DE19548222A1 - Verfahren zur mikrobiellen Herstellung von Aminosäuren durch gesteigerte Aktivität von Exportcarriern - Google Patents

Verfahren zur mikrobiellen Herstellung von Aminosäuren durch gesteigerte Aktivität von Exportcarriern

Info

Publication number
DE19548222A1
DE19548222A1 DE19548222A DE19548222A DE19548222A1 DE 19548222 A1 DE19548222 A1 DE 19548222A1 DE 19548222 A DE19548222 A DE 19548222A DE 19548222 A DE19548222 A DE 19548222A DE 19548222 A1 DE19548222 A1 DE 19548222A1
Authority
DE
Germany
Prior art keywords
gene
export
amino acid
sequence
regulatory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19548222A
Other languages
German (de)
English (en)
Inventor
Marina Vrlijc
Lothar Eggeling
Hermann Sahm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Forschungszentrum Juelich GmbH
Original Assignee
Forschungszentrum Juelich GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forschungszentrum Juelich GmbH filed Critical Forschungszentrum Juelich GmbH
Priority to DE19548222A priority Critical patent/DE19548222A1/de
Priority to ES96946220T priority patent/ES2281088T3/es
Priority to DK96946220T priority patent/DK0868527T3/da
Priority to RU98113861/13A priority patent/RU2225883C2/ru
Priority to BR9612666-3A priority patent/BR9612666A/pt
Priority to CA002241111A priority patent/CA2241111C/en
Priority to KR10-1998-0704822A priority patent/KR100444621B1/ko
Priority to DE59611412T priority patent/DE59611412D1/de
Priority to CNB961800968A priority patent/CN1283797C/zh
Priority to AU19218/97A priority patent/AU724536B2/en
Priority to JP52322297A priority patent/JP3942194B2/ja
Priority to PCT/DE1996/002485 priority patent/WO1997023597A2/de
Priority to EP96946220A priority patent/EP0868527B1/de
Priority to ARP960105827A priority patent/AR048561A1/es
Priority to ZA9610768A priority patent/ZA9610768B/xx
Publication of DE19548222A1 publication Critical patent/DE19548222A1/de
Priority to US09/105,117 priority patent/US6858406B1/en
Priority to MX9805050A priority patent/MX9805050A/es
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE19548222A 1995-12-22 1995-12-22 Verfahren zur mikrobiellen Herstellung von Aminosäuren durch gesteigerte Aktivität von Exportcarriern Withdrawn DE19548222A1 (de)

Priority Applications (17)

Application Number Priority Date Filing Date Title
DE19548222A DE19548222A1 (de) 1995-12-22 1995-12-22 Verfahren zur mikrobiellen Herstellung von Aminosäuren durch gesteigerte Aktivität von Exportcarriern
AU19218/97A AU724536B2 (en) 1995-12-22 1996-12-18 Process for the microbial production of amino acids by boosted activity of export carriers
JP52322297A JP3942194B2 (ja) 1995-12-22 1996-12-18 エキスポートキャリヤーの活性を増加してアミノ酸を微生物によって産生する方法
RU98113861/13A RU2225883C2 (ru) 1995-12-22 1996-12-18 Способ микробиологического получения аминокислот путем повышенной активности экспорт-носителей
BR9612666-3A BR9612666A (pt) 1995-12-22 1996-12-18 Processo para a produção microbial de aminoácidos pela atividade esforçada de veìculos exportadores.
CA002241111A CA2241111C (en) 1995-12-22 1996-12-18 Process for the microbial production of amino acids by boosted activity of export carriers
KR10-1998-0704822A KR100444621B1 (ko) 1995-12-22 1996-12-18 엑스포트캐리어의활성증대를통한미생물사용아미노산제조방법
DE59611412T DE59611412D1 (de) 1995-12-22 1996-12-18 Verfahren zur mikrobiellen herstellung von aminosäuren durch gesteigerte aktivität von exportcarriern
CNB961800968A CN1283797C (zh) 1995-12-22 1996-12-18 通过提高外运载体的活性而进行微生物生产氨基酸的方法
ES96946220T ES2281088T3 (es) 1995-12-22 1996-12-18 Procedimiento para la produccion microbiana de aminoacidos mediante un aumento de la actividad de vehiculos de exportacion.
DK96946220T DK0868527T3 (da) 1995-12-22 1996-12-18 Fremgangsmåde til mikrobiel fremstilling af aminosyrer ved hjælp af en öget aktivitet hos eksportcarriers
PCT/DE1996/002485 WO1997023597A2 (de) 1995-12-22 1996-12-18 Verfahren zur mikrobiellen herstellung von aminosäuren durch gesteigerte aktivität von exportcarriern
EP96946220A EP0868527B1 (de) 1995-12-22 1996-12-18 Verfahren zur mikrobiellen herstellung von aminosäuren durch gesteigerte aktivität von exportcarriern
ARP960105827A AR048561A1 (es) 1995-12-22 1996-12-20 Metodo para producir aminoacidos por medio de microbios, aumentando la actividad de transportadores
ZA9610768A ZA9610768B (en) 1995-12-22 1996-12-20 Process for the microbial manufacture of amino acids by increased activity of export carriers
US09/105,117 US6858406B1 (en) 1995-12-22 1998-06-17 Process for the microbial production of amino acids by boosted activity of export carriers
MX9805050A MX9805050A (es) 1995-12-22 1998-06-22 Procedimiento para la obtencion microbiana de aminoacidos mediante la actividad elevada de vehiculos de exportacion.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19548222A DE19548222A1 (de) 1995-12-22 1995-12-22 Verfahren zur mikrobiellen Herstellung von Aminosäuren durch gesteigerte Aktivität von Exportcarriern

