ATE531803T1 - Fermentierungsverfahren mittels veränderter bakterien mit einer erhöhten aufnahme von nebenprodukten - Google Patents

Fermentierungsverfahren mittels veränderter bakterien mit einer erhöhten aufnahme von nebenprodukten

Info

Publication number
ATE531803T1
ATE531803T1 AT04013158T AT04013158T ATE531803T1 AT E531803 T1 ATE531803 T1 AT E531803T1 AT 04013158 T AT04013158 T AT 04013158T AT 04013158 T AT04013158 T AT 04013158T AT E531803 T1 ATE531803 T1 AT E531803T1
Authority
AT
Austria
Prior art keywords
target substance
products
fermentation process
medium
increased absorption
Prior art date
Application number
AT04013158T
Other languages
English (en)
Inventor
Yoko Yamamoto
Hisao Ito
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33157205&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE531803(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Application granted granted Critical
Publication of ATE531803T1 publication Critical patent/ATE531803T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • C12P13/22Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67General methods for enhancing the expression
    • C12N15/69Increasing the copy number of the vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • C12P13/22Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/222Phenylalanine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT04013158T 2003-06-05 2004-06-03 Fermentierungsverfahren mittels veränderter bakterien mit einer erhöhten aufnahme von nebenprodukten ATE531803T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2003161181 2003-06-05

Publications (1)

Publication Number Publication Date
ATE531803T1 true ATE531803T1 (de) 2011-11-15

Family

ID=33157205

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04013158T ATE531803T1 (de) 2003-06-05 2004-06-03 Fermentierungsverfahren mittels veränderter bakterien mit einer erhöhten aufnahme von nebenprodukten

Country Status (7)

Country Link
US (1) US7335496B2 (de)
EP (1) EP1484410B1 (de)
JP (1) JP5287904B2 (de)
KR (1) KR101110580B1 (de)
CN (1) CN100564516C (de)
AT (1) ATE531803T1 (de)
BR (1) BRPI0401918B1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0304860A (pt) * 2002-11-11 2004-08-31 Ajinomoto Kk Método para produzir uma substância alvo pela utilização de uma-bactéria pertencente ao gênero escherichia
JP4380305B2 (ja) * 2003-11-21 2009-12-09 味の素株式会社 発酵法によるl−アミノ酸の製造法
US7344874B2 (en) * 2004-03-04 2008-03-18 Ajinomoto Co., Inc. L-glutamic acid-producing microorganism and a method for producing L-glutamic acid
US7482140B2 (en) * 2004-06-15 2009-01-27 Ajinomoto Co., Inc. L-tyrosine-producing bacterium and a method for producing L-tyrosine
US7205132B2 (en) * 2004-09-10 2007-04-17 Ajinomoto Co., Inc. L-glutamic acid-producing microorganism and a method for producing L-glutamic acid
EP2368905A3 (de) * 2004-12-17 2012-08-29 Metanomics GmbH Verfahren zur Steuerung der Herstellung von Feinchemikalien
US7794989B2 (en) 2004-12-28 2010-09-14 Ajinomoto Co., Inc. L-glutamic acid-producing microorganism and a method for producing L-glutamic acid
WO2006078039A1 (en) 2005-01-18 2006-07-27 Ajinomoto Co., Inc. L-amino acid producing microorganism and a method for producing l-amino acid
US20070004014A1 (en) * 2005-06-29 2007-01-04 Yuichiro Tsuji Method for producing l-threonine
JP2008283863A (ja) 2005-08-26 2008-11-27 Ajinomoto Co Inc L−アミノ酸生産菌及びl−アミノ酸の製造方法
JP2010017082A (ja) 2006-10-10 2010-01-28 Ajinomoto Co Inc L−アミノ酸の製造法
JP2010110216A (ja) 2007-02-20 2010-05-20 Ajinomoto Co Inc L−アミノ酸または核酸の製造方法
JP2011067095A (ja) 2008-01-10 2011-04-07 Ajinomoto Co Inc 発酵法による目的物質の製造法
WO2009093703A1 (ja) 2008-01-23 2009-07-30 Ajinomoto Co., Inc. L-アミノ酸の製造法
JP5609869B2 (ja) 2009-05-27 2014-10-22 味の素株式会社 有機酸の製造方法
JPWO2011013707A1 (ja) 2009-07-29 2013-01-10 味の素株式会社 L−アミノ酸の製造法
JP2012223092A (ja) 2009-08-28 2012-11-15 Ajinomoto Co Inc L−アミノ酸の製造法
JP2013013329A (ja) 2009-11-06 2013-01-24 Ajinomoto Co Inc L−アミノ酸の製造法
JP5831669B2 (ja) 2013-05-13 2015-12-09 味の素株式会社 L−アミノ酸の製造法
RU2628696C1 (ru) 2013-10-02 2017-08-21 Адзиномото Ко., Инк. Способ получения основной аминокислоты (варианты)
EP2886651B1 (de) 2013-10-21 2018-08-22 Ajinomoto Co., Inc. Verfahren zur herstellung von l-aminosäure
WO2015060391A1 (ja) 2013-10-23 2015-04-30 味の素株式会社 目的物質の製造法
JP6494738B2 (ja) * 2015-02-23 2019-04-03 国立大学法人静岡大学 2−アザ−8オキソヒポキサンチンの製造方法
RU2015114955A (ru) 2015-04-22 2016-11-10 Аджиномото Ко., Инк. Способ получения L-изолейцина с использованием бактерии семейства Enterobacteriaceae, в которой сверхэкспрессирован ген cycA
JP7066977B2 (ja) 2017-04-03 2022-05-16 味の素株式会社 L-アミノ酸の製造法
WO2020071538A1 (en) 2018-10-05 2020-04-09 Ajinomoto Co., Inc. Method for producing target substance by bacterial fermentation
CN114369559B (zh) * 2020-10-15 2024-05-03 宁夏伊品生物科技股份有限公司 一种产l-氨基酸的重组菌株及其构建方法与应用
CN114540261B (zh) * 2020-11-24 2024-02-02 北京化工大学 一种产氨基己二酸的基因工程菌
CN119012914A (zh) 2022-04-04 2024-11-22 味之素株式会社 防治寄生植物的方法

