WO1997029075A1 - Derives d'amides substitues - Google Patents

Derives d'amides substitues Download PDF

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Publication number
WO1997029075A1
WO1997029075A1 PCT/JP1997/000306 JP9700306W WO9729075A1 WO 1997029075 A1 WO1997029075 A1 WO 1997029075A1 JP 9700306 W JP9700306 W JP 9700306W WO 9729075 A1 WO9729075 A1 WO 9729075A1
Authority
WO
WIPO (PCT)
Prior art keywords
group represented
halogeno
hydroxy
lower alkyl
ethynylene
Prior art date
Application number
PCT/JP1997/000306
Other languages
English (en)
Japanese (ja)
Inventor
Yoshikazu Iwasawa
Tetsuya Aoyama
Kumiko Kawakami
Sachie Arai
Toshihiko Satoh
Yoshiaki Monden
Original Assignee
Banyu Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharmaceutical Co., Ltd. filed Critical Banyu Pharmaceutical Co., Ltd.
Priority to AU16194/97A priority Critical patent/AU1619497A/en
Publication of WO1997029075A1 publication Critical patent/WO1997029075A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des composés représentés par la formule générale (I), certains de leurs sels ou esters galéniques et des agents antitumoraux les utilisant comme principes actifs. Dans cette formule générale, Ar?1, Ar2 et Ar3¿ sont chacun aryle ou hétéroaryle. A1 est hydrocarbyle en C¿2-6? ou un groupe représenté par -A?1a-W1-A1b- (W1¿ représentant un oxygène, soufre, éthynylène, cyclopropylène ou un groupe représenté par -NRw-). A2 est un groupe hydrocarbyle en C¿2-8?. Q est un groupe représenté par -(CH2)m- ou -(CH2)n-W2-(CH2)p- (W?2¿ étant oxygène, soufre, vinylène, éthynylène ou un groupe représenté par -NHCOCH=CH-). R1 est hydrogène, halogéno, hydroxy, alkyle inférieur, alcoxy inférieur, aryle ou un groupe hétéroaryle. R?2, R6 et R7¿ sont chacun hydrogène, halogéno, hydroxy, alkyle inférieur, alcényle inférieur ou un alcoxy inférieur. R3 et R4 sont chacun hydrogène, halogéno, hydroxy, amino, nitro, cyano, carboxy, alcoxycarbonyle inférieur, carbamyle, alkylcarbamyle, alkyle inférieur, hydroxyalkyle inférieur, fluoroalkyle inférieur ou alcoxy inférieur. R5 est alkyle inférieur.
PCT/JP1997/000306 1996-02-07 1997-02-07 Derives d'amides substitues WO1997029075A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU16194/97A AU1619497A (en) 1996-02-07 1997-02-07 Substituted amide derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8/45504 1996-02-07
JP4550496 1996-02-07

Publications (1)

Publication Number Publication Date
WO1997029075A1 true WO1997029075A1 (fr) 1997-08-14

Family

ID=12721247

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1997/000306 WO1997029075A1 (fr) 1996-02-07 1997-02-07 Derives d'amides substitues

Country Status (2)

Country Link
AU (1) AU1619497A (fr)
WO (1) WO1997029075A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007201276B2 (en) * 2002-03-12 2009-11-05 Merck Sharp & Dohme Corp. Substituted amides
US9394287B2 (en) 2010-11-05 2016-07-19 Senomyx, Inc. Compounds useful as modulators of TRPM8
US9732071B2 (en) 2015-10-01 2017-08-15 Senomyx, Inc. Compounds useful as modulators of TRPM8

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07138214A (ja) * 1993-02-12 1995-05-30 Banyu Pharmaceut Co Ltd 置換アミド酸誘導体
WO1996005168A1 (fr) * 1994-08-11 1996-02-22 Banyu Pharmaceutical Co., Ltd. Derive d'amide substitue
WO1996005169A1 (fr) * 1994-08-12 1996-02-22 Banyu Pharmaceutical Co., Ltd. Derive d'acide amique n,n-bisubstitue
WO1997001275A1 (fr) * 1995-06-29 1997-01-16 Merck & Co., Inc. Combinaisons d'inhibiteurs de farnesyl-proteine transferase

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07138214A (ja) * 1993-02-12 1995-05-30 Banyu Pharmaceut Co Ltd 置換アミド酸誘導体
WO1996005168A1 (fr) * 1994-08-11 1996-02-22 Banyu Pharmaceutical Co., Ltd. Derive d'amide substitue
WO1996005169A1 (fr) * 1994-08-12 1996-02-22 Banyu Pharmaceutical Co., Ltd. Derive d'acide amique n,n-bisubstitue
WO1997001275A1 (fr) * 1995-06-29 1997-01-16 Merck & Co., Inc. Combinaisons d'inhibiteurs de farnesyl-proteine transferase

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007201276B2 (en) * 2002-03-12 2009-11-05 Merck Sharp & Dohme Corp. Substituted amides
US9394287B2 (en) 2010-11-05 2016-07-19 Senomyx, Inc. Compounds useful as modulators of TRPM8
US10016418B2 (en) 2010-11-05 2018-07-10 Seaomyx, Inc. Compounds useful as modulators of TRPM8
US10953007B2 (en) 2010-11-05 2021-03-23 Firmenich Incorporated Compounds useful as modulators of TRPM8
US9732071B2 (en) 2015-10-01 2017-08-15 Senomyx, Inc. Compounds useful as modulators of TRPM8

Also Published As

Publication number Publication date
AU1619497A (en) 1997-08-28

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