BG106346A - 8-ФЕНИЛ-6, 9-ДИХИДРО-[1,2,4] ТРИАЗОЛО [3,4-i] ПУРИН-5-ОНОВИ ПРОИЗВОДНИ - Google Patents

8-ФЕНИЛ-6, 9-ДИХИДРО-[1,2,4] ТРИАЗОЛО [3,4-i] ПУРИН-5-ОНОВИ ПРОИЗВОДНИ

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Publication number
BG106346A
BG106346A BG06346A BG10634602A BG106346A BG 106346 A BG106346 A BG 106346A BG 06346 A BG06346 A BG 06346A BG 10634602 A BG10634602 A BG 10634602A BG 106346 A BG106346 A BG 106346A
Authority
BG
Bulgaria
Prior art keywords
purin
triazolo
dihydro
phenyl
derivatives
Prior art date
Application number
BG06346A
Other languages
English (en)
Inventor
Ferrer Jordi Gracia
Gras Joan Feixas
Soto Jose Prieto
Noverola Armando Vega
Juan Bernat Vidal
Original Assignee
Almirall Prodesfarma, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Prodesfarma, S.A. filed Critical Almirall Prodesfarma, S.A.
Publication of BG106346A publication Critical patent/BG106346A/bg

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/22—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one sulfur atom

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретението се отнася до 8-фенил-6,9-дихидро-[1,2,4]триазоло[3,4-i]пурин-5-онови производни с формула или до техни фармацевтично приемливи соли, дометод за тяхното получаване, до фармацевтични състави, които ги съдържат, и до използването им катоPDE 5 инхибитори.
BG06346A 1999-07-27 2002-01-24 8-ФЕНИЛ-6, 9-ДИХИДРО-[1,2,4] ТРИАЗОЛО [3,4-i] ПУРИН-5-ОНОВИ ПРОИЗВОДНИ BG106346A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009901694A ES2166270B1 (es) 1999-07-27 1999-07-27 Derivados de 8-fenil-6,9-dihidro-(1,2,4,)triazolo(3,4-i)purin-5-ona.
PCT/EP2000/007062 WO2001007441A1 (en) 1999-07-27 2000-07-24 8-PHENYL-6,9-DIHYDRO-[1,2,4]TRIAZOLO[3,4-i]PURIN-5-ONE DERIVATIVES

Publications (1)

Publication Number Publication Date
BG106346A true BG106346A (bg) 2002-09-30

Family

ID=8309393

Family Applications (1)

Application Number Title Priority Date Filing Date
BG06346A BG106346A (bg) 1999-07-27 2002-01-24 8-ФЕНИЛ-6, 9-ДИХИДРО-[1,2,4] ТРИАЗОЛО [3,4-i] ПУРИН-5-ОНОВИ ПРОИЗВОДНИ

Country Status (34)

Country Link
US (1) US7034016B2 (bg)
EP (1) EP1198464B1 (bg)
JP (1) JP2003505461A (bg)
KR (1) KR20020022786A (bg)
CN (1) CN1198825C (bg)
AR (1) AR024969A1 (bg)
AT (1) ATE251625T1 (bg)
AU (1) AU777571B2 (bg)
BG (1) BG106346A (bg)
BR (1) BR0012764A (bg)
CA (1) CA2380181A1 (bg)
CO (1) CO5190717A1 (bg)
CZ (1) CZ2002311A3 (bg)
DE (1) DE60005838T2 (bg)
DK (1) DK1198464T3 (bg)
EE (1) EE200200046A (bg)
ES (2) ES2166270B1 (bg)
HK (1) HK1044332B (bg)
HU (1) HUP0202103A3 (bg)
IL (1) IL147770A0 (bg)
MY (1) MY129590A (bg)
NO (1) NO20020391L (bg)
NZ (1) NZ516780A (bg)
PE (1) PE20010401A1 (bg)
PL (1) PL353827A1 (bg)
PT (1) PT1198464E (bg)
RU (1) RU2258705C2 (bg)
SK (1) SK1352002A3 (bg)
TR (1) TR200200785T2 (bg)
TW (1) TW568912B (bg)
UA (1) UA73513C2 (bg)
UY (1) UY26258A1 (bg)
WO (1) WO2001007441A1 (bg)
ZA (1) ZA200200561B (bg)

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EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
PE20140960A1 (es) 2008-04-03 2014-08-15 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
BRPI0916997A2 (pt) 2008-08-06 2020-12-15 Boehringer Ingelheim International Gmbh Inibidor de dpp-4 e seu uso
AU2009290911A1 (en) 2008-09-10 2010-03-18 Boehringer Ingelheim International Gmbh Combination therapy for the treatment of diabetes and related conditions
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EA030121B1 (ru) 2011-07-15 2018-06-29 Бёрингер Ингельхайм Интернациональ Гмбх Замещенные хиназолины, их получение и их применение в фармацевтических композициях
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
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WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
RU2653054C2 (ru) 2012-06-18 2018-05-07 Дарт Нейросайенс (Кайман) Лтд Замещенные соединения пиридин азолопиримидин-5-(6н)-она
ES2950384T3 (es) 2014-02-28 2023-10-09 Boehringer Ingelheim Int Uso médico de un inhibidor de DPP-4
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Also Published As

Publication number Publication date
ATE251625T1 (de) 2003-10-15
AU777571B2 (en) 2004-10-21
BR0012764A (pt) 2002-07-02
AR024969A1 (es) 2002-10-30
DK1198464T3 (da) 2004-02-16
ES2166270B1 (es) 2003-04-01
SK1352002A3 (en) 2003-04-01
PL353827A1 (en) 2003-12-01
NO20020391D0 (no) 2002-01-25
EE200200046A (et) 2003-04-15
CO5190717A1 (es) 2002-08-29
PE20010401A1 (es) 2001-04-16
CA2380181A1 (en) 2001-02-01
ES2166270A1 (es) 2002-04-01
NZ516780A (en) 2004-01-30
HUP0202103A2 (en) 2002-10-28
RU2258705C2 (ru) 2005-08-20
CN1374962A (zh) 2002-10-16
DE60005838D1 (de) 2003-11-13
HUP0202103A3 (en) 2004-12-28
NO20020391L (no) 2002-03-25
MY129590A (en) 2007-04-30
TR200200785T2 (tr) 2002-09-23
UA73513C2 (en) 2005-08-15
HK1044332A1 (en) 2002-10-18
DE60005838T2 (de) 2004-08-19
HK1044332B (zh) 2004-10-15
TW568912B (en) 2004-01-01
WO2001007441A1 (en) 2001-02-01
US20030060627A1 (en) 2003-03-27
ES2208378T3 (es) 2004-06-16
UY26258A1 (es) 2000-12-29
ZA200200561B (en) 2003-06-25
EP1198464A1 (en) 2002-04-24
IL147770A0 (en) 2002-08-14
EP1198464B1 (en) 2003-10-08
PT1198464E (pt) 2004-02-27
KR20020022786A (ko) 2002-03-27
JP2003505461A (ja) 2003-02-12
US7034016B2 (en) 2006-04-25
AU6277200A (en) 2001-02-13
CZ2002311A3 (cs) 2003-01-15
CN1198825C (zh) 2005-04-27

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