片助剂,例如粘合剂、填充剂、润滑剂、崩解剂或包衣;抛射剂;干燥剂;遮光剂;增稠剂;蜡;增塑剂;白油。这种配置基于专业知识,例如在Fiedler,H.P.Lexikon der Hilfsstoffe fürPharmazie,Kosmetik und angrenzende Gebiete[Lexicon of Auxiliaries forPharmacy,Cosmetic and Related Fields],4th edition,Aulendorf:ECV-Editio-Kantor-Verlag,1996,或Hager’s Handbuch der Pharmazeutischen Praxis[Hager’sHandbook of Pharmaceutical Practice],Springer Verlag,Heidelberg中所述。
除了常规的添加剂或助剂,本发明的组合物可以另外包含美容化妆品和/或皮肤病学和/或药理学活性物质。
合适的其他活性物质的非限制性实例包括:
合适的美容化妆品和/或皮肤病学活性物质是例如着色活性剂、皮肤和头发色素沉着剂、着色剂、褐化剂、漂白剂、角蛋白硬化物质、抗微生物活性物质、光过滤活性物质、驱虫活性物质、充血性物质、角质分解和角质形成物质、去头皮屑活性物质、消炎剂、角质化物质、抗氧化剂活性物质和充当自由基清除剂的活性物质、皮肤保湿或湿润物质、加脂活性物质、抗红斑或抗过敏活性物质、支链脂肪酸(例如18-甲基二十二烷酸)及其混合物。
适于褐化皮肤而不需紫外线自然或人工照射的人造褐化活性物质;这些是例如二羟基丙酮、四氧嘧啶和胡桃壳提取物。合适的角蛋白硬化物质通常也是止汗剂中使用的活性物质,例如硫酸铝钾、羟基氯化铝、乳酸铝等。
用于破坏微生物或抑制其生长的抗微生物活性物质。因此,它们既用作防腐剂和降低体臭的发展或强度的除臭物质。这些包括例如本领域技术人员已知的常规防腐剂,例如对羟基苯甲酸酯、咪唑烷基脲、甲醛、山梨酸、苯甲酸、水杨酸等。这类除臭物质的实例包括蓖麻油酸锌、三氯生、undecylenoic acid、烷醇酰胺、柠檬酸三乙酯、洗必太等
用于生产毛发美容化妆品或皮肤美容化妆品制剂的合适的助剂和添加剂是本领域技术人员已知的,并且可以在美容化妆品手册中找到,例如Schrader,Grundlagen undRezepturen der Kosmetika[Fundamentals and Formulations of Cosmetics],HüthigVerlag,Heidelberg,1989,ISBN 3-7785-1491-1。助剂和添加剂优选是美容化妆品和/或药学上可接受的助剂。药学上可接受的助剂是已知在药学、食品技术和相关领域中使用的助剂,特别是在相关药典(例如DAB,Ph.Eur.,BP,NF)中列出的那些以及性能不排除生理应用的其他助剂。
合适的助剂可以是:润滑剂、润湿剂、乳化剂和助悬剂、防腐剂、抗氧化剂、抗刺激剂、螯合剂、乳剂稳定剂、成膜剂、凝胶形成剂、气味掩蔽剂、水胶体、溶剂、增溶剂、中和剂、渗透促进剂、颜料、季铵化合物、加脂剂和超脂剂、软膏、乳霜或油基、硅酮衍生物、稳定剂、消毒剂、抛射剂、干燥剂、遮光剂、增稠剂、蜡、增塑剂、白油。这种配置基于专业知识,例如在Fiedler,H.P.Lexikon der Hilfsstoffe für Pharmazie,Kosmetik und angrenzendeGebiete,4th ed.,Aulendorf:ECV-Editio-Kantor-Verlag,1996中所述。
其他合适的添加剂选自香料油、头发聚合物、头发和皮肤调理剂、接枝聚合物、水溶性或可分散的含硅酮聚合物、光稳定剂、漂白剂、护理剂、染色剂、着色剂、褐化剂、染料、稠化剂、保湿剂、加脂剂、胶原蛋白、蛋白质水解物、脂质、抗氧化剂、消泡剂、抗静电剂、润肤剂、增塑剂、过氧化物分解剂。
合适的助剂和添加剂的例子包括:
(1)抗氧化剂,其选自氨基酸(例如甘氨酸、组氨酸、酪氨酸、色氨酸)及其衍生物、咪唑(例如尿烷酸)及其衍生物,肽如D,L-肌肽、D-肌肽、L-肌肽及其衍生物(例如鹅肌肽)、类胡萝卜素、胡萝卜素(例如β-胡萝卜素、番茄红素)及其衍生物、绿原酸及其衍生物、硫辛酸及其衍生物(例如二氢硫辛酸)、金硫葡萄糖、丙硫氧嘧啶和其他硫醇(例如硫氧还蛋白、谷胱甘肽、半胱氨酸、胱氨酸、胱胺和其糖基、N-乙酰基、甲基、乙基、丙基、戊基、丁基和月桂基、棕榈酰基、油基、γ-亚油基、胆固醇和甘油基酯)及其盐、二月桂基硫代二丙酸酯、二硬脂基硫代二丙酸酯、硫代二丙酸及其衍生物(酯、醚、肽、脂质、核苷酸、核苷和盐)和亚砜亚胺化合物(例如丁硫氨酸亚砜亚胺、同型半胱氨酸亚砜亚胺、丁硫氨酸砜、戊-、己-、庚-硫氨酸亚砜亚胺),特别是在很小的耐受剂量下(例如pmol至μmol/kg的范围)、以及(金属)螯合剂(例如,α-羟基脂肪酸、棕榈酸、植酸、乳铁蛋白)、α-羟基酸(例如柠檬酸、乳酸、苹果酸)、腐殖酸、胆汁酸、胆汁提取物、胆红素、胆绿素、EDTA及其衍生物、不饱和脂肪酸及其衍生物(例如γ-亚麻酸、亚油酸、油酸)、叶酸及其衍生物、泛醌和泛醇及其衍生物、维生素C及其衍生物(例如抗坏血酸钠、棕榈酸抗坏血酸酯、磷酸抗坏血酸镁、乙酸抗坏血酸酯)、生育酚及其衍生物(例如乙酸维生素E、生育三烯酚)、维生素A及其衍生物(维生素A棕榈酸酯)和安息香的松柏基苯甲酸酯、芸香酸及其衍生物、α-糖基rutine、阿魏酸、亚糠基山梨醇、肌肽、丁基羟基甲苯、丁基羟基茴香醚、去甲二氢愈创木脂酸(nordihydroguaiac resin acid)、去甲二氢愈创木酸(nordihydroguaiaretic acid)、三羟基丁苯甲酮、尿酸及其衍生物、甘露糖及其衍生物、锌及其衍生物(例如ZnO、ZnSO4)、硒及其衍生物(例如硒代甲硫氨酸)、二苯乙烯及其衍生物(例如氧化二苯乙烯、反式-氧化二苯乙烯)。
(2)过氧化物分解剂,即能够分解过氧化物更优选脂质过氧化物的化合物。这些被理解为是指有机物质,例如吡啶-2-硫醇-3-甲酸、2-甲氧基嘧啶醇甲酸类、2-甲氧基吡啶甲酸类、2-二甲基氨基嘧啶醇甲酸类、2-二甲基氨基吡啶甲酸类。
(3)增稠剂,例如交联的聚丙烯酸及其衍生物;多糖及其衍生物,例如黄原胶、琼脂、藻酸盐或酪醇、纤维素衍生物,例如羧甲基纤维素或羟羧甲基纤维素、脂肪醇、甘油单酸酯和脂肪酸、聚乙烯醇和聚乙烯吡咯烷酮。特别地,使用非离子增稠剂。
(4)下列防腐剂,具有如下E号:
E 200 | 山梨酸 | E 227 | 亚硫酸氢钙 |
E 201 | 山梨酸钠 | E 228 | 亚硫酸氢钾 |
E 202 | 山梨酸钾 | E 230 | 联苯(二苯) |
E 203 | 山梨酸钙 | E 231 | 邻苯基苯酚 |
E 210 | 苯甲酸 | E 232 | 邻苯基苯酚钠 |
E 211 | 苯甲酸钠 | E 233 | 噻苯哒唑 |
E 212 | 苯甲酸钾 | E 235 | 纳他霉素 |
E 213 | 苯甲酸钙 | E 236 | 甲酸 |
E 214 | 对羟基苯甲酸乙酯 | E 237 | 甲酸钠 |
E 215 | 对羟基苯甲酸乙酯钠盐 | E 238 | 甲酸钙 |
E 216 | 对羟基苯甲酸正丙酯 | E 239 | 六亚甲基四胺 |
E 217 | 对羟基苯甲酸正丙酯钠盐 | E 249 | 亚硝酸钾 |
E 218 | 对羟基苯甲酸甲酯 | E 250 | 亚硝酸钠 |
E 219 | 对羟基苯甲酸甲酯钠盐 | E 251 | 硝酸钠 |
E 220 | 二氧化硫 | E 252 | 硝酸钾 |
E 221 | 亚硫酸钠 | E 280 | 丙酸 |
E 222 | 亚硫酸氢钠 | E 281 | 丙酸钠 |
E 223 | 二亚硫酸钠 | E 282 | 丙酸钙 |
E 224 | 二亚硫酸钾 | E 283 | 丙酸钾 |
E 226 | 亚硫酸钙 | E 290 | 二氧化碳 |
根据本发明也合适的是美容化妆品中常用的防腐剂或防腐助剂,例如二溴二氰基丁烷(2-溴-2-溴甲基戊二腈)、丁基氨基甲酸3-碘-2-丙炔基酯、2-溴-2-硝基丙烷-1,3-二醇、咪唑烷基脲、5-氯-2-甲基-4-异噻唑啉-3-酮、2-氯乙酰胺、苯扎氯铵、苯甲醇、甲醛释放剂。
苯基羟烷基醚也适合作为防腐剂,特别是被称为苯氧乙醇名称的化合物,其对多种微生物的杀细菌和杀真菌作用。
其他抗微生物剂同样也适合掺入本发明的制剂中。有利的物质是例如2,4,4'-三氯-2'-羟基二苯醚(irgasan)、1,6-二(4-氯苯基双胍基)己烷(氯己定)、3,4,4'-三氯均二苯脲、季铵盐铵化合物、丁香油、薄荷油、百里香油、柠檬酸三乙酯、法尼醇(3,7,11-三甲基-2,6,10-十二碳三烯-1-醇)以及早期公开的专利说明书DE-37 40 186、DE 39 38 140、DE-42 04 321、DE-42 29 707、DE-43 09 372、DE-44 11 664、DE-195 41 967、DE-195 43 695、DE-195 43 696、DE-195 47 160、DE-196 02 108、DE-196 02 110、DE 196 02 111、DE-19631 003、DE-196 31 004和DE-196 34 019以及专利说明书DE-42 29 737、DE-42 37 081、DE-43 24 219、DE-44 29 467、DE-44 23 410和DE-195 16 705中描述的活性物质或活性物质组合。也可以有利地使用碳酸氢钠。同样也可以使用抗微生物多肽。
(5)吸收UV-B和/或UV-A区域中的紫外线的光过滤活性物质。合适的UV滤光剂为例如2,4,6-三芳基-1,3,5-三嗪化合物,其中芳基在每种情况下可带有至少一个取代基,该取代基优选选自羟基、烷氧基特别是甲氧基、烷氧基羰基特别是甲氧羰基和乙氧羰基,及其混合物。另外合适的是对氨基苯甲酸酯、肉桂酸酯、二苯甲酮类、樟脑衍生物和阻止紫外线的颜料,例如二氧化钛、滑石粉和氧化锌。
有用的紫外线过滤物质包括任何所需的紫外线-A和紫外线-B过滤物质。
示例包括:
/>
/>
本发明的美容化妆品和皮肤病学组合物或制剂还可以有利地包含基于金属氧化物和/或其他微水溶性或水不溶性金属化合物的阻止紫外线的无机颜料,所述金属氧化物和/或其他微水溶性或水不溶性金属化合物选自以下金属的氧化物:锌(ZnO)、钛(TiO2)、铁(例如Fe2O3)、锆(ZrO2)、硅(SiO2)、锰(例如MnO)、铝(Al2O3)、铈(例如Ce2O3),相应金属的混合氧化物及所述氧化物的混合物。
此处的无机颜料可以是被涂覆的形式,即可以进行表面处理。这种表面处理可以例如包括通过本身已知的方法为颜料提供薄的疏水层,如DE-A-33 14 742中所述。
(6)驱虫活性物质,即能够抵御或驱赶某些动物特别是昆虫远离人类的化合物。这些包括例如2-乙基-1,3-己二醇、N,N-二乙基-m-甲苯酰胺。
(7)刺激皮肤灌注的合适的充血物质例如是精油,例如矮松树提取物、薰衣草提取物、迷迭香提取物、杜松子提取物、烤栗子提取物、桦树叶提取物、干草种子提取物、乙酸乙酯、樟脑、薄荷醇、薄荷油、迷迭香提取物、桉树油等。
(8)合适的角质分解和角质形成物质是例如水杨酸、巯基乙酸钙、巯基乙酸及其盐、硫等。合适的去头皮屑活性物质是例如硫、硫聚乙二醇脱水山梨糖醇单油酸酯、硫ricinol聚乙氧基化物、吡啶硫酮锌、吡啶硫酮铝等。
(9)对抗皮肤刺激的合适的消炎剂是例如尿囊素、没药醇、Dragosantol、甘菊提取物、泛醇等。
(10)美容化妆品或药学上可接受的聚合物例如阳离子、两性和不带电荷的聚合物。
合适的聚合物是例如INCI名称为Polyquaternium的阳离子聚合物,例如乙烯基吡咯烷酮/N-乙烯基咪唑鎓盐的共聚物(Luviquat FC,Luviquat HM,Luviquat MS,LuviquatCare)、N-乙烯基吡咯烷酮/甲基丙烯酸二甲氨基乙基酯的共聚物,用硫酸二乙酯季化(Luviquat PQ 11)、N-乙烯基己内酰胺/N-乙烯基吡咯烷酮/N-乙烯基咪唑鎓盐的共聚物(Luviquat E Hold)、阳离子纤维素衍生物(Polyquaternium-4和-10)、丙烯酰胺共聚物(Polyquaternium-7)和壳聚糖。
合适的阳离子(季铵化)聚合物还为Merquat(基于二甲基二烯丙基氯化铵的聚合物)、Gafquat(通过聚乙烯吡咯烷酮与季铵化合物反应形成的季聚合物)、聚合物JR(具有阳离子基团的羟乙基纤维素)和基于植物的阳离子聚合物,例如瓜尔胶聚合物,例如来自Rhodia的Jaguar产品。
其他合适的聚合物还为不带电荷的聚合物,例如聚乙烯基吡咯烷酮、N-乙烯基吡咯烷酮与乙酸乙烯酯和/或丙酸乙烯酯的共聚物、聚硅氧烷、聚乙烯基己内酰胺以及与N-乙烯基吡咯烷酮的其他共聚物、聚乙烯亚胺及其盐、聚乙烯胺及其盐、纤维素衍生物、聚天冬氨酸盐及其衍生物。这些包括例如Swing(聚乙酸乙烯酯和聚乙二醇的部分皂化的共聚物,BASF)。
合适的聚合物也是非离子的、水溶性或水分散性的聚合物或低聚物,例如聚乙烯基己内酰胺,例如Plus(BASF),或聚乙烯吡咯烷酮及其共聚物,尤其是与乙烯基酯(例如醋酸乙烯酯)的共聚物,例如/>VA 37(BASF);聚酰胺,例如基于衣康酸和脂肪族二胺的聚酰胺,例如DE-A-43 33 238中所述。
合适的聚合物也是两亲或两性离子聚合物,例如可以以名称Amphomer(NationalStarch)获得的辛基丙烯酰胺/甲基丙烯酸甲酯/甲基丙烯酸叔丁基氨基乙基酯/甲基丙烯酸羟丙酯共聚物,以及两性离子聚合物,例如在德国专利申请DE 39 29 973、DE 21 50557、DE 28 17 369和DE 37 08 451中公开的。丙烯酰氨基丙基三甲基氯化铵/丙烯酸或甲基丙烯酸共聚物及其碱金属盐和铵盐是优选的两性离子聚合物。其他合适的两性离子聚合物是甲基丙烯酰基乙基甜菜碱/甲基丙烯酸酯共聚物,其以Amersette名称(AMERCHOL)可商购,以及甲基丙烯酸羟乙酯、甲基丙烯酸甲酯、甲基丙烯酸N,N-二甲基氨基乙基酯和丙烯酸的共聚物(Jordapon(D))。
合适的聚合物也是非离子的、含硅氧烷的、水溶性的或水分散性的聚合物,例如,聚醚硅氧烷,例如(Goldschmidt)或Besi(Wacker)。
下面通过举例的方式详细阐明本发明的活性物质的各个特定使用形式。
清凉的护肤和护发产品:
在一个优选的实施方案中,本发明的组合物是清凉的护发或护肤产品或皮肤清洁剂或洗发剂。
优选的皮肤清洁剂或洗发剂是液体至凝胶稠度的肥皂,例如透明肥皂、豪华肥皂、除臭肥皂、乳霜肥皂、婴儿肥皂、皮肤保护肥皂、研磨性肥皂和合成洗涤剂(syndet)、糊状肥皂、多脂肥皂和洗洁膏、去角质肥皂、保湿湿巾、液体洗涤、淋浴和沐浴制剂,例如乳液、淋浴和凝胶、泡沫浴、油浴和磨砂制剂、剃须泡沫、乳液和乳霜。
在另一个优选的实施方案中,本发明的组合物是沐浴露、洗发剂或沐浴剂。这种类型的制剂包含至少一种本发明的活性剂,并且典型地包括作为基础表面活性剂的阴离子表面活性剂以及作为辅助表面活性剂的两性和/或非离子表面活性剂。其他合适的活性剂和/或助剂通常选自脂质、香料油、染料、有机酸、防腐剂和抗氧化剂、以及增稠剂/凝胶形成剂、皮肤调理剂和保湿剂。
原则上,活性成分的含量可以在宽的范围内变化,例如0.05ppm至10重量%,优选0.1ppm至10重量%。
i)用于应用至皮肤的组合物的具体配置:
合适的皮肤美容化妆品组合物是例如面部补品、面膜、除臭剂和其他美容化妆品乳液。用于装饰性美容化妆品的产品包括例如遮瑕棒、舞台化妆品、睫毛膏和眼影膏、口红、眼线笔、眼线膏、腮红、粉和眉笔。
此外,本发明的皮肤病学组合物可用于孔清洁的鼻条、抗痤疮组合物、驱虫剂、剃须组合物、剃须后和剃须前护理组合物、晒后护理组合物、脱毛组合物、染发剂、私密护理组合物、足部护理组合物和婴儿护理。
本发明的护肤组合物尤其是W/O或O/W护肤霜、日霜和晚霜、眼霜、面霜、抗皱霜、防晒霜、保湿霜、漂白霜、自褐化霜、维生素霜、皮肤乳液、护理乳液和保湿乳液。
皮肤美容化妆品和皮肤病学组合物特别地包含至少一种本发明的活性物质,基于组合物的总重量其比例为约0.05ppm至10重量%,优选为0.1ppm至10重量%。
根据应用领域,本发明的皮肤美容化妆品组合物可以以适合于护肤的形式施用,例如以乳霜、泡沫、凝胶、棒、摩丝、乳、喷雾剂(泵喷雾剂或含有抛射剂的喷雾剂)或乳液的形式施用。
除了本发明的活性物质和合适的载体之外,皮肤美容化妆品制剂还可以包含皮肤美容化妆品中常规的其他活性物质和助剂,如上所述。这些优选包括乳化剂、防腐剂、香料油、美容化妆品活性物质如植烷三醇、维生素A、E和C、视黄醇、没药醇、泛醇、光稳定剂、漂白剂、染色剂、着色剂、褐化剂、胶原蛋白、酶、蛋白质水解物、稳定剂、pH调节剂、染料、盐、增稠剂、凝胶形成剂、稠化剂、硅酮、保湿剂、加脂剂和其他常规添加剂
皮肤美容化妆品和皮肤病学组合物中优选的油和脂组分是上述矿物油和合成油,例如石蜡、硅油和具有大于8个碳原子的脂族烃、动物和植物油例如向日葵油、椰子油、鳄梨油、橄榄油、羊毛脂或蜡、脂肪酸、脂肪酸酯例如C6-至C30脂肪酸的三酸甘油酯、蜡酯(例如荷荷巴油)、脂肪醇、凡士林、氢化羊毛脂和乙酰化羊毛脂及其混合物。
为了建立特定的性质,例如改善触感、铺展性、耐水和/或活性物质和助剂例如颜料的结合,皮肤美容化妆品和皮肤病学制剂还可另外包含基于硅酮化合物的调理物质。合适的硅酮化合物是例如聚烷基硅氧烷、聚芳基硅氧烷、聚芳基烷基硅氧烷、聚醚硅氧烷或硅酮树脂。
美容化妆品或皮肤病学制剂通过本领域技术人员已知的常规方法生产。
本发明的皮肤病学组合物可以通过将活性物质与合适的助剂(赋形剂)混合或稀释来制备。赋形剂可以是固体、半固体或液体材料,它们可以用作活性物质的溶媒、载体或介质。如果需要,以本领域技术人员已知的方式添加其他助剂。另外,所述聚合物和分散体适合作为药学中的助剂,优选作为固体药物形式的包衣或粘合剂或用于固体药物形式的包衣或粘合剂中。它们还可以用于乳膏,作为片剂包衣和片剂粘合剂。
优选地,美容化妆品和皮肤病学组合物为乳剂形式,特别是油包水(W/O)或水包油(O/W)乳剂。但是,也可以选择其他类型的制剂,例如凝胶剂、油剂、油凝胶剂、多重乳剂,例如W/O/W或O/W/O乳剂、无水软膏或软膏基质。不含乳化剂的制剂例如水分散体、水凝胶或Pickering乳剂也是有利的实施方案。
乳剂通过已知方法生产。除本发明的至少一种活性剂外,乳剂中通常包含常规成分,例如脂肪醇、脂肪酸酯,尤其是脂肪酸甘油三酸酯、脂肪酸、羊毛脂及其衍生物、天然或合成油或蜡和乳化剂(在水存在下)。特定于乳剂类型的添加剂的选择和合适乳剂的生产例如描述于Schrader,Grundlagen und Rezepturen der Kosmetika,Hüthig Buch Verlag,Heidelberg,,1989,第三部分,在此通过引用明确地并入本文。
W/O乳剂形式的合适乳剂,例如用于护肤霜等,通常包含使用合适的乳化剂系统在油相或脂肪相中乳化的水相。为了提供水相,可以使用聚电解质复合物。
可能存在于乳剂的脂肪相中的优选的脂肪组分是:烃油,例如石蜡油、purcellin油、过氢角鲨烯和在这些油中的微晶蜡溶液;动物或植物油,例如甜杏仁油、鳄梨油、calophyllum油、羊毛脂及其衍生物、蓖麻油、芝麻油、橄榄油、荷荷巴油、karité油、hoplostethus油;在大气压下蒸馏起始点为约250℃且蒸馏终止点为410℃的矿物油,例如凡士林油;饱和或不饱和脂肪酸的酯,例如肉豆蔻酸烷基酯,例如肉豆蔻酸异丙酯、肉豆蔻酸丁基酯或肉豆蔻酸十六烷基酯、硬脂酸十六烷基酯、棕榈酸乙酯或棕榈酸异丙酯、辛酸或癸酸甘油三酸酯和蓖麻酸十六烷基酯。
脂肪相还可包含可溶于其他油中的硅油,例如二甲基聚硅氧烷、甲基苯基聚硅氧烷和硅酮二醇共聚物、脂肪酸和脂肪醇。
除了本发明的活性物质外,还可以使用蜡例如巴西棕榈蜡、小烛树蜡、蜂蜡、微晶蜡、地蜡、以及钙、镁和铝的油酸盐,钙、镁和铝的肉豆蔻酸盐,钙、镁和铝的亚油酸盐以及钙、镁和铝的硬脂酸盐。
另外,本发明的乳剂可以采取O/W乳剂的形式。这种乳剂通常包含油相、使油相稳定在水相中的乳化剂和通常呈增稠形式的水相。有用的乳化剂优选为O/W乳化剂,例如聚甘油酯、脱水山梨糖醇酯或部分酯化的甘油酯。
在另一个优选的实施方案中,本发明的组合物是沐浴露、洗发剂或沐浴剂。
这种类型的制剂包含至少一种本发明的活性剂,并且典型地包含作为基础表面活性剂的阴离子表面活性剂以及作为辅助表面活性剂的两性和/或非离子表面活性剂。其他合适的活性剂和/或助剂通常选自脂质、香料油、染料、有机酸、防腐剂和抗氧化剂、以及增稠剂/凝胶形成剂、皮肤调理剂和保湿剂。