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614396A (en) * 1990-06-14 1997-03-25 Baylor College Of Medicine Methods for the genetic modification of endogenous genes in animal cells by homologous recombination
EP0542810A1 (de) * 1990-08-02 1993-05-26 B.R. Centre Limited Verfahren zur herstellung von proteinen mit einer gewünschten funktion
ATE352612T1 (de) * 1990-08-29 2007-02-15 Pharming Intellectual Pty Bv Homologe rekombination in säugetier-zellen
AU3972893A (en) * 1992-04-03 1993-11-08 Baylor College Of Medicine Gene therapy using the intestine
US5792751A (en) * 1992-04-13 1998-08-11 Baylor College Of Medicine Tranformation of cells associated with fluid spaces
US5645986A (en) * 1992-05-13 1997-07-08 Board Of Reagents, The University Of Texas System Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US5645829A (en) * 1993-06-18 1997-07-08 Beth Israel Hospital Association Mesothelial cell gene therapy
WO1995010613A1 (de) 1993-10-08 1995-04-20 Lonza Ag Gene für den butyrobetain/crotonobetain-l-carnitin-stoffwechsel und ihre verwendung zur mikrobiologischen herstellung von l-carnitin
US5665350A (en) * 1994-11-23 1997-09-09 University Of Massachusetts Medical Center Cell cycle dependent transplantation and ex vivo gene therapy
US5780296A (en) * 1995-01-17 1998-07-14 Thomas Jefferson University Compositions and methods to promote homologous recombination in eukaryotic cells and organisms
US5824655A (en) * 1995-02-15 1998-10-20 The University Of Utah Anti-transforming growth factor-β gene therapy
US5760062A (en) * 1995-04-18 1998-06-02 Geron Corporation Telomerase inhibitors
US5703116A (en) * 1995-04-18 1997-12-30 Geron Corporation Telomerase Inhibitors
US5863936A (en) * 1995-04-18 1999-01-26 Geron Corporation Telomerase inhibitors
US5656638A (en) * 1995-04-18 1997-08-12 Geron Corporation Telomerase inhibitors
EP0826034A4 (de) * 1995-04-21 2002-06-19 Cell Genesys Inc Herstellung grosser genomischer dna-deletionen
US5756283A (en) * 1995-06-05 1998-05-26 The Trustees Of The University Of Pennsylvania Method for improved production of recombinant adeno-associated viruses for gene therapy
US5776744A (en) * 1995-06-07 1998-07-07 Yale University Methods and compositions for effecting homologous recombination
DE19523279A1 (de) 1995-06-27 1997-01-09 Forschungszentrum Juelich Gmbh Verfahren zur mikrobiellen Herstellung von Aminosäuren mittels rekombinanter Mikroorganismen mit erhöhter Sekretionsrate
US5770613A (en) * 1995-09-29 1998-06-23 Geron Corporation Telomerase inhibitors
US5767278A (en) * 1995-10-06 1998-06-16 Geron Corporation Telomerase inhibitors
AU727348B2 (en) * 1995-10-13 2000-12-14 President And Fellows Of Harvard College Phosphopantetheinyl transferases and uses thereof
DE19548222A1 (de) 1995-12-22 1997-06-26 Forschungszentrum Juelich Gmbh Verfahren zur mikrobiellen Herstellung von Aminosäuren durch gesteigerte Aktivität von Exportcarriern
