HUP0400266A2 - Imidazo[1,2-a]piridin-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk herpeszvírus-fertőzések megelőzésére vagy kezelésére - Google Patents

Imidazo[1,2-a]piridin-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk herpeszvírus-fertőzések megelőzésére vagy kezelésére

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Publication number
HUP0400266A2
HUP0400266A2 HU0400266A HUP0400266A HUP0400266A2 HU P0400266 A2 HUP0400266 A2 HU P0400266A2 HU 0400266 A HU0400266 A HU 0400266A HU P0400266 A HUP0400266 A HU P0400266A HU P0400266 A2 HUP0400266 A2 HU P0400266A2
Authority
HU
Hungary
Prior art keywords
nr9r11
nr7ay
cycloalkyl
nr7r8
het
Prior art date
Application number
HU0400266A
Other languages
English (en)
Inventor
Kristjan Gudmundsson
Brian A. Johns
Original Assignee
Smithkline Beecham Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp. filed Critical Smithkline Beecham Corp.
Publication of HUP0400266A2 publication Critical patent/HUP0400266A2/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A találmány tárgya (I) általános képletű vegyület és gyógyászatilagelfogadható sói, szolvátjai és fiziológiás funkciós származékai, ahola képletben p értéke 0, 1, 2, 3 vagy 4; Rl jelentése halogénatom,alkil-, alkenil-, alkinil-, cikloalkil-, cikloalkenilcsoport, Ay, Het,-OR7, -OAy, -OR1oAy, -OHet, -OR16Het, -C(O)R9, -C(O)Ay, -C(O)Het, -CO2R9, -C(O)NR7R8, -C(O)NR7Ay, -C(O)NHRl0Ay, -C(O)NHRl0Het, -C(S)NR9R11, -C(NH)NR7R8, -C(NH)NR7Ay, -S(O)nR9, -S(O)nAy, -S(O)nHet, -S(O)2NR7R8, -S(O)2NR7Ay, -NR7R8, -NR7Ay, -NHHet, -NHRl0Ay, -NHRl0Het,-Rl0cikloalkil, -R10Ay, -R10Het, -R10O-C(O)R9, -Rl0O-C(O)Ay, -Rl0O-C(O)Het, -Rl0O-S(O)nR9, -R10R9, -R10C(O)R9, -R10CO2R9, R10C(O)NR9R11y,-R10C(O)NR7Ay, -R10C(O)NHRl0Het, -R10C(S)NR9R11,, -R10C(NH)NR9R11, -R10SO2R9, -Rl0SO2NR9R11, -R10SO2NHCOR9, -Rl0NR7R8, -R10NR7Ay, -Rl0NHC(NH)NR9R11, ciano-, nitro- vagy azidocsoport; vagy kétszomszédos R1 csoport egy cikloalkilcsoportot vagy egy heterociklusosgyűrűt képez; R7 és R8 jelentése hidrogénatom, alkil-, cikloalkil-,alkenil-, cikloalkenil-, -OR9, -C(O)R9, -CO2R9, -C(O)NR9R11, -C(S)NR9R11, -C(NH)NR9R11, -SO2R10, -SO2NR9R11, -Rl0cikloalkil, -Rl0OR9, -R10C(O)R9, -R10CO2R9, -R10C(O)NR9R11, -R10C(S)NR9R11, -R10C(NH)NR9R11, -R10SO2Rl0, -R10SO2NR9R11, -R10SO2NHCOR9, -R10NR9R11,-Rl0NHCOR9, -Rl0NHSO2R9 vagy -Rl0NHC(NH)NR9R11 általános képletűcsoport; R9 és R11 jelentése hidrogénatom, alkil-, cikloalkil-, -R10cikloalkil, -R10OH, -Rl0(OR10) w ahol w értéke 1-10, vagy -R10NR10R10 csoport; R10 jelentése alkil-, alkenil-, alkinil-,cikloalkil- vagy cikloalkenilcsoport; Ay jelentése arilcsoport; Hetjelentése heterociklusos vagy heteroarilcsoport; R2 jelentésehalogénatom, alkenil-, cikloalkil-, cikloalkenil-, Ay, Het, -OR7, -OAy, -OHet, -ORl0Het, -S(O)nR9, -S(O)nAy, -S(O)nNR7R8, -S(O)nHet, -NR7R8, -NHHet, -NHRl0Ay, -NHRl0Het, -R10NR7R8 vagy -Rl0NR7Ay csoport;n értéke 0, 1 vagy 2; Y jelentése N vagy CH; R3 és R4 jelentésehidrogén-, halogénatom, alkil-, alkenil-, cikloalkilcsoport, Ay, Het,-OR7, -OAy, -C(O)R7, -C(O)Ay, -CO2R7, -CO2Ay, -SO2NHR9, -NR7R8, -NR7Ay, -NHHet, -NHR10Het, -Rl0cikloalkil, -Rl0OR7, -Rl0OAy, -Rl0NR7R8vagy -R10NR7Ay csoport; q értéke 0, 1, 2, 3, 4 vagy 5: és alkinil-, R5jelentése halogénatom, alkil-, alkenil, cikloalkil-, cikloalkenil-,Ay, Het, -OR7, -OAy, -OHet, -OR10Ay, -OR10Het, -C(O)R9, -C(O)Ay, -C(O)Het, -CO2R9, -C(O)NR7R8, -C(O)NR7Ay, -C(O)NHRl0Het, -C(S)NR9R11, -C(NH)NR7R8, -C(NH)NR7Ay, -S(O)nR9, -S(O)2NR7R8, -S(O)2NR7Ay, -NR7R8, -NR7Ay, -NHHet, -NHRl0Ay, -NHRl0Het, -Rl0cikloalkil, -Rl0Het, -R10OR9,-R10C(O)R9, -R10CO2R9, -R10C(O)NR9R11, -R10C(O)NR7Ay, -R10C(O)NHRl0Het, -R10C(S)NR9R11, -R10C(NH)NR9R11, -R10SO2R9, -R10SO2NR9R11, -R10SO2NHCOR9, -R10NR7R8, -R10NR7Ay, -Rl0NHC(NH)NR7R11,ciano-, nitro- vagy azidocsoport; vagy két szomszédos R5 csoportcikloalkil- vagy arilcsoportot képez; ahol ha Y jelentése
HU0400266A 2001-06-21 2002-06-10 Imidazo[1,2-a]piridin-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk herpeszvírus-fertőzések megelőzésére vagy kezelésére HUP0400266A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30000901P 2001-06-21 2001-06-21
PCT/US2002/018520 WO2003000689A1 (en) 2001-06-21 2002-06-10 Imidazo`1,2-a!pyridine derivatives for the prophylaxis and treatment of herpes viral infections

