BG64599B1 - Платинов комплекс, метод за получаването му и терапевтичното му приложение - Google Patents

Платинов комплекс, метод за получаването му и терапевтичното му приложение Download PDF

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Publication number
BG64599B1
BG64599B1 BG104972A BG10497200A BG64599B1 BG 64599 B1 BG64599 B1 BG 64599B1 BG 104972 A BG104972 A BG 104972A BG 10497200 A BG10497200 A BG 10497200A BG 64599 B1 BG64599 B1 BG 64599B1
Authority
BG
Bulgaria
Prior art keywords
complex
formula
carbon atoms
platinum
group
Prior art date
Application number
BG104972A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG104972A (en
Inventor
Frantisek Zak
Adolf Mistr
Anna Poulova
Milan Melka
Jaroslav Turanek
Dana Zaluska
Original Assignee
Pliva-Lachema, A.S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva-Lachema, A.S. filed Critical Pliva-Lachema, A.S.
Publication of BG104972A publication Critical patent/BG104972A/xx
Publication of BG64599B1 publication Critical patent/BG64599B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
BG104972A 1998-05-27 2000-11-21 Платинов комплекс, метод за получаването му и терапевтичното му приложение BG64599B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ19981628A CZ288912B6 (cs) 1998-05-27 1998-05-27 Komplex platiny v oxidačním čísle IV, způsob přípravy tohoto komplexu, tento komplex jako léčivo a farmaceutická kompozice tento komplex obsahující
PCT/CZ1999/000015 WO1999061451A1 (en) 1998-05-27 1999-05-24 Platinum complex, its preparation and therapeutic application

Publications (2)

Publication Number Publication Date
BG104972A BG104972A (en) 2001-08-31
BG64599B1 true BG64599B1 (bg) 2005-08-31

Family

ID=5463562

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104972A BG64599B1 (bg) 1998-05-27 2000-11-21 Платинов комплекс, метод за получаването му и терапевтичното му приложение

Country Status (24)

Country Link
US (1) US6503943B1 (cs)
EP (1) EP1082330B1 (cs)
JP (1) JP3575686B2 (cs)
CN (1) CN1124279C (cs)
AU (1) AU741380B2 (cs)
BG (1) BG64599B1 (cs)
BR (1) BR9910669B1 (cs)
CA (1) CA2332054C (cs)
CZ (1) CZ288912B6 (cs)
DE (1) DE69901177T2 (cs)
ES (1) ES2175968T3 (cs)
HR (1) HRP20000791B1 (cs)
HU (1) HU224716B1 (cs)
IL (1) IL139529A (cs)
MX (1) MXPA00011621A (cs)
NO (1) NO328930B1 (cs)
PL (1) PL191132B1 (cs)
PT (1) PT1082330E (cs)
RS (1) RS49738B (cs)
RU (1) RU2200164C2 (cs)
SI (1) SI1082330T1 (cs)
SK (1) SK284436B6 (cs)
UA (1) UA56315C2 (cs)
WO (1) WO1999061451A1 (cs)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0408805A (pt) * 2003-03-31 2006-03-28 Pliva Lachema As composição farmacêutica contendo complexo de platina e método de fabricação da mesma
CZ296045B6 (cs) * 2003-03-31 2005-12-14 Pliva-Lachema A. S. Farmaceutická kompozice obsahující jako účinnou látku komplex čtyřmocné platiny a způsob její výroby
CZ295584B6 (cs) * 2004-02-12 2005-08-17 Pliva-Lachema A. S. Farmaceutická kompozice obsahující jako účinnou látku platinový komplex a způsob výroby této kompozice
CA2584493A1 (en) 2004-06-18 2006-01-05 Gpc Biotech, Inc. Kinase inhibitors for treating cancers
US20080272022A1 (en) * 2004-07-14 2008-11-06 Gpc Biotech Ag Variable-Dose Packaging System
CZ296169B6 (cs) * 2004-09-08 2006-01-11 Pliva - Lachema A. S. Farmaceutická kompozice pro rektální nebo vaginální podání, zpusob její prípravy a tato kompozice pro pouzití jako lécivo
CZ2004964A3 (cs) * 2004-09-14 2006-03-15 Pliva-Lachema A. S. Perorální farmaceutická kompozice pro cílený transport komplexu platiny do kolorektální oblasti, zpusob její prípravy a tato kompozice pro pouzití jako lécivo
WO2007008247A2 (en) * 2004-11-10 2007-01-18 University Of South Florida Platinum complexes for targeted drug delivery
EP1859797A4 (en) * 2005-02-28 2011-04-13 Eisai R&D Man Co Ltd NEW SIMULTANEOUS USE OF A SULPHONAMIDE COMPOUND AND A MEDIUM AGAINST CANCER
EP1792622A1 (en) 2005-11-11 2007-06-06 GPC Biotech AG Anti-proliferative combination therapy comprising a platinum-based chemotherapeutic agent and EGFR inhibitors or pyrimidine analogues
CZ300424B6 (cs) * 2006-06-20 2009-05-13 Pliva - Lachema A. S. Farmaceutická kompozice pro perorální podání
CZ300120B6 (cs) * 2006-06-20 2009-02-11 Pliva - Lachema A. S. Farmaceutická kompozice pro injekcní podání
CZ300590B6 (cs) * 2006-06-20 2009-06-24 Pliva - Lachema A. S. Farmaceutická kompozice pro injekcní podání
KR100829173B1 (ko) * 2006-09-19 2008-05-13 광주과학기술원 물에 대한 용해도가 우수한 플라틴 복합체의 포접복합체 및그 제조방법
GB2457453B (en) * 2008-02-12 2010-05-12 Pliva Lachema As Polymorphic crystalline form III of (OC-6-43)-bis(acetate)(1-tricyclo[3,3,1,13,7]decylamine) ammine dichloroplatinum (IV)
GB2457452B (en) * 2008-02-12 2010-05-12 Pliva Lachema As Amorphous form of (OC-6-43)-bis(acetate)(1-tricyclo[3,3,1,13,7]decylamine) amminedichloroplatinum (IV)
GB2457454B (en) * 2008-02-12 2010-05-12 Pliva Lachema As Polymorphic crystalline form II of (OC-6-43)-bis(acetate)(1-tricyclo[3,3,1,13,7]decylamine) ammine dichloroplatinum (IV)
GB2457455B (en) * 2008-02-12 2010-04-21 Pliva Lachema As Polymorphic crystalline form (I) of (OC-6-43)-Bis(Acetato)-1-(Tricyclo[3,3,1,1 (3,7)]Decylamine)Amminedichloroplatinum(IV)
WO2010149666A1 (en) 2009-06-22 2010-12-29 Medexis S.A. Methods for treating neoplasia
US20120238488A1 (en) 2009-09-08 2012-09-20 Konstantinos Alevizopoulos Compounds and methods for treating neoplasia
WO2012013816A1 (en) 2010-07-30 2012-02-02 Medexis S.A. Compounds and methods for treating neoplasia
DK3189064T3 (en) 2014-09-03 2018-11-12 Vuab Pharma A S PLATIN (IV) complex with increased antitumor effect
CN104984356A (zh) * 2015-05-14 2015-10-21 昆明贵研药业有限公司 赛特铂的环糊精复合物及制备方法
RU2613513C2 (ru) * 2015-07-17 2017-03-16 Федеральное государственное бюджетное учреждение науки Институт проблем химической физики Российской академии наук (ИПХФ РАН) Способ получения комплексов платины (IV) с аминонитроксильными радикалами
RU2726826C2 (ru) * 2016-12-27 2020-07-15 Общество с ограниченной ответственностью "Плат-АН" (ООО "Плат-АН") Композиция на основе аминонитроксильного комплекса платины и доксорубицина и способ лечения опухолей
CN114341147B (zh) 2019-09-05 2024-05-07 韦埃博制药公司 具有显著增强的抗肿瘤功效的铂ⅳ配合物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0328274A1 (en) * 1988-02-02 1989-08-16 Johnson Matthey, Inc., Pt (IV) complexes
EP0423707A2 (en) * 1989-10-17 1991-04-24 Bristol-Myers Squibb Company Platinum complexes
EP0503830A1 (en) * 1991-03-09 1992-09-16 Johnson Matthey Public Limited Company Trans-platinum compounds with anti-tumor activity, process for their preparation and compositions containing them

