AU724536B2 - Process for the microbial production of amino acids by boosted activity of export carriers - Google Patents

Process for the microbial production of amino acids by boosted activity of export carriers Download PDF

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Publication number
AU724536B2
AU724536B2 AU19218/97A AU1921897A AU724536B2 AU 724536 B2 AU724536 B2 AU 724536B2 AU 19218/97 A AU19218/97 A AU 19218/97A AU 1921897 A AU1921897 A AU 1921897A AU 724536 B2 AU724536 B2 AU 724536B2
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AU
Australia
Prior art keywords
gene
export
sequence
amino acid
process according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU19218/97A
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English (en)
Other versions
AU1921897A (en
Inventor
Lothar Eggeling
Hermann Sahm
Marina Vrlijc
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Evonik Operations GmbH
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Forschungszentrum Juelich GmbH
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Publication of AU1921897A publication Critical patent/AU1921897A/en
Application granted granted Critical
Publication of AU724536B2 publication Critical patent/AU724536B2/en
Assigned to EVONIK DEGUSSA GMBH reassignment EVONIK DEGUSSA GMBH Alteration of Name(s) in Register under S187 Assignors: FORSCHUNGSZENTRUM JULICH GMBH
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU19218/97A 1995-12-22 1996-12-18 Process for the microbial production of amino acids by boosted activity of export carriers Ceased AU724536B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19548222 1995-12-22
DE19548222A DE19548222A1 (de) 1995-12-22 1995-12-22 Verfahren zur mikrobiellen Herstellung von Aminosäuren durch gesteigerte Aktivität von Exportcarriern
PCT/DE1996/002485 WO1997023597A2 (de) 1995-12-22 1996-12-18 Verfahren zur mikrobiellen herstellung von aminosäuren durch gesteigerte aktivität von exportcarriern

Publications (2)

Publication Number Publication Date
AU1921897A AU1921897A (en) 1997-07-17
AU724536B2 true AU724536B2 (en) 2000-09-21

Family

ID=7781070

Family Applications (1)

Application Number Title Priority Date Filing Date
AU19218/97A Ceased AU724536B2 (en) 1995-12-22 1996-12-18 Process for the microbial production of amino acids by boosted activity of export carriers

Country Status (16)

Country Link
US (1) US6858406B1 (enExample)
EP (1) EP0868527B1 (enExample)
JP (1) JP3942194B2 (enExample)
KR (1) KR100444621B1 (enExample)
CN (1) CN1283797C (enExample)
AR (1) AR048561A1 (enExample)
AU (1) AU724536B2 (enExample)
BR (1) BR9612666A (enExample)
CA (1) CA2241111C (enExample)
DE (2) DE19548222A1 (enExample)
DK (1) DK0868527T3 (enExample)
ES (1) ES2281088T3 (enExample)
MX (1) MX9805050A (enExample)
RU (1) RU2225883C2 (enExample)
WO (1) WO1997023597A2 (enExample)
ZA (1) ZA9610768B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7335506B2 (en) 2002-11-20 2008-02-26 Ajinomoto Co., Inc. Method for producing L-lysine or L-arginine by using methanol-assimilating bacterium
US7439038B2 (en) 2002-11-20 2008-10-21 Ajinomoto Co., Inc. Method for producing L-amino acid using methylotroph
US7993885B2 (en) 2001-06-12 2011-08-09 Ajinomoto Co., Inc. Method for producing L-lysine or L-arginine by using methanol assimilating bacterium