Publications (1)

Publication Number Publication Date
HUP0400266A2 true HUP0400266A2 (hu) 2004-08-30

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Country Status (19)

Country Link
US (3) US7186714B2 (hu)
EP (1) EP1401836B1 (hu)
JP (1) JP2005500315A (hu)
KR (1) KR20040018281A (hu)
CN (1) CN1518550A (hu)
AT (1) ATE337316T1 (hu)
BR (1) BR0210464A (hu)
CA (1) CA2451008A1 (hu)
CO (1) CO5540312A2 (hu)
CZ (1) CZ20033518A3 (hu)
DE (1) DE60214179T2 (hu)
ES (1) ES2271273T3 (hu)
HU (1) HUP0400266A2 (hu)
IL (1) IL158667A0 (hu)
MX (1) MXPA03011906A (hu)
NO (1) NO20035583D0 (hu)
PL (1) PL366827A1 (hu)
WO (1) WO2003000689A1 (hu)
ZA (1) ZA200308726B (hu)

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EP1401836A1 (en) 2004-03-31
DE60214179T2 (de) 2007-01-04
MXPA03011906A (es) 2004-03-26
ES2271273T3 (es) 2007-04-16
US20070135451A1 (en) 2007-06-14
BR0210464A (pt) 2004-07-20
CZ20033518A3 (en) 2004-05-12
IL158667A0 (en) 2004-05-12
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JP2005500315A (ja) 2005-01-06
CN1518550A (zh) 2004-08-04
EP1401836B1 (en) 2006-08-23
CA2451008A1 (en) 2003-01-03
US20050228004A1 (en) 2005-10-13
CO5540312A2 (es) 2005-07-29
DE60214179D1 (de) 2006-10-05
ZA200308726B (en) 2005-02-10
WO2003000689A1 (en) 2003-01-03
NO20035583D0 (no) 2003-12-15
US20060167252A1 (en) 2006-07-27
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ATE337316T1 (de) 2006-09-15
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