这些制剂特别包含基于制剂总重量的2重量%至50重量%、例如5重量%至40重量%、或8重量%至30重量%的表面活性剂。
在洗涤、淋浴和沐浴制剂中,可以使用通常用于个人清洁剂中的任何阴离子、不带电、两性或阳离子表面活性剂。
合适的阴离子表面活性剂是例如烷基硫酸盐、烷基醚硫酸盐、烷基磺酸盐、烷基芳基磺酸盐、烷基琥珀酸盐、烷基磺基琥珀酸盐、N-烷酰基肌氨酸盐、酰基牛磺酸盐、酰基羟乙基磺酸盐、烷基磷酸盐、烷基醚磷酸盐、烷基醚羧酸盐、α-烯烃磺酸盐,特别是碱金属和碱土金属盐,例如钠、钾、镁、钙、铵和三乙醇胺盐。烷基醚硫酸盐、烷基醚磷酸盐和烷基醚羧酸盐在分子中可具有1-10个环氧乙烷或环氧丙烷单元,优选1-3个环氧乙烷单元。
这些包括例如月桂基硫酸钠、月桂基硫酸铵、月桂基醚硫酸钠、月桂基醚硫酸铵、月桂基肌氨酸钠、油基琥珀酸钠、月桂基磺基琥珀酸钠、十二烷基苯磺酸钠、十二烷基苯磺酸三乙醇胺盐。
合适的两性表面活性剂是例如烷基甜菜碱、烷基酰氨基丙基甜菜碱、烷基磺基甜菜碱、烷基甘氨酸盐、烷基羧基甘氨酸盐、烷基两性乙酸盐或烷基两性丙酸盐、烷基两性二乙酸盐或烷基两性二丙酸盐。
例如,可以使用椰油基二甲基磺基丙基甜菜碱、月桂基甜菜碱、椰油酰氨基丙基甜菜碱或椰油基两性丙酸钠。
合适的非离子表面活性剂的实例是在可为直链或支链的烷基链中具有6至20个碳原子的脂族醇或烷基酚与环氧乙烷和/或环氧丙烷的反应产物。环氧烷的量为每摩尔醇约6至60摩尔。另外,合适的是烷基胺氧化物、单或二烷基烷醇酰胺、聚乙二醇的脂肪酸酯、乙氧基化的脂肪酸酰胺、烷基多糖苷或脱水山梨醇醚酯。
洗涤、淋浴和沐浴制剂还可以包含常规的阳离子表面活性剂,例如季铵化合物,例如十六烷基三甲基氯化铵。
另外,沐浴露/洗发剂制剂可包含增稠剂,例如氯化钠、PEG 55、丙二醇油酸酯、PEG120甲基葡萄糖二油酸酯和其他,以及防腐剂、其他活性剂和助剂以及水。
ii)用于头发的组合物的具体配置:
在另一个优选的实施方案中,本发明的组合物是头发处理组合物。
基于组合物的总重量,本发明的头发处理组合物特别包含至少一种本发明的活性物质,其量为约0.05ppm至10重量%,优选0.1ppm至10重量%。
优选地,本发明的头发处理组合物采取定型泡沫、头发摩丝、发胶、洗发剂、喷发剂、头发泡沫、端液(end fluid)、用于永久波的中和剂,染发剂和漂白剂或热油处理的形式。根据应用领域,可以以(气溶胶)喷雾剂、(气溶胶)泡沫剂、凝胶、凝胶喷雾剂、乳霜、乳液或蜡的形式施用毛发美容化妆品制剂。喷发剂既包括气溶胶喷雾剂,又包括不含抛射剂气体的泵喷雾剂。头发泡沫既包括气溶胶泡沫,又包括不含抛射剂气体的泵送泡沫。喷发剂和头发泡沫优选主要或仅包含水溶性或水分散性组分。如果用于本发明的喷发剂和头发泡沫中的化合物是水分散性的,则它们可以以粒径通常为1-350nm,优选1-250nm的含水微分散体的形式使用。这些制剂的固体含量通常在约0.5ppm至20重量%的范围内。这些微分散体通常不需要任何乳化剂或表面活性剂来使其稳定。
在一个具体的实施方案中,本发明的头发美容化妆品制剂包括:a)0.0001重量%至50重量%或0.001重量%至10重量%或0.005重量%至1重量%的本发明的至少一种活性物质,b)20重量%至99.95重量%的水和/或醇,c)0重量%至50重量%至少一种抛射剂气体,d)0重量%至5%重量的至少一种乳化剂,e)0%至3%重量的至少一种增稠剂,和至多25%重量的其他组分。
“醇”应理解为是指美容化妆品中惯用的任何醇,例如乙醇、异丙醇、正丙醇。
这里还包括美容化妆品中已知的所有定型和调理聚合物,如果要建立非常特定的性能,它们可以与本发明的活性物质结合使用。
合适的常规头发美容化妆品聚合物是例如前述的阳离子、阴离子、不带电、非离子和两性聚合物,在此将其引用。
为了建立某些性质,所述制剂还可以另外包含基于硅酮化合物的调理物质。合适的硅酮化合物是例如聚烷基硅氧烷、聚芳基硅氧烷、聚芳基烷基硅氧烷、聚醚硅氧烷、硅酮树脂或聚二甲基硅氧烷共聚多元醇(CTFA)和氨基官能的硅酮化合物如氨基聚二甲基硅氧烷(amodimethicones)(CTFA)。
本发明的聚合物特别适合在头发定型制剂尤其是喷发剂(气溶胶喷雾剂和无抛射剂气体的泵喷雾剂)和毛发摩丝(气溶胶摩丝和无抛射剂气体的泵摩丝)中用作定型剂。
在一个优选的实施方案中,喷雾制剂包含a)0.0001重量%至50重量%或0.001重量%至10重量%或0.005重量%至1重量%的本发明的至少一种活性物质,b)20重量%至99.9重量%的水和/或醇;c)0%至70重量%的至少一种抛射剂,d)0%至20重量%的其他成分。
抛射剂是通常用于喷发剂或气溶胶泡沫的抛射剂。优选丙烷/丁烷的混合物、戊烷、二甲醚、1,1-二氟乙烷(HFC-152a)、二氧化碳、氮气或压缩空气。
根据本发明优选的用于气溶胶头发泡沫的制剂包含:a)0.0001重量%至50重量%或0.001重量%至10重量%或0.005重量%至1重量%的至少一种本发明的活性物质,b)55重量%至99.8%重量的水和/或醇,c)5重量%至20重量%的抛射剂,d)0.1重量%至5重量%的乳化剂,e)0重量%至10重量%的其他成分。
所使用的乳化剂可以是通常在头发泡沫中使用的任何乳化剂。合适的乳化剂可以是非离子、阳离子或阴离子或两性的。
非离子乳化剂(INCI命名法)的实例是月桂醇聚醚,例如Laureth-4;鲸蜡醇聚醚,例如Ceteth-1、聚乙二醇十六烷基醚;鲸蜡硬脂醇聚醚,例如Ceteareth-25、聚乙二醇脂肪酸甘油酯、羟基化卵磷脂、脂肪酸的乳酸酯、烷基多糖苷。
阳离子乳化剂的实例是十六烷基二甲基-2-羟乙基铵磷酸二氢盐、氯化十六烷基三铵、溴化十六烷基三铵,甲基硫酸椰油基三铵、Quaternium-1至x(INCI)。
阴离子乳化剂可选自例如烷基硫酸盐、烷基醚硫酸盐、烷基磺酸盐、烷基芳基磺酸盐、烷基琥珀酸盐、烷基磺基琥珀酸盐、N-烷酰基肌氨酸盐、酰基牛磺酸盐、酰基羟乙基磺酸盐、烷基磷酸盐、烷基醚磷酸盐、烷基醚羧酸盐、α-烯烃磺酸盐,特别是碱金属和碱土金属盐,例如钠、钾、镁、钙、铵和三乙醇胺盐。烷基醚硫酸盐、烷基醚磷酸盐和烷基醚羧酸盐在分子中可具有1-10个环氧乙烷或环氧丙烷单元,优选1-3个环氧乙烷单元。
根据本发明适合用于定型凝胶的制剂可以例如具有以下组成:a)0.0001重量%至50重量%或0.001重量%至10重量%或0.005重量%至1重量%的至少一种本发明的活性物质,b)80重量%至99.85重量%的水和/或醇,c)0%至3%重量,优选0.05%至2%重量的凝胶形成剂,d)0%至20%重量的其他成分。
为了建立凝胶的特定流变学或其他性能,使用凝胶形成剂可能是有利的。所使用的凝胶形成剂可以是美容化妆品中常规的任何凝胶形成剂。这些包括轻度交联的聚丙烯酸,例如卡波姆(INCI)、纤维素衍生物例如羟丙基纤维素、羟乙基纤维素、阳离子改性纤维素、多糖例如黄原胶、辛酸/癸酸甘油三酸酯,丙烯酸钠共聚物、Polyquaternium-32(和)石蜡油(Paraffinum Liquidum)(INCI)、丙烯酸钠共聚物(和)石蜡油(和)PPG-1Trideceth-6、氯化丙烯酰氨基丙基trimonium/丙烯酰胺共聚物,Steareth-10烯丙基醚丙烯酸酯共聚物、Polyquaternium-37(和)石蜡油(和)PPG-1Trideceth-6,Polyquaternium 37(和)丙二醇二癸酸酯二辛酸酯(和)PPG-1Trideceth-6、Polyquaternium-7、Polyquaternium-44。
具体的洗发剂制剂包含:a)0.0001重量%至50重量%或0.001重量%至10重量%或0.005重量%至1重量%的本发明的至少一种活性物质,b)25重量%至94.95重量%的水,c)5重量%至50重量%的表面活性剂,c)0重量%至5重量%的其他调理剂,d)0重量%至10重量%的其他美容化妆品成分。
在洗发剂制剂中,可以使用洗发剂中通常使用的任何阴离子、不带电、两性或阳离子表面活性剂。
合适的阴离子表面活性剂是例如烷基硫酸盐、烷基醚硫酸盐、烷基磺酸盐、烷基芳基磺酸盐、烷基琥珀酸盐、烷基磺基琥珀酸盐、N-烷酰基肌氨酸盐、酰基牛磺酸盐、酰基羟乙基磺酸盐、烷基磷酸盐、烷基醚磷酸盐、烷基醚羧酸盐、α-烯烃磺酸盐,特别是碱金属和碱土金属盐,例如钠、钾、镁、钙、铵和三乙醇胺盐。烷基醚硫酸盐、烷基醚磷酸盐和烷基醚羧酸盐在分子中可具有1-10个环氧乙烷或环氧丙烷单元,优选1-3个环氧乙烷单元。
例如,月桂基硫酸钠、月桂基硫酸铵、月桂基醚硫酸钠、月桂基醚硫酸铵、月桂基肌氨酸钠、油基琥珀酸钠、月桂基磺基琥珀酸钠、十二烷基苯磺酸钠、十二烷基苯磺酸三乙醇胺盐是合适的。
合适的两性表面活性剂是例如烷基甜菜碱、烷基酰氨基丙基甜菜碱、烷基磺基甜菜碱、烷基甘氨酸盐、烷基羧基甘氨酸盐、烷基两性乙酸盐或烷基两性丙酸盐、烷基两性二乙酸盐或烷基两性二丙酸盐。
例如,可以使用椰油基二甲基磺基丙基甜菜碱、月桂基甜菜碱、椰油酰氨基丙基甜菜碱或椰油基两性丙酸钠。
合适的非离子表面活性剂的实例是在可为直链或支链的烷基链中具有6至20个碳原子的脂族醇或烷基酚与环氧乙烷和/或环氧丙烷的反应产物。环氧烷的量为每摩尔醇约6至60摩尔。另外,合适的是烷基胺氧化物、单或二烷基烷醇酰胺、聚乙二醇的脂肪酸酯、烷基多糖苷或脱水山梨醇醚酯。
另外,洗发剂制剂可以包含常规的阳离子表面活性剂,例如季铵化合物,例如十六烷基三甲基氯化铵。
在洗发剂制剂中,与本发明的活性物质组合使用常规调理剂可以达到特定的效果。
这些包括例如上述INCI名称Polyquaternium的阳离子聚合物,尤其乙烯基吡咯烷酮/N-乙烯基咪唑鎓盐的共聚物(Luviquat FC,Luviquat HM,Luviquat MS,LuviquatCare)、N-乙烯基吡咯烷酮/甲基丙烯酸二甲氨基乙基酯的共聚物,用硫酸二乙酯季铵化(Luviquat PQ 11)、N-乙烯基己内酰胺/N-乙烯基吡咯烷酮/N-乙烯基咪唑鎓盐的共聚物(Luviquat E Hold)、阳离子纤维素衍生物(Polyquaternium-4和-10)、丙烯酰胺共聚物(Polyquaternium-7)。另外,可以使用蛋白质水解物和基于硅酮化合物的调理物质,例如聚烷基硅氧烷、聚芳基硅氧烷、聚芳基烷基硅氧烷、聚醚硅氧烷或硅酮树脂。其他合适的硅酮化合物是聚二甲基硅氧烷共聚醇(CTFA)和氨基官能化的硅酮化合物,例如氨基聚二甲基硅氧烷(CTFA)。另外,可以使用阳离子瓜尔胶衍生物,例如氯化瓜尔胶羟丙基trimonium(INCI)。
清凉口腔护理组合物:
本发明的口腔护理组合物可以以本身已知的方式配制,例如制成牙膏、牙凝胶或水性漱口水或含水-醇性漱口水。
基于组合物的重量,本发明的口腔护理组合物包含优选0.05ppm至10重量%,更优选0.1ppm至10重量%的总量的本发明的至少一种活性物质。
另外,口腔护理组合物,尤其是牙膏,也可以包含研磨剂,例如水合氧化硅、二水合磷酸二钙、碳酸钙、碳酸氢钠、焦磷酸钙和氧化铝。例如,也可以使用增稠的沉淀硅和研磨性沉淀的硅的混合物[Handbook of Pharmaceutical Excipients,The PharmaceuticalSociety of Great Britain,1Lambeth High Street,London SE 1 7JN,England,第253-256页]。前者是由于其触变性而使用的,后者是由于其在去除粘附在牙齿表面的物质方面具有更好的功效而使用的。使用这些产品可确保较小的磨蚀效果,因为这些材料是中等硬度的无定形固体,同时与用作矿化剂的氟化物完全和充分相容,因为它们不含任何会导致它们不溶和降低其生物利用度的水垢盐。
本发明的口腔护理组合物的制剂,例如牙膏,也可以包含合适的添加剂和溶媒,以改善其性能并促进生产。这些例如选自粘合剂、增稠剂、香料、染料、防腐剂、润湿剂或湿润剂、表面活性剂、润滑剂、遮光剂、再矿化剂、表面活性剂、缓冲剂、醇、维生素、水、其他活性物质及其混合物。
所用的粘合剂可以是通常用于生产这种制剂的任何试剂,例如黄蓍胶。粘合剂可以以总量的0.5-1.5%的量存在于制剂中。
有机增稠剂也可以掺入口腔护理组合物中,例如羧甲基纤维素钠、纤维素醚、黄原胶、角叉菜胶、藻酸钠和卡波姆。也可以使用无机增稠剂,例如二氧化硅增稠剂、硅酸钠铝和粘土来提供适当的流变性。增稠剂可以以总量的0.5-5重量%的量存在于制剂中。
牙膏可以通过添加合适的常规芳香物例如薄荷调味剂来加香。精油尤其适合包括丁香油、肉桂油、薄荷油和留兰香油。芳香物可以以总量的0.5-15重量%的量存在于制剂中。
通常在牙膏生产中使用的任何染料都可以用作染料,例如亮蓝FCF,C.42090[KIRSCH PHARMA]。染料可以以总量的0.001-0.005重量%的量存在于制剂中。
防腐剂可以是任何常规试剂,例如苯甲酸的衍生物,例如苯甲酸对羟基甲基酯。防腐剂可以以总量的0.1-0.3重量%的量存在于制剂中。
糖精钠或环拉酸及其衍生物,例如环拉酸钠,可用作甜味剂。甜味剂可以以总量的0.08-0.15%的量存在于制剂中。
用于防止牙膏变干和变硬的润湿剂或湿润剂尤其选自甘油、山梨糖醇、丙二醇、木糖醇和液体聚乙二醇,特别是山梨糖醇、甘油和木糖醇的混合物,例如占总重量的1-60%的比例。
润滑剂可以是通常用于牙膏制剂中的任何物质,例如聚二甲硅氧烷(二甲基聚硅氧烷的聚合物),它是一种表面活性剂,有助于赋予本发明的牙膏良好的流变性。润滑剂可以以总量的0.25重量%至0.75重量%的量存在于制剂中。
通常使用的任何物质都可以用作遮光剂,例如二氧化钛。遮光剂可以以总量的0.05重量%至1重量%的量存在于制剂中。
氟化物源被用作再矿化剂,例如氟化钠、氟化锡(II)和一氟磷酸钠,因为以此方式,100%的活性氟化物可作为由细菌代谢产生的有机酸引起的白色损害的再矿化的物质。所述再矿化剂可以以总量的0.2重量%至0.4重量%的量存在于制剂中。
通常,另外可能存在常规成分,例如阴离子表面活性剂,例如月桂基硫酸钠、N-月桂基肌氨酸钠、磺基乙酸月桂基酯钠和烷基甘油基醚磺酸钠。表面活性剂可以以总量的0.05重量%至5重量%的量存在于制剂中。
如果需要,本发明所述的牙膏还可包含选自维生素A、维生素B5、维生素C和维生素E及其混合物的维生素。在使用的情况下,每种维生素可以以总量的0.1重量%至5重量%的量存在于制剂中。这些维生素可以维生素原的形式或以药学上可接受的盐形式使用。维生素A通常以其棕榈酸盐的形式使用,可促进口腔粘膜的上皮形成并保护牙龈。维生素B5(更具体地说是D-泛醇)具有止痛、愈合和抗炎作用,保护上皮粘膜,促进伤口上皮形成并抚平疤痕。它适用于治疗因拔牙而引起的伤口、牙龈炎、口腔炎、插入义齿后的疼痛、溃疡、粘膜外伤、慢性和复发性口疮。维生素C使口腔粘膜的上皮再生,促进胶原蛋白的合成和免疫系统(炎症机制),并增强吞噬细胞防御细菌的能力。维生素E通常以其乙酸盐的形式使用,具有止痛和抗炎作用,保护口腔粘膜免受自由基导致的脂肪过度氧化和来自环境的污染物质(臭氧、香烟烟雾等)的伤害,并促进伤口愈合。通过添加这些维生素中的一种或多种,本发明提供了一种牙膏,该牙膏除了具有上述特性外,还具有抗炎特性和止痛作用,从而增加了口腔粘膜的膜能力,提供保护并减少牙菌斑和牙垢形成的指数以及细菌污染的指数。
另外的活性剂是例如抗微生物剂和斑块穿透剂,例如β-萘酚、百里酚、氯百里酚和己基间苯二酚;或抗菌化合物,例如季铵化合物;牙垢控制剂,例如焦磷酸四钠、GANTREZS-70、三聚磷酸钠和柠檬酸锌;过氧化物化合物,例如过氧化氢和无机过氧化物。
也可以任选地使用缓冲剂,其浓度适合于维持约6-8的pH,例如碱金属磷酸盐缓冲剂。钾离子的存在还起到了缓解过度敏感的作用。
水或醇可以以占组合物总量的1重量%至20重量%的比例存在。
与醇组合或代替醇,也可以使用二醇化合物,例如甘油、山梨糖醇或丙二醇。
通过在例如配备有搅拌桨的反应器中混合合适量的各种成分,可以容易地制备本发明的口腔护理组合物。
清凉贴:
原则上,活性物质的含量可以在宽的范围内变化,例如0.05ppm至10重量%,优选0.1ppm至10重量%。
本发明的贴剂可以以任何期望的方式来构造,例如通过基质系统、膜系统或无纺织系统(Drug Dev.Ind.Pharm.14(1988),183-209;Drug Dev.Ind.Pharm.13(1987),589-651;Drugs of Today 23(1987),625-646)。
最简单形式的基质系统由3部分组成:柔性支撑箔、包含活性物质的粘合剂基质和可移除的箔。如果使用非粘性基质,则必须在支撑箔片的边缘区域提供粘合剂以粘附到皮肤上。
相比之下,膜系统具有至少5个部分:柔性支撑箔、包含溶解或悬浮的活性物质的储器、用于控制活性释放的膜、附着在该膜上的粘合剂层以及用于去除的箔。
在无纺织系统中,包含活性物质的层由浸渍有活性物质溶液或混悬液的吸附性无纺织或多孔聚合物组成。牢固地粘合到支撑箔上的该层被可去除的箔覆盖。支撑箔片的边缘已涂有用于皮肤的粘合剂。
原则上,可以这种方式配制本发明的所有活性物质。
所使用的助剂是用于生产贴剂的常规助剂。与粘合剂一样,经常加入通常具有-70至-10℃,尤其是-55至-25℃的玻璃化转变温度的聚合物,以及涂有该粘合剂的载体膜和活性剂、乳化剂、增稠剂和旨在影响活性释放的物质和其他助剂。
具有上述低玻璃化转变温度的粘性聚合物是已知的,例如从美国专利2 973 282和3 307 544中获知。自粘带和膜仅接触即可粘在人的皮肤上,但是粘着层的内聚力和其对载体膜的粘附力应大于对皮肤的粘附力,以使它们可以再次大量除去而没有残留物。这些通常包含基于具有2至12个碳原子、尤其是4至8个碳原子的醇的丙烯酸和甲基丙烯酸的共聚物,并且可以包含许多其他共聚形式的共聚单体,例如(甲基)丙烯酸、(甲基)丙烯腈、(甲基)丙烯酰胺、N-叔丁基(甲基)丙烯酰胺、乙烯基酯(例如乙酸乙烯酯、丙酸乙烯酯或丁酸乙烯酯),其他乙烯基化合物例如苯乙烯和丁二烯。应特别强调丙烯酸丁酯和丙烯酸2-乙基己酯。可以通过添加少量具有2个或更多个可共聚双键的共聚单体进行交联,所述共聚单体例如二丙烯酸酯(例如丁二醇二丙烯酸酯)或二乙烯基化合物(例如二乙烯基苯)来交联聚合物,或者通过添加其他交联剂例如三聚氰胺-甲醛树脂进行交联。所使用的粘性聚合物也可以是分子量不同的聚异丁烯和聚乙烯醚。
分散体的粒径应在50至500nm之间,特别是在50至200nm之间。可以根据聚合条件和共聚单体以已知的方式调节粒径和交联度。较小的粒度和升高的交联度可导致活性物质释放增加。
基质贴剂可以通过将活性物质溶解或精细分散在合适的聚合物溶液中,然后通过辊涂或刮涂施用法将这种含活性物质的自粘组合物下拉成膜,来以常规方式生产。在某些情况下,在添加到聚合物溶液中前,将活性物质溶解或超细分散在有机溶剂例如乙醇或丙酮中是合适的。这可以使活性物质更好地分布在聚合物中。
还可以根据德国专利申请P 38 07 283.1来制备贴剂:将细粉状活性物质(粒径小于200μm,特别是小于50μm)掺入含水胶乳分散体中,或将其分散或溶解在乳化剂水溶液,并将该混合物在10至80℃,特别是30至70℃的温度下混合到含水胶乳分散体中。另外,在水溶液中的活性物质的盐也可以在活性物质主要为水溶性离子化形式的pH下与聚合物分散体混合。通过调节pH,然后将活性物质转化为不带电荷的水不溶性形式,并同时乳化成分散体。
适当地,首先加入活性物质,加入乳化剂和水,然后将它们与聚合物分散体混合。如此获得的含活性物的分散体任选地提供有另外的助剂,如上所述,以本身已知的方式在支撑箔上牵伸以形成膜并干燥。此处的干燥温度可以在室温至100℃之间,在快速干燥和避免膜中形成水泡的目的之间以及通常在35至45℃下对活性物质的热应力最佳化。
该方法具有避免有机溶剂的巨大优点。但是,原则上,所有其他常规的基质贴剂生产方法也是有用的。
所得膜的厚度为10至800μm,优选50至300μm。膜可以连续或分批生产。施用方法可以重复多次,直到膜达到所需的厚度。粘性聚合物层包含的活性物质的浓度为1-40重量%,特别是5-25重量%。相同的浓度也适用于膜系统中的储存液以及活性物质溶液或分散体,在无纺织系统的情况下,无纺织布或多孔聚合物被浸入其中。
用于活性物质和聚合物的乳化剂都是为此目的而惯用的表面活性剂,例如相对长链脂肪酸的钠盐和(任选乙氧基化)脂肪醇的硫酸单酯的钠盐,作为阴离子表面活性剂的例子;和聚乙氧基化烷基酚和相对长链的脂肪醇(例如十六烷-1-醇)和甘油脂肪酸偏酯,作为非离子表面活性剂和助乳化剂的实例。
例如,可以使用聚丙烯酸或纤维素衍生物来调节准备用于拖拽的物料的期望粘度。
可用于改善内聚性并因此改善膜的粘合性能的其他交联剂的实例包括三聚氰胺-甲醛树脂。