Publications (1)

Publication Number Publication Date
DE19548222A1 true DE19548222A1 (de) 1997-06-26

Family

ID=7781070

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19548222A Withdrawn DE19548222A1 (de) 1995-12-22 1995-12-22 Verfahren zur mikrobiellen Herstellung von Aminosäuren durch gesteigerte Aktivität von Exportcarriern
DE59611412T Expired - Lifetime DE59611412D1 (de) 1995-12-22 1996-12-18 Verfahren zur mikrobiellen herstellung von aminosäuren durch gesteigerte aktivität von exportcarriern

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59611412T Expired - Lifetime DE59611412D1 (de) 1995-12-22 1996-12-18 Verfahren zur mikrobiellen herstellung von aminosäuren durch gesteigerte aktivität von exportcarriern

Country Status (16)

Country Link
US (1) US6858406B1 (enExample)
EP (1) EP0868527B1 (enExample)
JP (1) JP3942194B2 (enExample)
KR (1) KR100444621B1 (enExample)
CN (1) CN1283797C (enExample)
AR (1) AR048561A1 (enExample)
AU (1) AU724536B2 (enExample)
BR (1) BR9612666A (enExample)
CA (1) CA2241111C (enExample)
DE (2) DE19548222A1 (enExample)
DK (1) DK0868527T3 (enExample)
ES (1) ES2281088T3 (enExample)
MX (1) MX9805050A (enExample)
RU (1) RU2225883C2 (enExample)
WO (1) WO1997023597A2 (enExample)
ZA (1) ZA9610768B (enExample)

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0885962A1 (de) * 1997-06-19 1998-12-23 Consortium für elektrochemische Industrie GmbH Mikroorganismen und Verfahren zur fermentativen Herstellung von L-Cystein, L-Cystin, N-Acetyl-Serin oder Thiazolindinderivaten
EP1067192A1 (de) * 1999-07-07 2001-01-10 Degussa-Hüls Aktiengesellschaft L-Lysin produzierende coryneforme Bakterien und Verfahren zur Herstellung von L-Lysin
EP1067193A1 (de) * 1999-07-07 2001-01-10 Degussa-Hüls Aktiengesellschaft L-Lysin produzierende coryneforme Bakterien und Verfahren zur Herstellung von Lysin
WO2001004325A1 (en) 1999-07-09 2001-01-18 Degussa Ag Nucleotide sequences for the tal gene
EP1096010A1 (de) 1999-10-27 2001-05-02 Degussa AG Für den Export verzweigtkettiger Aminosäuren kodierende Nukleotidsequenzen, Verfahren zu deren Isolierung und ihre Verwendung
WO2002018428A3 (en) * 2000-09-02 2002-06-06 Degussa Sequences which code for the sige gene of corynebacterium glutamicum
FR2847262A1 (fr) * 2002-11-20 2004-05-21 Ajinomoto Kk Bacterie capable de produire de la l-lysine ou de la l-arginine et procede de production de l-lysine ou de l-arginine l'utilisant
US6746855B2 (en) 1999-07-07 2004-06-08 Dégussa-Hüls Aktiengesellschaft L-lysine-producing corynebacteria and process for the preparation of L-lysine
US6861246B2 (en) 1999-07-07 2005-03-01 Degussa Ag L-lysine-producing corynebacteria and process for the preparation of lysine
US6913908B2 (en) 2000-09-02 2005-07-05 Degussa Ag Methods of making L-amino acids in coryneform using the sigE gene
US7083942B2 (en) 2002-03-09 2006-08-01 Degussa Ag Alleles of the aceA gene from coryneform bacteria
WO2006100211A1 (de) 2005-03-24 2006-09-28 Degussa Gmbh Mutierte allele des zwg-gens (g6pdh) aus coryneformen bakterien zur gesteigerten lysin produktion
WO2006125714A2 (de) 2005-05-24 2006-11-30 Evonik Degussa Gmbh Allele des opca-gens aus coryneformen bakterien
DE102007005072A1 (de) 2007-02-01 2008-08-07 Evonik Degussa Gmbh Verfahren zur fermentativen Herstellung von Cadaverin
US7585650B2 (en) 2005-03-24 2009-09-08 Degussa Ag Alleles of the zwf gene from coryneform bacteria
US7859250B2 (en) 2004-07-19 2010-12-28 Continental Automotive Gmbh Sensor for measuring the position of an actuator
EP2311937A1 (en) 2004-12-06 2011-04-20 Sage Biosciences Inc. Method of growing bacteria to deliver bioactive compounds to the intestine of ruminants
WO2012114256A1 (en) 2011-02-22 2012-08-30 Basf Se Processes and recombinant microorganisms for the production of cadaverine
US9394346B2 (en) 1998-12-23 2016-07-19 Ajinomoto Co., Inc. Method for producing an amino acid using a bacterium overexpressing an rhtC gene
WO2017085241A1 (en) * 2015-11-19 2017-05-26 Danmarks Tekniske Universitet A family of microbial lysine transporter polypeptides
WO2017100376A2 (en) 2015-12-07 2017-06-15 Zymergen, Inc. Promoters from corynebacterium glutamicum
US9988624B2 (en) 2015-12-07 2018-06-05 Zymergen Inc. Microbial strain improvement by a HTP genomic engineering platform
WO2018226964A2 (en) 2017-06-07 2018-12-13 Zymergen Inc. Promoters from corynebacterium glutamicum and uses thereof in regulating ancillary gene expression
US10544411B2 (en) 2016-06-30 2020-01-28 Zymergen Inc. Methods for generating a glucose permease library and uses thereof
US10544390B2 (en) 2016-06-30 2020-01-28 Zymergen Inc. Methods for generating a bacterial hemoglobin library and uses thereof
US11208649B2 (en) 2015-12-07 2021-12-28 Zymergen Inc. HTP genomic engineering platform