US5874304A (en) * 1996-01-18 1999-02-23 University Of Florida Research Foundation, Inc. Humanized green fluorescent protein genes and methods
DE19644566A1 (de) * 1996-10-26 1998-04-30 Forschungszentrum Juelich Gmbh Mikrobielle Herstellung von Substanzen aus dem aromatischen Stoffwechsel / I
DE19644567A1 (de) 1996-10-26 1998-04-30 Forschungszentrum Juelich Gmbh Mikrobielle Herstellung von Substanzen aus dem aromatischen Stoffwechsel / II
EP0839909A1 (de) 1996-10-29 1998-05-06 Rijksuniversiteit te Groningen Nukleinsäuresequenzen die für Citrat-Transporterproteine Kodieren
US5925544A (en) * 1996-11-18 1999-07-20 Novo Nordisk A/S Method of homologous recombination followed by in vivo selection of DNA amplification
US5830698A (en) * 1997-03-14 1998-11-03 Idec Pharmaceuticals Corporation Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same
US5948653A (en) * 1997-03-21 1999-09-07 Pati; Sushma Sequence alterations using homologous recombination
ID25613A (id) 1997-07-18 2000-10-19 Ajinomoto Kk Metode untuk menghasilkan purin nukleosida melalui fermentasi
WO1999053035A1 (en) * 1998-04-13 1999-10-21 The University Of Georgia Research Foundation, Inc. Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells
US6027488A (en) * 1998-06-03 2000-02-22 Genetronics, Inc. Flow-through electroporation system for ex vivo gene therapy
RU2144564C1 (ru) * 1998-10-13 2000-01-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" ФРАГМЕНТ ДНК rhtB, КОДИРУЮЩИЙ СИНТЕЗ БЕЛКА RhtB, ПРИДАЮЩЕГО УСТОЙЧИВОСТЬ К L-ГОМОСЕРИНУ БАКТЕРИЯМ ESCHERICHIA COLI, И СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ
JP2002293797A (ja) 1998-12-18 2002-10-09 Ajinomoto Co Inc Abcトランスポーター及びそれをコードする遺伝子
RU2148642C1 (ru) * 1998-12-23 2000-05-10 ЗАО "Научно-исследовательский институт АДЖИНОМОТО-Генетика" (ЗАО "АГРИ") Фрагмент днк rhtc, кодирующий синтез белка rhtc, придающего повышенную устойчивость к l-треонину бактериям escherichia coli, и способ получения l-аминокислоты
JP4061769B2 (ja) 1999-03-25 2008-03-19 味の素株式会社 L−グルタミン酸の製造法
CN1298854C (zh) 1999-07-02 2007-02-07 味之素株式会社 编码蔗糖pts酶ⅱ的dna
JP2003159065A (ja) 1999-07-19 2003-06-03 Ajinomoto Co Inc 発酵法による目的物質の製造法
KR20020073153A (ko) * 1999-12-24 2002-09-19 아지노모토 가부시키가이샤 L-아미노산의 제조법 및 신규 유전자
RU2212447C2 (ru) * 2000-04-26 2003-09-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Штамм escherichia coli - продуцент аминокислоты (варианты) и способ получения аминокислот (варианты)
JP4380029B2 (ja) * 2000-07-05 2009-12-09 味の素株式会社 微生物を利用した物質の製造法
WO2002012481A2 (en) 2000-08-04 2002-02-14 Genencor International, Inc. Enhancement of industrial production by increasing substrate transport
CN1245215C (zh) * 2001-02-28 2006-03-15 四川省生物工程研究中心 重组高效复合干扰素用作乙型肝炎表面抗原和e抗原抑制剂
JP2002330763A (ja) * 2001-05-02 2002-11-19 Ajinomoto Co Inc 発酵法による目的物質の製造法
EP1407028B1 (de) 2001-07-18 2009-06-24 Evonik Degussa GmbH Verfahren zur herstellung von l-threonin durch enterobakteriaceae-stämmen mit verstärkter exprimierung der suca und sucb gene