溶胀剂如聚乙烯吡咯烷酮、纤维素衍生物或聚丙烯酸酯对于改善活性物质释放是有效的,因为该膜可以吸收增加量的水,因此抗扩散性下降。活性物质的释放还可以通过添加亲水增塑剂例如甘油、丙烷-1,2-二醇、聚乙二醇和亲脂性增塑剂例如三醋精、邻苯二甲酸二丁酯或肉豆蔻酸异丙酯来改善。
基质贴通常会提供一级活性物质释放。使用吸附活性物质的填料(如二氧化硅气溶胶、微晶纤维素或乳糖)会导致接近0级的释放。
含有活性物质的自粘组合物在其上干燥的支撑箔实际上对于活性物质和水蒸气都是不渗透的。它可以例如由铝-塑料复合箔、金属化塑料箔、例如在活性物质侧上设有聚亚乙烯氯的阻挡层的聚合物膜或简单的聚合物膜例如聚酯膜组成。
由膜系统构造的本发明的贴剂同样以常规方式生产(例如,EP 0 186 071 A2,US4 262 003)。
如下来制造由无纺织系统构造的贴剂:用亲水或亲脂性溶剂或溶剂混合物中的活性物质的溶液或分散体浸渍固定到支撑箔上的无纺织品或多孔聚合物。随后,附着用于去除的不可渗透的箔。
清凉食品:
本发明的清凉食品(在环境温度下)可以是固体、液体、半固体、糊状、乳膏状或泡沫状。与常规食品成分一样,它们包含至少有效量(即清凉有效量)的本发明的至少一种活性物质。
这里的典型成分是脂肪、碳水化合物、蛋白质、膳食纤维、水、醇等。
基于食品的总重量,蛋白质含量可以例如为0重量%至50重量%;
基于食品的总重量,脂肪含量可以例如为0重量%至50重量%;
基于食品的总重量,碳水化合物含量可以例如为0重量%至90重量%;
基于食品的总重量,膳食纤维含量可以例如为0重量%至90重量%;
基于食品的总重量,水含量可以例如为0重量%至95重量%;
基于食品的总重量,醇含量可以例如为0重量%至15重量%;
基于食品的总重量,本发明的活性物质的比例可以例如在0.05ppm至10重量%,优选0.1ppm至10重量%的范围内。
碳水化合物的实例是例如单糖和二糖,葡萄糖、半乳糖、甘露糖、乳糖、麦芽糖和蔗糖;果糖和甘露糖;多糖,例如淀粉,麦芽糊精;面粉。
术语“膳食纤维”涉及可溶性、不溶性、可发酵、不可发酵的或此类膳食纤维的任何组合。膳食纤维可以包括例如大豆纤维、果胶,特别是抗性淀粉、低聚果糖、菊粉、燕麦纤维、豌豆纤维、瓜尔豆胶、阿拉伯胶、改性纤维素。
脂肪成分可以是已知适合用于食品的任何脂质或脂肪。典型的脂肪包括乳脂肪、红花油、卡诺拉油、蛋黄脂质、橄榄油、棉籽油、椰子油、棕榈油、棕榈仁油、大豆油、葵花籽油、鱼油以及从中衍生出的所有上述油的馏分,例如棕榈油精(palmolein)、中链甘油三酸酯(MCT)和脂肪酸酯,其中脂肪酸是例如花生四烯酸、亚油酸、棕榈酸、硬脂酸、二十二碳六烯酸、二十碳五烯酸、亚麻酸、油酸、月桂酸、癸酸、辛酸、己酸。具有高油酸含量的各种油的形式也被认为适合本应用,例如高油酸向日葵油和高油酸红花油。
蛋白质可以是已知适用于食品的任何蛋白质和/或氨基酸混合物。典型的蛋白质是动物蛋白、植物蛋白(例如大豆蛋白)、乳蛋白(例如脱脂乳蛋白、乳清蛋白和酪蛋白)以及氨基酸(或其盐),例如异亮氨酸、苯丙氨酸、亮氨酸、赖氨酸、甲硫氨酸、苏氨酸、色氨酸、精氨酸、谷氨酰胺、牛磺酸、缬氨酸。优选的蛋白质来源是乳清蛋白、酪蛋白酸钠或酪蛋白酸钙,任选地添加氨基酸。对于某些应用,优选的蛋白质来源是水解的蛋白质(蛋白质水解物),任选地具有添加的氨基酸。
蛋白质水解物可以是在食品中使用的任何合适的蛋白质水解物,例如大豆蛋白水解物、酪蛋白水解物、乳清蛋白水解物、其他动植物蛋白水解物及其混合物。本发明的组合物中的蛋白质水解物优选为大豆蛋白、乳清蛋白或酪蛋白蛋白质水解物,其包含短肽和氨基酸并且任选地添加有额外的氨基酸。在一个优选的实施方案中,根据本发明合适的蛋白质水解物包含高比例的游离氨基酸(例如大于40%)和低分子量肽片段。
为了提供营养平衡的氨基酸含量,本发明组合物中的水解蛋白还优选与各种游离氨基酸混合。此类游离氨基酸的实例包括L-色氨酸、L-甲硫氨酸、L-胱氨酸、L-酪氨酸和L-精氨酸。
本发明的食品还任选地包含维生素和矿物质。本领域技术人员熟悉已为正常生理功能所需的特定维生素和矿物质的确定的最低要求。本领域技术人员还知道,必须添加适合食品的额外量的维生素和矿物质成分,以补偿此类组合物的加工和储存中的某些损失。为了营养目的,本发明的组合物任选地包含大量的维生素和矿物质。
可存在于本发明的组合物中的矿物质、维生素和其他营养素的实例包括维生素A、维生素B6、维生素B12、维生素E、维生素K、维生素C、维生素D、肌醇、牛磺酸、叶酸、硫胺素、核黄素、烟酸、生物素、泛酸、胆碱、钙、磷、碘、铁、镁、铜、锌、锰、氯化物、钾、钠、β-胡萝卜素、核苷酸、硒、铬、钼和L-肉碱。矿物质通常以盐形式添加。
本发明的组合物通常还任选地包含乳化剂和/或稳定剂,例如卵磷脂(例如来自蛋或大豆的卵磷脂)、改性卵磷脂(例如酶促或乙酰化的)、角叉菜胶、黄原胶、甘油一酸酯和甘油二酸酯、瓜尔豆胶、羧甲基纤维素、硬脂酰乳酸酯、琥珀酰化单酸甘油酯、脂肪酸的蔗糖酯、单酸甘油酯的二乙酰酒石酸酯、脂肪酸的聚甘油酯或其任何混合物。
本发明的组合物任选地包含一种或多种天然或合成的风味载体以改善适口性。可以使用该领域中使用的任何风味载体,例如草莓、樱桃、巧克力、橙子、椰子、香草;肉豆蔻和肉桂等香料;或柠檬酸。在使用天然风味载体如椰子片的某些情况下,该成分有助于组合物的总体营养状况,这意味着其有助于脂肪、蛋白质和/或碳水化合物成分的质量和数量。
本发明的组合物还任选地包含多种其他成分,这些成分有助于组合物的营养状况和/或可以赋予所需的风味特性,例如增强风味或口感。这些成分包括花生、葡萄干、奶酪粉、醋、盐、碳酸氢钠。在条形的情况下,该组合物通常具有巧克力或芳香化的涂层(例如巧克力、香草、草莓等)。
本发明的组合物还任选地包含天然或合成染料,以改善视觉印象。
本发明的组合物可以以多种物理表现形式,例如以成人或儿童的液体肠内食品或饮料的形式,以半固体形式例如牛奶冻、奶油、慕斯,或固体形式例如营养棒或饼干。
本发明的组合物可以通过食品技术中已知的标准方法来生产,例如通过与以下出版物中描述的那些方法类似的方法生产:美国专利4,670,268;4,497,800;4,900,566;5,104,677;5,389,395;和5,223,285;Chocolate,Cocoa and Confectionery:Science andTechnology,第3版,Bernard W.Minifie,Van Nostrand Reinhold,New York,1989,p.502-506;通过引用将其全部引入。
对于营养棒和饼干,目的通常是在物理成形后烘烤组合物。
如果需要,本发明的组合物可以通过已知方法灭菌,例如通过热处理诸如高压灭菌或灭菌或辐照,或通过无菌方法生产和包装。
本发明的组合物可以包装在已知适合于存储食品的任何种类的容器或包装中,例如纸、玻璃、带涂层的硬纸板、塑料或带涂层的金属罐。
本发明的组合物可以是营养平衡的。术语“营养平衡”应理解为是指该组合物包含适当的营养物以在延长的时间段内维持健康的人类生活。
用本发明的活性物质改性的纺织品:
从多种角度来看,用本发明的活性物质对纺织品进行改性是令人关注的。
例如,尤其是在衣物直接与皮肤接触的情况下,可以使用清凉化合物对纺织品进行改性,从而使活性物质可以通过透皮转移,例如局部或全身地发挥作用。最近有关于用“健康添加剂”(即促进健康的物质)改性的纺织品的报告R.Breier"Megatrend Wellness-Innovative Ideen für die Textilausrüstung[Wellness,The Megatrend–InnovativeIdeas for Textile Modification]",31.Aachener Tex-tiltage 2004年11月)。
在材料保护方面,杀虫改性也是令人感兴趣的,例如对纺织品进行改性以抵抗蛾的损害等,但是尤其是为了抵御寄生虫如蚊子。
用活性物质改性纺织品的基本问题是活性物质与纺织品载体的结合,这一方面必须确保改性的持久性,另一方面必须选择使得活性物质不丧失其作用。为此,在现有技术中提出了各种方法。
例如,已经提出环糊精用于使活性物质与纺织品结合(参见例如DE-A-19810951和EP-A-0 392 608)。环糊精是通过淀粉的酶促降解形成的环状寡糖。最常见的环糊精是α-、β-和γ-环糊精,分别由六个、七个和八个α-1,4-键合的葡萄糖单元组成。环糊精分子的特征是其环结构的尺寸基本不变。环的内径对于α-环糊精为约570pm,对于β-环糊精为约780pm,对于γ-环糊精为约950pm。由于其结构,环糊精能够以变化的量(直至饱和)容纳客体分子,特别是疏水客体分子。
EP-A-1710345描述了用通过直链淀粉含量至少为30%的含直链淀粉的物质与纺织品结合的芳香物和其他低分子量有机活性物质改性纺织品。
由于含直链淀粉的物质中直链淀粉的含量,使活性剂结合到纺织品上并以受控的方式释放,从而使效果长期保持。假定活性物质以类似于环糊精的方式以包合物的方式可逆地结合在由直链淀粉的螺旋构象形成的空腔内,这首先实现了将活性物质固定在纺织品载体表面上,并且其次实现控释。
对于本发明的纺织品以及直链淀粉来说,所有物质原则上都是合适的,特别是含有直链淀粉的淀粉,即天然淀粉、改性淀粉和淀粉衍生物,具有至少为30重量%,且尤其是至少为40重量%的直链淀粉含量。所述淀粉可以是天然的,例如玉米淀粉、小麦淀粉、马铃薯淀粉、高粱淀粉、大米淀粉或竹芋淀粉,或者可以通过天然淀粉的部分消化获得或化学改性。同样合适的是纯直链淀粉,例如通过酶促方法获得的直链淀粉,例如获自蔗糖的直链淀粉。直链淀粉和淀粉的混合物也是合适的,条件是直链淀粉的总含量基于混合物的总重量为至少30重量%。显而易见的是,在直链淀粉和淀粉的混合物的情况下,除非另有明确说明,否则此处和下文中与直链淀粉或含直链淀粉的物质有关的所有重量%数字始终基于直链淀粉+淀粉的总重量。
根据本发明特别合适的是含直链淀粉的物质,尤其是直链淀粉和含直链淀粉的淀粉以及直链淀粉/淀粉混合物,其中直链淀粉的含量基于物质的总重量计为至少40重量%,尤其是至少45重量%。通常,直链淀粉含量将不超过90重量%,特别是80重量%。这样的物质是已知的并且可商购。例如,含直链淀粉的淀粉由Cerestar以品牌出售,由National Starch以/>V和VII品牌出售。
为了实现活性物质和纺织品的结合,在各情况中基于纺织品的重量,纺织品可以通常用至少0.5重量%、优选至少1重量%、特别是至少2重%的量的含直链淀粉的物质改性。通常,基于纺织品的重量,含直链淀粉的物质以不超过25重量%、通常不超过20重量%、尤其是不超过15重量%的量使用,为了不负面影响纺织品的触觉特性。
首先,将纺织材料本身用含直链淀粉的物质进行修饰,然后用合适的活性物质制剂对如此修饰的纺织品进行处理。以这种方式,存在于纺织材料上的含直链淀粉的物质负载有活性物质。
或者,可以将含直链淀粉的物质与活性物质一起使用以改性纺织品。在此可以将活性物质和含直链淀粉的物质作为单独组分的混合物或以直链淀粉/活性物质复合物的已经预制的形式使用。
通常,活性物质以足以达到所需的效果的量使用。上限由所使用的含直链淀粉的物质的直链淀粉单元的最大吸收能力确定,并且基于该物质的直链淀粉含量,通常将不超过20重量%、通常不超过10重量%。如果需要,活性物质通常以0.00001重量%至15重量%、0.0001重量%至10重量%、0.001重量%至5重量%、0.005重量%至1重量%或0.1重量%至10重量%或0.5重量%至5重量%的量使用,基于含直链淀粉的物质的直链淀粉含量计。
还可通过使用本发明的活性剂与本身已知的其他适合于纺织品改性的活性剂的组合来实现纺织品改性。
合适的其他活性物质原则上是如下的所有有机化合物和有机化合物的混合物,它们已知为活性物质并在诸如人类和动物(包括微生物)的生命形式中引起生理作用。这些包括已知与环糊精形成包合物的那些活性物质。特别合适的活性物质是具有烃基并且特别是脂族、脂环族和/或芳族结构的那些。活性物质的分子量通常低于1000道尔顿,通常为100至600道尔顿。众所周知,无机化合物如过氧化氢也可以结合在环糊精中(就此而言,参见F.Supramolecular Chemistry,第2版,B.G.Teubner,Stuttgart 1992,cyclodextrins和其中引用的文献)。
所述另外的活性物质尤其包括药物活性物质和能促进生命形式特别是人类的健康的活性物质,并且通常也被称为“健康添加剂”。与药物活性物质不同,健康添加剂不一定需要具有治疗作用。相反,促进健康的效果可以基于多种因素,例如护理作用、诱导作用、美容作用或其他作用。同样合适的是能对抗寄生生物的有机活性物质。这些包括例如对抗真菌和/或微生物的活性物质,例如杀真菌剂和杀菌剂,或对付动物害虫诸如蛞蝓、蠕虫、螨虫、昆虫和/或啮齿类的活性物质,例如杀线虫剂、杀软体动物剂、杀虫剂、杀螨剂、灭鼠剂和驱虫活性剂,以及针对杂草的活性物质,即除草剂或芳香物。
优选的药物活性物质是已知可通过皮肤吸收的那些。这些包括例如布洛芬、氟比洛芬、乙酰水杨酸、对乙酰氨基酚、阿朴吗啡、丁基羟基甲苯、菊薁、愈创蓝油烃、氯噻酮、胆钙化醇、双香豆素、地高辛、二苯基乙内酰脲、呋塞米、氢氟噻嗪、吲哚美辛、磷酸异丙烟肼、硝化甘油、尼古丁、烟酰胺、哇巴因、氧烯洛尔、罂粟碱生物碱例如罂粟碱、劳丹素、ethaverine和那可丁,还有小檗碱,以及另外的视黄醇、反式维甲酸、pretinol、螺内酯、舒必利、茶碱、可可碱、皮质类固醇和衍生物例如睾酮、17-甲基睾酮、可的松、皮质酮、地塞米松、曲安西龙、甲基泼尼松龙、氟氢可的松、氟可龙、泼尼松、泼尼松龙、孕酮,尤其雌激素和促孕激素,例如雌二醇、雌三醇、炔雌醇3-甲醚、炔诺酮和炔孕酮,以及苯乙胺及其衍生物,例如酪胺、肾上腺素、去甲肾上腺素和多巴胺。
根据本发明合适的对寄生生物有作用的活性物质的实例是在www.reith-pfister.de/w.list.html和www.hclrss.demon.co.uk/class_pesticides.html中引用的杀线虫剂、杀菌剂、杀真菌剂、杀虫剂、驱虫剂、杀螨剂和杀软体动物剂。
杀菌和杀真菌物质的例子包括:
抗生素,例如环己酰亚胺(cycloheximide)、灰黄霉素、春雷霉素、纳他霉素、多氧菌素、链霉素、青霉素或庆大霉素;
有机化合物和杀生物金属的络合物,例如银、铜、锡和/或锌的络合物,例如双(三丁基锡)氧化物,铜、锌和锡的环烷酸盐,喔星-铜,例如Cu-8,三-N-(环己基diazenium二氧基)铝、N-(环己基diazenium二氧基)三丁基锡、双-N-(环己基diazenium二氧基)铜;
季铵盐,例如苄基-C8-至C18-烷基二甲基卤化铵,尤其是氯化物(苯扎氯铵);
脂族氮杀真菌剂和杀菌剂,例如霜脲氰、dodin、多地辛、guazidine、iminoctadin、吗菌灵(dodemorph)、丁苯吗啉、苯锈啶(fenpropidin)、克啉菌(tridemorph);
具有过氧化物基团的物质,例如过氧化氢和有机过氧化物,例如过氧化二苯甲酰;
有机氯化合物,例如洗必泰;
三唑类杀真菌剂,例如阿扎康唑(Azaconazole)、环唑醇(cyproconazole)、苄氯三唑醇(diclobutrazole)、苯醚甲环唑(difenoconazole)、烯唑醇(diniconazole)、氟环唑(epoxiconazole)、腈苯唑(fenbuconazole)、氟喹唑(fluquinconazole)、氟硅唑(flusilazole)、粉唑醇(flutriafol)、己唑醇(hexaconazole)、叶菌唑(metconazole)、丙环唑(propiconazole)、氟醚唑(tetraconazole)、戊唑醇(tebuconazole)和灭菌唑(triticonazole)。
甲氧基丙烯酸酯类杀菌剂(strobilurins)例如醚菌胺(dimoxystrobin)、氟嘧菌酯(fluoxastrobin)、醚菌酯(kresoxim methyl)、苯氧菌胺(metominostrobin)、肟醚菌胺(orysastrobin)、啶氧菌酯(picoxystrobin)、唑菌胺酯(pyraclostrobin)和肟菌酯(trifloxystrobin)。
磺酰胺类,例如甲苯氟磺胺(tolylfluanide)和diclofluanide;
碘化合物,如二碘甲基对甲苯基砜、napcocide、3-碘-2-丙炔醇、4-氯苯基3-碘炔丙基甲醛、碳酸3-溴-2,3-二碘-3-丙烯基酯乙基酯、2,3,3-三碘烯丙醇、正己基氨基甲酸3-碘-2-丙炔基酯、3-溴-2,3-二碘-2-丙炔醇、苯基氨基甲酸3-碘-2-丙炔基酯、正丁基氨基甲酸3-碘-2-丙炔基酯、苯基氨基甲酸O-1-(6-碘-3-氧代己-5-炔基)酯、丁基氨基甲酸O-1-(6-碘-3-氧代己-5炔基)酯;
异噻唑啉酮,例如N-甲基异噻唑啉-3-酮、5-氯-N-甲基异噻唑啉-3-酮、4,5-二氯-N-辛基异噻唑啉-3-酮、1,2-苯并异噻唑-3(2H)酮,4,5-三甲基异噻唑-3-酮和N-辛基异噻唑啉-3-酮。
杀虫剂和杀螨剂的例子是
有机磷酸酯类,例如乙酰甲胺磷(acephate)、甲基吡噁磷(azamethiphos)、甲基谷硫磷(azinphos-methyl)、毒死蜱(chlorpyrifos)、甲基毒死蜱(chlorpyrifos-methyl)、毒虫畏(chlorfenvinphos)、二嗪农(diazinon)、敌敌畏(dichlorvos)、百治磷(dicrotophos)、乐果(dimethoate)、乙拌磷(disulfoton)、乙硫磷(ethion)、杀螟硫磷(fenitrothion)、倍硫磷(fenthion)、噁唑磷(isoxathion)、马拉松(malathion)、甲胺磷(methamidophos)、杀扑磷(methidathion)、甲基对硫磷(methyl-parathion)、速灭磷(mevinphos)、久效磷(monocrotophos)、砜吸磷(oxydemeton-methyl)、对氧磷(paraoxon)、对硫磷(parathion)、稻丰散(phenthoate)、伏杀磷(phosalone)、亚胺硫磷(phosmet)、磷胺(phosphamidon)、甲拌磷(phorate)、辛硫磷(phoxim)、甲基嘧啶磷(pirimiphos-methyl)、丙溴磷(profenofos)、丙硫磷(prothiofos)、硫丙磷(sulprophos)、三唑磷(triazophos)、敌百虫(trichlorfon);
尤其是拟除虫菊酯,例如氟丙菊酯(acrinathrin)、丙烯菊酯(allethrin)、生物丙烯菊酯(bioallethrin)、熏虫菊(barthrin)、联苯菊酯(bifenthrin)、bioethanomethrin、环虫菊(cyclethrin)、乙氰菊酯(cycloprothrin)、氟氯氰菊酯(cyfluthrin)、β-氟氯氰菊酯(beta-cyfluthrin)、三氟氯氰菊酯(cyhalothrin)、γ-三氟氯氰菊酯(gamma-cyhalothrin)、λ-三氟氯氰菊酯(lambda-cyhalothrin)、氯氰菊酯(cypermethrin)、α-氯氰菊酯(α-cypermethrin)、β-氯氰菊酯(β-cypermethrin)、λ-氯氰菊酯(λ-cypermethrin)、ζ-氯氰菊酯(zeta-cypermethrin)、苯氰菊酯(cyphenothrin)、溴氰菊酯(deltamethrin)、四氟甲醚菊酯(dimefluthrin)、苄菊酯(dimethrin)、烯炔菊酯(empenthrin)、五氟苯菊酯(fenfluthrin)、fenprithrin、甲氰菊酯(fenpropathrin)、氰戊菊酯(fenvalerate)、高氰戊菊酯(esfenvalerate)、氟氰戊菊酯(flucythrinate)、fluvinate、tau-fluvinate、糠醛菊酯(furethrin)、苄氯菊酯(permethrin)、生物氯菊酯(biopermethrin)、反式-苄氯菊酯(trans-permethrin)、苯醚菊酯(phenothrin)、炔丙菊酯(prallethrin)、丙氟菊酯(profluthrin)、pyresmethrin、苄呋菊脂(resmethrin)、生物苄呋菊酯(bioresmethrin)、顺式苄呋菊酯(cismethrin)、七氟菊酯(tefluthrin)、环戊烯丙菊酯(terallethrin)、胺菊酯(tetramethrin)、四溴菊酯(tralomethrin)、四氟苯菊酯(transfluthrin)、依芬普司(etofenprox)、三氟醚菊酯(flufenprox)、苄螨醚(halfenprox)、protrifenbute和silafulfen;