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2144564C1 (ru) 1998-10-13 2000-01-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" ФРАГМЕНТ ДНК rhtB, КОДИРУЮЩИЙ СИНТЕЗ БЕЛКА RhtB, ПРИДАЮЩЕГО УСТОЙЧИВОСТЬ К L-ГОМОСЕРИНУ БАКТЕРИЯМ ESCHERICHIA COLI, И СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ
RU2175351C2 (ru) 1998-12-30 2001-10-27 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО "АГРИ") Фрагмент днк из escherichia coli, определяющий повышенную продукцию l-аминокислот (варианты), и способ получения l-аминокислот
BR122013017187B1 (pt) 2001-02-13 2016-03-01 Ajinomoto Kk bactéria transgênica produtora de l-aminoácido pertencente ao gênero escherichia, e, método para produzir l-aminoácido
EP1266966B1 (en) * 2001-06-12 2009-04-29 Ajinomoto Co., Inc. Method for producing L-lysine or L-arginine by using methanol assimilating bacterium
US7252978B2 (en) 2001-07-25 2007-08-07 Ajinomoto Co., Inc. Method for producing L-arginine
DE10154179A1 (de) * 2001-11-05 2003-05-08 Basf Ag Gene die für membeansynthese-und Membrantransport-Proteine codieren
PL207852B1 (pl) 2001-11-23 2011-02-28 Ajinomoto Co Inc Bakteria z rodzaju Escherichia wytwarzająca L-aminokwas, sposób wytwarzania L-fenyloalaniny lub L-tryptofanu i sposób wytwarzania niższych estrów alkilowych α-L-aspartylo-L-fenyloalaniny
RU2229513C2 (ru) 2001-11-23 2004-05-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Способ получения l-аминокислот, штамм escherichia coli - продуцент l-аминокислоты (варианты)
JP2004166592A (ja) 2002-11-20 2004-06-17 Ajinomoto Co Inc メチロトローフを用いたｌ−アミノ酸の製造法
DE102004001674B4 (de) 2003-01-29 2019-01-24 Ajinomoto Co., Inc. Verfahren zur Herstellung von L-Lysin unter Einsatz von Methanol verwertenden Bakterien
EP1484410B1 (en) 2003-06-05 2011-11-02 Ajinomoto Co., Inc. Fermentation methods using modified bacteria with increased byproduct uptake.
ES2331956T3 (es) 2004-01-30 2010-01-21 Ajinomoto Co., Inc. Microorganismo que produce l-aminoacidos y procedimiento para producir l-aminoacidos.
JP4665537B2 (ja) * 2004-01-30 2011-04-06 味の素株式会社 Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JP4665558B2 (ja) * 2004-03-04 2011-04-06 味の素株式会社 Ｌ−グルタミン酸生産微生物及びｌ−グルタミン酸の製造法
US7344874B2 (en) * 2004-03-04 2008-03-18 Ajinomoto Co., Inc. L-glutamic acid-producing microorganism and a method for producing L-glutamic acid
BRPI0516261A (pt) 2004-10-07 2008-08-26 Ajinomoto Kk método para produzir uma substãncia básica por fermentação, e, caldo de fermentação ou produto de fermentação contendo uma substáncia básica
EP1979486B1 (en) 2006-01-30 2013-04-17 Ajinomoto Co., Inc. L-amino acid producing bacterium and method of producing l-amino acid
JP2009089603A (ja) 2006-02-02 2009-04-30 Ajinomoto Co Inc メタノール資化性細菌を用いたｌ−リジンの製造法
