HUP0401642A2 - Staurosporinszármazékok felhasználása gyógyszerkészítmények előállítására - Google Patents

Staurosporinszármazékok felhasználása gyógyszerkészítmények előállítására

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Publication number
HUP0401642A2
HUP0401642A2 HU0401642A HUP0401642A HUP0401642A2 HU P0401642 A2 HUP0401642 A2 HU P0401642A2 HU 0401642 A HU0401642 A HU 0401642A HU P0401642 A HUP0401642 A HU P0401642A HU P0401642 A2 HUP0401642 A2 HU P0401642A2
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HU
Hungary
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group
optionally
substituted
doubly
singly
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HU0401642A
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English (en)
Inventor
James Douglas Griffin
Paul William Manley
Original Assignee
Novartis Ag
Dana-Farber Cancer Institute Inc.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26991080&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0401642(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag, Dana-Farber Cancer Institute Inc. filed Critical Novartis Ag
Publication of HUP0401642A2 publication Critical patent/HUP0401642A2/hu
Publication of HUP0401642A3 publication Critical patent/HUP0401642A3/hu
Publication of HU230798B1 publication Critical patent/HU230798B1/hu

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)

Abstract

A találmány (A), (B), (C) vagy (D) általános képletűstaurosporinszármazékoknak - amelyek képletében Rl és R2 adott esetbenszubsztituált alkilcsoport, hidrogén-, halogénatom, adott esetbenéteresített vagy észteresített hidroxicsoport, adott esetben mono-vagy diszubsztituált aminocsoport, ciano-, nitrocsoport, adott esetbenszubsztituált merkaptocsoport, adott esetben észteresítettkarboxicsoport, adott esetben egyszeresen vagy kétszeresen N-szubsztituált karbamoilcsoport, szulfocsoport, szubsztituáltszulfonilcsoport vagy adott esetben egyszeresen vagy kétszeresen N-szubsztituált szulfamoilcsoport; n és m értéke egymástól függetlenül0, 1, 2, 3 vagy 4; R5 hidrogénatom, legfeljebb 29 szénatomos alifás,karbociklusos vagy karbociklusos-alifás csoport, vagy legfeljebb 20szénatomos és legfeljebb 9 heteroatomos heterociklusos vagyheterociklusos-alifás csoport, vagy legfeljebb 30 szénatomosacilcsoport; X jelentése két hidrogénatom; vagy egy hidrogénatom éshidroxicsoport; oxigénatom; vagy hidrogénatom és rövid szénláncúalkoxicsoport; Q és Q' gyógyszerészetileg elfogadható szerves csoport,vagy hidrogén-, halogénatom, adott esetben éteresített vagyészteresített hidroxicsoport, adott esetben mono- vagy diszubsztituáltaminocsoport, ciano-, nitrocsoport, adott esetben szubsztituáltmerkaptocsoport, adott esetben észteresített karboxicsoport, adottesetben egyszeresen vagy kétszeresen N-szubsztituált karbamoilcsoport,szulfocsoport, szubsztituált szulfonilcsoport vagy adott esetbenegyszeresen vagy kétszeresen N-szubsztituált szulfamoilcsoport vagy -ha legalább egy sóképző csoport van a vegyületekben sóiknak dereguláltFLT3 receptor tirozin-kroáz aktivitást magukban foglaló betegségek,különösen leukémiák és myelodysplasticus szindrómák kuratív és/vagyprofilaktikus kezelésére alkalmas gyógyszerkészítmények előállításáratörténő felhasználására vonatkozik. Ó
HU0401642A 2001-10-30 2002-10-29 Staurosporin-származékok mint az FLT3 receptor tirozin-kináz aktivitás inhibitorai HU230798B1 (hu)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US33903101P 2001-10-30 2001-10-30
US60/339,031 2001-10-30
US33818501P 2001-12-07 2001-12-07
US60/338,185 2001-12-07
PCT/EP2002/012076 WO2003037347A1 (en) 2001-10-30 2002-10-29 Staurosporine derivatives as inhibitors of flt3 receptor tyrosine kinase activity

Publications (3)

Publication Number Publication Date
HUP0401642A2 true HUP0401642A2 (hu) 2004-11-29
HUP0401642A3 HUP0401642A3 (en) 2008-05-28
HU230798B1 HU230798B1 (hu) 2018-06-28

Family

ID=26991080

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0401642A HU230798B1 (hu) 2001-10-30 2002-10-29 Staurosporin-származékok mint az FLT3 receptor tirozin-kináz aktivitás inhibitorai

Country Status (26)

Country Link
US (3) US7973031B2 (hu)
EP (1) EP1441737B1 (hu)
JP (1) JP4959918B2 (hu)
KR (2) KR100926194B1 (hu)
CN (2) CN101703509A (hu)
AT (1) ATE335490T1 (hu)
AU (1) AU2006249245B2 (hu)
BR (1) BRPI0213739B8 (hu)
CA (1) CA2462657C (hu)
CY (1) CY1106199T1 (hu)
DE (1) DE60213842T2 (hu)
DK (1) DK1441737T3 (hu)
ES (1) ES2269793T3 (hu)
FR (1) FR18C1012I2 (hu)
HK (1) HK1068262A1 (hu)
HU (1) HU230798B1 (hu)
IL (2) IL161156A0 (hu)
MX (1) MXPA04004137A (hu)
NO (1) NO335685B1 (hu)
NZ (1) NZ532136A (hu)
PL (1) PL211461B1 (hu)
PT (1) PT1441737E (hu)
RU (1) RU2337692C3 (hu)
TW (1) TWI302836B (hu)
WO (1) WO2003037347A1 (hu)
ZA (1) ZA200402498B (hu)

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KR20090087139A (ko) 2009-08-14
BRPI0213739B1 (pt) 2020-06-09
ZA200402498B (en) 2005-07-27
BR0213739A (pt) 2004-10-19
RU2337692C3 (ru) 2020-11-09
FR18C1012I1 (fr) 2018-04-27
US7973031B2 (en) 2011-07-05
US20050020570A1 (en) 2005-01-27
DE60213842T2 (de) 2007-09-06
MXPA04004137A (es) 2005-01-25
NO335685B1 (no) 2015-01-19
BRPI0213739B8 (pt) 2021-05-25
FR18C1012I2 (fr) 2021-06-11
WO2003037347A1 (en) 2003-05-08
TWI302836B (en) 2008-11-11
RU2337692C2 (ru) 2008-11-10
CN1582150B (zh) 2011-09-07
RU2004116472A (ru) 2005-05-10
DE60213842D1 (de) 2006-09-21
CN1582150A (zh) 2005-02-16
KR100926194B1 (ko) 2009-11-09
HUP0401642A3 (en) 2008-05-28
NZ532136A (en) 2006-08-31
PL211461B1 (pl) 2012-05-31
US20110224194A1 (en) 2011-09-15
AU2006249245A1 (en) 2007-01-04
US8222244B2 (en) 2012-07-17
JP4959918B2 (ja) 2012-06-27
IL161156A0 (en) 2004-08-31
NO20042123L (no) 2004-07-13
PT1441737E (pt) 2006-12-29
CA2462657C (en) 2011-04-26
CY1106199T1 (el) 2011-06-08
IL161156A (en) 2011-02-28

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