吡咯和吡唑类杀虫剂,例如乙酰虫腈(acetoprole)、乙虫腈(ethiprole)、氟虫腈(fipronil)、吡螨胺(tebufenpyrad)、唑虫酰胺(tolfenpyrad)、溴虫腈(chlorfenapyr)和vaniliprole。
驱虫活性物质的实例尤其是蒽醌、吖啶碱、环烷酸铜、避蚊酮(butopyronoxyl)、邻苯二甲酸二丁酯、邻苯二甲酸二甲酯、驱蚊灵(dimethyl carbate)、乙基己二醇、己酰胺、methoquin-butyl、N-甲基新癸酰胺、樟脑、佛手柑油、除虫菊、丁香油、天竺葵油、百里香油,尤其是二乙基-m-甲苯酰胺和1-哌啶甲酸2-(2-羟基乙基)-1-甲基丙基酯(Picaridin)。
健康添加剂的例子尤其是下面列出的物质和物质混合物,例如
脂肪,优选植物来源的脂肪,例如卵磷脂,
植物油,例如荷荷巴油、茶树油、丁香油、月见草油、杏仁油、椰子油、鳄梨油、大豆油等,
脂肪酸,例如ω-6-脂肪酸、亚麻酸、亚油酸,
动物或植物来源的蜡,例如蜂蜡、小烛树蜡、乳木果油、肖塔黄油(shoreabutter)、芒果仁黄油、日本蜡等,
维生素,尤其是脂溶性维生素,例如生育酚、维生素E、维生素A等,
皮质类固醇,例如可的松、皮质酮、地塞米松、曲安西龙、甲基强的松龙、氟可的松、氟可酮、泼尼松、泼尼松龙、孕酮,
氨基酸,例如精氨酸、甲硫氨酸,
植物提取物,例如藻类提取物、七叶树提取物、芒果提取物等。
为了改善本发明改性的洗涤持久性,发现当含直链淀粉的物质用粘合剂固定在纺织品上时是有用的。有用的粘合剂首先包括成膜的水不溶性聚合物和其次包括在加热时聚合的低分子量反应性物质。通常,粘合剂以如下量使用:含直链淀粉的物质与不溶于水的聚合物的重量比为1:1至100:1,优选为1.5:1至50:1,尤其是在2:1到20:1的范围内。
通常,成膜聚合物以微细的聚合物颗粒的水分散体形式使用。粒度对于本发明的成功至关重要。但是,它通常是5μm以下(重均),通常为50nm至2μm。
所述成膜聚合物的玻璃化转变温度TG尤其可以为-40至100℃,优选为-30至+60℃,尤其为-20至+40℃。如果聚合物粘合剂包含多种聚合物组分,则至少主要成分应具有该范围内的玻璃化转变温度。主要成分的玻璃化转变温度特别是在-30℃至+60℃的范围内,更优选在-20℃至+40℃的范围内。所有聚合物成分优选具有在这些范围内的玻璃化转变温度。所报道的玻璃化转变温度涉及根据ASTM-D 3418-82通过DSC测定的中点温度。在可交联粘合剂的情况下,玻璃化转变温度与未交联状态有关。
合适的成膜聚合物的实例基于以下聚合物类别:
(1)聚氨酯树脂;
(2)丙烯酸酯树脂(直的丙烯酸酯:丙烯酸烷基酯和甲基丙烯酸烷基酯的共聚物);
(3)苯乙烯丙烯酸酯(苯乙烯和丙烯酸烷基酯的共聚物);
(4)苯乙烯/丁二烯共聚物;
(5)聚乙烯酯,尤其是聚乙酸乙烯酯,以及乙酸乙烯酯与丙酸乙烯酯的共聚物;
(6)乙烯基酯-烯烃共聚物,例如乙酸乙烯酯/乙烯共聚物;
(7)乙烯基酯-丙烯酸酯共聚物,例如乙酸乙烯酯/丙烯酸烷基酯共聚物和乙酸乙烯酯/丙烯酸烷基酯/乙烯三元共聚物。
这样的聚合物是已知的并且是可商购的,例如以以下名称的水分散体形式的(2)至(7)类聚合物:ACRONAL、STYROFAN、BUTOFAN(BASF AG)、MOWILITH、MOWIPLUS、APPRETAN(Clariant)、VINNAPAS、VINNOL(WACKER)。适用于本发明方法的聚氨酯水分散体(1)尤其是那些用于纺织品涂层的那些(参见,例如,J.Hemmrich,Int.Text.Bull.39,1993,No.2,p.53-56;"Polyurethan-Beschichtungssysteme”[Aqueous Polyurethane CoatingSystems]Chemiefasern/Textilind.39 91(1989)T149,T150;W./>Textilveredelung[Textile finishing]22,1987,p.459-467)。聚氨酯水分散体是可商购的,例如以以下商品名:来自Alberdingk的/>来自BAYER AG的/>其来自Stahl,Waalwijk,the Netherlands,来自BASF SE,或者它们可以通过已知的方法制备,例如,在"Herstellverfahren für Polyurethane"[Production methods forpolyurethanes]in Houben-Weyl,"Methoden der organischen Chemie”[Methods ofOrganic Chemistry],volume E 20/Makromolekulare Stoffe[MacromolecularSubstances],p.1587,D.Dietrich等人.,Angew.Chem.82(1970),p.53ff.,Angew.Makrom.Chem.76,1972,85ff.和Angew.Makrom.Chem.98,1981,133-165,Progressin Organic Coatings,9,1981,p.281-240,或/>Chemielexikon[/>ChemicalLexicon],第9版,第5卷,p.3575中所述的方法。
成膜聚合物可以是自交联的,这意味着聚合物具有官能团(可交联的基团),当干燥组合物时,任选地在加热下,它们彼此之间、与直链淀粉的官能团或与低级直链的官能团反应,形成键。
可交联的官能团的实例包括脂族键合的OH基团、NH-CH2-OH基团、羧酸酯基团、酸酐基团、封端的异氰酸酯基团和氨基。将经常使用仍然具有作为反应性基团的游离OH基的聚合物。通常,反应性官能团的比例为0.1至3mol/kg聚合物。交联可以通过具有互补反应性的官能团的反应在聚合物内引起。优选地,通过添加具有反应性基团的交联剂来实现聚合物的交联,所述反应性基团在其对交联剂的官能团的反应性方面是互补的。具有互补反应性的合适的官能团对是本领域技术人员已知的。此类对的例子是OH/COOH、OH/NCO、NH2/COOH、NH2/NCO和M2+/COOH,其中M2+是二价金属离子,例如Zn2+、Ca2+或Mg2+。合适的交联剂的例子是下面提到的用于聚氨酯的二元醇或多元醇;伯或仲二胺,优选伯二胺,例如亚烷基二胺,如六亚甲基二胺、二亚乙基三胺、三亚乙基四胺、四亚乙基戊胺、N,N-双[(氨基丙基)氨基]乙烷、3,6-二氧杂辛烷二胺、3,7-二氧杂壬烷二胺、3,6,9-三氧杂十一碳二胺或Jeffamines、(4,4'-二氨基二环己基)甲烷、(4,4'-二氨基-3,3-二甲基二环己基)甲烷;氨基醇,例如乙醇胺、羟丙胺;乙氧基化的二胺和低聚胺;脂族或芳族二羧酸的二酰肼,例如己二酸二酰肼;二醛,如乙二醛;部分或完全O-甲基化的三聚氰胺,以及平均具有两个或更多个,优选三个或更多个异氰酸酯基或可逆地被封闭的例如亚硫酸氢酯封闭的异氰酸酯基团的化合物或低聚物。在这种情况下,交联剂与聚合物粘合剂的比例这样的:使得聚合物粘合剂中的反应性基团(聚合物中的反应性基团的总量)与交联剂中的反应性基团的摩尔比通常在1:10至10:1的范围内,优选在3:1至1:3的范围内。通常,聚合物粘合剂(以固体计)与交联剂的重量比为100:1至1:1,尤其是50:1至5:1。
作为用水不溶性聚合物固定含直链淀粉的物质的替代方法,直链淀粉或含直链淀粉的物质也可以用具有至少一个对直链淀粉的OH基具有反应性的基团和至少一个对纺织材料纤维上的官能团具有反应性的其它官能团,例如OH基团、NH2基团或COOH基团的反应性化合物固定在纺织材料上。反应性化合物包括上述交联剂和DE-A 40 35 378中提出的用于固定环糊精的物质,例如脲的N-羟甲基和N-烷氧基甲基衍生物或类脲化合物如二羟甲基脲(双(羟甲基)脲)、二(甲氧基甲基)脲、二羟甲基烷烃二醇二尿烷,例如N,N-二羟甲基亚乙基脲(N,N-双(羟甲基)咪唑啉-2-酮)、N,N-二羟甲基二羟基亚乙基脲(N,N-双(羟甲基)-4,5-二羟基咪唑啉-2-酮)、二羟甲基亚丙基脲等。这样的材料是用于纺织品的商业改性的含水制剂的形式,例如以来自BASF SE的商品名和/>-eco。可用于将含直链淀粉的物质固定在纺织材料上的反应性材料尤其还包括具有2、3、4或更多个(任选可逆地封闭)异氰酸酯基的化合物,特别是已用亚硫酸氢盐或CH酸性化合物或oximenes例如丁酮肟可逆地封闭的多异氰酸酯预聚物,并且基于聚醚和聚酯尿烷(polyesterurethanes),其描述于DE 2837851、DE 19919816和在先的欧洲专利申请03015121中。此类产品也是可商购的,例如以来自Rotta GmbH,Mannheim的/>367和/>357商品名购得。
含直链淀粉的物质也可以使用已知的固定环糊精的方法以类似的方式固定,其中环糊精,或在当前情况中,含直链淀粉的物质具有反应性锚,例如通过使其以本身已知的方式与二羧酸或二羧酸酐,例如马来酸、富马酸、马来酸酐、琥珀酸、琥珀酸酐或己二酸、以及异氰酸酯,例如甲苯二异氰酸酯、异佛尔酮二异氰酸酯、四亚甲基二异氰酸酯或六亚甲基二异氰酸酯反应,或与氨基羧酸反应,以使这些化合物中存在的仅一种官能团与含直链淀粉的物质的OH基团发生反应,而另一种则保守地与纤维材料的反应性基团结合。通过与1,3,5-三氯三嗪、2,3-二氯喹喔啉-5,6-羰基氯以及与氯二氟嘧啶反应,还可以在含直链淀粉的物质上生成反应性锚。
另外,直链淀粉的固定也可以使用烷氧基硅烷,例如二乙氧基二甲基硅烷、二甲氧基二甲基硅烷、三乙氧基苯基硅烷、四乙氧基硅烷、以及这些化合物的二聚、三聚和更高缩合产物来完成。
以此方式,原则上可以改性所有纺织材料,即非成品材料或成品材料。此处和下文中的纺织材料包括机织织物、拉环针织物(loop-drawn knitted fabrics)、成环针织物(loop-formed knitted fabrics)和无纺布。纺织材料可以由天然纤维纱线、合成纤维纱线和/或混合纱线构成。原则上,有用的纤维材料包括通常用于纺织品生产的所有纤维材料。这些包括棉、羊毛、大麻纤维、剑麻纤维、亚麻、苎麻、聚丙烯腈纤维、聚酯纤维、聚酰胺纤维、粘胶纤维、丝绸、醋酸纤维、三醋酸纤维、芳纶纤维等以及这些纤维材料的混合物。
可以以本身已知的方式,例如通过DE-A 4035378中描述的用环糊精对纺织品进行改性的方法,来进行用含直链淀粉的物质对纺织品材料的改性或处理。
应当提及这样的实例,其中含直链淀粉的物质,任选地作为与活性物质的复合物,已经被纺制成从其制备出织物的纤维、长丝和/或纱线。
然而,通常在精加工之前或之后,用含直链淀粉的物质或含直链淀粉的物质与活性物质的复合物处理纺织材料。通常,为此目的,将用含水液体处理纺织品,所述含水液体包含足量的含直链淀粉的物质和任选的活性物质。根据施用方式和所要施用的含直链淀粉的物质的期望量,液体中的含直链淀粉的物质的浓度为1重量%至40重量%、特别是2重量%至20重量%、尤其是4重量%至15重量%。
处理方式的重要性不高,例如可以以最小施用的形式,例如通过喷雾施用,以垫轧布机形式的正常施用形式或以高水分施用的形式进行。这里的纺织材料被含水液体浸泡。任选地,此后可以除去过量的液体,例如通过将其挤压到约30%至120%的液体拾取量。
用含直链淀粉的物质或含直链淀粉的物质和活性物质的复合物处理纺织品的另一种方法是用水配制液体,其中存在所需量的含直链淀粉的物质和任选的活性物质,例如0.5%至20%(重量)(基于要改性的纺织品的质量)。在一定的时间段内例如10-60分钟,将纺织材料用处理液一起浸入适合目的的改性骨料(modification aggregate)中(例如绞盘贝克(beck);辊筒贝克;桨叶等),然后按照上面的说明挤压和/或旋转。此处的液体比通常在1:2至1:50的范围内,尤其是在1:3至1:20的范围内。
这样的方法是本领域技术人员已知的,例如从H.K.Rouette,Lexikon derTextilveredlung[Lexicon of Textile Finishing],Laumann-Verlag,Dülmen 1995,p.669ff已知。
通常,用液体处理之后进行干燥操作。这里的温度通常在100至200℃的范围内,优选在120至180℃的范围内。干燥可以在用于该目的的常规设备中进行,在成品材料的情况下,例如通过在上述指定温度下进行滚筒干燥。在非成品材料的情况下,通常将在应用之后,通过一个或多个拉幅机引导纺织材料。
如果含直链淀粉的物质与成膜聚合物一起使用,则干燥导致含直链淀粉的物质固着在纺织纤维上。通常,在这种情况下的干燥温度将不小于100℃,并且优选在120至200℃的范围内,特别是在140至180℃的范围内。通常,干燥进行1至10分钟,特别是1至2分钟,尽管更长的干燥时间同样是合适的。
对于用含水液体进行处理,发现含水液体除含直链淀粉的物质和任选的活性物质外包含至少一种适于将含直链淀粉的物质和活性物质分散在含水液体中的表面活性物质(或界面活性物质)是有利的。所述表面活性物质优选为低聚物或聚合物分散剂。与低分子量表面活性物质相反,术语“低聚物或聚合物分散剂”包括数均分子量通常为至少2000道尔顿,例如2000至约100 000道尔顿,特别是范围从约3000到70 000道尔顿的那些分散剂。
通常,基于含直链淀粉的物质计,含水溶液包含0.5重量%至20重量%,优选1重量%至18重量%,尤其是5重量%至15重量%的量的聚合物或低聚物分散剂。
合适的低聚物或聚合物分散剂是水溶性的,并且包括不带电荷的和两性的水溶性聚合物以及阳离子和阴离子聚合物,后者是优选的。
不带电荷的聚合物分散剂的实例是聚环氧乙烷、环氧乙烷/环氧丙烷共聚物优选嵌段共聚物、聚乙烯吡咯烷酮和乙酸乙烯酯与乙烯基吡咯烷酮的共聚物。
优选的阴离子低聚物或聚合物分散剂的特征在于它们具有羧基和/或磺酸基,并且通常用作盐,例如用作碱金属盐或铵盐。
优选的阴离子分散剂是例如纤维素的羧基化衍生物,例如羧甲基纤维素、烯键式不饱和C3-C8-单羧酸和C4-C8-二羧酸的均聚物,例如丙烯酸、甲基丙烯酸、马来酸、衣康酸的均聚物。至少两种不同的上述烯键式不饱和C3-C8-单羧酸和C4-C8-二羧酸的共聚物,以及至少一种上述烯键式不饱和C3-C8-单羧酸或C4-C8-二羧酸与至少一种不带电荷的共聚单体的共聚物。不带电荷的共聚单体的例子是N-乙烯基内酰胺,例如N-乙烯基吡咯烷酮,脂族C2-至C16羧酸的乙烯基酯,例如乙酸乙烯酯、丙酸乙烯酯,上述烯键式不饱和羧酸的酰胺例如丙烯酰胺、甲基丙烯酰胺和如(甲基)丙烯酸羟基-C1-C4烷基酯如丙烯酸羟乙酯和甲基丙烯酸羟乙酯、烯键式不饱和C3-C8-单羧酸或C4-C8-二羧酸与聚醚的酯,例如丙烯酸或甲基丙烯酸与聚环氧乙烷或环氧乙烷/环氧丙烷嵌段共聚物的酯,乙烯基芳族化合物例如苯乙烯和C2-至C16烯烃例如乙烯、丙烯、1-己烯、1-辛烯、1-癸烯、1-十二碳烯等。还优选烯键式不饱和磺酸如苯乙烯磺酸和丙烯酰氨基丙烷磺酸的均聚物以及它们与上述共聚单体的共聚物。在共聚物中,烯键式不饱和酸的比例通常为至少20重量%,并且不超过90重量%、特别是80重量%的值,在每种情况下基于构成聚合物的所有单体的总重量计。
为此目的,至少一种上述酸和至少一种共聚单体的共聚物是已知的并且是可商购的,例如丙烯酸和马来酸的共聚物,如BASF SE的Sokalan品牌。
同样优选的阴离子分散剂是苯酚磺酸-甲醛缩合物和萘磺酸-甲醛缩合物(例如来自BASF的Tamol和Setamol品牌)和木质素磺酸盐。
可用的分散剂还为低分子量的阴离子、非离子、阳离子、两亲和两性离子表面活性剂。合适的表面活性剂是例如C8至C18烷基硫酸的碱金属盐、铵盐或胺盐,例如十二烷基硫酸钠;C8至C18的烷基磺酸盐,例如十二烷基磺酸盐;C8至C18烷基醚硫酸盐;和C8至C18烷基乙氧基化物;聚氧乙烯山梨糖醇酯;C8至C18烷基甘氨酸盐;C8至C18-烷基二甲基胺氧化物;甜菜碱等。优选烷基硫酸盐和烷基磺酸盐。
如果不将含直链淀粉的物质与成膜的、水不溶性聚合物一起使用,则可以在单独的步骤中用聚合物处理纺织品。更特别地,处理与含直链淀粉的物质一起进行。因此,一个特定的实施方案涉及一种方法,其中含水液体还包含上述类型的分散的、成膜的、水不溶性聚合物。在此选择成膜聚合物的量,以使得含直链淀粉的物质与水不溶性聚合物的重量比为1:1至100:1,优选为1.5:1至50:1,尤其是2:1至20:1。
可以在单独的操作中或在与用含直链淀粉的物质进行改性一起的操作中用活性物质对纺织品进行改性。
如果纺织品在单独的操作中用活性物质改性,则纺织品将同样适当地用活性物质的含水液体处理。为此目的,通常为水不溶性的活性物质通常将被乳化或分散在水中,任选地使用合适的表面活性物质。合适的表面活性物质尤其是上述低分子量表面活性剂,其中优选非离子表面活性剂,特别是聚氧乙烯山梨糖醇酯,单糖或低聚糖与C6至C18脂肪酸的酯,更优选C8至C18烷基乙氧基化物,特别是乙氧基化水平范围为6至50的那些。通常,含水液体包含的活性物质的量为0.1重量%至10重量%,尤其是0.2重量%至5重量%。基于活性物质计,表面活性物质的量通常为0.5重量%至50重量%,尤其是3重量%至30重量%。可以通过用于该目的的常规方法从含水液体中施加活性物质,例如借助于垫轧布机。
或者,可以在一次操作中用活性物质和含直链淀粉的物质进行改性。此处的方法原则上可以如对含直链淀粉的物质进行改性所描述的那样,其中含直链淀粉的物质的含水液体现在另外包含至少一种活性物质。可以将活性物质单独地或以包合物的形式即与含直链淀粉的物质的主体-客体复合物的形式加入液体中。
本发明可用于任何织物的改性,包括机织织物、针织织物、无纺布等。纺织材料的类型主要取决于所需的最终用途。
待改性的纺织品可以是制成品,例如服装,包括内衣和外套,例如衬衫、裤子、夹克、户外、徒步旅行和军用服装、屋顶、帐篷、网(例如防虫网)和窗帘、手和浴巾、床单之类。
以相同的方式,可以以捆或卷的形式对原材料进行改性。
用抗寄生生物如昆虫和螨类的活性物质改性的纺织品不仅适用于保护人类,而且尤其适用于动物保护,以防止虱子、螨虫、跳蚤等。
纺织材料可以由天然纤维纱线、合成纤维纱线和/或混合纱线构成,其中织物的基重通常为10至500g/m2,优选20至250g/m2。原则上,有用的纤维材料包括通常用于纺织品生产的所有纤维材料。这些包括棉、羊毛、大麻纤维、剑麻纤维、亚麻、苎麻、聚丙烯腈纤维、聚酯纤维、聚酰胺纤维、粘胶纤维、丝绸、醋酸纤维、三醋酸纤维、芳纶纤维等以及这些纤维材料的混合物。玻璃纤维以及上述纤维材料与玻璃纤维的混合物例如玻璃纤维/Kevlar混合物也是合适的。
利用上述的基于直链淀粉的活性物质改性,即使经过几次洗涤,活性物质仍保留在改性的纺织品中。另外,如此改性的纺织品具有令人愉悦的手感,这尤其有利于由这些纺织品制造的衣服的穿着舒适性。
清凉烟草产品:
原则上,活性成分的含量可以在宽的范围内变化,例如0.05ppm至10重量%,优选0.1ppm至10重量%。
本发明的活性物质也可以有利地用于生产烟草制品。这种烟草产品的例子包括雪茄、香烟、烟斗烟、咀嚼烟和鼻烟。
补充有清凉添加剂的烟草制品的生产本身是已知的,并且例如在US 3,111,127,US 5,752,529和US 2005/0000529中进行了描述,这些文献通过引用明确地并入。
清凉包装材料:
本发明的活性物质也有利地适用于包装材料的生产。
它们同样以本身已知的方式生产。活性物质可以以游离的或例如包封的形式掺入包装材料中,或以游离的或包封的形式施加到包装材料上。
例如,可以根据涉及聚合物膜生产的文献(例如,Ullmann,第6版,2003.Vol.36,p.567)中的细节来生产相应改性的塑料包装材料。以合适的方式涂布的纸的生产同样是已知的,并且例如描述在Ullmann,Vol.25,p.106ff,第6版,2003中。
通过以下实施例和所附权利要求书,本发明的其他方面将变得显而易见。
实施例:
实施例用来说明本发明而不是限制本发明。除非另有说明,否则所有数字均基于重量。
活性物质生产:
根据本发明使用的结构类型1的活性物质是本身已知的化合物,或者可以由有机合成领域的技术人员基于已知的合成方法来制备。
人TRPM8的克隆:
人TRPM8受体的克隆的起点是LnCaP cDNA库。这例如是可商购的(例如,来自BioChain,Hayward,USA),或可以使用标准试剂盒从雄激素敏感的人前列腺腺癌细胞系(例如,ATCC、CRL1740或ECACC、89110211)产生。
编码的TRPM8序列(例如,请参见
http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nuccore&id=109689694)可以使用标准方法进行PCR扩增和克隆。由此分离出的人TRPM8基因用于质粒pInd_M8的产生。
备选地,TRPM8基因也可以合成产生。
HEK293测试细胞的产生:
具有人TRPM8 DNA的生产的测试细胞系统是稳定转染的HEK293细胞系。这里优选HEK293,其通过引入的质粒,提供了通过四环素诱导TRPM8表达的选项。
合适的测试细胞系统的生产方法是本领域技术人员已知的。例如,所用细胞的生产可以从Behrendt H.J.等人.,Br.J.Pharmacol.141,2004,737-745的细节中或Behrendt的论文“Vergleichende funktionale Untersuchungen des Hitze-Capsaicin-Rezeptors(TRPV1)und des-Menthol-Rezeptors(TRPM8)in rekombinanten und nativenZellssystemen”中推断出来,其例如可获自http://www-brs.ub.ruhr-uni-bochum.de/netahtml/HSS/Diss/BehrendtHansJoerg/diss.pdf。这些出版物的公开内容通过引用明确地并入。
TRPM8调节剂的测定:
进行与Behrendt H.J.等人.,Br.J.Pharmacol.141,2004,737-745的文献中所述的测试类似的测试。受体的激动或拮抗作用可以通过对Ca2+敏感的染料(例如FURA、Fluo-4等)来定量。激动剂本身会导致Ca2+信号增加;例如,在薄荷醇存在下,拮抗剂会导致Ca2+信号的减少(在每种情况下都是通过Fluo-4染料检测的,Fluo-4染料会因Ca2+而具有不同的荧光特性)。
首先,以本身已知的方式,在细胞培养瓶中制备转化的HEK细胞的新鲜培养物。用胰蛋白酶将HEK293-TRPM8测试细胞从细胞培养瓶中取出,用100μl培养基以40 000个细胞/孔播种并在96孔板(Greiner#655948聚D-赖氨酸包被的)中。为了诱导TRPM8受体,将四环素加入生长培养基(DMEM/HG,不含四环素的10%FCS、4mM L-谷氨酰胺、15μg/mL杀稻瘟素、100μg/mL潮霉素B、1μg/mL四环素)。第二天,用Fluo-4AM染料装载细胞,然后进行测试。为此目的的步骤如下:
-对于每100μl培养基(DMEM/HG、无四环素的10%FCS、4mM L-谷氨酰胺、15μg/mL杀稻瘟素、100μg/mL潮霉素B、1μg/mL四环素),向每孔加入100μl/孔Ca-4 Kit染色液(RB 141,Molecular Devices)。
-在培养箱中孵育,30分钟/37℃/5%CO2,30分钟/RT
-制备测试物质(200μl HBSS缓冲液中的不同浓度)、阳性对照(200μl HBSS缓冲液中不同浓度的薄荷醇、icilin和离子霉素)和阴性对照(仅200μl HBSS缓冲液)
-以50μl/孔的量添加测试物质,并测量激发485nm、发射520nm处的荧光变化(例如,在FLIPR分析仪中,Molecular Devices或NovoStar,BMG),并评估不同物质/浓度的作用强度以及测定EC50值。
测试物质在测试中一式三份使用,浓度为0.1-200μM。通常,将化合物保存在DMSO溶液中,并稀释以用于测定,至2%的最大DMSO浓度。
令人惊奇地,在进行所述测定的情况下的内部评估表明,根据本发明使用的化合物(如本文所述的)特别适合作为TRPM8的激动剂。
下表显示了通过例举选择的本发明的调节剂的测定EC 50值。
/>
/>
/>
合成实施例:
1)N-乙基-2-甲基硫烷基乙胺的制备
将1,1-二甲氧基-2-(甲硫基)乙烷(21.5mL,161.07mmol,1.0eq)溶解在HCl溶液(0.5M,323mL,1.0eq)中,并在50℃下搅拌1h。将反应混合物冷却至室温,并用CH2Cl2(500mL)萃取。合并的有机相经Na2SO4干燥。将醛溶液用THF(500mL)稀释,冷却至0℃,然后与乙胺(70%水溶液,15.57mL,241.61mmol,1.5eq)、乙酸(9.1mL,161.07mmol,1.0eq)和Na2SO4(250g)混合。16小时后,将反应混合物通过Na2SO4过滤,并与三乙酰氧基硼氢化钠(37.6g,177.17mmol,1.1eq)混合。将反应混合物在室温搅拌16小时。将固体通过硅藻土过滤,并将溶液在减压下浓缩。减压(7mbar,60℃)蒸馏粗产物。无需进一步分析,使用该化合物。
产率:23%.
2)N-乙基-3-甲基硫烷基丙-1-胺的制备
将甲硫基丙醛(25.0g,240.0mmol,1.0eq)溶于THF(1000mL),冷却至0℃,然后与乙胺(70%的水溶液,23.2mL,360.0mmol,1.5eq)、乙酸(13.6mL,240.0mmol,1.0eq)和Na2SO4(250g)混合。16小时后,将反应混合物通过Na2SO4过滤,并与三乙酰氧基硼氢化钠(55.95g,264.0mmol,1.1eq)混合。将反应混合物在室温搅拌16小时。将固体通过硅藻土过滤,并将溶液在减压下浓缩。减压(7mbar,60℃)蒸馏粗产物。无需进一步分析,使用该化合物。
产率:31%.
3)N-吡啶-,N-苯基-和N-1H-吡唑胺的制备
将1,1-二甲氧基-2-(甲硫基)乙烷(1.0eq)溶于HCl溶液(0.5M,1.0当量)中,并在50℃下搅拌1h。将反应混合物冷却至室温,并用CH2Cl2(总共3mL/mmol)萃取。合并的有机相经Na2SO4干燥。将醛溶液冷却至0℃,然后与胺(1.0当量)、三乙酰氧基硼氢化钠(1.5当量)和乙酸(1.0当量)混合。将反应混合物在室温搅拌16小时。通过添加NaHCO3溶液终止反应。将水相用CH2Cl2萃取三次,并将合并的有机相用Na2SO4干燥并在减压下浓缩。粗产物通过快速色谱法纯化(己烷∶EtOAc=19∶1)。
N-(2-甲基硫烷基乙基)吡啶-2-胺
84%产率
无需进一步分析,使用所述化合物。
N-(2-甲基硫烷基乙基)苯胺
产率:85%
无需进一步分析,使用所述化合物。
N-(2-甲基硫烷基乙基)-1H-吡唑-5-胺
产率:84%
无需进一步分析,使用所述化合物。
4)N-(2-甲氧基乙基)苯胺的制备
将1,1-二甲氧基-2-(甲基氧基)乙烷(10g,83.23mmol,1.0eq)溶解在HCl溶液(0.5M,1.0eq)中,并在50℃下搅拌1h。将反应混合物冷却至室温,并用CH2Cl2(总共3mL/mmol)萃取。合并的有机相经Na2SO4干燥。将醛溶液冷却至0℃,然后与苯胺(7.75g,83.23mmol,1.0eq)、氰基硼氢化钠(5.75g,91.55mmol,1.1eq)和乙酸(4.7mL,83.23mmol,1.0eq)混合。将反应混合物在室温搅拌16小时。通过添加NaHCO3溶液终止反应。将水相用CH2Cl2萃取三次,并将合并的有机相用Na2SO4干燥并在减压下浓缩。粗产物通过快速色谱法纯化(己烷∶EtOAc=19∶1)。
收益率:19%
无需进一步分析,使用该化合物。
5)本发明的肉桂酰胺类或苯氧乙酰胺类的制备
方法A
将肉桂酸或苯氧乙酸(1.5当量)和N-甲基甲酰苯胺(MFA)(1滴)溶解在CH2Cl2(5mL/mmol)中,冷却至0℃,并与草酰氯(3.0当量)混合。将反应混合物在室温搅拌2h,并在40℃搅拌1h,并减压浓缩。将三乙胺(4.0当量)和相应的胺(1.0当量)溶于CH2Cl2(4mL/mmol)中,冷却至0℃。将粗产物溶于CH2Cl2(1mL/mmol)中,并缓慢滴加。将反应混合物在室温搅拌16小时。通过添加NaHCO3溶液终止反应。将水相用CH2Cl2(3×)萃取,并将合并的有机相用Na2SO4干燥并在减压下浓缩。粗产物通过快速色谱纯化。
方法B:
将肉桂酸或苯氧乙酸(2.0eq)和MFA(1滴)溶于CH2Cl2(5mL/mmol),冷却至0℃,并与草酰氯(4.2eq)混合。将反应混合物在室温搅拌2h,并在40℃搅拌1h,并减压浓缩。将吡啶(2.0eq)和相应的胺(1.0eq)溶解在CH2Cl2(4mL/mmol)中,并冷却至0℃。将粗产物溶于CH2Cl2(1mL/mmol)中,并缓慢滴加。将反应混合物在室温搅拌16小时。通过添加NaHCO3溶液终止反应。将水相用CH2Cl2(3×)萃取,并将合并的有机相用Na2SO4干燥并在减压下浓缩。将粗产物溶解在乙醇(15mL/mmol)中,并与NaOH(5.0eq)混合。15分钟后,减压除去溶剂,并将粗产物与水混合并用CH2Cl2萃取三次。合并的有机相经Na2SO4干燥并在减压下浓缩。产物通过快速色谱法纯化(EtOAc∶己烷=25:75→45:55)。
6)(E)-3-(1,3-苯并间二氧杂环戊烯-5-基)-N-(2-甲基硫烷基乙基)-N-苯基丙-2-烯酰胺的制备
方法A:71%产率
1H NMR(400MHz,氯仿-d)δ7.59(d,J=15.5Hz,1H),7.49–7.41(m,2H),7.41–7.35(m,1H),7.28–7.22(m,2H),6.85(dd,J=8.1,1.7Hz,1H),6.73(d,J=8.1Hz,1H),6.73(d,J=1.7Hz,1H),6.10(d,J=15.4Hz,1H),5.93(s,2H),4.06–3.99(m,2H),2.74–2.68(m,2H),2.16(s,3H).
7)2-(4-甲基苯氧基)-N-(2-甲基硫烷基乙基)-N-苯基乙酰胺的制备
方法A:87%产率
1H NMR(400MHz,氯仿-d)δ7.46(dd,J=8.3,6.4Hz,2H),7.43–7.37(m,1H),7.30–7.23(m,2H),7.01(d,J=8.4Hz,2H),6.67(d,J=8.6Hz,2H),4.34(s,2H),3.98–3.90(m,2H),2.70–2.61(m,2H),2.25(s,3H),2.13(s,3H).
8)(E)-3-(1,3-苯并间二氧杂环戊烯-5-基)-N-乙基-N-(2-甲基硫烷基乙基)丙-2-烯酰胺的制备
方法A:31%产率
1H NMR(400MHz,氯仿-d)δ7.63(d,J=15.2Hz,2H),7.06–6.96(m,4H),6.81(d,J=8.0Hz,2H),6.66(dd,J=15.0,6.4Hz,2H),6.00(s,4H),3.62(dd,J=8.6,6.4Hz,4H),3.52(q,J=7.2Hz,4H),2.78–2.68(m,4H),2.19(s,6H),1.26(t,J=7.2HZ,3H),1.19(t,J=7.3Hz,3H).
9)(E)-3-(1,3-苯并间二氧杂环戊烯-5-基)-N-(2-甲基硫烷基乙基)-N-(2-吡啶基)丙-2-烯酰胺的制备
方法A:5%产率
1H NMR(400MHz,氯仿-d)δ8.55(ddd,J=4.9,2.0,0.9Hz,1H),7.75(td,J=7.7,2.0Hz,1H),7.64(d,J=15.4Hz,1H),7.23(ddd,J=7.4,2.7,1.0Hz,2H),6.90(dd,J=8.2,1.7Hz,1H),6.81(d,J=1.7Hz,1H),6.76(d,J=8.0Hz,1H),6.26(d,J=15.4Hz,1H),5.96(s,2H),4.26–4.16(m,2H),2.89–2.75(m,2H),2.15(s,3H).
10)(E)-N-(2-甲基硫烷基乙基)-3-(p-甲苯基)-N-(2-吡啶基)丙-2-烯酰胺的制备
方法A:10%产率
1H NMR(400MHz,氯仿-d)δ8.55(dd,J=5.4,2.0Hz,1H),7.75(td,J=7.8,2.0Hz,1H),7.71(d,J=15.4Hz,1H),7.29–7.21(m,4H),7.12(d,J=7.9Hz,2H),6.40(d,J=15.5Hz,1H),4.30–4.16(m,2H),2.87–2.74(m,2H),2.33(s,3H),2.15(s,3H).
11)(E)-3-(1,3-苯并间二氧杂环戊烯-5-基)-N-(2-甲基硫烷基乙基)-N-(1H-吡唑-3-基)丙-2-烯酰胺的制备
方法B:10%产率
1H NMR(400MHz,氯仿-d)δ7.63(d,J=15.2Hz,1H),7.61(d,J=2.4Hz,1H),6.90(d,J=7.9Hz,1H),6.83(s,1H),6.74(d,J=8.0Hz,1H),6.35(d,J=14.7Hz,1H),6.25(s,1H),5.95(s,2H),4.03(t,J=7.3Hz,2H),2.78(t,J=7.6Hz,2H),2.16(s,3H).
12)(E)-N-乙基-N-(2-甲基硫烷基乙基)-3-(p-甲苯基)丙-2-烯酰胺的制备
方法A:41%产率
在波谱中显示在氮处的两个旋转异构体。
1H NMR(400MHz,氯仿-d)δ7.69(d,J=15.3Hz,2H),7.42(d,J=7.8Hz,4H),7.18(d,J=7.9Hz,4H),6.79(dd,J=15.4,5.7Hz,2H),3.67–3.57(m,4H),3.53(q,J=7.1Hz,4H),2.78–2.68(m,4H),2.37(s,6H),2.19(s,6H),1.27(t,J=7.1Hz,3H),1.20(t,J=7.1Hz,3H).
13)(E)-N-乙基-3-(4-甲氧基苯基)-N-(2-甲基硫烷基乙基)丙-2-烯酰胺的制备
方法A:12%产率
1H NMR(400MHz,氯仿-d)δ7.69(d,J=15.3Hz,1H),7.53–7.44(m,2H),6.96–6.83(m,2H),6.70(d,J=15.3Hz,1H),3.83(s,3H),3.62(dd,J=8.5,6.6Hz,2H),3.53(q,J=7.1Hz,2H),2.78–2.69(m,2H),2.19(s,3H),1.27–1.19(m,3H).
14)(E)-N-(2-甲基硫烷基乙基)-N-苯基-3-(p-甲苯基)丙-2-烯酰胺的制备
方法A:79%产率
1H NMR(400MHz,氯仿-d)δ7.65(d,J=15.5Hz,1H),7.48–7.41(m,2H),7.41–7.35(m,1H),7.29–7.23(m,2H),7.19(d,J=8.1Hz,2H),7.08(d,J=8.0Hz,2H),6.23(d,J=15.5Hz,1H),4.07–3.99(m,2H),2.75–2.67(m,2H),2.31(s,3H),2.16(s,3H).
15)(E)-3-(4-甲氧基苯基)-N-(2-甲基硫烷基乙基)-N-苯基丙-2-烯酰胺的制备
方法A:85%产率
1H NMR(400MHz,氯仿-d)δ7.64(d,J=15.5Hz,1H),7.48–7.41(m,2H),7.42–7.34(m,1H),7.28–7.21(m,4H),6.82–6.78(m,2H),6.15(d,J=15.5Hz,1H),4.06–4.00(m,2H),3.78(s,3H),2.75–2.67(m,2H),2.16(s,3H).
16)2-(4-甲氧基苯氧基)-N-(2-甲基硫烷基乙基)-N-苯基乙酰胺的制备
方法A:89%产率
1H NMR(400MHz,氯仿-d)δ7.50–7.41(m,2H),7.40(s,1H),7.29–7.22(m,2H),6.76(t,J=9.1Hz,2H),6.71(s,2H),4.32(s,2H),3.99–3.88(m,2H),3.73(s,3H),2.72–2.59(m,2H),2.13(s,3H).
17)(E)-N-乙基-N-(3-甲基硫烷基丙基)-3-(p-甲苯基)丙-2-烯酰胺的制备
方法A:50%产率
在波谱中显示在氮处的两个旋转异构体。
1H NMR(400MHz,氯仿-d)δ7.69(d,J=15.3Hz,2H),7.47–7.39(m,4H),7.18(d,J=7.9Hz,4H),6.93(d,J=15.4Hz,1H),6.79(d,J=15.4Hz,1H),3.51(dt,J=14.2,7.8Hz,8H),2.55(t,J=7.0Hz,4H),2.37(s,6H),2.11(s,6H),1.99–1.87(m,4H),1.39–1.08(m,6H).
18)(E)-3-(1,3-苯并间二氧杂环戊烯-5-基)-N-乙基-N-(3-甲基硫烷基丙基)丙-2-烯酰胺的制备
方法A:66%产率
在波谱中显示在氮处的两个旋转异构体。
1H NMR(400MHz,氯仿-d)δ7.62(d,J=15.3Hz,2H),7.11–6.97(m,4H),6.87–6.76(m,2H),6.66(d,J=15.3Hz,2H),5.99(s,4H),3.59–3.43(m,8H),2.62–2.49(m,4H),2.12(s,6H),1.99–1.90(m,4H),1.26(t,J=7.1Hz,3H),1.19(t,J=7.1Hz,3H).
19)(E)-3-(1,3-苯并间二氧杂环戊烯-5-基)-N-(3-甲基硫烷基丙基)-N-苯基丙-2-烯酰胺的制备
方法A:98%产率
1H NMR(400MHz,氯仿-d)δ7.57(d,J=15.4Hz,1H),7.48–7.42(m,2H),7.41–7.34(m,1H),7.23–7.18(m,2H),6.85(dd,J=8.1,1.7Hz,1H),6.73–6.72(m,2H),6.72(d,J=8.0Hz,1H),6.10(d,J=15.4Hz,1H),5.93(s,2H),3.95–3.89(m,2H),2.56–2.49(m,2H),2.06(s,3H),1.94-1.84(m,2H).
20)(E)-3-(1,3-苯并间二氧杂环戊烯-5-基)-N-(2-甲氧基乙基)-N-苯基丙-2-烯酰胺的制备
方法A:61%产率
1H NMR(400MHz,氯仿-d)δ7.58(d,J=15.5Hz,1H),7.46–7.40(m,2H),7.40–7.33(m,1H),7.29–7.24(m,2H),6.85(dd,J=8.1,1.6Hz,1H),6.73(d,J=1.8Hz,1H),6.73(d,J=8.0Hz,1H),6.12(d,J=15.4Hz,1H),5.93(s,2H),4.00(t,J=5.8Hz,2H),3.60(t,J=5.8Hz,2H),3.33(s,3H).
21)(E)-3-(4-甲氧基苯基)-N-(2-甲基硫烷基乙基)-N-(2-吡啶基)丙-2-烯酰胺的制备
方法A:10%产率
1H NMR(400MHz,氯仿-d)δ8.55(d,J=5.7Hz,1H),7.75(td,J=7.7,2.0Hz,1H),7.69(d,J=15.5Hz,1H),7.35–7.28(m,2H),7.23(dd,J=7.5,4.5Hz,2H),6.94–6.73(m,2H),6.31(d,J=15.4Hz,1H),4.26–4.18(m,2H),3.80(s,3H),2.85–2.76(m,2H),2.15(s,3H).
22)2-(4-甲基苯氧基)-N-(2-甲基硫烷基乙基)-N-(2-吡啶基)乙酰胺的制备
方法A:19%产率
1H NMR(400MHz,氯仿-d)δ8.50–8.44(m,1H),7.77(td,J=7.8,2.0Hz,1H),7.30–7.25(m,1H),7.23(ddd,J=7.3,5.0,0.7Hz,1H),7.01(d,J=8.3Hz,2H),6.64(d,J=8.5Hz,2H),4.68(s,2H),4.10–4.00(m,2H),2.77–2.69(m,2H),2.25(s,3H),2.12(s,3H).
23)(E)-N-(2-甲基硫烷基乙基)-3-(p-甲苯基)-N-(1H-吡唑-3-基)丙-2-烯酰胺的制备
方法B:50%产率
1H NMR(600MHz,氯仿-d)δ10.91(s,1H),7.69(d,J=15.5Hz,1H),7.60(d,J=1.6Hz,1H),7.26(d,J=5.5Hz,2H),7.10(d,J=7.5Hz,2H),6.46(d,J=14.6Hz,1H),6.24(s,1H),4.04(t,J=13.1,6.2Hz,2H),2.78(t,J=7.4Hz,2H),2.32(s,3H),2.16(s,3H).