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19726083A1 (de) * 1997-06-19 1998-12-24 Consortium Elektrochem Ind Mikroorganismen und Verfahren zur fermentativen Herstellung von L-Cystein, L-Cystin, N-Acetyl-Serin oder Thiazolidinderivaten
DE19931317A1 (de) * 1999-07-07 2001-01-11 Degussa L-Lysin produzierende coryneforme Bakterien und Verfahren zur Herstellung von L-Lysin
RU2144564C1 (ru) 1998-10-13 2000-01-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" ФРАГМЕНТ ДНК rhtB, КОДИРУЮЩИЙ СИНТЕЗ БЕЛКА RhtB, ПРИДАЮЩЕГО УСТОЙЧИВОСТЬ К L-ГОМОСЕРИНУ БАКТЕРИЯМ ESCHERICHIA COLI, И СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ
RU2148642C1 (ru) 1998-12-23 2000-05-10 ЗАО "Научно-исследовательский институт АДЖИНОМОТО-Генетика" (ЗАО "АГРИ") Фрагмент днк rhtc, кодирующий синтез белка rhtc, придающего повышенную устойчивость к l-треонину бактериям escherichia coli, и способ получения l-аминокислоты
RU2175351C2 (ru) 1998-12-30 2001-10-27 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО "АГРИ") Фрагмент днк из escherichia coli, определяющий повышенную продукцию l-аминокислот (варианты), и способ получения l-аминокислот
DE19931314A1 (de) * 1999-07-07 2001-01-11 Degussa L-Lysin produzierende coryneforme Bakterien und Verfahren zur Herstellung von Lysin
US6861246B2 (en) 1999-07-07 2005-03-01 Degussa Ag L-lysine-producing corynebacteria and process for the preparation of lysine
US20020086371A1 (en) 1999-07-07 2002-07-04 Degussa-Huls Aktiengesellschaft L-lysine-producing corynebacteria and process for the preparation of L-lysine
US6797509B1 (en) 1999-07-09 2004-09-28 Degussa-Huls Ag Nucleotide sequences which code for the tal gene
DE19951708A1 (de) 1999-10-27 2001-05-03 Degussa Für den Export verzweigtkettiger Aminosäuren kodierende Nikleotidsequenzen, Verfahren zu deren Isolierung und ihre Verwendung
US6913908B2 (en) 2000-09-02 2005-07-05 Degussa Ag Methods of making L-amino acids in coryneform using the sigE gene
AU2001285843A1 (en) * 2000-09-02 2002-03-13 Degussa A.G. Sequences which code for the sige gene
BR122013017187B1 (pt) 2001-02-13 2016-03-01 Ajinomoto Kk bactéria transgênica produtora de l-aminoácido pertencente ao gênero escherichia, e, método para produzir l-aminoácido
US7252978B2 (en) 2001-07-25 2007-08-07 Ajinomoto Co., Inc. Method for producing L-arginine
DE10154179A1 (de) * 2001-11-05 2003-05-08 Basf Ag Gene die für membeansynthese-und Membrantransport-Proteine codieren
PL207852B1 (pl) 2001-11-23 2011-02-28 Ajinomoto Co Inc Bakteria z rodzaju Escherichia wytwarzająca L-aminokwas, sposób wytwarzania L-fenyloalaniny lub L-tryptofanu i sposób wytwarzania niższych estrów alkilowych α-L-aspartylo-L-fenyloalaniny
RU2229513C2 (ru) 2001-11-23 2004-05-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Способ получения l-аминокислот, штамм escherichia coli - продуцент l-аминокислоты (варианты)
DE10210527A1 (de) 2002-03-09 2003-09-18 Degussa Allele des aceA-Gens aus coryneformen Bakterien
DE102004001674B4 (de) 2003-01-29 2019-01-24 Ajinomoto Co., Inc. Verfahren zur Herstellung von L-Lysin unter Einsatz von Methanol verwertenden Bakterien
EP1484410B1 (en) 2003-06-05 2011-11-02 Ajinomoto Co., Inc. Fermentation methods using modified bacteria with increased byproduct uptake.
ES2331956T3 (es) 2004-01-30 2010-01-21 Ajinomoto Co., Inc. Microorganismo que produce l-aminoacidos y procedimiento para producir l-aminoacidos.
JP4665537B2 (ja) * 2004-01-30 2011-04-06 味の素株式会社 Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JP4665558B2 (ja) * 2004-03-04 2011-04-06 味の素株式会社 Ｌ−グルタミン酸生産微生物及びｌ−グルタミン酸の製造法
US7344874B2 (en) * 2004-03-04 2008-03-18 Ajinomoto Co., Inc. L-glutamic acid-producing microorganism and a method for producing L-glutamic acid
DE102004034865A1 (de) 2004-07-19 2006-02-16 Siemens Ag Sensor zur Messung der Position eines Stellgliedes
BRPI0516261A (pt) 2004-10-07 2008-08-26 Ajinomoto Kk método para produzir uma substãncia básica por fermentação, e, caldo de fermentação ou produto de fermentação contendo uma substáncia básica
EP1831349B1 (en) * 2004-12-06 2011-09-21 Sage Biosciences Inc. Method of growing bacteria to deliver bioactive compounds to the intestine of ruminants
DE102005013676A1 (de) 2005-03-24 2006-09-28 Degussa Ag Allele des zwf-Gens aus coryneformen Bakterien
US20070092951A1 (en) 2005-03-24 2007-04-26 Degussa Ag Alleles of the zwf gene from coryneform bacteria
DE102005023829A1 (de) 2005-05-24 2006-11-30 Degussa Ag Allele des opcA-Gens aus coryneformen Bakterien
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JP2009089603A (ja) 2006-02-02 2009-04-30 Ajinomoto Co Inc メタノール資化性細菌を用いたｌ−リジンの製造法
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DE102007005072A1 (de) 2007-02-01 2008-08-07 Evonik Degussa Gmbh Verfahren zur fermentativen Herstellung von Cadaverin
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EP3467099A1 (en) 2017-10-05 2019-04-10 Evonik Degussa GmbH Method for the fermentative production of l-amino acids
KR101968317B1 (ko) 2018-02-23 2019-04-11 씨제이제일제당 주식회사 신규 l-트립토판 배출 단백질 및 이를 이용한 l-트립토판을 생산하는 방법
RU2019128538A (ru) 2018-09-26 2021-03-11 Эвоник Оперейшенс ГмбХ Способ ферментативного получения l-лизина
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US20220411835A1 (en) 2019-09-03 2022-12-29 Ningxia Eppen Biotech Co., Ltd Application of transport carrier gene which improves l-tryptophan production efficiency in escherichia coli
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KR102251948B1 (ko) * 2019-10-31 2021-05-17 대상 주식회사 mdfA 유전자 불활성 및 yicL 유전자 도입에 의해 방향족 아미노산 생산능력이 향상된 균주
CN115724925B (zh) * 2020-01-19 2025-06-03 中国科学院天津工业生物技术研究所 谷氨酸转运变体蛋白及其应用
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KR102617168B1 (ko) * 2020-12-09 2023-12-21 씨제이제일제당 (주) 쉬와넬라 오네이덴시스 유래 단백질을 발현하는 미생물, 및 이를 이용한 l-아미노산 생산 방법
CN114763372B (zh) 2021-01-13 2024-12-10 中国科学院天津工业生物技术研究所 具有l-脯氨酸外排功能的蛋白及其应用
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KR20230131654A (ko) 2022-03-07 2023-09-14 씨제이제일제당 (주) 변이형 l-쓰레오닌 배출 단백질 및 이를 이용한 l-쓰레오닌 생산 방법
JPWO2023195475A1 (enExample) 2022-04-04 2023-10-12
KR102770475B1 (ko) * 2022-06-02 2025-02-20 씨제이제일제당 주식회사 L-오르니틴 생산능을 가지는 미생물 및 이를 이용한 l-오르니틴 생산방법
KR102801078B1 (ko) * 2022-06-23 2025-04-24 씨제이제일제당 (주) L-히스티딘 배출 단백질 및 이를 이용한 l-히스티딘 생산 방법
CN115806601B (zh) * 2022-10-24 2024-12-20 天津科技大学 一种转录调控因子LysG突变体及其应用

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JPS575693A (en) * 1980-06-13 1982-01-12 Ajinomoto Co Inc Production of l-arginine through fermentation process
DE4400926C1 (de) * 1994-01-14 1995-06-01 Forschungszentrum Juelich Gmbh Herstellung von L-Isoleucin mittels rekombinanter Mikroorganismen mit deregulierter Threonindehydratase

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US7993885B2 (en) 2001-06-12 2011-08-09 Ajinomoto Co., Inc. Method for producing L-lysine or L-arginine by using methanol assimilating bacterium
US7335506B2 (en) 2002-11-20 2008-02-26 Ajinomoto Co., Inc. Method for producing L-lysine or L-arginine by using methanol-assimilating bacterium
US7439038B2 (en) 2002-11-20 2008-10-21 Ajinomoto Co., Inc. Method for producing L-amino acid using methylotroph

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US6858406B1 (en) 2005-02-22
AR048561A1 (es) 2006-05-10
EP0868527B1 (de) 2007-01-10
CN1209169A (zh) 1999-02-24
JP2000507086A (ja) 2000-06-13
EP0868527A2 (de) 1998-10-07
JP3942194B2 (ja) 2007-07-11
ZA9610768B (en) 1998-07-31
DK0868527T3 (da) 2007-05-07
BR9612666A (pt) 1999-10-05
AU1921897A (en) 1997-07-17
DE59611412D1 (de) 2007-02-22
CN1283797C (zh) 2006-11-08
RU2225883C2 (ru) 2004-03-20
WO1997023597A2 (de) 1997-07-03
CA2241111A1 (en) 1997-07-03
CA2241111C (en) 2009-09-22
KR100444621B1 (ko) 2004-11-16
WO1997023597A3 (de) 1997-10-09
ES2281088T3 (es) 2007-09-16
MX9805050A (es) 1998-10-31
KR19990076708A (ko) 1999-10-15
DE19548222A1 (de) 1997-06-26

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