DK0868527T3 - Fremgangsmåde til mikrobiel fremstilling af aminosyrer ved hjælp af en öget aktivitet hos eksportcarriers - Google Patents

Fremgangsmåde til mikrobiel fremstilling af aminosyrer ved hjælp af en öget aktivitet hos eksportcarriers

Info

Publication number
DK0868527T3
DK0868527T3 DK96946220T DK96946220T DK0868527T3 DK 0868527 T3 DK0868527 T3 DK 0868527T3 DK 96946220 T DK96946220 T DK 96946220T DK 96946220 T DK96946220 T DK 96946220T DK 0868527 T3 DK0868527 T3 DK 0868527T3
Authority
DK
Denmark
Prior art keywords
amino acids
increased activity
microbial production
export
carriers
Prior art date
Application number
DK96946220T
Other languages
Danish (da)
English (en)
Inventor
Marina Vrlijc
Lothar Eggeling
Hermann Sahm
Original Assignee
Forschungszentrum Juelich Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forschungszentrum Juelich Gmbh filed Critical Forschungszentrum Juelich Gmbh
Application granted granted Critical
Publication of DK0868527T3 publication Critical patent/DK0868527T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK96946220T 1995-12-22 1996-12-18 Fremgangsmåde til mikrobiel fremstilling af aminosyrer ved hjælp af en öget aktivitet hos eksportcarriers DK0868527T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19548222A DE19548222A1 (de) 1995-12-22 1995-12-22 Verfahren zur mikrobiellen Herstellung von Aminosäuren durch gesteigerte Aktivität von Exportcarriern
PCT/DE1996/002485 WO1997023597A2 (de) 1995-12-22 1996-12-18 Verfahren zur mikrobiellen herstellung von aminosäuren durch gesteigerte aktivität von exportcarriern

Publications (1)

Publication Number Publication Date
DK0868527T3 true DK0868527T3 (da) 2007-05-07

Family

ID=7781070

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96946220T DK0868527T3 (da) 1995-12-22 1996-12-18 Fremgangsmåde til mikrobiel fremstilling af aminosyrer ved hjælp af en öget aktivitet hos eksportcarriers

Country Status (16)

Country Link
US (1) US6858406B1 (enExample)
EP (1) EP0868527B1 (enExample)
JP (1) JP3942194B2 (enExample)
KR (1) KR100444621B1 (enExample)
CN (1) CN1283797C (enExample)
AR (1) AR048561A1 (enExample)
AU (1) AU724536B2 (enExample)
BR (1) BR9612666A (enExample)
CA (1) CA2241111C (enExample)
DE (2) DE19548222A1 (enExample)
DK (1) DK0868527T3 (enExample)
ES (1) ES2281088T3 (enExample)
MX (1) MX9805050A (enExample)
RU (1) RU2225883C2 (enExample)
WO (1) WO1997023597A2 (enExample)
ZA (1) ZA9610768B (enExample)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19726083A1 (de) * 1997-06-19 1998-12-24 Consortium Elektrochem Ind Mikroorganismen und Verfahren zur fermentativen Herstellung von L-Cystein, L-Cystin, N-Acetyl-Serin oder Thiazolidinderivaten
DE19931317A1 (de) * 1999-07-07 2001-01-11 Degussa L-Lysin produzierende coryneforme Bakterien und Verfahren zur Herstellung von L-Lysin
RU2144564C1 (ru) 1998-10-13 2000-01-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" ФРАГМЕНТ ДНК rhtB, КОДИРУЮЩИЙ СИНТЕЗ БЕЛКА RhtB, ПРИДАЮЩЕГО УСТОЙЧИВОСТЬ К L-ГОМОСЕРИНУ БАКТЕРИЯМ ESCHERICHIA COLI, И СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ
RU2148642C1 (ru) 1998-12-23 2000-05-10 ЗАО "Научно-исследовательский институт АДЖИНОМОТО-Генетика" (ЗАО "АГРИ") Фрагмент днк rhtc, кодирующий синтез белка rhtc, придающего повышенную устойчивость к l-треонину бактериям escherichia coli, и способ получения l-аминокислоты
RU2175351C2 (ru) 1998-12-30 2001-10-27 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО "АГРИ") Фрагмент днк из escherichia coli, определяющий повышенную продукцию l-аминокислот (варианты), и способ получения l-аминокислот
DE19931314A1 (de) * 1999-07-07 2001-01-11 Degussa L-Lysin produzierende coryneforme Bakterien und Verfahren zur Herstellung von Lysin
US6861246B2 (en) 1999-07-07 2005-03-01 Degussa Ag L-lysine-producing corynebacteria and process for the preparation of lysine
US20020086371A1 (en) 1999-07-07 2002-07-04 Degussa-Huls Aktiengesellschaft L-lysine-producing corynebacteria and process for the preparation of L-lysine
US6797509B1 (en) 1999-07-09 2004-09-28 Degussa-Huls Ag Nucleotide sequences which code for the tal gene
DE19951708A1 (de) 1999-10-27 2001-05-03 Degussa Für den Export verzweigtkettiger Aminosäuren kodierende Nikleotidsequenzen, Verfahren zu deren Isolierung und ihre Verwendung
US6913908B2 (en) 2000-09-02 2005-07-05 Degussa Ag Methods of making L-amino acids in coryneform using the sigE gene
AU2001285843A1 (en) * 2000-09-02 2002-03-13 Degussa A.G. Sequences which code for the sige gene
BR122013017187B1 (pt) 2001-02-13 2016-03-01 Ajinomoto Kk bactéria transgênica produtora de l-aminoácido pertencente ao gênero escherichia, e, método para produzir l-aminoácido
EP1266966B1 (en) * 2001-06-12 2009-04-29 Ajinomoto Co., Inc. Method for producing L-lysine or L-arginine by using methanol assimilating bacterium
US7252978B2 (en) 2001-07-25 2007-08-07 Ajinomoto Co., Inc. Method for producing L-arginine
DE10154179A1 (de) * 2001-11-05 2003-05-08 Basf Ag Gene die für membeansynthese-und Membrantransport-Proteine codieren
PL207852B1 (pl) 2001-11-23 2011-02-28 Ajinomoto Co Inc Bakteria z rodzaju Escherichia wytwarzająca L-aminokwas, sposób wytwarzania L-fenyloalaniny lub L-tryptofanu i sposób wytwarzania niższych estrów alkilowych α-L-aspartylo-L-fenyloalaniny
RU2229513C2 (ru) 2001-11-23 2004-05-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Способ получения l-аминокислот, штамм escherichia coli - продуцент l-аминокислоты (варианты)
DE10210527A1 (de) 2002-03-09 2003-09-18 Degussa Allele des aceA-Gens aus coryneformen Bakterien
JP4120364B2 (ja) * 2002-11-20 2008-07-16 味の素株式会社 メタノール資化性菌を用いたｌ−リジンまたはｌ−アルギニンの製造法
JP2004166592A (ja) 2002-11-20 2004-06-17 Ajinomoto Co Inc メチロトローフを用いたｌ−アミノ酸の製造法
DE102004001674B4 (de) 2003-01-29 2019-01-24 Ajinomoto Co., Inc. Verfahren zur Herstellung von L-Lysin unter Einsatz von Methanol verwertenden Bakterien
EP1484410B1 (en) 2003-06-05 2011-11-02 Ajinomoto Co., Inc. Fermentation methods using modified bacteria with increased byproduct uptake.
ES2331956T3 (es) 2004-01-30 2010-01-21 Ajinomoto Co., Inc. Microorganismo que produce l-aminoacidos y procedimiento para producir l-aminoacidos.
JP4665537B2 (ja) * 2004-01-30 2011-04-06 味の素株式会社 Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JP4665558B2 (ja) * 2004-03-04 2011-04-06 味の素株式会社 Ｌ−グルタミン酸生産微生物及びｌ−グルタミン酸の製造法
US7344874B2 (en) * 2004-03-04 2008-03-18 Ajinomoto Co., Inc. L-glutamic acid-producing microorganism and a method for producing L-glutamic acid
DE102004034865A1 (de) 2004-07-19 2006-02-16 Siemens Ag Sensor zur Messung der Position eines Stellgliedes
BRPI0516261A (pt) 2004-10-07 2008-08-26 Ajinomoto Kk método para produzir uma substãncia básica por fermentação, e, caldo de fermentação ou produto de fermentação contendo uma substáncia básica
EP1831349B1 (en) * 2004-12-06 2011-09-21 Sage Biosciences Inc. Method of growing bacteria to deliver bioactive compounds to the intestine of ruminants
DE102005013676A1 (de) 2005-03-24 2006-09-28 Degussa Ag Allele des zwf-Gens aus coryneformen Bakterien
US20070092951A1 (en) 2005-03-24 2007-04-26 Degussa Ag Alleles of the zwf gene from coryneform bacteria
DE102005023829A1 (de) 2005-05-24 2006-11-30 Degussa Ag Allele des opcA-Gens aus coryneformen Bakterien
EP1979486B1 (en) 2006-01-30 2013-04-17 Ajinomoto Co., Inc. L-amino acid producing bacterium and method of producing l-amino acid
JP2009089603A (ja) 2006-02-02 2009-04-30 Ajinomoto Co Inc メタノール資化性細菌を用いたｌ−リジンの製造法
JP2009153382A (ja) 2006-03-30 2009-07-16 Ajinomoto Co Inc メタノール資化性細菌を用いたカルボン酸の製造法
DE102007005072A1 (de) 2007-02-01 2008-08-07 Evonik Degussa Gmbh Verfahren zur fermentativen Herstellung von Cadaverin
CN101715484B (zh) 2007-04-06 2014-02-19 协和发酵生化株式会社 二肽的制造方法
BRPI0810011B1 (pt) 2007-04-17 2021-11-30 Ajinomoto Co., Inc Método para produzir uma substância ácida tendo um grupo carboxila
DE102008001874A1 (de) 2008-05-20 2009-11-26 Evonik Degussa Gmbh Verfahren zur Herstellung von L-Aminosäuren
JP5662167B2 (ja) 2009-02-09 2015-01-28 協和発酵バイオ株式会社 Ｌ−アミノ酸の製造法
WO2011073278A1 (en) 2009-12-17 2011-06-23 Basf Se Processes and recombinant microorganisms for the production of cadaverine
DE102010003419B4 (de) 2010-03-30 2019-09-12 Evonik Degussa Gmbh Verfahren zur fermentativen Herstellung von L-Ornithin
DE102010019059A1 (de) * 2010-05-03 2011-11-03 Forschungszentrum Jülich GmbH Sensoren zur intrazellulären Metabolit-Detektion
US9387279B2 (en) 2010-05-05 2016-07-12 The Governing Council Of The University Of Toronto Implantable-glucose responsive insulin delivery device
EP2678421B1 (en) 2011-02-22 2018-04-11 Basf Se Processes and recombinant microorganisms for the production of cadaverine
EP3061828B1 (en) 2013-10-23 2024-08-28 Ajinomoto Co., Inc. Method for producing target substance
CN103695454A (zh) * 2013-12-18 2014-04-02 山东寿光巨能金玉米开发有限公司 表达l-赖氨酸转运蛋白的重组质粒、工程菌及应用
WO2017085241A1 (en) * 2015-11-19 2017-05-26 Danmarks Tekniske Universitet A family of microbial lysine transporter polypeptides
US9988624B2 (en) 2015-12-07 2018-06-05 Zymergen Inc. Microbial strain improvement by a HTP genomic engineering platform
JP6821598B2 (ja) 2015-12-07 2021-01-27 ザイマージェン インコーポレイテッド Ｃｏｒｙｎｅｂａｃｔｅｒｉｕｍ ｇｌｕｔａｍｉｃｕｍ由来のプロモーター
US11208649B2 (en) 2015-12-07 2021-12-28 Zymergen Inc. HTP genomic engineering platform
JP2019519241A (ja) 2016-06-30 2019-07-11 ザイマージェン インコーポレイテッド グルコース透過酵素ライブラリーを生成するための方法およびその使用
US10544390B2 (en) 2016-06-30 2020-01-28 Zymergen Inc. Methods for generating a bacterial hemoglobin library and uses thereof
CN110283823B (zh) * 2016-08-31 2023-05-12 Cj第一制糖株式会社 新型启动子及其应用
JP7066977B2 (ja) 2017-04-03 2022-05-16 味の素株式会社 Ｌ－アミノ酸の製造法
KR20200026881A (ko) 2017-06-07 2020-03-11 지머젠 인코포레이티드 코리네박테리움 글루타미컴으로부터의 프로모터 및 보조 유전자 발현을 조절하는 데 이의 용도
EP3467099A1 (en) 2017-10-05 2019-04-10 Evonik Degussa GmbH Method for the fermentative production of l-amino acids
KR101968317B1 (ko) 2018-02-23 2019-04-11 씨제이제일제당 주식회사 신규 l-트립토판 배출 단백질 및 이를 이용한 l-트립토판을 생산하는 방법
RU2019128538A (ru) 2018-09-26 2021-03-11 Эвоник Оперейшенс ГмбХ Способ ферментативного получения l-лизина
EP3861109A1 (en) 2018-10-05 2021-08-11 Ajinomoto Co., Inc. Method for producing target substance by bacterial fermentation
KR102205717B1 (ko) 2019-04-05 2021-01-22 씨제이제일제당 주식회사 신규 l-트립토판 배출 단백질 변이체 및 이를 이용한 l-트립토판을 생산하는 방법
US20220411835A1 (en) 2019-09-03 2022-12-29 Ningxia Eppen Biotech Co., Ltd Application of transport carrier gene which improves l-tryptophan production efficiency in escherichia coli
KR102183209B1 (ko) 2019-09-09 2020-11-26 씨제이제일제당 주식회사 L-쓰레오닌 배출 단백질의 변이체 및 이를 이용한 l-쓰레오닌 생산 방법
KR102251948B1 (ko) * 2019-10-31 2021-05-17 대상 주식회사 mdfA 유전자 불활성 및 yicL 유전자 도입에 의해 방향족 아미노산 생산능력이 향상된 균주
CN115724925B (zh) * 2020-01-19 2025-06-03 中国科学院天津工业生物技术研究所 谷氨酸转运变体蛋白及其应用
KR102139806B1 (ko) * 2020-02-13 2020-07-30 씨제이제일제당 (주) 변이형 LysE를 포함하는 미생물, 및 이를 이용한 L-아미노산 생산 방법
KR102647745B1 (ko) 2020-05-27 2024-03-14 씨제이제일제당 주식회사 신규 l-타이로신 배출 단백질 변이체 및 이를 이용한 l-타이로신을 생산하는 방법
KR102616694B1 (ko) * 2020-12-09 2023-12-20 씨제이제일제당 (주) 쉬와넬라 아틀란티카 유래 단백질을 발현하는 미생물, 및 이를 이용한 l-아미노산 생산 방법
KR102617168B1 (ko) * 2020-12-09 2023-12-21 씨제이제일제당 (주) 쉬와넬라 오네이덴시스 유래 단백질을 발현하는 미생물, 및 이를 이용한 l-아미노산 생산 방법
CN114763372B (zh) 2021-01-13 2024-12-10 中国科学院天津工业生物技术研究所 具有l-脯氨酸外排功能的蛋白及其应用
WO2022155554A1 (en) * 2021-01-17 2022-07-21 Genomatica, Inc. Methods and compositions for making amide compounds
CN115746110B (zh) * 2021-09-02 2024-10-18 中国科学院天津工业生物技术研究所 一种转录调控因子LysG的突变体及其应用
KR102875556B1 (ko) * 2021-10-26 2025-10-23 씨제이제일제당 주식회사 LysE 변이체 및 이를 이용한 L-아르기닌 생산방법
KR102801642B1 (ko) 2022-03-07 2025-04-29 씨제이제일제당 주식회사 변이형 l-쓰레오닌 배출 단백질 및 이를 이용한 l-쓰레오닌 생산 방법
KR20230131654A (ko) 2022-03-07 2023-09-14 씨제이제일제당 (주) 변이형 l-쓰레오닌 배출 단백질 및 이를 이용한 l-쓰레오닌 생산 방법
JPWO2023195475A1 (enExample) 2022-04-04 2023-10-12
KR102770475B1 (ko) * 2022-06-02 2025-02-20 씨제이제일제당 주식회사 L-오르니틴 생산능을 가지는 미생물 및 이를 이용한 l-오르니틴 생산방법
KR102801078B1 (ko) * 2022-06-23 2025-04-24 씨제이제일제당 (주) L-히스티딘 배출 단백질 및 이를 이용한 l-히스티딘 생산 방법
CN115806601B (zh) * 2022-10-24 2024-12-20 天津科技大学 一种转录调控因子LysG突变体及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5618596A (en) * 1979-07-23 1981-02-21 Ajinomoto Co Inc Production of l-lysine through fermentation process
JPS575693A (en) * 1980-06-13 1982-01-12 Ajinomoto Co Inc Production of l-arginine through fermentation process
DE4400926C1 (de) * 1994-01-14 1995-06-01 Forschungszentrum Juelich Gmbh Herstellung von L-Isoleucin mittels rekombinanter Mikroorganismen mit deregulierter Threonindehydratase