24)2-(4-甲基苯氧基)-N-(2-甲基硫烷基乙基)-N-(1H-吡唑-3-基)乙酰胺的制备
方法B:64%产率
1H NMR(400MHz,氯仿-d)δ7.57(d,J=2.5Hz,1H),7.00(d,J=8.2Hz,2H),6.71(d,J=8.4Hz,2H),6.23(d,J=2.4Hz,1H),4.53(s,2H),4.01–3.83(m,2H),2.77–2.62(m,2H),2.23(s,3H),2.11(s,3H).
25)2-(4-甲氧基苯氧基)-N-(2-甲基硫烷基乙基)-N-(1H-吡唑-3-基)乙酰胺的制备
方法B:53%产率
1H NMR(400MHz,氯仿-d)δ10.72(s,1H),7.58(d,J=2.4Hz,1H),6.77(s,4H),6.24(d,J=2.4Hz,1H),4.54(s,2H),3.93(dd,J=8.5,6.3Hz,2H),3.73(s,3H),2.72(dd,J=8.6,6.2Hz,2H),2.13(s,3H).
26)(E)-3-(1,3-苯并间二氧杂环戊烯-5-基)丙-2-烯酰氯的制备
将52.7g(274.2mmol)的3,4-亚甲二氧基肉桂酸、529mL的甲苯和1.60g的DMF的初始装料加热至57℃。在30分钟内,在57至60℃的温度下滴加44.1g(371mmol)的亚硫酰氯。将溶液在60至65℃再搅拌1小时,然后浓缩至约300mL的体积。加入3×289mL的甲苯,并且将每份在标准压力下再次蒸馏。
27)(E)-3-(1,3-苯并间二氧杂环戊烯-5-基)-N-苯基-N-四氢呋喃-3-基丙-2-烯酰胺的制备
在50℃下,向在7.5g甲苯中的0.72克(3.44mmol)3,4-亚甲二氧基肉桂酰氯中,加入0.52g(5.14mmol)三乙胺,然后加入0.52g(3.19mmol)N-苯基环氧戊烷-3-胺溶于4mL甲苯中。将混合物在60℃下搅拌8小时,然后冷却至室温。用水、1N盐酸、水、饱和NaHCO3溶液和再次的水洗涤有机相,经Na2SO4干燥,过滤并浓缩。
产率:39%
1H NMR(500MHz,CDCl3)δ7.56(d,J=15.4Hz,1H);7.50–7.38(m,3H);7.22–7.12(m,2H);6.81(dd,J=8.2,1.6Hz,1H);6.71(d,J=8.0Hz,1H);6.67(d,J=1.6Hz,1H);5.96–5.85(m,3H);5.29(dq,J=8.3,5.5Hz,2H);4.04(dd,J=9.3,6.7Hz,1H);3.79(dd,J=9.3,5.1Hz,1H);3.74–3.53(m,1H);2.20–2.12(m,1H);1.96–1.77(m,1H).
28)(E)-N-苯基-3-(p-甲苯基)-N-四氢呋喃-3-基丙-2-烯酰胺的制备
向0.56g(3.0mmol)的4-甲基肉桂酰氯在7.5mL的甲苯中的溶液中滴加0.46g(4.5mmol)的三乙胺。随后,在2分钟内,计量加入0.46g(2.8mmol)N-苯基四氢呋喃-3-胺在4mL甲苯中的混悬液。将混合物在室温搅拌46小时,在50℃搅拌11小时。加入20mL水用于后处理,除去有机相并在旋转蒸发仪上浓缩。残余物从乙酸乙酯/庚烷中重结晶。
产率:0.32g产物
1H NMR(500MHz,CDCl3)δ7.63(d,1H),7.50–7.40(m,3H),7.22(d,2H),7.14(d,2H),7.07(d,2H),6.06(d,1H),5.34–5.26(m,1H),4.05(t,1H),3.83-3.78(m,1H),3.71(dd,1H),3.61(dd,1H),2.30(s,3H);2.25-2.14(m,1H);1.90–1.81(m,1H).
29)N-苯基四氢噻吩-3-胺的制备
首先向反应器中装入91.1g(0.968mol)的2-氨基吡啶、1591mL甲苯、98.4g(0.963mol)的四氢噻吩-3-酮和81.6g的乙酸。在室温下,在30分钟内分批添加288g(1.36mol)三乙酰氧基硼氢化钠。将残留物用115mL甲苯冲洗,并将混合物在室温搅拌21h。随后,将混合物在15℃下计量加入4.85L 10%Na2CO3水溶液中,并与另外500mL甲苯混合。在15-20℃下继续搅拌约20分钟,除去水相,再用500mL甲苯萃取。合并有机相,并与2L水和280g 10%HCl混合。将混合物再搅拌10分钟,并将有机相除去并丢弃。每次用500mL甲苯将水相洗涤两次,同样将其丢弃。随后,将水相与2L水和1L甲苯混合,并用274mL的10%NaOH调节至pH 10.3。将混合物再搅拌10分钟,除去有机相,并将水相再次用250mL的甲苯再次萃取。合并的有机相用200mL水洗涤1次,用Na2SO4干燥并浓缩。
残留物:45.3g(28%)
30)(E)-3-(1,3-苯并间二氧杂环戊烯-5-基)-N-(2-吡啶基)-N-四氢噻吩-3-基丙-2-烯酰胺的制备
在约50℃下,向约57.7g(274mmol)3,4-亚甲基二氧基肉桂酰氯在约235mL甲苯中的溶液中加入在264mL甲苯中的41.6g(0.411mol)三乙胺和46.5g(258mmol)N-苯基四氢噻吩-3-胺。将混合物在55℃搅拌1h,然后在室温搅拌过夜。将混悬液冷却至0℃并过滤。将滤器残余物吸取在2L乙酸乙酯中,并在40℃下洗涤3次,每次用500mL水。在标准压力下将混合物浓缩至约600mL的体积水平,在3小时内冷却至约0℃,并再搅拌1小时。然后过滤并用80mL冰冷的乙酸乙酯洗涤滤饼。将滤饼干燥,吸取在1670mL的异丙醇中,并加热至回流(溶液)。将混合物浓缩至670mL的体积水平,冷却至20℃并过滤。将残余物用50mL冰冷的i-PrOH洗涤并干燥。
残留物:59.8g(产率:62%)
1H NMR(500MHz,CDCl3)δ8.63(d,1H);7.84(td,J=7.7,2.0Hz,1H);7.60(d,J=15.3Hz,1H);7.39(ddd,J=7.5,4.9,0.9Hz,1H);7.22(d,J=7.8Hz,1H),6.82(d,1H);6.72(d,J=8.0Hz,1H);6.68(d,J=1.6Hz,1H);5.94(s,2H);5.80(d,J=15.3Hz,1H);5.32–5.15(m,1H);3.12(dd,J=10.1,6.9Hz,1H);2.94–2.81(m,2H);2.72(ddd,J=10.3,7.8,2.4Hz,1H);2.35–2.25(m,1H);1.90–1.79(m,1H).
31)(E)-3-(p-甲苯基)-N-(2-吡啶基)-N-四氢噻吩-3-基丙-2-烯酰胺的制备
向在10mL甲苯中的0.74g(4.1mmol)的4-甲基肉桂酰氯的初始进料中添加0.52g(5.1mmol)的三乙胺。随后,计量加入在4.8mL甲苯中的0.65g(3.4mmol)N-四氢噻吩-3-基吡啶-2-胺,并将混合物在50℃下搅拌1h。将混合物在室温下用20mL水淬灭。滤出沉淀的固体,用水和少量MTBE洗涤,并干燥。
产率:57%
1H NMR(500MHz,CDCl3)δ8.64(br s,1H);7.83(td,J=7.7,2.0Hz,1H);7.67(d,J=15.4Hz,1H);7.39(dd,J=7.5,4.9Hz,1H);7.22(d,J=7.8Hz,1H);7.16(d,J=8.1Hz,2H);7.07(d,J=8.0Hz,2H);5.94(d,J=15.4Hz,1H);5.32–5.20(m,1H);3.13(dd,J=10.2,6.9Hz,1H);2.96–2.80(m,2H);2.78–2.66(m,1H);2.40–2.23(m,4H);1.94–1.78(m,1H).
32)(E)-3-(4-甲氧基苯基)-N-(2-吡啶基)-N-四氢噻吩-3-基丙-2-烯酰胺的制备
向在11mL甲苯中的0.81g(4.1mmol)的4-甲氧基肉桂酰氯的初始装料中加入0.52g(5.1mmol)的三乙胺。随后,计量加入在4.8mL甲苯中的0.65g(3.4mmol)的N-四氢噻吩-3-基吡啶-2-胺,并将混合物在50至60℃下搅拌1h。将混合物在室温下用20mL水淬灭。滤出沉淀的固体,用水和少量MTBE洗涤,并干燥。
产率:69%
1H NMR(500MHz,CDCl3)δ8.65(d,1H);7.83(td,J=7.7,1.8Hz,1H);7.65(d,J=15.4Hz,1H);7.39(dd,J=7.3,5.0Hz,1H);7.22(d,J=8.6Hz,3H);6.80(d,J=8.7Hz,2H);5.85(d,J=15.4Hz,1H);5.32–5.20(m.1H),3.78(s,3H);3.13(dd,J=10.1,6.9Hz,1H);2.97–2.80(m,2H);2.75–2.69(m,1H);2.35–2.25(m,1H);1.94–1.74(m,1H).
33)(E)-3-苯基-N-(2-吡啶基)-N-四氢噻吩-3-基丙-2-烯酰胺的制备
向在9mL甲苯中的0.68g(4.1mmol)的肉桂酰氯的初始装料中添加0.52g(5.1mmol)的三乙胺。随后,计量加入在4.8mL甲苯中的0.65g(3.4mmol)的N-四氢噻吩-3-基吡啶-2-胺,并将混合物在50至60℃下搅拌1h。将混合物在室温下用20mL水淬灭,并将有机相再次用20mL水洗涤。有机相经Na2SO4干燥,过滤并通过旋转蒸发浓缩。然后从正庚烷/EtOAc中重结晶。
产率:50%
1H NMR(500MHz,CDCl3)δ8.65(dd,J=4.8,1.8Hz,1H);7.84(td,J=7.7,2.0Hz,1H);7.70(d,J=15.4Hz,1H);7.42–7.35(m,1H);7.32–7.12(m,6H);5.99(d,J=15.4Hz,1H);5.35–5.13(m,1H);3.14(dd,J=10.2,6.9Hz,1H);2.97–2.81(m,2H);2.72(m,1H);2.31(m,Hz,1H);1.99–1.70(m,1H).
34)N-(四氢呋喃-2-基甲基)苯胺的制备
首先将96.1g(1.0mol)糠醛加入400g二氯甲烷中。随后,在40℃下滴加111.8g(1.2mol)的苯胺。将混合物冷却至0℃,并小心加入400g甲醇和56.7g(1.5mol)硼酸钠,并将混合物在0至5℃搅拌1h。将混合物用水淬灭,并蒸馏出甲醇。之后,将混合物用450g HCl(10%)中并用MTBE萃取。将有机相干燥并浓缩,将产物蒸馏并使用而无需进一步纯化。
最初将100g糠基苯胺装入250mL乙醇中,然后添加4g Pd/C。向反应器中供应氢气(10bar),并将混合物在50℃搅拌18小时。将混合物在室温下过滤并直接蒸馏。
产率:58%
(E)-3-81,3-苯并间二氧杂环戊烯-5-基)-N-苯基-N-(四氢呋喃-2-基甲基)丙-2-烯酰胺的制备
首先将1.14g(11.3mmol)的三乙胺和1.95g(11mmol)的2-四氢糠基苯基胺装入30g的甲苯中。随后,计量加入4.52g(21.5mmol)的3,4-亚甲二氧基肉桂酰氯,并将混合物在100℃下再搅拌2h。将混合物在室温下倒入50g水中,并通过抽吸滤出固体。相分离后,将有机相干燥,过滤并通过旋转蒸发浓缩。随后通过硅胶柱(AcOEt)。
产率:76%
1H NMR(400MHz,氯仿-d)δ7.58(d,J=15.5Hz,1H),7.47–7.39(m,2H),7.39–7.33(m,2H),7.33–7.28(m,1H),6.84(dd,J=8.1,1.7Hz,1H),6.72(d,J=1.6Hz,1H),6.70(d,J=7.9Hz,1H),6.13(d,J=15.5Hz,1H),5.92(s,2H),4.21–4.08(m,1H),4.00(dd,J=13.7,4.8Hz,1H),3.89–3.81(m,1H),3.84–3.75(m,1H),3.77–3.68(m,1H),1.98(ddd,J=6.9,4.2,1.9Hz,1H),1.96–1.79(m,2H),1.68–1.54(m,1H).
35)也可以类似于上述方法制备以下化合物:
(E)-3-(4-甲氧基苯基)-N-苯基-N-四氢呋喃-3-基丙-2-烯酰胺
1H NMR(500MHz,CD2Cl2)δ7.52(d,1H);7.48–7.35(m,3H);7.27–7.11(m,4H);6.77(d,2H);5.97(d,1H);5.29–5.13(m,1H);3.95(dd,1H);3.74(s,3H);3.70(dd,1H);3.63(q,1H);3.54(td,1H);2.21–2.05(m,1H);1.74–1.36(m,1H).
2-(4-甲基苯氧基)-N-苯基-N-四氢呋喃-3-基乙酰胺
1H NMR(500MHz,CDCl3)δ7.56–7.36(m,3H);7.30–7.16(m,2H);7.02(d,2H);6.66(d,2H);5.25–5.09(m,1H);4.25(d,1H);4.21(d,1H);3.98(dd,1H);3.78(dd,1H);3.67(td,1H);3.60–2.48(m,1H),2.25(s,3H);2.23–2.07(m,1H);1.85–1.75(m,1H).
2-(4-甲基苯氧基)-N-苯基-N-四氢噻吩-3-基乙酰胺
1H NMR(500MHz,CDCl3)δ7.55–7.35(m,3H);7.24–7.15(m,2H);7.02(d,2H);6.66(d,2H);5.34–4.97(m,1H);4.22(s,2H);3.04(dd,1H);2.84(td,1H);2.74–2.50(m,2H);2.37–2.10(m,4H);1.65(qd,1H).
(E)-N-环己基-3-(4-甲氧基苯基)-N-(3-噻吩基)丙-2-烯酰胺
1H NMR(500MHz,CDCl3)δ7.60(d,1H);7.37(dd,1H);7.25(d,2H);7.08(dd,1H);6.88(dd,1H);6.81(d,2H);6.05(d,1H);4.71–4.61(m,1H);3.79(s,3H);1.86(d,2H);1.76(d,2H);1.61(d,1H);1.44(qt,2H);1.13(qd,2H);1.03–0.90(m,1H).
N-环己基-2-(4-甲基苯氧基)-N-(3-噻吩基)乙酰胺
1H NMR(500MHz,CDCl3)δ7.45-7.30(m,1H);7.16-7.08(m,1H);7.02(d,2H);6.87(dd,1H);6.69(d,2H);4.61–4.49(m,1H);4.28(s,2H);2.25(s,3H);1.83(m,2H);1.74(d,2H);1.59(d,1H);1.39(q,2H);1.09(qd,2H);0.94(qt,1H).
N-环己基-2-(4-甲氧基苯氧基)-N-(3-噻吩基)乙酰胺
1H NMR(500MHz,CDCl3)δ7.38(dd,1H);7.11(dd,1H);6.87(dd,1H);6.82–6.62(m,4H);4.62–4.48(m,1H);4.26(s,2H);3.74(s,3H);1.82(d,2H);1.73(d,2H);1.59(d,1H);1.39(qt,2H);1.09(qd,2H);0.94(qt,1H).
(E)-3-(1,3-苯并间二氧杂环戊烯-5-基)-N-(1H-吡唑-3-基)-N-(四氢噻吩-2-基甲基)丙-2-烯酰胺
1H NMR(500MHz,CDCl3)δ7.68–7.54(m,2H);6.89(d,1H);6.81(s,1H);6.74(d,1H);6.31(d,1H);6.24(s,1H);5.96(s,2H);4.29–4.17(m,1H);3.67(br s,2H);2.92(dt,1H);2.81(dt,1H);2.18–1.81(m,4H).
(E)-3-(p-甲苯基)-N-(1H-吡唑-3-基)-N-(四氢噻吩-2-基甲基)丙-2-烯酰胺
制备采用N-(四氢噻吩-2-基甲基)-1-(2-三甲基甲硅烷基乙氧基甲基)吡唑-3-胺进行,并用四丁基氟化铵的THF溶液最终脱保护。
1H NMR(500MHz,CDCl3)δ7.75–7.55(m,2H);7.32–7.20(m,2H);7.09(d,2H);6.43(d,1H);6.22(s,1H);4.30–4.18(m,1H);3.75–3.62(m,2H);2.96–2.86(m,1H);2.85–2.74(m,1H);2.31(s,3H);2.13–1.77(m,4H).
(E)-3-(4-甲氧基苯基)-N-(1H-吡唑-3-基)-N-(四氢噻吩-2-基甲基)丙-2-烯酰胺
制备采用N-(四氢噻吩-2-基甲基)-1-(2-三甲基甲硅烷基乙氧基甲基)吡唑-3-胺进行,并用四丁基氟化铵的THF溶液最终脱保护。
1H NMR(500MHz,CDCl3)δ7.73(d,1H);7.65(s,1H);7.32(d,2H);6.84(d,2H);6.38(d 1H);6.26(s,1H);4.37–4.21(m,1H);3.79(s,3H);3.75–3.61(m,2H);3.00–2.89(m,1H);2.89–2.79(m,1H);2.18–1.83(m,4H).
2-(4-甲基苯氧基)-N-(1H-吡唑-3-基)-N-(四氢噻吩-2-基甲基)乙酰胺
1H NMR(500MHz,CDCl3)δ7.57(d,1H);7.00(d,2H);6.71(d,2H);6.24(d,1H);4.55(q,2H);4.18–4.04(m,1H);3.68–3.50(m,2H);2.93–2.67(m,2H);2.23(s,3H);2.08–1.80(m,4H).
2-(4-甲氧基苯氧基)-N-(1H-吡唑-3-基)-N-(四氢噻吩-2-基甲基)乙酰胺
1H NMR(500MHz,CDCl3)δ7.58(d,1H);6.76(s,,4H),6.24(d,1H);4.53(q,2H);4.13(q,1H);3.72(s,3H);3.65–3.46(m,2H);2.94–2.84(m,1H);2.84–2.74(m,1H);2.09–1.73(m,4H).
(E)-3-(p-甲苯基)-N-(1H-吡唑-3-基)-N-四氢噻吩-3-基丙-2-烯酰胺
1H NMR(500MHz,CDCl3)δ7.76–7.56(m,2H);7.21(d,2H);7.07(d,2H);6.24(d,1H);6.17(d,1H);5.37–5.22(m,1H);3.10(dd,1H);2.92–2.80(m,1H);2.76(t,1H);2.69(ddd,1H);2.36–2.22(m,4H);1.78(qd,1H).
(E)-3-(4-甲氧基苯基)-N-(1H-吡唑-3-基)-N-四氢噻吩-3-基丙-2-烯酰胺
1H NMR(500MHz,CDCl3)δ7.77–7.53(m,2H);7.25(d,2H);6.79(d,2H);6.24(d,1H);6.09(d,1H);5.40–5.16(m,1H);3.79(s,3H);3.10(dd,1H);2.92–2.82(m,1H);2.76(t,1H);2.75–2.65(m,1H);2.31–2.22(m,1H);1.85–1.70(m,1H).
2-(4-甲氧基苯氧基)-N-(1H-吡唑-3-基)-N-四氢噻吩-3-基乙酰胺
1H NMR(500MHz,CDCl3)δ7.62(d,1H);6.76(s,4H);6.23(d,1H);5.25–5.14(m,1H);4.35(s,2H);3.73(s,3H);3.07(dd,1H);2.84(dd,1H);2.78–2.59(m,2H);2.34–2.15(m,1H);1.84–1.70(m,1H).
(E)-3-(1,3-苯并间二氧杂环戊烯-5-基)-N,N-双(2-吡啶基)丙-2-烯酰胺
1H NMR(400MHz,CDCl3)δ8.48(d,2H);7.80(t,2H);7.73(d,1H);7.52(d,2H);7.25–7.16(m,2H);6.92(d,1H);6.80(s,1H);6.77(d,1H);6.19(d,1H);5.97(s,2H).
(E)-3-(1,3-苯并间二氧杂环戊烯-5-基)-N-(1H-吡唑-3-基)-N-(四氢呋喃-2-基甲基)丙-2-烯酰胺
1H NMR(400MHz,氯仿-d)δ7.61(d,J=15.5Hz,1H),7.57(d,J=2.1Hz,1H),6.90(d,J=7.7Hz,1H),6.83(s,1H),6.74(d,J=8.0Hz,1H),6.42(d,J=15.2Hz,1H),6.21(s,1H),5.95(s,2H),4.22(qd,J=7.2,4.2Hz,1H),4.13(dd,J=13.8,4.1Hz,1H),3.95–3.84(m,1H),3.78(td,J=7.9,6.2Hz,1H),3.68–3.60(m,1H),2.10–1.96(m,1H),1.99–1.82(m,2H),1.62(ddt,J=15.6,12.0,8.1Hz,1H).
(E)-3-(p-甲苯基)-N-(1H-吡唑-3-基)-N-(四氢呋喃-2-基甲基)丙-2-烯酰胺
1H NMR(400MHz,氯仿-d)δ11.26(s,1H),7.68(d,J=15.5Hz,1H),7.56(d,J=2.2Hz,1H),7.27(d,J=8.0Hz,2H),7.10(d,J=7.8Hz,2H),6.55(d,J=15.6Hz,1H),6.21(s,1H),4.22(qd,J=7.1,4.1Hz,1H),4.18–4.10(m,1H),3.90(dt,J=8.3,6.8Hz,1H),3.78(td,J=7.9,6.1Hz,1H),3.73–3.57(m,1H),2.32(s,3H),2.12–1.96(m,1H),1.98–1.80(m,2H),1.61(ddt,J=12.0,8.4,7.2Hz,1H).
(E)-3-(4-甲氧基苯基)-N-(1H-吡唑-3-基)-N-(四氢呋喃-2-基甲基)丙-2-烯酰胺
1H NMR(600MHz,氯仿-d)δ8.15(d,J=3.0Hz,1H),7.90(d,J=15.8Hz,1H),7.63–7.61(m,2H),7.62(d,J=15.9Hz,1H),6.93(d,J=8.7Hz,2H),5.92(d,J=3.0Hz,1H),4.14(qd,J=7.1,3.6Hz,1H),3.97–3.87(m,1H),3.85(s,3H),3.83–3.73(m,1H),3.57–3.47(m,1H),3.32–3.25(m,1H),2.04(dddt,J=9.5,8.4,6.9,4.9Hz,1H),1.98–1.88(m,2H),1.69(ddt,J=12.1,8.6,7.1Hz,1H).
