CA2241111C - Process for the microbial production of amino acids by boosted activity of export carriers - Google Patents

Process for the microbial production of amino acids by boosted activity of export carriers Download PDF

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Publication number
CA2241111C
CA2241111C CA002241111A CA2241111A CA2241111C CA 2241111 C CA2241111 C CA 2241111C CA 002241111 A CA002241111 A CA 002241111A CA 2241111 A CA2241111 A CA 2241111A CA 2241111 C CA2241111 C CA 2241111C
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CA
Canada
Prior art keywords
gene
process according
microorganism
export
amino acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002241111A
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English (en)
French (fr)
Other versions
CA2241111A1 (en
Inventor
Marina Vrlijc
Lothar Eggeling
Hermann Sahm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Forschungszentrum Juelich GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Publication of CA2241111A1 publication Critical patent/CA2241111A1/en
Application granted granted Critical
Publication of CA2241111C publication Critical patent/CA2241111C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA002241111A 1995-12-22 1996-12-18 Process for the microbial production of amino acids by boosted activity of export carriers Expired - Fee Related CA2241111C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19548222.0 1995-12-22
DE19548222A DE19548222A1 (de) 1995-12-22 1995-12-22 Verfahren zur mikrobiellen Herstellung von Aminosäuren durch gesteigerte Aktivität von Exportcarriern
PCT/DE1996/002485 WO1997023597A2 (de) 1995-12-22 1996-12-18 Verfahren zur mikrobiellen herstellung von aminosäuren durch gesteigerte aktivität von exportcarriern

Publications (2)

Publication Number Publication Date
CA2241111A1 CA2241111A1 (en) 1997-07-03
CA2241111C true CA2241111C (en) 2009-09-22

Family

ID=7781070

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002241111A Expired - Fee Related CA2241111C (en) 1995-12-22 1996-12-18 Process for the microbial production of amino acids by boosted activity of export carriers

Country Status (16)

Country Link
US (1) US6858406B1 (enExample)
EP (1) EP0868527B1 (enExample)
JP (1) JP3942194B2 (enExample)
KR (1) KR100444621B1 (enExample)
CN (1) CN1283797C (enExample)
AR (1) AR048561A1 (enExample)
AU (1) AU724536B2 (enExample)
BR (1) BR9612666A (enExample)
CA (1) CA2241111C (enExample)
DE (2) DE19548222A1 (enExample)
DK (1) DK0868527T3 (enExample)
ES (1) ES2281088T3 (enExample)
MX (1) MX9805050A (enExample)
RU (1) RU2225883C2 (enExample)
WO (1) WO1997023597A2 (enExample)
ZA (1) ZA9610768B (enExample)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
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RU2148642C1 (ru) * 1998-12-23 2000-05-10 ЗАО "Научно-исследовательский институт АДЖИНОМОТО-Генетика" (ЗАО "АГРИ") Фрагмент днк rhtc, кодирующий синтез белка rhtc, придающего повышенную устойчивость к l-треонину бактериям escherichia coli, и способ получения l-аминокислоты
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US20020086371A1 (en) 1999-07-07 2002-07-04 Degussa-Huls Aktiengesellschaft L-lysine-producing corynebacteria and process for the preparation of L-lysine
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KR102770475B1 (ko) * 2022-06-02 2025-02-20 씨제이제일제당 주식회사 L-오르니틴 생산능을 가지는 미생물 및 이를 이용한 l-오르니틴 생산방법
KR102801078B1 (ko) * 2022-06-23 2025-04-24 씨제이제일제당 (주) L-히스티딘 배출 단백질 및 이를 이용한 l-히스티딘 생산 방법
CN115806601B (zh) * 2022-10-24 2024-12-20 天津科技大学 一种转录调控因子LysG突变体及其应用

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JP3942194B2 (ja) 2007-07-11
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US6858406B1 (en) 2005-02-22
CN1209169A (zh) 1999-02-24
WO1997023597A3 (de) 1997-10-09
RU2225883C2 (ru) 2004-03-20
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AU724536B2 (en) 2000-09-21
AR048561A1 (es) 2006-05-10
DE19548222A1 (de) 1997-06-26
AU1921897A (en) 1997-07-17
KR100444621B1 (ko) 2004-11-16
WO1997023597A2 (de) 1997-07-03
CA2241111A1 (en) 1997-07-03
KR19990076708A (ko) 1999-10-15
EP0868527A2 (de) 1998-10-07
JP2000507086A (ja) 2000-06-13
ES2281088T3 (es) 2007-09-16
BR9612666A (pt) 1999-10-05
DE59611412D1 (de) 2007-02-22

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