BR0013476A - Composto, uso do mesmo, processo para preparar um composto, e, composição farmacêutica - Google Patents

Composto, uso do mesmo, processo para preparar um composto, e, composição farmacêutica

Info

Publication number
BR0013476A
BR0013476A BR0013476-7A BR0013476A BR0013476A BR 0013476 A BR0013476 A BR 0013476A BR 0013476 A BR0013476 A BR 0013476A BR 0013476 A BR0013476 A BR 0013476A
Authority
BR
Brazil
Prior art keywords
compound
same
values
different
defined here
Prior art date
Application number
BR0013476-7A
Other languages
English (en)
Inventor
Andrew Peter Thomas
Gloria Anne Breault
John Franklin Beattie
Philip John Jewsbury
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR0013476A publication Critical patent/BR0013476A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"COMPOSTO, USO DO MESMO, PROCESSO PARA PREPARAR UM COMPOSTO, E, COMPOSIçãO FARMACêUTICA". é descrito um composto de fórmula (I), em que o Anel A é imidazol[1,2a]pirid-3-ila ou pirazolo[2,3a]pirid-3-ila; R^ 2^ é como definido aqui; m é 0-5; em que os valores de R^ 2^ podem ser iguais ou diferentes; R^ 1^ é como definido aqui; n é 0 a 2, em que os valores de R^ 1^ podem ser iguais ou diferentes; o Anel B é fenila ou fenila fundida em um anel C~ 5-7~ cicloalquila; R^ 3~ é como definido aqui; p é 0-4; em que os valores de R~ 3~ podem ser iguais ou diferentes; R^ 4^ é como definido aqui; q é 0-2; em que os valores de R^ 4^ podem ser iguais ou diferentes; e em que p+q <243> 5; ou um sal farmaceuticamente aceitável ou um seu éster hidrolisável in vivo. O uso de compostos de fórmula (I) na inibição das quinases de ciclo celular CDK2, CDK4 e CDK6 é também descrito. São detalhados composições farmacêuticas, métodos e processos para preparação dos compostos de fórmula (I).
BR0013476-7A 1999-08-21 2000-08-15 Composto, uso do mesmo, processo para preparar um composto, e, composição farmacêutica BR0013476A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9919778.2A GB9919778D0 (en) 1999-08-21 1999-08-21 Chemical compounds
PCT/GB2000/003139 WO2001014375A1 (en) 1999-08-21 2000-08-15 Imidazo[1,2-a]pyridine and pyrazolo[2,3-a]pyridine derivatives

Publications (1)

Publication Number Publication Date
BR0013476A true BR0013476A (pt) 2002-04-30

Family

ID=10859538

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0013476-7A BR0013476A (pt) 1999-08-21 2000-08-15 Composto, uso do mesmo, processo para preparar um composto, e, composição farmacêutica

Country Status (33)

Country Link
US (1) US6855719B1 (pt)
EP (1) EP1214318B1 (pt)
JP (1) JP4280442B2 (pt)
KR (1) KR100737259B1 (pt)
CN (1) CN1174981C (pt)
AR (1) AR031075A1 (pt)
AT (1) ATE251623T1 (pt)
AU (1) AU757639B2 (pt)
BG (1) BG65566B1 (pt)
BR (1) BR0013476A (pt)
CA (1) CA2376293A1 (pt)
CO (1) CO5460265A1 (pt)
CZ (1) CZ2002617A3 (pt)
DE (1) DE60005850T2 (pt)
DK (1) DK1214318T3 (pt)
EE (1) EE04964B1 (pt)
ES (1) ES2208397T3 (pt)
GB (1) GB9919778D0 (pt)
HK (1) HK1045510B (pt)
HU (1) HUP0202494A3 (pt)
IL (2) IL147752A0 (pt)
IS (1) IS2068B (pt)
MX (1) MXPA02001674A (pt)
MY (1) MY123390A (pt)
NO (1) NO322818B1 (pt)
NZ (1) NZ516740A (pt)
PL (1) PL199615B1 (pt)
PT (1) PT1214318E (pt)
RU (1) RU2248976C2 (pt)
SK (1) SK287033B6 (pt)
UA (1) UA73522C2 (pt)
WO (1) WO2001014375A1 (pt)
ZA (1) ZA200200028B (pt)

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