2-(4-甲基苯氧基)-N-(1H-吡唑-3-基)-N-(四氢呋喃-2-基甲基)乙酰胺
1H NMR(400MHz,氯仿-d)δ7.54(d,J=2.4Hz,1H),7.01(d,J=8.1Hz,2H),6.72(d,J=8.0Hz,2H),6.28(s,1H),4.66–4.48(m,2H),4.2–4.1(m,1H),4.0–3.9(m,1H),3.9–3.8(m,1H),3.8–3.7(m,1H),3.64(dd,J=13.6,7.7Hz,1H),2.24(s,3H),2.03–1.78(m,3H),1.66–1.52(m,1H).
(E)-3-(1,3-苯并间二氧杂环戊烯-5-基)-N-(2-吡啶基)-N-(四氢呋喃-2-基甲基)丙-2-烯酰胺
1H NMR(600MHz,氯仿-d)δ8.53(ddd,J=4.9,2.0,0.8Hz,1H),7.75(ddd,J=8.1,7.4,2.0Hz,1H),7.63(d,J=15.3Hz,1H),7.33(dt,J=8.1,1.0Hz,1H),7.22(ddd,J=7.4,4.9,1.0Hz,1H),6.89(dd,J=8.1,1.6Hz,1H),6.80(d,J=1.7Hz,1H),6.75(d,J=8.0Hz,1H),6.27(d,J=15.3Hz,1H),5.95(s,2H),4.24–4.18(m,2H),4.04–3.98(m,1H),3.73(ddd,J=8.3,7.2,6.5Hz,1H),3.67(td,J=8.0,5.9Hz,1H),1.99(dddd,J=11.9,8.6,6.5,5.2Hz,1H),1.94–1.87(m,1H),1.87–1.79(m,1H),1.63(ddt,J=12.2,8.6,6.9Hz,1H).
(E)-3-(p-甲苯基)-N-(2-吡啶基)-N-(四氢呋喃-2-基甲基)丙-2-烯酰胺
1H NMR(600MHz,氯仿-d)δ8.53(dt,J=4.8,1.9,0.7Hz,1H),7.74(td,J=7.7,2.0Hz,1H),7.69(d,J=15.5Hz,1H),7.32(d,J=8.0Hz,1H),7.25(s,2H),7.22(ddd,J=7.4,4.9,0.9Hz,1H),7.11(d,J=8.0Hz,2H),6.40(d,J=15.4Hz,1H),4.25–4.21(m,2H),4.05–3.99(m,1H),3.77–3.70(m,1H),3.67(td,J=8.0,6.0Hz,1H),2.33(s,3H),2.04–1.96(m,1H),1.96–1.87(m,1H),1.87–1.78(m,1H),1.64(ddt,J=12.3,8.5,7.0Hz,1H).
(E)-3-(4-甲氧基苯基)-N-(2-吡啶基)-N-(四氢呋喃-2-基甲基)丙-2-烯酰胺
1H NMR(400MHz,氯仿-d)δ8.53(ddd,J=5.0,2.0,0.8Hz,1H),7.74(td,J=7.7,2.0Hz,1H),7.68(d,J=15.4Hz,1H),7.34(dd,J=7.5,1.0Hz,1H),7.32–7.28(m,2H),7.21(ddd,J=7.4,4.9,1.0Hz,1H),6.85–6.78(m,2H),6.33(d,J=15.4Hz,1H),4.27–4.17(m,2H),4.07–3.96(m,1H),3.80(s,3H),3.93–3.62(m,2H),2.09–1.75(m,3H),1.64(ddt,J=11.6,8.2,6.7Hz,1H).
(E)-3-(1,3-苯并间二氧杂环戊烯-5-基)-N-乙基-N-(四氢呋喃-2-基甲基)丙-2-烯酰胺
在波谱中显示在氮处的两个旋转异构体。
1H NMR(400MHz,氯仿-d)δ7.66–7.55(m,2H),7.06–6.95(m,4H),6.81–6.74(m,3H),6.70(d,J=15.3Hz,1H),5.98(s,4H),4.17–4.02(m,2H),3.93–3.82(m,3H),3.82–3.69(m,2H),3.69–3.56(m,4H),3.56–3.42(m,2H),3.20(dd,J=13.8,7.3Hz,1H),2.08–1.97(m,2H),1.97–1.79(m,3H),1.63–1.52(m,3H),1.23(t,J=7.0Hz,3H),1.18(t,J=7.1Hz,3H).
N-乙基-2-(4-甲氧基苯氧基)-N-(四氢呋喃-2-基甲基)乙酰胺
在波谱中显示在氮处的两个旋转异构体。
1H NMR(400MHz,氯仿-d)δ6.93–6.86(m,4H),6.82(dd,J=9.2,1.7Hz,4H),4.71(dd,J=14.6,1.3Hz,2H),4.66(dd,J=14.1,1.0Hz,2H),4.15–4.06(m,1H),4.06–3.99(m,1H),3.90–3.80(m,2H),3.76(s,6H),3.79–3.69(m,2H),3.66–3.57(m,1H),3.54(q,J=7.1Hz,2H),3.47–3.31(m,3H),3.13(dd,J=13.9,7.5Hz,2H),2.07–1.94(m,2H),1.94–1.78(m,4H),1.58–1.44(m,2H),1.21(t,J=7.1Hz,3H),1.13(t,J=7.1Hz,3H).
(E)-N-苯基-3-(p-甲苯基)-N-(四氢呋喃-2-基甲基)丙-2-烯酰胺
1H NMR(400MHz,氯仿-d)δ7.65(d,J=15.5Hz,1H),7.45–7.38(m,2H),7.38–7.33(m,1H),7.33–7.28(m,2H),7.18(d,J=8.1Hz,2H),7.06(d,J=8.0Hz,2H),6.26(d,J=15.5Hz,1H),4.21–4.14(m,1H),4.01(dd,J=13.7,4.8Hz,1H),3.88–3.69(m,3H),2.30(s,3H),2.02–1.78(m,3H),1.67–1.56(m,1H).
(E)-3-(4-甲氧基苯基)-N-苯基-N-(四氢呋喃-2-基甲基)丙-2-烯酰胺
/>
1H NMR(400MHz,氯仿-d)δ7.63(d,J=15.5Hz,1H),7.46–7.39(m,2H),7.38–7.32(m,1H),7.32–7.28(m,2H),7.27–7.21(m,2H),6.79(d,J=8.8Hz,2H),6.17(d,J=15.5Hz,1H),4.17(qd,J=6.8,4.9Hz,1H),4.02(dd,J=13.6,4.9Hz,1H),3.88–3.80(m,1H),3.82–3.75(m,1H),3.78(s,3H),3.73(ddd,J=8.3,7.4,5.8Hz,1H),2.06–1.94(m,1H),2.03–1.78(m,2H),1.68–1.56(m,1H).
2-(4-甲基苯氧基)-N-苯基-N-(四氢呋喃-2-基甲基)乙酰胺
1H NMR(400MHz,氯仿-d)δ7.43(dd,J=8.2,6.4Hz,2H),7.41–7.35(m,1H),7.34–7.29(m,2H),7.01(d,J=8.3Hz,2H),6.72–6.64(m,2H),4.36(d,J=14.6Hz,1H),4.31(d,J=14.7Hz,1H),4.12(qd,J=6.6,4.6Hz,1H),3.89–3.78(m,2H),3.72(td,J=7.8,5.9Hz,2H),2.24(s,3H),2.04–1.78(m,3H),1.62–1.53(m,1H).
2-(4-甲氧基苯氧基)-N-苯基-N-(四氢呋喃-2-基甲基)乙酰胺
1H NMR(400MHz,氯仿-d)δ7.47–7.40(m,2H),7.40–7.34(m,1H),7.34–7.28(m,2H),6.77(d,J=9.3Hz,2H),6.72(d,J=9.4Hz,2H),4.38–4.24(m,2H),4.17–4.06(m,1H),3.88–3.78(m,2H),3.78–3.69(m,2H),3.73(s,3H),2.05–1.77(m,3H),1.64–1.53(m,1H).
(E)-3-(1,3-苯并间二氧杂环戊烯-5-基)-N-乙基-N-[2-(2-噻吩基)乙基]丙-2-烯酰胺
1H NMR(400MHz,氯仿-d)δ7.65(d,J=15.2Hz,1H),7.54(d,J=15.2Hz,1H),7.18–7.10(m,2H),7.06–6.98(m,2H),6.97–6.89(m,4H),6.88–6.83(m,2H),6.79(t,J=8.2Hz,2H),6.66(d,J=15.3Hz,1H),6.44(d,J=15.3Hz,1H),5.98(s,4H),3.66(t,J=7.5Hz,4H),3.50(q,J=7.1Hz,2H),3.37(q,J=7.2Hz,2H),3.19–3.09(m,4H),1.19(t,J=7.1Hz,6H).
感官评估:
与FEMA 4809相比,本发明酰胺化合物的清凉强度:
由训练有素的专家组(n=10至11)感官评估在5%的糖溶液中含有2或20ppm的本发明酰胺化合物的测试溶液,并将其与含有2ppm的比较化合物FEMA 4809的溶液进行比较。初始清凉强度、总体清凉强度和持久作用,范围从1(非常弱)到9(非常强)。
/>
N.B.:将化合物预溶解为1%乙醇溶液。
显而易见的是,清凉作用的起效更快,与参考相当或更好的清晰的清凉性质,以及本发明酰胺的明显持久的清凉作用。
与参考化合物(FEMA 4809、4496)和WS3相比,本发明酰胺的时间强度概况:
为了建立时间强度概况,将训练有素的专家组(n=8至11)的口腔用一口样品溶液(2ppm FEMA 4809或50ppm FEMA 4496或50ppm 1)至5))冲洗40秒。随后,使用标尺(scale)在定义的时间间隔内评估感知到的清凉强度。
/>
1)(E)-3-(1,3-苯并间二氧杂环戊烯-5-基)-N-苯基-N-四氢呋喃-3-基丙-2-烯酰胺
2)(E)-3-(1,3-苯并间二氧杂环戊烯-5-基)-N-(2-吡啶基)-N-四氢噻吩-3-基丙-2-烯酰胺
3)(E)-3-(p-甲苯基)-N-(2-吡啶基)-N-四氢噻吩-3-基丙-2-烯酰胺
4)(E)-3-苯基-N-(2-吡啶基)-N-四氢噻吩-3-基丙-2-烯酰胺
5)(E)-3-(1,3-苯并间二氧杂环戊烯-5-基)-N-(2-甲基硫烷基乙基)-N-(2-吡啶基)丙-2-烯酰胺
对于本发明的酰胺,发现相对于WS3明显更快速或至少可比快速地开始清凉活性。此外,与WS3相比,清凉效果的持续时间更长,并且与参考化合物(FEMA 4809、FEMA 4496)有可比的长持续的时间,但是后者显示出明显延迟的清凉作用起效。
应用实施例:
牙膏
可以根据以下基本制剂生产合适的牙膏:
/>
评估示例性牙膏中根据本发明使用的化合物的清凉强度随时间变化的进展:
将根据本发明使用的清凉物质如下掺入牙膏中:
/>
所有数字均以重量%计
由训练有素的专家组(6人)评估所得牙膏的感官特性。为此目的,首先用包含本发明化合物的牙膏清洁牙齿30秒,然后将牙膏泡沫吐出,并用水漱口一次。测试人员以从0(无冷感)到9(极强的冷感)的等级评估了冷感的强度。在30秒后和1、5、10、20、30、45和60分钟后评估冷感。
通过实例测试的本发明的化合物是这些化合物(E)-N-苯基-3-(p-甲苯基)-N-四氢呋喃-3-基丙-2-烯酰胺、(E)-3-(4-甲氧基苯基)-N-(2-吡啶基)-N-四氢噻吩-3-基丙-2-烯酰胺、(E)-3-(1,3-苯并间二氧杂环戊烯-5-基)-N-苯基-N-(四氢呋喃-2-基甲基)丙-2-烯酰胺、(E)-3-(1,3-苯并间二氧杂环戊烯-5-基)-N-(2-甲基硫烷基乙基)-N-苯基丙-2-烯酰胺、2-(4-甲基苯氧基)-N-(2-甲基硫烷基乙基)-N-苯基乙酰胺、(E)-3-(1,3-苯并间二氧杂环戊烯-5-基)-N-乙基-N-(2-甲基硫烷基乙基)丙-2-烯酰胺和(E)-N-(2-甲基硫烷基乙基)-3-(p-甲苯基)-N-(2-吡啶基)丙-2-烯酰胺,但尤其是化合物(E)-3-(1,3-苯并间二氧杂环戊烯-5-基)-N-(2-吡啶基)-N-四氢噻吩-3-基丙-2-烯酰胺、(E)-3-(1,3-苯并间二氧杂环戊烯-5-基)-N-(2-甲基硫烷基乙基)-N-(2-吡啶基)丙-2-烯酰胺、(E)-3-(p-甲苯基)-N-(2-吡啶基)-N-四氢噻吩-3-基丙-2-烯酰胺、(E)-3-苯基-N-(2-吡啶基)-N-四氢噻吩-3-基丙-2-烯酰胺、(E)-3-(1,3-苯并间二氧杂环戊烯-5-基)-N-苯基-N-四氢呋喃-3-基丙-2-烯酰胺和(E)-3-(1,3-苯并间二氧杂环戊烯-5-基)-N-(2-甲基硫烷基乙基)-N-(1H-吡唑-3-基)丙-2-烯酰胺。
通过比较,测试了具有相同组成但包含作为常规清凉物质的N-乙基薄荷烷-3-甲酰胺("WS 3",也参见US 4,150,052)的牙膏。
结果表明,就快速可感知的强度和对清凉感的持续时间而言,本发明的清凉物质明显优于常规使用的清凉物质。因此,即使在清洁牙齿后1小时后,本发明的清凉物质仍提供非常明显的可察觉的冷感,而在常规比较化合物的情况下,在该时间后这种感觉已完全消失。
口香糖
可以根据以下基本制剂生产合适的口香糖:
%重量 | 成分 |
15-25% | 口香糖胶基质 |
20-30% | 葡萄糖浆 |
50-60% | 糖粉 |
0.001-10% | TRPM8激动剂 |
1-2% | 柔软剂(例如甘油) |
3-6% | 水 |
对于“无糖配方”,也可以用糖醇甘露醇、木糖醇和山梨糖醇,“Palatinit”和其他合成甜味剂如糖精、环己氨基磺酸盐(cyclamate)、乙酰舒泛(acesulfame-K)和阿斯巴甜代替葡萄糖浆和糖粉。
美容化妆品防晒制剂
随后的制剂描述了包括至少无机颜料和有机UV过滤剂的组合的美容化妆品防晒制剂。
下文中指定的制剂以本领域技术人员已知的常规方式生产。
牛奶冻
配方(对于100ml)
成分 | 量 |
无脂奶粉 | 10.715g |
蔗糖 | 5g |
Novelose淀粉,National Starch | 7g |
植物油混合物 | 2.2g |
角叉菜胶 | 0.016g |
香草调味料 | 0.5g |
硬脂酰-2-乳酸钠 | 0.095g |
黄色染料(Yellow dye) | 0.189g |
磷酸镁 | 0.165g |
维生素预混合物 | 1.84g |
微量元素预混合物 | 0.015g |
活性成分 | 0.5g |
水 | 81.94g |
制备:
将十分之九的水加热到43.3℃。将脱脂奶粉溶解在水中。将油加热至60℃,并向油中添加角叉菜胶和油溶性维生素。将油混入产品中。添加除了改性淀粉、香草调味料和维生素预混物之外的其它组分。均化混合物。逐渐添加淀粉。
添加活性物质、维生素和调味料。标准化固体含量。在无菌单位中加热并按剂量包装。
用本发明的活性物质进行纺织品改性
首先,制备含直链淀粉的淀粉的含水浆料:将570克去离子水与10克标准商业防腐剂混合。将20g的羧甲基纤维素溶解在其中,然后添加400g的直链淀粉含量为50重量%的含直链淀粉的淀粉,并且在搅拌下制备浆料。
这跟随有通过以下两种方法之一生产具有含直链淀粉的淀粉的含水液体:
方法1:通过用水稀释将各自的浆料调节至淀粉含量为5重量%或15重量%。
方法2:首先将各自的浆料用水稀释至淀粉含量为5重量%或15重量%,然后与30g/L的30重量%的含水聚氨酯分散体(非离子型)混合。
随后用含直链淀粉的淀粉和本发明的活性物质改性机织织物。
用上述制备的液体之一,通过垫式轧布机将基重为124g/m2的样本棉织物进行处理,至液体的拾取量高达80重量%(基于织物重量计)。随后在120℃下干燥2分钟。
随后,通过使用垫式轧布机将具有1重量%至7%重量的本发明活性物质的本发明的活性物质的含水乳剂/混悬液施用于织物样品,高达79-80%(重量)的液体拾取量,从而用含水活性物质制剂处理如此改性的织物样品。随后,将如此处理的织物样品在家用干燥机中干燥至残留水分含量为15%。
然后可以进一步就例如它们在与皮肤接触时的清凉作用或对昆虫的驱虫作用检查由此生产的负载有活性物质的织物。
漱口剂调味品
使用本发明的清凉物质生产具有清凉作用的漱口调味品:
混合以下各项(除非另有说明,所有数字均以重量%计):
将调味品各自以0.15重量%的浓度掺入即用型漱口水中,或以3重量%的浓度掺入漱口水浓缩物中。由训练有素的专家小组进行的感官评估显示,调味品可导致非常持久的新鲜效果,迅速起效,这种效果在漱口水使用后持续了几乎1小时。
可咀嚼糖果
使用本发明的清凉物质生产具有清凉树莓风味的可咀嚼的糖果。
除非另有说明,所有数字均以重量%计:
/>
生产说明:
a)使明胶在70℃用水(明胶量的1.8倍)溶胀2小时;
b)在123℃下煮糖、糖浆、水、脂肪和卵磷脂;
c)将明胶溶液与沸腾的混合物逐渐混合;
d)将树莓调味剂、乳酸薄荷酯和本发明的清凉物质混合,并任选地搅拌上色;
e)将所得物质在冷藏台上变至约70℃,然后加入方旦糖并在拉拔机上充气约3分钟;
f)然后切碎可咀嚼的糖果混合物并包装。
一旦食用可咀嚼的糖果,咀嚼时会感觉到新鲜的清凉树莓味。
水果胶
使用本发明的清凉物质生产具有持久的新鲜清凉味的水果胶。
除非另有说明,所有数字均以%重量计:
上述应用实施例可以适用于各产品组中的其他产品-如果合适,可以通过本领域技术人员不会觉得困难的修改来应用。基于本说明书,对于本领域技术人员而言,不难发现本发明的化合物(可能进行较小的修饰)可以相互互换而没有太大的复杂性。对于本领域技术人员显而易见的是,所使用的本发明的化合物或混合物的浓度也是可变的。此外,在各自的应用实例中,以本领域技术人员容易理解的方式,特定于产品的其他成分也可以交换为其他典型产品的成分,或者可以由此进行补充。上面的描述中公开了许多这种特定于产品的成分。
Claims (27)
1.一种体外和/或体内调节冷薄荷醇受体TRPM8的非治疗方法,其中使所述受体与至少一种调节剂接触,所述调节剂选自由以下化合物组成的A组:
和这些化合物的盐;
和任选的立体异构纯形式的这些化合物或其立体异构体的混合物。
2.根据权利要求1所述的方法,其中所述化合物的盐选自与无机或有机一元和多元羧酸的酸加成盐。
3.根据权利要求1所述的方法,其中使所述受体与至少一种调节剂接触,所述调节剂在使用重组表达人TRPM8受体的细胞的细胞活性测试中调节这些细胞对Ca2+离子的渗透性。
4.根据权利要求1或3所述的方法,其中所述调节剂对细胞Ca2+离子渗透性具有激动作用。
5.根据权利要求1或3所述的方法,其中所述调节剂是TRPM8受体激动剂。
6.权利要求5所述的方法中的调节剂用于非治疗性诱导人和/或动物的冷感觉的用途。
7.根据权利要求6所述的用途,其用于通过包含所述调节剂的包装或纺织品来非治疗性诱导冷感觉。
8.根据权利要求6所述的用途,其中包含至少一种、两种、三种或更多种根据权利要求5所述的方法中的调节剂的组合物用于实现如下清凉效果:与其中仅仅调节剂被替换为相同浓度的N-乙基薄荷烷甲酰胺的相同组成的组合物的清凉效果相比,在皮肤或粘膜上实现清凉效果,和/或与其中仅仅调节剂被替换为相同浓度的FEMA 4809或FEMA 4496的相同组成的组合物的清凉效果相比,更早出现清凉效果。
9.根据权利要求8所述的用途,其中所述组合物包含以组合物的总重量为基准的量为0.1ppm至10重量%的至少一种、两种、三种或更多种根据权利要求5所述的方法中的调节剂。
10.根据权利要求8所述的用途,其中所述皮肤或粘膜上实现的清凉效果是与其中仅仅调节剂被替换为相同浓度的N-乙基薄荷烷甲酰胺的相同组成的组合物的清凉效果相比延长的皮肤或粘膜上的清凉效果。
11.根据权利要求10所述的用途,其中所述延长的清凉效果是延长至少10分钟的清凉效果。
12.根据权利要求7或8所述的用途,其中所述调节剂选自如权利要求1所述的方法中的A组。
13.根据权利要求1所述的方法中的调节剂,其用作TRPM8受体的调节剂。
14.根据权利要求1所述的方法中的调节剂,其用于调节TRPM8受体的非治疗方法。
15.化合物,其选自由以下化合物组成的A组:
/>
/>
或所述化合物的盐。
16.根据权利要求15所述的化合物,其中所述化合物的盐选自与无机或有机、一元或多元羧酸的酸加成盐。
17.一种包含根据权利要求15或16所述的化合物的组合物。
18.包含至少一种权利要求1-5中任一项所述的方法中的调节剂的组合物,其用作TRPM8受体的调节剂。
19.根据权利要求18所述的组合物,其用于调节TRPM8受体的治疗方法。
20.根据权利要求18或19所述的组合物,或根据权利要求17所述的组合物,其中所述组合物选自:
a)食品,
b)口腔护理产品,
c)个人护理产品,
d)泡沫和凝胶。
21.根据权利要求20所述的组合物,其中
所述食品选自冰淇淋、慕斯、奶油、饮料和糖果;
所述口腔护理产品选自牙膏、漱口水和口香糖;和/或
所述个人护理产品选自护肤或护发产品。
22.根据权利要求21所述的组合物,其中所述个人护理产品选自防晒霜、晒斑霜、乳液和洗发剂以及贴剂。
23.根据权利要求18-19中任何一项所述的组合物,或根据权利要求17所述的组合物,其中所述组合物选自:芳香混合物和用于营养、口腔卫生、娱乐目的或美容化妆的制剂,其包含一种、两种、三种或更多种权利要求1-5中任一项所述的方法中的调节剂,其中以芳香混合物或制剂的总重量为基准计,所述调节剂以0.05ppm-10重量%的量存在。
24.根据权利要求23所述的组合物,其中以芳香混合物或制剂的总重量为基准计,所述调节剂以0.1ppm-10重量%的量存在。
25.根据权利要求18-19中任何一项所述的组合物,或根据权利要求17所述的组合物,其中所述组合物还包含:
(1)具有生理清凉作用的一种或多种其他物质,其中该其他物质或一种、多于一种或全部所述其他物质(i)引起调味作用,或(ii)不会引起调味作用,
和/或
(2)一种或多种没有生理清凉作用的芳香物
和/或
(3)一种或多种具有三叉神经或令人垂涎作用而没有生理清凉作用的物质
和/或
(4)(iii)一种化合物或(iv)两种或更多种化合物,其,在情况(iv)中独立地或共同地,另外引起风味调节作用和/或三叉神经和/或令人垂涎的刺激。
26.权利要求17至25中任一项所述的组合物的用途,其用于非治疗性地诱导人和/或动物的冷感,以实现对皮肤和/或粘膜的下述生理清凉效果,与其中仅仅调节剂被替换为相同浓度的N-乙基薄荷烷甲酰胺的相同组成的组合物的清凉效果相比,清凉效果被延长至少10分钟,和/或与其中仅仅调节剂被替换为相同浓度的FEMA 4809或FEMA 4496的相同组成的组合物的清凉效果相比,更早出现清凉效果,其包括以下步骤:
施用足以对皮肤和/或粘膜实现生理清凉效果的量的权利要求17至25中任一项所述的组合物。
27.根据权利要求26所述的用途,其中所述调节剂选自如权利要求1所述的A组。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17188719 | 2017-08-31 | ||
EP17188719.3 | 2017-08-31 | ||
PCT/EP2018/073486 WO2019043164A1 (de) | 2017-08-31 | 2018-08-31 | Verwendung physiologischer kühlwirkstoffe und mittel enthaltend solche wirkstoffe |
Publications (2)
Publication Number | Publication Date |
---|---|
CN111343963A CN111343963A (zh) | 2020-06-26 |
CN111343963B true CN111343963B (zh) | 2023-09-12 |
Family
ID=59811082
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201880056223.6A Active CN111343963B (zh) | 2017-08-31 | 2018-08-31 | 生理清凉活性成分的用途以及包含此类活性成分的组合物 |
Country Status (7)
Country | Link |
---|---|
US (1) | US11434220B2 (zh) |
EP (1) | EP3675809B1 (zh) |
JP (1) | JP7231617B2 (zh) |
CN (1) | CN111343963B (zh) |
ES (1) | ES2967435T3 (zh) |
MX (1) | MX2020002347A (zh) |
WO (1) | WO2019043164A1 (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112057468A (zh) * | 2020-09-23 | 2020-12-11 | 上海交通大学 | 一种氢化镁在制备防治慢性牙周炎的组合物中的应用及氢化镁牙膏 |
WO2022207944A2 (en) | 2022-07-11 | 2022-10-06 | Symrise Ag | Novel mixtures and uses of (2e)-3-(1,3-benzodioxol-5-yl)-n-phenyl-n-(tetrahydro-3-furanyl)-2-propenamide |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102137660A (zh) * | 2008-08-26 | 2011-07-27 | 巴斯夫欧洲公司 | 冷薄荷醇受体trpm8的低分子量调节剂的检测和用途 |
Family Cites Families (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US771114A (en) | 1901-01-14 | 1904-09-27 | Direct Line General Telephone Company | Switching mechanism for intercommunicating telephone-lines. |
DE442946C (de) | 1924-02-20 | 1927-04-12 | Siemens Schuckertwerke G M B H | Verfahren und Vorrichtung zum Bestimmen des Wassergehalts von Isolieroelen |
US2973282A (en) | 1955-07-23 | 1961-02-28 | Degussa | Process for the surface treatment of finely-divided oxides or oxide mixtures |
US3111127A (en) | 1961-06-27 | 1963-11-19 | Brown & Williamson Tobacco | Smoking tobacco product and method of making the same |
US3307544A (en) | 1963-09-10 | 1967-03-07 | Johnson & Johnson | Surgical pressure-sensitive adhesive sheet with n-tert-butylacrylamide copolymer adhesive |
FR2110268B1 (zh) | 1970-10-07 | 1976-06-04 | Minnesota Mining & Mfg | |
US3699323A (en) | 1970-12-23 | 1972-10-17 | Ibm | Error detecting and correcting system and method |
US4150052A (en) | 1971-02-04 | 1979-04-17 | Wilkinson Sword Limited | N-substituted paramenthane carboxamides |
US4262003A (en) | 1975-12-08 | 1981-04-14 | Alza Corporation | Method and therapeutic system for administering scopolamine transdermally |
DE2608226A1 (de) | 1976-02-28 | 1977-09-08 | Haarmann & Reimer Gmbh | Mittel mit physiologischer kuehlwirkung |
SU636236A1 (ru) | 1976-05-25 | 1978-12-05 | Институт Биоорганической Химии Ан Белорусской Сср | Производные 8-аза-16-оксагонана, обладающие противоспалительным действием и способ их получени |
US4237253A (en) | 1977-04-21 | 1980-12-02 | L'oreal | Copolymers, their process of preparation, and cosmetic compounds containing them |
JPS54112882A (en) | 1978-02-23 | 1979-09-04 | Mitsubishi Chem Ind Ltd | Preparation of pyrimidine derivative |
RU704083C (ru) | 1978-07-05 | 1993-10-30 | Институт биоорганической химии АН БССР | Производные D-гомо-8-азагонана, обладающие противовоспалительной, мембраностабилизирующей и антикоагул ционной активностью |
SU704082A1 (ru) | 1978-07-05 | 1989-10-23 | Институт биоорганической химии АН БССР | Производные 8,16-диазагонана, обладающие противовоспалительной активностью и мембранозащитным действием |
DE2837851A1 (de) | 1978-08-30 | 1980-03-20 | Iws Nominee Co Ltd | Verfahren zur behandlung von textilien und damit behandelte textilien |
SU776048A1 (ru) | 1979-06-05 | 1983-09-23 | Институт Бисорганической Химии Ан Бсср | Производные 8-аза-16-оксагона-17-онов, про вл ющие противовоспалительную,мембраностабилизирующую и антифибринолитическую активность,и способ их получени |
US4497800A (en) | 1982-07-06 | 1985-02-05 | Mead Johnson & Company | Stable liquid diet composition |