Also Published As

Publication number Publication date
US6858406B1 (en) 2005-02-22
AR048561A1 (es) 2006-05-10
EP0868527B1 (de) 2007-01-10
CN1209169A (zh) 1999-02-24
JP2000507086A (ja) 2000-06-13
EP0868527A2 (de) 1998-10-07
JP3942194B2 (ja) 2007-07-11
ZA9610768B (en) 1998-07-31
BR9612666A (pt) 1999-10-05
AU1921897A (en) 1997-07-17
DE59611412D1 (de) 2007-02-22
CN1283797C (zh) 2006-11-08
RU2225883C2 (ru) 2004-03-20
WO1997023597A2 (de) 1997-07-03
CA2241111A1 (en) 1997-07-03
CA2241111C (en) 2009-09-22
KR100444621B1 (ko) 2004-11-16
WO1997023597A3 (de) 1997-10-09
ES2281088T3 (es) 2007-09-16
AU724536B2 (en) 2000-09-21
MX9805050A (es) 1998-10-31
KR19990076708A (ko) 1999-10-15
DE19548222A1 (de) 1997-06-26

Similar Documents

Publication Publication Date Title
DK0868527T3 (da) Fremgangsmåde til mikrobiel fremstilling af aminosyrer ved hjælp af en öget aktivitet hos eksportcarriers
DK0877090T3 (da) Fremgangsmåde til produktion af L-aminosyrer
DK0841395T3 (da) Fremgangsmåde til at fremstille L-lysin
EP0557996A3 (en) Process for the production of amino acids by fermentation
FR2734577B1 (fr) Procede de rincage aux acides percarboxyliques
AU1789797A (en) Process for producing L-glutamic acid by fermentation
NO953282L (no) Fremgangsmåte for bedring av produktiviteten hos en brönn
MX9705005A (es) Inhibidores de la proteina de transferencia de trigliceridos microsomicos y metodo.
DE69834533D1 (de) Verfahren zur Protein-Herstellung
ATE243789T1 (de) Enzymatisches verfahren zum färben
FI954037A7 (fi) Menetelmä karboksyylihapon puhdistamiseksi
FI973365A0 (fi) Menetelmä PHA-polymeerien mikrobiologiseksi tuottamiseksi
DK0770687T3 (da) Fremgangsmåde til fremstilling af nicotinsyreamid
HUP9900149A3 (en) Process for producing l-lysine by fermentation
EP1004671A4 (en) METHOD FOR THE PRODUCTION OF L-GLUTAMIC ACID BY FERMENTATION
SE9501285D0 (sv) a process for the production of biologically active proteins
DE69610187D1 (de) Verfahren zum Herstellen von aromatischen Carbonaten
DE69825639D1 (de) Reinigungsverfahren für Arylcarbonsäuren
DK0786012T3 (da) Enzymatisk fremgangsmåde til fremstilling af kiral-alfa-tertiære carboxylsyreestere
DE69605460D1 (de) Verfahren zur Herstellung von Isopropylalkohol
FI962820A7 (fi) Uusi hyvin enantioselektiivinen menetelmä enantiomeeripuhtaiden syklopentaani- ja -penteeni-Beta aminohappojen valmistamiseksi
DE59600108D1 (de) Verfahren zum Herstellen von unterschiedlich dimensionierten Sattelspulen
IS4860A (is) Bætt aðferð til að framleiða enantíómerískt hreina asetidín-2-karboxýlsýru
EP0731171A3 (en) Process for the production of optically active amino acid
DE69505347D1 (de) Verfahren zum Reinigen von alpha,beta-ungesättigten Estern