BG61125B2 - Циклични вазоактивни пептидни аналози - Google Patents

Циклични вазоактивни пептидни аналози Download PDF

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Publication number
BG61125B2
BG61125B2 BG098608A BG9860894A BG61125B2 BG 61125 B2 BG61125 B2 BG 61125B2 BG 098608 A BG098608 A BG 098608A BG 9860894 A BG9860894 A BG 9860894A BG 61125 B2 BG61125 B2 BG 61125B2
Authority
BG
Bulgaria
Prior art keywords
lys
asp
ala
peptide
seq
Prior art date
Application number
BG098608A
Other languages
Bulgarian (bg)
English (en)
Inventor
David Bolin
Margaret O'donnell
Original Assignee
F. Hoffmann - La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann - La Roche Ag filed Critical F. Hoffmann - La Roche Ag
Publication of BG61125B2 publication Critical patent/BG61125B2/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/17—Vasoactive intestinal peptides; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BG098608A 1991-10-11 1994-02-28 Циклични вазоактивни пептидни аналози BG61125B2 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77374791A 1991-10-11 1991-10-11

Publications (1)

Publication Number Publication Date
BG61125B2 true BG61125B2 (bg) 1996-11-29

Family

ID=25099195

Family Applications (1)

Application Number Title Priority Date Filing Date
BG098608A BG61125B2 (bg) 1991-10-11 1994-02-28 Циклични вазоактивни пептидни аналози

Country Status (26)

Country Link
US (1) US5677419A (cg-RX-API-DMAC7.html)
EP (1) EP0536741B1 (cg-RX-API-DMAC7.html)
JP (1) JP2515473B2 (cg-RX-API-DMAC7.html)
KR (1) KR970001580B1 (cg-RX-API-DMAC7.html)
CN (3) CN1034943C (cg-RX-API-DMAC7.html)
AT (1) ATE132165T1 (cg-RX-API-DMAC7.html)
AU (1) AU656230B2 (cg-RX-API-DMAC7.html)
BG (1) BG61125B2 (cg-RX-API-DMAC7.html)
BR (1) BR9203959A (cg-RX-API-DMAC7.html)
CA (1) CA2080272C (cg-RX-API-DMAC7.html)
CZ (1) CZ281818B6 (cg-RX-API-DMAC7.html)
DE (1) DE69207138T2 (cg-RX-API-DMAC7.html)
DK (1) DK0536741T3 (cg-RX-API-DMAC7.html)
ES (1) ES2082317T3 (cg-RX-API-DMAC7.html)
FI (2) FI111646B (cg-RX-API-DMAC7.html)
GR (1) GR3019326T3 (cg-RX-API-DMAC7.html)
HU (2) HUT62606A (cg-RX-API-DMAC7.html)
IL (3) IL117252A (cg-RX-API-DMAC7.html)
MX (1) MX9205822A (cg-RX-API-DMAC7.html)
NO (3) NO304523B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ244644A (cg-RX-API-DMAC7.html)
RU (1) RU2095368C1 (cg-RX-API-DMAC7.html)
SK (1) SK279399B6 (cg-RX-API-DMAC7.html)
TW (1) TW305846B (cg-RX-API-DMAC7.html)
UY (2) UY23488A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA927724B (cg-RX-API-DMAC7.html)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6872803B1 (en) 1993-09-21 2005-03-29 Kyowa Hakko Kogyo Co., Ltd. Peptides
KR100493795B1 (ko) * 1996-02-09 2005-09-09 에프. 호프만-라 로슈 아게 혈관활성장펩타이드유사체의합성방법
ATE380038T1 (de) 1996-07-12 2007-12-15 Immunomedics Inc Radiometall-bindende peptide analoge
WO1998002453A2 (en) * 1996-07-15 1998-01-22 Universite Libre De Bruxelles Peptidic ligands having a higher selectivity for the vip1 receptor than for the vip2 receptor
WO2001023420A2 (en) * 1999-09-28 2001-04-05 Bayer Corporation Pituitary adenylate cyclase activating peptide (pacap) receptor 3 (r3) agonists and their pharmacological methods of use
US6972319B1 (en) 1999-09-28 2005-12-06 Bayer Pharmaceuticals Corporation Pituitary adenylate cyclase activating peptide (PACAP)receptor 3 (R3) agonists and their pharmacological methods of use
EP1257575B1 (en) 2000-02-18 2007-02-28 Dabur Research Foundation Radiolabeled vasoactive intestinal peptide analogs for diagnosis and radiotherapy
US6489297B1 (en) 2000-02-18 2002-12-03 Dabur Research Foundation Vasoactive intestinal peptide analogs
US6828304B1 (en) 2000-07-31 2004-12-07 Dabur Research Foundation Peptides for treatment of cancer
US7507714B2 (en) * 2000-09-27 2009-03-24 Bayer Corporation Pituitary adenylate cyclase activating peptide (PACAP) receptor 3 (R3) agonists and their pharmacological methods of use
AU2002220720B2 (en) 2000-11-28 2006-09-14 Mondobiotech Ag Compounds with the biological activity of vasoactive intestinal peptide for the treatment of pulmonary and arteriolar hypertension
DK1515745T3 (da) 2002-06-10 2009-07-13 Mondobiotech Ag Anvendelse af forbindelser med biologiskaktivitet af vasoaktivt intestinalt peptid til behandlingen af sarkoidose
CA2554475A1 (en) * 2004-01-27 2005-08-11 Bayer Pharmaceuticals Corporation Pituitary adenylate cyclase activating peptide (pacap) receptor (vpac2) agonists and their pharmacological methods of use
WO2006023359A2 (en) * 2004-08-18 2006-03-02 Eli Lilly And Company Selective vpac2 receptor peptide agonists
US20080085860A1 (en) * 2004-08-18 2008-04-10 Eli Lilly And Company Selective Vpac2 Receptor Peptide Agonists
RU2304146C2 (ru) * 2005-10-17 2007-08-10 Закрытое акционерное общество "Эпитек" Способ стабилизации петлеобразной структуры синтетических пептидов с помощью n- и c-концевых модификаций
CN101389647A (zh) * 2006-02-28 2009-03-18 伊莱利利公司 选择性vpac2受体肽激动剂
JP2009542593A (ja) * 2006-07-06 2009-12-03 エフ．ホフマン−ラ ロシュ アーゲー 血管作動性腸管ペプチドの類似体
CN101906144B (zh) * 2009-06-03 2013-06-19 首都医科大学 一根Arg-Gly-Asp-Val链通过Asp与两根脂肪醇链的偶联物、它们的合成及在医学中的应用
KR101943420B1 (ko) 2009-08-14 2019-04-17 파세비오 파마수티컬스 인코포레이티드 변형된 혈관활성 장 펩티드
WO2011133948A2 (en) 2010-04-22 2011-10-27 Longevity Biotech, Inc. Highly active polypeptides and methods of making and using the same
EP2717902B1 (en) 2011-06-06 2018-01-24 Phasebio Pharmaceuticals, Inc. Use of modified vasoactive intestinal peptides in the treatment of hypertension
US9789164B2 (en) 2013-03-15 2017-10-17 Longevity Biotech, Inc. Peptides comprising non-natural amino acids and methods of making and using the same
GB201421647D0 (en) * 2014-12-05 2015-01-21 Amcure Gmbh And Ruprecht-Karls-Universitat And Karlsruher Institut F�R Technologie CD44v6-derived cyclic peptides for treating cancers and angiogenesis related diseases
CN107427556B (zh) 2015-02-09 2022-02-25 费斯生物制药公司 用于治疗肌肉疾病和病症的方法和组合物
EP4043479A1 (en) 2016-09-30 2022-08-17 FUJIFILM Corporation Cyclic peptide, affinity chromatography support, labeled antibody, antibody-drug conjugate, and pharmaceutical preparation
AU2021224412A1 (en) * 2020-02-22 2022-09-15 Jcr Pharmaceuticals Co., Ltd. Human transferrin receptor binding peptide