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2089555C1 (ru) * 1995-05-04 1997-09-10 Новосибирский институт биоорганической химии СО РАН Бисимидазол-(1,10)-фенантролинплатина (iii) дихлорид, проявляющий цитостатическую противоопухолевую активность
JPH10265380A (ja) * 1997-03-17 1998-10-06 Bristol Myers Squibb Co 抗ガン剤

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0328274A1 (en) * 1988-02-02 1989-08-16 Johnson Matthey, Inc., Pt (IV) complexes
EP0423707A2 (en) * 1989-10-17 1991-04-24 Bristol-Myers Squibb Company Platinum complexes
EP0503830A1 (en) * 1991-03-09 1992-09-16 Johnson Matthey Public Limited Company Trans-platinum compounds with anti-tumor activity, process for their preparation and compositions containing them

Also Published As

Publication number Publication date
EP1082330B1 (en) 2002-04-03
BR9910669A (pt) 2001-01-30
NO20005990L (no) 2000-11-27
ES2175968T3 (es) 2002-11-16
RS49738B (sr) 2008-04-04
CA2332054A1 (en) 1999-12-02
PT1082330E (pt) 2002-09-30
NO20005990D0 (no) 2000-11-27
HU224716B1 (en) 2006-01-30
JP3575686B2 (ja) 2004-10-13
SK17732000A3 (sk) 2001-05-10
MXPA00011621A (es) 2003-03-12
HUP0102549A3 (en) 2004-04-28
AU741380B2 (en) 2001-11-29
SK284436B6 (sk) 2005-04-01
CZ162898A3 (cs) 1999-12-15
HRP20000791A2 (en) 2001-02-28
IL139529A0 (en) 2001-11-25
PL191132B1 (pl) 2006-03-31
RU2200164C2 (ru) 2003-03-10
JP2002516332A (ja) 2002-06-04
CN1303388A (zh) 2001-07-11
HUP0102549A2 (hu) 2001-11-28
AU3809399A (en) 1999-12-13
SI1082330T1 (en) 2002-08-31
PL344346A1 (en) 2001-11-05
YU71900A (sh) 2002-10-18
HRP20000791B1 (en) 2006-07-31
CA2332054C (en) 2005-06-28
UA56315C2 (uk) 2003-05-15
CZ288912B6 (cs) 2001-09-12
CN1124279C (zh) 2003-10-15
EP1082330A1 (en) 2001-03-14
IL139529A (en) 2004-06-20
NO328930B1 (no) 2010-06-21
US6503943B1 (en) 2003-01-07
DE69901177D1 (de) 2002-05-08
BG104972A (en) 2001-08-31
BR9910669B1 (pt) 2011-07-26
DE69901177T2 (de) 2002-10-02
WO1999061451A1 (en) 1999-12-02

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