BG64599B1 - Платинов комплекс, метод за получаването му и терапевтичното му приложение - Google Patents

Платинов комплекс, метод за получаването му и терапевтичното му приложение Download PDF

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Publication number
BG64599B1
BG64599B1 BG104972A BG10497200A BG64599B1 BG 64599 B1 BG64599 B1 BG 64599B1 BG 104972 A BG104972 A BG 104972A BG 10497200 A BG10497200 A BG 10497200A BG 64599 B1 BG64599 B1 BG 64599B1
Authority
BG
Bulgaria
Prior art keywords
complex
formula
carbon atoms
platinum
group
Prior art date
Application number
BG104972A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG104972A (en
Inventor
Frantisek Zak
Adolf Mistr
Anna Poulova
Milan Melka
Jaroslav Turanek
Dana Zaluska
Original Assignee
Pliva-Lachema, A.S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva-Lachema, A.S. filed Critical Pliva-Lachema, A.S.
Publication of BG104972A publication Critical patent/BG104972A/xx
Publication of BG64599B1 publication Critical patent/BG64599B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
BG104972A 1998-05-27 2000-11-21 Платинов комплекс, метод за получаването му и терапевтичното му приложение BG64599B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ19981628A CZ288912B6 (cs) 1998-05-27 1998-05-27 Komplex platiny v oxidačním čísle IV, způsob přípravy tohoto komplexu, tento komplex jako léčivo a farmaceutická kompozice tento komplex obsahující
PCT/CZ1999/000015 WO1999061451A1 (en) 1998-05-27 1999-05-24 Platinum complex, its preparation and therapeutic application

Publications (2)

Publication Number Publication Date
BG104972A BG104972A (en) 2001-08-31
BG64599B1 true BG64599B1 (bg) 2005-08-31

Family

ID=5463562

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104972A BG64599B1 (bg) 1998-05-27 2000-11-21 Платинов комплекс, метод за получаването му и терапевтичното му приложение

Country Status (24)

Country Link
US (1) US6503943B1 (cs)
EP (1) EP1082330B1 (cs)
JP (1) JP3575686B2 (cs)
CN (1) CN1124279C (cs)
AU (1) AU741380B2 (cs)
BG (1) BG64599B1 (cs)
BR (1) BR9910669B1 (cs)
CA (1) CA2332054C (cs)
CZ (1) CZ288912B6 (cs)
DE (1) DE69901177T2 (cs)
ES (1) ES2175968T3 (cs)
HR (1) HRP20000791B1 (cs)
HU (1) HU224716B1 (cs)
IL (1) IL139529A (cs)
MX (1) MXPA00011621A (cs)
NO (1) NO328930B1 (cs)
PL (1) PL191132B1 (cs)
PT (1) PT1082330E (cs)
RS (1) RS49738B (cs)
RU (1) RU2200164C2 (cs)
SI (1) SI1082330T1 (cs)
SK (1) SK284436B6 (cs)
UA (1) UA56315C2 (cs)
WO (1) WO1999061451A1 (cs)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ296045B6 (cs) * 2003-03-31 2005-12-14 Pliva-Lachema A. S. Farmaceutická kompozice obsahující jako účinnou látku komplex čtyřmocné platiny a způsob její výroby
US20060063832A1 (en) * 2003-03-31 2006-03-23 Pliva-Lachema A.S. A Czech Republic Corporation Pharmaceutical composition containing platinum complex as active substance and method of manufacturing thereof
CZ2004235A3 (cs) * 2004-02-12 2005-08-17 Pliva-Lachema A. S. Farmaceutická kompozice obsahující jako účinnou látku platinový komplex a způsob výroby této kompozice
EP2027853A3 (en) 2004-06-18 2011-01-05 Agennix USA Inc. Kinase inhibitors for treating cancers
JP2008506463A (ja) * 2004-07-14 2008-03-06 ゲーペーツェー ビオテック アーゲー 可変投与量パッケージシステム
CZ2004945A3 (cs) * 2004-09-08 2006-01-11 Pliva - Lachema A. S. Farmaceutická kompozice pro rektální nebo vaginální podání, zpusob její prípravy a tato kompozice pro pouzití jako lécivo
CZ296459B6 (cs) * 2004-09-14 2006-03-15 Pliva-Lachema A. S. Perorální farmaceutická kompozice pro cílený transport komplexu platiny do kolorektální oblasti, zpusob její prípravy a tato kompozice pro pouzití jako lécivo
US7977500B2 (en) * 2004-11-10 2011-07-12 University Of South Florida Platinum complexes for targeted drug delivery
JP5106098B2 (ja) * 2005-02-28 2012-12-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 スルホンアミド化合物の抗癌剤との新規併用
EP1792622A1 (en) 2005-11-11 2007-06-06 GPC Biotech AG Anti-proliferative combination therapy comprising a platinum-based chemotherapeutic agent and EGFR inhibitors or pyrimidine analogues
CZ300120B6 (cs) * 2006-06-20 2009-02-11 Pliva - Lachema A. S. Farmaceutická kompozice pro injekcní podání
CZ300424B6 (cs) * 2006-06-20 2009-05-13 Pliva - Lachema A. S. Farmaceutická kompozice pro perorální podání
CZ300590B6 (cs) * 2006-06-20 2009-06-24 Pliva - Lachema A. S. Farmaceutická kompozice pro injekcní podání
KR100829173B1 (ko) * 2006-09-19 2008-05-13 광주과학기술원 물에 대한 용해도가 우수한 플라틴 복합체의 포접복합체 및그 제조방법
GB2457455B (en) * 2008-02-12 2010-04-21 Pliva Lachema As Polymorphic crystalline form (I) of (OC-6-43)-Bis(Acetato)-1-(Tricyclo[3,3,1,1 (3,7)]Decylamine)Amminedichloroplatinum(IV)
GB2457453B (en) * 2008-02-12 2010-05-12 Pliva Lachema As Polymorphic crystalline form III of (OC-6-43)-bis(acetate)(1-tricyclo[3,3,1,13,7]decylamine) ammine dichloroplatinum (IV)
GB2457454B (en) * 2008-02-12 2010-05-12 Pliva Lachema As Polymorphic crystalline form II of (OC-6-43)-bis(acetate)(1-tricyclo[3,3,1,13,7]decylamine) ammine dichloroplatinum (IV)
GB2457452B (en) * 2008-02-12 2010-05-12 Pliva Lachema As Amorphous form of (OC-6-43)-bis(acetate)(1-tricyclo[3,3,1,13,7]decylamine) amminedichloroplatinum (IV)
WO2010149666A1 (en) 2009-06-22 2010-12-29 Medexis S.A. Methods for treating neoplasia
US20120238488A1 (en) 2009-09-08 2012-09-20 Konstantinos Alevizopoulos Compounds and methods for treating neoplasia
EP2598513A1 (en) 2010-07-30 2013-06-05 Medexis S.A. Compounds and methods for treating neoplasia
DK3189064T3 (en) * 2014-09-03 2018-11-12 Vuab Pharma A S PLATIN (IV) complex with increased antitumor effect
CN104984356A (zh) * 2015-05-14 2015-10-21 昆明贵研药业有限公司 赛特铂的环糊精复合物及制备方法
RU2613513C2 (ru) * 2015-07-17 2017-03-16 Федеральное государственное бюджетное учреждение науки Институт проблем химической физики Российской академии наук (ИПХФ РАН) Способ получения комплексов платины (IV) с аминонитроксильными радикалами
RU2726826C2 (ru) * 2016-12-27 2020-07-15 Общество с ограниченной ответственностью "Плат-АН" (ООО "Плат-АН") Композиция на основе аминонитроксильного комплекса платины и доксорубицина и способ лечения опухолей
FI4025581T3 (fi) * 2019-09-05 2024-03-01 Vuab Pharma A S Uusia platina(iv)-komplekseja, joilla on olennaisesti suurempi kasvaimen vastainen teho