CH651445A5 (en) | 1982-07-28 | 1985-09-30 | Ciba Geigy Ag | Composition and method for the selective control of weeds in transplanted rice or rice which is sown in water |
DE3314742A1 (de) | 1983-04-23 | 1984-10-25 | Degussa Ag, 6000 Frankfurt | An der oberflaeche modifizierte natuerliche oxidische oder silikatische fuellstoffe, ein verfahren zur herstellung und deren verwendung |
US4752478A (en) | 1984-12-17 | 1988-06-21 | Merck & Co., Inc. | Transdermal system for timolol |
US4670268A (en) | 1985-01-29 | 1987-06-02 | Abbott Laboratories | Enteral nutritional hypoallergenic formula |
GB8603171D0 (en) | 1986-02-08 | 1986-03-12 | Howard A N | Dietary product |
DE3708451A1 (de) | 1987-03-16 | 1988-10-06 | Henkel Kgaa | Zwitterionische polymere und deren verwendung in haarbehandlungsmitteln |
DE3740186A1 (de) | 1987-06-24 | 1989-01-05 | Beiersdorf Ag | Desodorierende und antimikrobielle zusammensetzung zur verwendung in kosmetischen oder topischen zubereitungen |
DE3807283A1 (de) | 1988-03-05 | 1989-09-14 | Basf Ag | Verfahren zur herstellung eines pflasters zur transdermalen anwendung pharmazeutischer wirkstoffe |
JPH02122979A (ja) | 1988-11-02 | 1990-05-10 | Oji Paper Co Ltd | 感熱記録体 |
DK0392608T3 (da) | 1989-04-12 | 1995-11-20 | Procter & Gamble | Faste konsumentproduktsammensætninger, der indeholder cyclodextrinkomplekser af lille partikelstørrelse |
CA2017287A1 (en) | 1989-05-23 | 1990-11-23 | Shunji Naruto | Substituted phenol derivatives and their use |
DE3929973A1 (de) | 1989-09-08 | 1991-03-14 | Henkel Kgaa | Haarpflegemittel |
DE3938140A1 (de) | 1989-11-16 | 1991-08-08 | Beiersdorf Ag | Desodorierende kosmetische mittel |
DE4035378C2 (de) | 1990-11-07 | 2000-11-02 | Oeffentliche Pruefstelle Und T | Textiles Material sowie Verfahren zur Herstellung eines derartigen textilen Materials |
DE4110973A1 (de) | 1991-04-05 | 1992-10-08 | Haarmann & Reimer Gmbh | Mittel mit physiologischem kuehleffekt und fuer diese mittel geeignete wirksame verbindungen |
US5104677A (en) | 1991-06-27 | 1992-04-14 | Abbott Laboratories | Liquid nutritional product |
DE4204321A1 (de) | 1992-02-13 | 1993-08-19 | Beiersdorf Ag | Verfahren zur isolierung und reinigung von fettsaeuren und hydroxyfettsaeuren und verwendungen von hydroxyfettsaeuren sowie zubereitungen, die sie enthalten |
US5223285A (en) | 1992-03-31 | 1993-06-29 | Abbott Laboratories | Nutritional product for pulmonary patients |
DE4226043A1 (de) | 1992-08-06 | 1994-02-10 | Haarmann & Reimer Gmbh | Mittel mit physiologischem Kühleffekt und für diese Mittel geeignete wirksame Verbindungen |
DE4229737C2 (de) | 1992-09-05 | 1996-04-25 | Beiersdorf Ag | Desodorierende kosmetische Mittel mit einem Gehalt an Fettsäuren |
DE4229707A1 (de) | 1992-09-05 | 1994-03-10 | Beiersdorf Ag | Germicide Wirkstoffkombinationen |
DE4237081C2 (de) | 1992-11-03 | 1996-05-09 | Beiersdorf Ag | Verwendung von Di- oder Triglycerinestern als Deowirkstoffe |
CA2110565A1 (en) | 1992-12-04 | 1994-06-05 | Robert Louis Joseph | Nutritional bar for a protein-sparing diet of the very-low-calorie type |
DE4309372C2 (de) | 1993-03-23 | 1997-08-21 | Beiersdorf Ag | Kosmetische Desodorantien, enthaltend Gemische aus Wollwachssäuren oder Wollwachssäurekomponenten und Fettsäurepartialglyceriden unverzweigter Fettsäuren |
DE4324219C2 (de) | 1993-07-20 | 1995-08-10 | Beiersdorf Ag | Desodorierende Wirkstoffkombinationen auf der Basis von alpha, omega-Alkandicarbonsäuren und Wollwachssäuren |
DE4333238A1 (de) | 1993-09-30 | 1995-04-06 | Basf Ag | Pyrrolidongruppenhaltige Polyester und Polyamide |
DE4411664A1 (de) | 1994-04-05 | 1995-10-12 | Beiersdorf Ag | Neue desodorierende und antimikrobielle Zusammensetzungen zur Verwendung in kosmetischen oder topischen Zubereitungen |
DE4423410C2 (de) | 1994-07-04 | 1996-07-18 | Beiersdorf Ag | Desodorierende Wirkstoffkombinationen auf der Basis von alpha, omega-Alkandicarbonsäuren und Monocarbonsäureestern von Oligoglyceriden |
DE4429467C2 (de) | 1994-08-19 | 1997-10-02 | Beiersdorf Ag | Desodorierende kosmetische Mittel |
DE19516705C2 (de) | 1995-05-06 | 1997-10-02 | Beiersdorf Ag | Gegen Bakterien, Mycota und Viren wirksame Substanzen |
US5725865A (en) | 1995-08-29 | 1998-03-10 | V. Mane Fils S.A. | Coolant compositions |
US5752529A (en) | 1996-08-21 | 1998-05-19 | V. Mane Fils S.A. | Tobacco products containing coolant compositions |
US5843466A (en) | 1995-08-29 | 1998-12-01 | V. Mane Fils S.A. | Coolant compositions |
DE19541967A1 (de) | 1995-11-10 | 1997-05-15 | Beiersdorf Ag | Gegen Bakterien, Mycota und Viren wirksame Zusammensetzungen auf der Basis von Partialglyceriden und Arylverbindungen |
DE19543696A1 (de) | 1995-11-23 | 1997-05-28 | Beiersdorf Ag | Gegen Bakterien, Mycota und Viren wirksame Wirkstoffkombinationen auf der Basis von Partialglyceriden und dialkylsubstituierte Essigsäuren |
DE19543695A1 (de) | 1995-11-23 | 1997-05-28 | Beiersdorf Ag | Gegen Bakterien, Mycota und Viren wirksame Zusammensetzungen auf der Basis von alpha-Hydroxyalkansäuren und Squalen |
US20020165168A1 (en) | 1995-12-16 | 2002-11-07 | Joachim Bunger | Use of sugar derivatives as antimicrobial, antimycotic and/or antiviral active substances |
DE19602110A1 (de) | 1996-01-22 | 1997-07-24 | Beiersdorf Ag | Gegen Bakterien, Parasiten, Protozoen, Mycota und Viren wirksame Zusammensetzungen auf der Basis von Squalen und Sphingolipiden |
DE19602108A1 (de) | 1996-01-22 | 1997-07-24 | Beiersdorf Ag | Gegen Bakterien, Parasiten, Protozoen, Mycota und Viren wirksame Substanzen |
DE19602111A1 (de) | 1996-01-22 | 1997-07-24 | Beiersdorf Ag | Gegen Bakterien, Mycota, Parasiten, Protozoen und Viren wirksame Zusammensetzungen auf der Basis von Squalen, Sphingolipiden und Fettsäuren |
DE19631004A1 (de) | 1996-08-01 | 1998-02-05 | Beiersdorf Ag | Desodorierende Wirkstoffkombinationen auf der Basis von Wollwsaschsäuren, Partialglyceriden und Arylverbindungen |
DE19631003A1 (de) | 1996-08-01 | 1998-02-05 | Beiersdorf Ag | Gegen Bakterien, Mycota und Viren wirksame Wirkstoffkombinationen auf der Basis von Partialglyceriden und dialkylsubstituierten Essigsäuren |
DE19634019A1 (de) | 1996-08-23 | 1998-02-26 | Beiersdorf Ag | Gegen Mikroogranismen, Viren, Parasiten und Protozoen wirksame Glycoglycerolipide |
DE19810951B4 (de) | 1998-03-13 | 2005-09-29 | Ciba Speciality Chemicals Holding Inc. | Verwendung eines textilen Materials als transdermales Abgabesystem sowie Verfahren zu seiner Herstellung |
NO306533B1 (no) | 1998-04-21 | 1999-11-22 | Gunnar Volden | Insektmiddel |
DE19919816A1 (de) | 1999-04-30 | 2000-11-02 | Rotta Gmbh | Wässrige Zusammensetzung zur Filzfreiausrüstung von Wolle |
WO2002000590A1 (en) | 2000-06-23 | 2002-01-03 | California Institute Of Technology | Synthesis of functionalized and unfunctionalized olefins via cross and ring-closing metathesis |
AU2001287696A1 (en) | 2000-08-24 | 2002-03-04 | Givaudan Sa | Composition having insect repellent characteristics |
EP1455609A2 (en) | 2001-12-19 | 2004-09-15 | Vector Tobacco Inc. | Method and compositions for imparting cooling effect to tobacco products |
WO2003064602A2 (en) | 2002-01-25 | 2003-08-07 | The Regents Of The University Of California | Methods of modulating cold sensory perception |
US6919348B2 (en) | 2002-05-02 | 2005-07-19 | Edward T. Wei | Therapeutic 1,2,3,6-tetrahydropyrimidine-2-one compositions and methods therewith |
GB0214342D0 (en) | 2002-06-21 | 2002-07-31 | Givaudan Sa | Insect repellents |
JP2004059474A (ja) | 2002-07-26 | 2004-02-26 | T Hasegawa Co Ltd | p−メンタン誘導体およびこれを含有する冷感剤 |
BR0314196A (pt) | 2002-09-10 | 2005-07-26 | Scios Inc | Inibidores de tgf-beta |
GB0221697D0 (en) | 2002-09-18 | 2002-10-30 | Unilever Plc | Novel compouds and their uses |
US6893626B2 (en) | 2003-02-18 | 2005-05-17 | Edward T. Wei | Compositions for TRP-M8 binding and radioreceptor methods therewith |
US7169377B2 (en) | 2003-10-15 | 2007-01-30 | Wei Edward T | Radioligands for the TRP-M8 receptor and methods therewith |
US7189760B2 (en) | 2004-04-02 | 2007-03-13 | Millennium Specialty Chemicals | Physiological cooling compositions containing highly purified ethyl ester of N-[[5-methyl-2-(1-methylethyl) cyclohexyl] carbonyl]glycine |
US7560464B2 (en) | 2004-04-13 | 2009-07-14 | Icagen, Inc. | Polycyclic pyrimidines as potassium ion channel modulators |
JP2005343795A (ja) | 2004-05-31 | 2005-12-15 | Takasago Internatl Corp | グリオキシル酸メンチルエステル類及びそれを含有する冷感剤組成物 |
CA2583015A1 (en) | 2004-10-13 | 2006-04-20 | Bayer Healthcare Ag | Substituted 4-benzyloxy-phenylmethylamide derivatives as cold menthol receptor-1 (cmr-1) antagonists for the treatment of urological disorder |
US20060161001A1 (en) | 2004-12-20 | 2006-07-20 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
DE102005015699A1 (de) | 2005-04-05 | 2006-10-12 | Ritter, Wolfgang, Dr. | Verfahren zur Ausrüstung von Textilien mit Wirkstoffen |
WO2007017093A1 (en) | 2005-08-04 | 2007-02-15 | Bayer Healthcare Ag | Substituted 2-benzyloxy-benzoic acid amide derivatives |
BRPI0616821B1 (pt) | 2005-08-15 | 2022-06-07 | Givaudan Sa | Método para proporcionar um efeito refrescante em um produto e produto possuindo um efeito refrescante |
US8263046B2 (en) | 2005-10-25 | 2012-09-11 | Givaudan S.A. | N-phenyl-N-pyridinyl-benzamides and benzenesulfonomides having cooling properties |
WO2007073505A2 (en) | 2005-12-22 | 2007-06-28 | Hydra Biosciences, Inc. | Trpa1 inhibitors for treating pain |
RO122199B1 (ro) | 2006-04-06 | 2009-02-27 | Ana-Corina Ioniţă | Procedeu de obţinere a derivaţilor de 2-fenoxiacetildifenilamină |
US7897781B2 (en) | 2006-05-10 | 2011-03-01 | Janssen Pharmaceutica Nv | Cold menthol receptor-1 antagonists |
GB0615136D0 (en) | 2006-07-29 | 2006-09-06 | Univ Edinburgh | Induction of analgesia in neuropathic pain |
EP1913976A1 (de) | 2006-10-18 | 2008-04-23 | Symrise GmbH & Co. KG | N-alpha-(Menthancarbonyl)aminosäureamide und deren Verwendung als physiologische Kühlwirkstoffe |
EP1958627A3 (de) | 2007-01-04 | 2010-09-01 | Symrise GmbH & Co. KG | Verwendung bestimmter Menthyl-3-oxocarbonsäureester als physiologisch wirksame Kühlsubstanzen |
GB2448535A (en) | 2007-04-19 | 2008-10-22 | Gw Pharma Ltd | New use for cannabinoid-containing plant extracts |
JP5539868B2 (ja) | 2007-07-18 | 2014-07-02 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Trpm8モジュレーターとしてのスルホンアミド類 |
ES2395682T3 (es) | 2007-08-20 | 2013-02-14 | Symrise Ag | Derivados de ácido oxálico y su uso como principios activos refrescantes fisiológicos |
US20110124649A1 (en) | 2007-11-09 | 2011-05-26 | The Johns Hopkins University | Inhibitors of human methionine aminopeptidase 1 and methods of treating disorders |
AU2008345225A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
EP2251001A4 (en) | 2008-02-08 | 2013-01-09 | Shiseido Co Ltd | SKIN BLEACHING AND EXTERNAL PREPARATION FOR THE SKIN |
WO2010010435A2 (en) | 2008-07-22 | 2010-01-28 | Glenmark Pharmaceutical S.A. | Fused oxazole and thiazole derivatives as trpms modulators |
AR077999A1 (es) | 2009-09-02 | 2011-10-05 | Vifor Int Ag | Antagonistas de pirimidin y triazin-hepcidina |
DE102010002558A1 (de) * | 2009-11-20 | 2011-06-01 | Symrise Ag | Verwendung physiologischer Kühlwirkstoffe und Mittel enthaltend solche Wirkstoffe |
JP5990526B2 (ja) * | 2010-11-05 | 2016-09-14 | セノミックス インコーポレイテッド | Trpm8の活性調節因子として有用な化合物 |
CN108853105B (zh) | 2012-12-12 | 2021-10-15 | 西姆莱斯股份公司 | 化妆品组合物、药品组合物和食品组合物 |
JP6107186B2 (ja) | 2013-02-05 | 2017-04-05 | セイコーエプソン株式会社 | 光学モジュール、電子機器、及び分光カメラ |
EP3015121B1 (en) | 2014-10-29 | 2017-11-29 | Cardia Innovation AB | An arrangement for cardiopulmonary bypass |
JP6865743B2 (ja) | 2015-10-01 | 2021-04-28 | フィルメニッヒ インコーポレイテッドFirmenich Incorporated | Trpm8の活性調節因子として有用な化合物 |
-
2018
- 2018-08-31 MX MX2020002347A patent/MX2020002347A/es unknown
- 2018-08-31 ES ES18759965T patent/ES2967435T3/es active Active
- 2018-08-31 WO PCT/EP2018/073486 patent/WO2019043164A1/de active Search and Examination
- 2018-08-31 US US16/642,954 patent/US11434220B2/en active Active
- 2018-08-31 CN CN201880056223.6A patent/CN111343963B/zh active Active
- 2018-08-31 EP EP18759965.9A patent/EP3675809B1/de active Active
- 2018-08-31 JP JP2020512032A patent/JP7231617B2/ja active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102137660A (zh) * | 2008-08-26 | 2011-07-27 | 巴斯夫欧洲公司 | 冷薄荷醇受体trpm8的低分子量调节剂的检测和用途 |
Non-Patent Citations (1)
Title |
---|
Input of Isosteric and Bioisosteric Approach in Drug Design;GOWHAR ALI et al.;《Jorunal of the Chemical Society of Pakistan》;20140228;第150-169页,图3 * |
Also Published As
Publication number | Publication date |
---|---|
WO2019043164A1 (de) | 2019-03-07 |
JP7231617B2 (ja) | 2023-03-01 |
EP3675809B1 (de) | 2023-09-27 |
US11434220B2 (en) | 2022-09-06 |
BR112020003942A2 (pt) | 2020-09-08 |
MX2020002347A (es) | 2020-10-28 |
JP2020531552A (ja) | 2020-11-05 |
US20200190052A1 (en) | 2020-06-18 |
CN111343963A (zh) | 2020-06-26 |
ES2967435T3 (es) | 2024-04-30 |
EP3675809A1 (de) | 2020-07-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US10584134B2 (en) | Use of physiological cooling active ingredients, and agents containing such active ingredients | |
US11044931B2 (en) | Low molecular weight modulators of the cold menthol receptor TRPM8 and use thereof | |
CN111343963B (zh) | 生理清凉活性成分的用途以及包含此类活性成分的组合物 | |
US20240000746A1 (en) | New Cooling Agents and Preparations Containing Them | |
ES2861268T3 (es) | Moduladores de bajo peso molecular del receptor de mentol frío TRPM8 y su uso | |
BR112020003942B1 (pt) | Método de modulação não-terapêutico, composto, composição, e, uso de um modulador e de uma composição | |
WO2023143741A1 (de) | Neue kühlstoffe und zubereitungen, die diese enthalten |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |