GB2457455B - Polymorphic crystalline form (I) of (OC-6-43)-Bis(Acetato)-1-(Tricyclo[3,3,1,1 (3,7)]Decylamine)Amminedichloroplatinum(IV) - Google Patents

Polymorphic crystalline form (I) of (OC-6-43)-Bis(Acetato)-1-(Tricyclo[3,3,1,1 (3,7)]Decylamine)Amminedichloroplatinum(IV)

Info

Publication number
GB2457455B
GB2457455B GB0802595A GB0802595A GB2457455B GB 2457455 B GB2457455 B GB 2457455B GB 0802595 A GB0802595 A GB 0802595A GB 0802595 A GB0802595 A GB 0802595A GB 2457455 B GB2457455 B GB 2457455B
Authority
GB
United Kingdom
Prior art keywords
amminedichloroplatinum
acetato
decylamine
tricyclo
bis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB0802595A
Other versions
GB0802595D0 (en
GB2457455A (en
Inventor
Petr Sova
Ales Kroutil
Ales Franc
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pliva Lachema AS
Original Assignee
Pliva Lachema AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Lachema AS filed Critical Pliva Lachema AS
Priority to GB0802595A priority Critical patent/GB2457455B/en
Publication of GB0802595D0 publication Critical patent/GB0802595D0/en
Priority to PCT/CZ2009/000011 priority patent/WO2009100688A1/en
Publication of GB2457455A publication Critical patent/GB2457455A/en
Application granted granted Critical
Publication of GB2457455B publication Critical patent/GB2457455B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/38—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/65—Metal complexes of amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB0802595A 2008-02-12 2008-02-12 Polymorphic crystalline form (I) of (OC-6-43)-Bis(Acetato)-1-(Tricyclo[3,3,1,1 (3,7)]Decylamine)Amminedichloroplatinum(IV) Expired - Fee Related GB2457455B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB0802595A GB2457455B (en) 2008-02-12 2008-02-12 Polymorphic crystalline form (I) of (OC-6-43)-Bis(Acetato)-1-(Tricyclo[3,3,1,1 (3,7)]Decylamine)Amminedichloroplatinum(IV)
PCT/CZ2009/000011 WO2009100688A1 (en) 2008-02-12 2009-02-12 Polymorphic form ( i ) of the adamantylamino-platinum (iv) complex la-12

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0802595A GB2457455B (en) 2008-02-12 2008-02-12 Polymorphic crystalline form (I) of (OC-6-43)-Bis(Acetato)-1-(Tricyclo[3,3,1,1 (3,7)]Decylamine)Amminedichloroplatinum(IV)

Publications (3)

Publication Number Publication Date
GB0802595D0 GB0802595D0 (en) 2008-03-19
GB2457455A GB2457455A (en) 2009-08-19
GB2457455B true GB2457455B (en) 2010-04-21

Family

ID=39247531

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0802595A Expired - Fee Related GB2457455B (en) 2008-02-12 2008-02-12 Polymorphic crystalline form (I) of (OC-6-43)-Bis(Acetato)-1-(Tricyclo[3,3,1,1 (3,7)]Decylamine)Amminedichloroplatinum(IV)

Country Status (2)

Country Link
GB (1) GB2457455B (en)
WO (1) WO2009100688A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999061451A1 (en) * 1998-05-27 1999-12-02 Pliva-Lachema A.S. Platinum complex, its preparation and therapeutic application

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999061451A1 (en) * 1998-05-27 1999-12-02 Pliva-Lachema A.S. Platinum complex, its preparation and therapeutic application

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. Med. Chem. Vol. 47, No. 3, 2004, Frantisek Zak et al, "Platinum (IV) Complex with Adamantylamine as Nonleaving Amine Group: Synthesis, Characterization, and in Vitro Antitumor Activity against a Panel of Cisplatin-Resistant Cancer Cell Lines", *

Also Published As

Publication number Publication date
WO2009100688A1 (en) 2009-08-20
GB0802595D0 (en) 2008-03-19
GB2457455A (en) 2009-08-19

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20150212