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0328274A1 (en) * 1988-02-02 1989-08-16 Johnson Matthey, Inc., Pt (IV) complexes
EP0423707A2 (en) * 1989-10-17 1991-04-24 Bristol-Myers Squibb Company Platinum complexes
EP0503830A1 (en) * 1991-03-09 1992-09-16 Johnson Matthey Public Limited Company Trans-platinum compounds with anti-tumor activity, process for their preparation and compositions containing them

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2089555C1 (ru) * 1995-05-04 1997-09-10 Новосибирский институт биоорганической химии СО РАН Бисимидазол-(1,10)-фенантролинплатина (iii) дихлорид, проявляющий цитостатическую противоопухолевую активность
JPH10265380A (ja) * 1997-03-17 1998-10-06 Bristol Myers Squibb Co 抗ガン剤

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0328274A1 (en) * 1988-02-02 1989-08-16 Johnson Matthey, Inc., Pt (IV) complexes
EP0423707A2 (en) * 1989-10-17 1991-04-24 Bristol-Myers Squibb Company Platinum complexes
EP0503830A1 (en) * 1991-03-09 1992-09-16 Johnson Matthey Public Limited Company Trans-platinum compounds with anti-tumor activity, process for their preparation and compositions containing them

Also Published As

Publication number Publication date
WO1999061451A1 (en) 1999-12-02
NO20005990D0 (no) 2000-11-27
RU2200164C2 (ru) 2003-03-10
NO328930B1 (no) 2010-06-21
HUP0102549A2 (hu) 2001-11-28
EP1082330B1 (en) 2002-04-03
BG104972A (en) 2001-08-31
CA2332054C (en) 2005-06-28
DE69901177T2 (de) 2002-10-02
JP3575686B2 (ja) 2004-10-13
IL139529A (en) 2004-06-20
RS49738B (sr) 2008-04-04
US6503943B1 (en) 2003-01-07
SK17732000A3 (sk) 2001-05-10
CA2332054A1 (en) 1999-12-02
CN1303388A (zh) 2001-07-11
IL139529A0 (en) 2001-11-25
PL344346A1 (en) 2001-11-05
SK284436B6 (sk) 2005-04-01
CZ162898A3 (cs) 1999-12-15
PL191132B1 (pl) 2006-03-31
BR9910669A (pt) 2001-01-30
AU3809399A (en) 1999-12-13
AU741380B2 (en) 2001-11-29
DE69901177D1 (de) 2002-05-08
HU224716B1 (en) 2006-01-30
UA56315C2 (uk) 2003-05-15
CZ288912B6 (cs) 2001-09-12
ES2175968T3 (es) 2002-11-16
HUP0102549A3 (en) 2004-04-28
MXPA00011621A (es) 2003-03-12
BR9910669B1 (pt) 2011-07-26
JP2002516332A (ja) 2002-06-04
YU71900A (sh) 2002-10-18
EP1082330A1 (en) 2001-03-14
NO20005990L (no) 2000-11-27
HRP20000791A2 (en) 2001-02-28
SI1082330T1 (en) 2002-08-31
PT1082330E (pt) 2002-09-30
CN1124279C (zh) 2003-10-15
HRP20000791B1 (en) 2006-07-31

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