BG106383A - Производни на имидазо [1,2-a] пиридин и пиразоло [2,3-a] пиридин - Google Patents
Производни на имидазо [1,2-a] пиридин и пиразоло [2,3-a] пиридинInfo
- Publication number
- BG106383A BG106383A BG06383A BG10638302A BG106383A BG 106383 A BG106383 A BG 106383A BG 06383 A BG06383 A BG 06383A BG 10638302 A BG10638302 A BG 10638302A BG 106383 A BG106383 A BG 106383A
- Authority
- BG
- Bulgaria
- Prior art keywords
- values
- pyridine
- different
- same
- pyrazolo
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Съединенията имат формула (I), посочена в описанието, в която пръстен А е имидазо[1,2a]пирид-3-ил или пиразоло[2,3a]пирид-3-ил; m има стойност от 0 до 5; n - от 0 до 2, пръстенът В е фенил или фенил,кондензиран към С5-7 циклоалкилов пръстен; р е от 0 до 4; q е от 0 до 2; R1, R2, R3 и R4 имат значения, посочени в описанието, като стойностите им могат да бъдат еднакви или различни, и където р+q<5.Изобретението се отнася и до фармацевтично приемлива сол или хидролизиращ се in vivo естер на посоченото съединение, до приложението им при инхибиране на киназиCDK2, CDK4 и CDK6 в клетъчния цикъл, както и до фармацевтичните състави, до методите и процедурите за получаване на тези съединения.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9919778.2A GB9919778D0 (en) | 1999-08-21 | 1999-08-21 | Chemical compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
BG106383A true BG106383A (bg) | 2002-09-30 |
BG65566B1 BG65566B1 (bg) | 2008-12-30 |
Family
ID=10859538
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG106383A BG65566B1 (bg) | 1999-08-21 | 2002-02-04 | Производни на имидазо[1,2-a] пиридин и пиразоло[2,3-a]пиридин |
Country Status (33)
Country | Link |
---|---|
US (1) | US6855719B1 (bg) |
EP (1) | EP1214318B1 (bg) |
JP (1) | JP4280442B2 (bg) |
KR (1) | KR100737259B1 (bg) |
CN (1) | CN1174981C (bg) |
AR (1) | AR031075A1 (bg) |
AT (1) | ATE251623T1 (bg) |
AU (1) | AU757639B2 (bg) |
BG (1) | BG65566B1 (bg) |
BR (1) | BR0013476A (bg) |
CA (1) | CA2376293A1 (bg) |
CO (1) | CO5460265A1 (bg) |
CZ (1) | CZ2002617A3 (bg) |
DE (1) | DE60005850T2 (bg) |
DK (1) | DK1214318T3 (bg) |
EE (1) | EE04964B1 (bg) |
ES (1) | ES2208397T3 (bg) |
GB (1) | GB9919778D0 (bg) |
HK (1) | HK1045510B (bg) |
HU (1) | HUP0202494A3 (bg) |
IL (2) | IL147752A0 (bg) |
IS (1) | IS2068B (bg) |
MX (1) | MXPA02001674A (bg) |
MY (1) | MY123390A (bg) |
NO (1) | NO322818B1 (bg) |
NZ (1) | NZ516740A (bg) |
PL (1) | PL199615B1 (bg) |
PT (1) | PT1214318E (bg) |
RU (1) | RU2248976C2 (bg) |
SK (1) | SK287033B6 (bg) |
UA (1) | UA73522C2 (bg) |
WO (1) | WO2001014375A1 (bg) |
ZA (1) | ZA200200028B (bg) |
Families Citing this family (137)
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KR100382619B1 (ko) | 1997-09-05 | 2003-05-09 | 글락소 그룹 리미티드 | 2,3-디아릴-피라졸로[1,5-b]피리다진 유도체, 그의 제조방법 및 시클로옥시게나제 2(cox-2) 억제제로서의 용도 |
JP2002523498A (ja) | 1998-08-29 | 2002-07-30 | アストラゼネカ・アクチエボラーグ | ピリミジン化合物 |
DE69933680T2 (de) | 1998-08-29 | 2007-08-23 | Astrazeneca Ab | Pyrimidine verbindungen |
ES2228127T3 (es) | 1998-11-03 | 2005-04-01 | Glaxo Group Limited | Derivados de pirazolopiridina como inhibidores selectivos de cox-2. |
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ES2216631T3 (es) | 1999-02-27 | 2004-10-16 | Glaxo Group Limited | Pirazolpiridinas. |
GB9905075D0 (en) | 1999-03-06 | 1999-04-28 | Zeneca Ltd | Chemical compounds |
GB9907658D0 (en) | 1999-04-06 | 1999-05-26 | Zeneca Ltd | Chemical compounds |
GB9930358D0 (en) | 1999-12-22 | 2000-02-09 | Glaxo Group Ltd | Process for the preparation of chemical compounds |
CN1429222A (zh) * | 2000-02-17 | 2003-07-09 | 安姆根有限公司 | 激酶抑制剂 |
GB0004888D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
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US7129242B2 (en) | 2000-12-06 | 2006-10-31 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto |
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SE0100569D0 (sv) | 2001-02-20 | 2001-02-20 | Astrazeneca Ab | New compounds |
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ATE332301T1 (de) | 2001-04-10 | 2006-07-15 | Smithkline Beecham Corp | Antivirale pyrazolopyridin verbindungen |
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