GB2457454B - Polymorphic crystalline form II of (OC-6-43)-bis(acetate)(1-tricyclo[3,3,1,13,7]decylamine) ammine dichloroplatinum (IV) - Google Patents

Polymorphic crystalline form II of (OC-6-43)-bis(acetate)(1-tricyclo[3,3,1,13,7]decylamine) ammine dichloroplatinum (IV)

Info

Publication number
GB2457454B
GB2457454B GB0802592A GB0802592A GB2457454B GB 2457454 B GB2457454 B GB 2457454B GB 0802592 A GB0802592 A GB 0802592A GB 0802592 A GB0802592 A GB 0802592A GB 2457454 B GB2457454 B GB 2457454B
Authority
GB
United Kingdom
Prior art keywords
dichloroplatinum
ammine
decylamine
tricyclo
bis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB0802592A
Other versions
GB0802592D0 (en
GB2457454A (en
Inventor
Petr Sova
Ales Kroutil
Ales Franc
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pliva Lachema AS
Original Assignee
Pliva Lachema AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Lachema AS filed Critical Pliva Lachema AS
Priority to GB0802592A priority Critical patent/GB2457454B/en
Publication of GB0802592D0 publication Critical patent/GB0802592D0/en
Priority to PCT/CZ2009/000012 priority patent/WO2009100689A1/en
Publication of GB2457454A publication Critical patent/GB2457454A/en
Application granted granted Critical
Publication of GB2457454B publication Critical patent/GB2457454B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/38—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB0802592A 2008-02-12 2008-02-12 Polymorphic crystalline form II of (OC-6-43)-bis(acetate)(1-tricyclo[3,3,1,13,7]decylamine) ammine dichloroplatinum (IV) Expired - Fee Related GB2457454B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB0802592A GB2457454B (en) 2008-02-12 2008-02-12 Polymorphic crystalline form II of (OC-6-43)-bis(acetate)(1-tricyclo[3,3,1,13,7]decylamine) ammine dichloroplatinum (IV)
PCT/CZ2009/000012 WO2009100689A1 (en) 2008-02-12 2009-02-12 Polymorphic form ( ii ) of adamantylamino- platinum ( iv) complex la-12

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0802592A GB2457454B (en) 2008-02-12 2008-02-12 Polymorphic crystalline form II of (OC-6-43)-bis(acetate)(1-tricyclo[3,3,1,13,7]decylamine) ammine dichloroplatinum (IV)

Publications (3)

Publication Number Publication Date
GB0802592D0 GB0802592D0 (en) 2008-03-19
GB2457454A GB2457454A (en) 2009-08-19
GB2457454B true GB2457454B (en) 2010-05-12

Family

ID=39247530

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0802592A Expired - Fee Related GB2457454B (en) 2008-02-12 2008-02-12 Polymorphic crystalline form II of (OC-6-43)-bis(acetate)(1-tricyclo[3,3,1,13,7]decylamine) ammine dichloroplatinum (IV)

Country Status (2)

Country Link
GB (1) GB2457454B (en)
WO (1) WO2009100689A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999061451A1 (en) * 1998-05-27 1999-12-02 Pliva-Lachema A.S. Platinum complex, its preparation and therapeutic application

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999061451A1 (en) * 1998-05-27 1999-12-02 Pliva-Lachema A.S. Platinum complex, its preparation and therapeutic application

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"Platinum (IV) complex with adamantylamine as nonleaving amine group: Synthesis, characterization and in vitro antitumour activity against a panel of cisplatin-resistant cancer cell lines" *

Also Published As

Publication number Publication date
WO2009100689A1 (en) 2009-08-20
GB0802592D0 (en) 2008-03-19
GB2457454A (en) 2009-08-19

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20150212