HUP0302925A2 - Gyulladásgátló szerekként alkalmazható amino-szubsztituált tetraciklusos vegyületek és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Gyulladásgátló szerekként alkalmazható amino-szubsztituált tetraciklusos vegyületek és ezeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0302925A2
HUP0302925A2 HU0302925A HUP0302925A HUP0302925A2 HU P0302925 A2 HUP0302925 A2 HU P0302925A2 HU 0302925 A HU0302925 A HU 0302925A HU P0302925 A HUP0302925 A HU P0302925A HU P0302925 A2 HUP0302925 A2 HU P0302925A2
Authority
HU
Hungary
Prior art keywords
group
alkyl
compouds
amino
useful
Prior art date
Application number
HU0302925A
Other languages
English (en)
Inventor
Francis Beaulieu
Makonen Belema
Carl Ouellet
Yuping Qiu
Xuejie Yang
Fred C. Zusi
Original Assignee
Bristol-Myers Squibb Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Co. filed Critical Bristol-Myers Squibb Co.
Publication of HUP0302925A2 publication Critical patent/HUP0302925A2/hu
Publication of HUP0302925A3 publication Critical patent/HUP0302925A3/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A találmány tárgyát az általános képletű vegyületek - ahol X -NR1, -CR1 általános képletű csoport vagy -S- atom; Y1 és Y2 nitrogén- vagyszénatom; R1 hidrogénatom, halogénatom, alkil, szubsztituált alkil,cianocsoport, -OR5, -NR5R6, -C(=O)R5, -CO2R5 általános képletű csoportvagy arilcsoport; R2 alkil, szubsztituált alkil, alkenil, alkinil,alkoxi, alkil-tio, aril, heteroaril, heterociklo, cikloalkil- vagyszubsztituált cikloalkilcsoport; R3 és R4 egymástól függetlenülhalogénatom, alkil, szubsztituált alkil, nitro, cianocsoport, -OR7, -NR7R8, -C(=O)R7, -CO2R7, -SR7, -C(=O)NR7R8, -NR7C(=O)R8, -NR7C(=O)OR8,-S(O)qR7, -NR7SO2R8 vagy -SO2NR7R8 általános képletű csoport; R5-R8egymástól függetlenül hidrogénatom, alkil, szubsztituált alkil vagyfenilcsoport, vagy ha ugyanahhoz a nitrogénatomhoz kapcsolódnak (mintaz -NR5R6 vagy -NR7R8 csoportban) egymáshoz kapcsolódva egyheterociklusos vagy heteroaril-csoportot képezhetnek; és m, n és q =0, 1, vagy 2 - és gyógyászatilag alkalmazható sóik, valamintimmunbetegségek és rendellenességek kezelésében való alkalmazásaikképezik. Ó
HU0302925A 2000-10-03 2001-09-27 Amino-substituted tetracyclic compouds useful as anti-inflammatory agents and pharmaceutical compositions comprising same HUP0302925A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22330400P 2000-10-03 2000-10-03
PCT/US2001/042387 WO2002028860A2 (en) 2000-10-03 2001-09-27 Amino-substituted tetracyclic compounds useful as anti-inflammatory agents and pharmaceutical compositions comprising same

Publications (2)

Publication Number Publication Date
HUP0302925A2 true HUP0302925A2 (hu) 2003-12-29
HUP0302925A3 HUP0302925A3 (en) 2004-10-28

Family

ID=22835931

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0302925A HUP0302925A3 (en) 2000-10-03 2001-09-27 Amino-substituted tetracyclic compouds useful as anti-inflammatory agents and pharmaceutical compositions comprising same

Country Status (10)

Country Link
US (1) US6960585B2 (hu)
EP (1) EP1325009B1 (hu)
JP (1) JP5021148B2 (hu)
AT (1) ATE319713T1 (hu)
AU (2) AU1182702A (hu)
CA (1) CA2424303A1 (hu)
DE (1) DE60117835T2 (hu)
ES (1) ES2260300T3 (hu)
HU (1) HUP0302925A3 (hu)
WO (1) WO2002028860A2 (hu)

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AR037641A1 (es) 2001-12-05 2004-11-17 Tularik Inc Moduladores de inflamacion
EP1556053A4 (en) 2002-10-31 2006-04-19 Amgen Inc ANTI-INFLAMMATORY AGENTS
AR050253A1 (es) 2004-06-24 2006-10-11 Smithkline Beecham Corp Compuesto derivado de indazol carboxamida, composicion que lo comprende y su uso para la preparacion de un medicamento
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WO2007019295A1 (en) 2005-08-05 2007-02-15 Cylene Pharmaceuticals, Inc. Methods of preparing quinolone analogs
US20090175852A1 (en) 2006-06-06 2009-07-09 Schering Corporation Imidazopyrazines as protein kinase inhibitors
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PE20081889A1 (es) 2007-03-23 2009-03-05 Smithkline Beecham Corp Indol carboxamidas como inhibidores de ikk2
AU2009298981B2 (en) 2008-10-02 2012-09-27 Asahi Kasei Pharma Corporation 8-substituted isoquinoline derivative and use thereof
US8354539B2 (en) 2009-03-10 2013-01-15 Glaxo Group Limited Indole derivatives as IKK2 inhibitors
CN102288753A (zh) * 2011-05-10 2011-12-21 重庆市科学技术研究院 快速检测四环素、金霉素、土霉素与多西环素残留的四联胶体金免疫层析试纸条及其制备方法
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Also Published As

Publication number Publication date
US20020072523A1 (en) 2002-06-13
AU1182702A (en) 2002-04-15
EP1325009A2 (en) 2003-07-09
DE60117835D1 (de) 2006-05-04
HUP0302925A3 (en) 2004-10-28
WO2002028860A2 (en) 2002-04-11
ATE319713T1 (de) 2006-03-15
JP5021148B2 (ja) 2012-09-05
AU2002211827B2 (en) 2006-12-14
WO2002028860A3 (en) 2002-09-06
JP2004512281A (ja) 2004-04-22
CA2424303A1 (en) 2002-04-11
ES2260300T3 (es) 2006-11-01
US6960585B2 (en) 2005-11-01
DE60117835T2 (de) 2006-10-19
EP1325009B1 (en) 2006-03-08

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