JP2009153382A (ja) 2006-03-30 2009-07-16 Ajinomoto Co Inc メタノール資化性細菌を用いたカルボン酸の製造法
CN101715484B (zh) 2007-04-06 2014-02-19 协和发酵生化株式会社 二肽的制造方法
BRPI0810011B1 (pt) 2007-04-17 2021-11-30 Ajinomoto Co., Inc Método para produzir uma substância ácida tendo um grupo carboxila
DE102008001874A1 (de) 2008-05-20 2009-11-26 Evonik Degussa Gmbh Verfahren zur Herstellung von L-Aminosäuren
JP5662167B2 (ja) 2009-02-09 2015-01-28 協和発酵バイオ株式会社 Ｌ−アミノ酸の製造法
WO2011073278A1 (en) 2009-12-17 2011-06-23 Basf Se Processes and recombinant microorganisms for the production of cadaverine
DE102010003419B4 (de) 2010-03-30 2019-09-12 Evonik Degussa Gmbh Verfahren zur fermentativen Herstellung von L-Ornithin
DE102010019059A1 (de) * 2010-05-03 2011-11-03 Forschungszentrum Jülich GmbH Sensoren zur intrazellulären Metabolit-Detektion
US9387279B2 (en) 2010-05-05 2016-07-12 The Governing Council Of The University Of Toronto Implantable-glucose responsive insulin delivery device
EP3061828B1 (en) 2013-10-23 2024-08-28 Ajinomoto Co., Inc. Method for producing target substance
CN103695454A (zh) * 2013-12-18 2014-04-02 山东寿光巨能金玉米开发有限公司 表达l-赖氨酸转运蛋白的重组质粒、工程菌及应用
CN110283823B (zh) * 2016-08-31 2023-05-12 Cj第一制糖株式会社 新型启动子及其应用
JP7066977B2 (ja) 2017-04-03 2022-05-16 味の素株式会社 Ｌ－アミノ酸の製造法
EP3467099A1 (en) 2017-10-05 2019-04-10 Evonik Degussa GmbH Method for the fermentative production of l-amino acids
KR101968317B1 (ko) 2018-02-23 2019-04-11 씨제이제일제당 주식회사 신규 l-트립토판 배출 단백질 및 이를 이용한 l-트립토판을 생산하는 방법
RU2019128538A (ru) 2018-09-26 2021-03-11 Эвоник Оперейшенс ГмбХ Способ ферментативного получения l-лизина
EP3861109A1 (en) 2018-10-05 2021-08-11 Ajinomoto Co., Inc. Method for producing target substance by bacterial fermentation
KR102205717B1 (ko) 2019-04-05 2021-01-22 씨제이제일제당 주식회사 신규 l-트립토판 배출 단백질 변이체 및 이를 이용한 l-트립토판을 생산하는 방법
US20220411835A1 (en) 2019-09-03 2022-12-29 Ningxia Eppen Biotech Co., Ltd Application of transport carrier gene which improves l-tryptophan production efficiency in escherichia coli
KR102183209B1 (ko) 2019-09-09 2020-11-26 씨제이제일제당 주식회사 L-쓰레오닌 배출 단백질의 변이체 및 이를 이용한 l-쓰레오닌 생산 방법
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JP2000507086A (ja) 2000-06-13
EP0868527A2 (de) 1998-10-07
JP3942194B2 (ja) 2007-07-11
ZA9610768B (en) 1998-07-31
DK0868527T3 (da) 2007-05-07
BR9612666A (pt) 1999-10-05
AU1921897A (en) 1997-07-17
DE59611412D1 (de) 2007-02-22
CN1283797C (zh) 2006-11-08
RU2225883C2 (ru) 2004-03-20
WO1997023597A2 (de) 1997-07-03
CA2241111A1 (en) 1997-07-03
CA2241111C (en) 2009-09-22
KR100444621B1 (ko) 2004-11-16
WO1997023597A3 (de) 1997-10-09
ES2281088T3 (es) 2007-09-16
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MX9805050A (es) 1998-10-31
KR19990076708A (ko) 1999-10-15

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