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8427651D0 (en) * 1984-11-01 1984-12-05 Beecham Group Plc Compounds
US4835252A (en) * 1987-02-26 1989-05-30 The Salk Institute Biotechnology/Industrial Associates, Inc. Vasoactive intestinal peptide analogs
GB8729802D0 (en) * 1987-12-22 1988-02-03 Beecham Group Plc Novel compounds
US5084442A (en) * 1988-09-06 1992-01-28 Hoffmann-La Roche Inc. Cyclic growth hormone releasing factor analogs and method for the manufacture thereof
US5141924A (en) * 1989-06-30 1992-08-25 Hoffmann-La Roche, Inc. Synthetic vasoactive intestinal peptide analogs

Also Published As

Publication number Publication date
TW305846B (cg-RX-API-DMAC7.html) 1997-05-21
NO975023D0 (no) 1997-10-31
EP0536741A2 (en) 1993-04-14
CN1152579A (zh) 1997-06-25
DE69207138D1 (de) 1996-02-08
SK308692A3 (en) 1995-03-08
DE69207138T2 (de) 1996-06-13
UY25084A1 (es) 1998-12-21
EP0536741A3 (cg-RX-API-DMAC7.html) 1994-04-06
ATE132165T1 (de) 1996-01-15
FI924580L (fi) 1993-04-12
GR3019326T3 (en) 1996-06-30
SK279399B6 (sk) 1998-11-04
IL117252A (en) 1999-11-30
JP2515473B2 (ja) 1996-07-10
ZA927724B (en) 1994-04-07
NO304523B1 (no) 1999-01-04
JPH05213996A (ja) 1993-08-24
NZ244644A (en) 1995-04-27
FI20002041A7 (fi) 2000-09-15
HU9203194D0 (en) 1992-12-28
KR930007972A (ko) 1993-05-20
ES2082317T3 (es) 1996-03-16
HU211534A9 (en) 1995-12-28
MX9205822A (es) 1993-06-01
IL103396A (en) 1997-11-20
CN1153785A (zh) 1997-07-09
KR970001580B1 (ko) 1997-02-11
EP0536741B1 (en) 1995-12-27
NO923929L (no) 1993-04-13
NO975023L (no) 1993-04-13
DK0536741T3 (da) 1996-04-22
FI924580A0 (fi) 1992-10-09
IL117252A0 (en) 1996-06-18
AU656230B2 (en) 1995-01-27
BR9203959A (pt) 1993-04-27
NO923929D0 (no) 1992-10-09
CZ308692A3 (en) 1993-08-11
RU2095368C1 (ru) 1997-11-10
CN1072415A (zh) 1993-05-26
CN1225473C (zh) 2005-11-02
AU2622892A (en) 1993-04-22
NO980377L (no) 1993-04-13
CN1198841C (zh) 2005-04-27
FI20002041L (fi) 2000-09-15
FI111646B (fi) 2003-08-29
CZ281818B6 (cs) 1997-02-12
US5677419A (en) 1997-10-14
NO980377D0 (no) 1998-01-28
CA2080272A1 (en) 1993-04-12
HUT62606A (en) 1993-05-28
IL103396A0 (en) 1993-03-15
CN1034943C (zh) 1997-05-21
CA2080272C (en) 2002-09-17
UY23488A1 (es) 1993-04-20

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