Also Published As

Publication number Publication date
KR20040105568A (ko) 2004-12-16
EP1484410B1 (de) 2011-11-02
EP1484410A1 (de) 2004-12-08
US7335496B2 (en) 2008-02-26
US20050170474A1 (en) 2005-08-04
CN1572868A (zh) 2005-02-02
JP2011103899A (ja) 2011-06-02
CN100564516C (zh) 2009-12-02
BRPI0401918A (pt) 2005-06-28
KR101110580B1 (ko) 2012-02-15
BRPI0401918B1 (pt) 2014-12-09
JP5287904B2 (ja) 2013-09-11

Similar Documents

Publication Publication Date Title
ATE531803T1 (de) Fermentierungsverfahren mittels veränderter bakterien mit einer erhöhten aufnahme von nebenprodukten
BR0106255A (pt) Método papa produzir uma substância alvo pela utilização de um microorganismo
DK1352966T3 (da) Fremgangsmåde til fremstilling af L-aminosyrer
BRPI0506369A (pt) microorganismos, e, métodos para produzir um l-aminoácido
ATE371743T1 (de) Verfahren zur herstellung einer zielsubstanz durch fermentation mittels eines bakteriellen stamms, dem das arca-gen fehlt
DK1411116T3 (da) Peptidsyntasegen, peptidsyntase samt fremgangsmåde til fremstilling af dipeptid
EA200100990A1 (ru) Способ амплификации последовательности нуклеиновой кислоты
DK1651758T3 (da) Fremgangsmåde tl fremstilling af L-lysin eller L-threonin ved anvendelse af Escherichia bakterier med svækket æblesyreenzymaktivitet
ATE442453T1 (de) Verfahren zur herstellung von l-aminosäure oder nucleinsäure unter verwendung von mikroorganismen
ATE403742T1 (de) Glucosesensor unter verwendung von glucosedehydrogenase
RU2012157541A (ru) Обнаружение и подсчет микроорганизмов
CN103103153B (zh) 一株具有脱氮除磷效果的厌氧反硝化聚磷菌及其应用
BRPI0513362A (pt) sìntese bioquìmica de 1,4-butanodiamina
RU2002123836A (ru) Способ получения целевого вещества
Silveston et al. Forced modulation of biological processes: A review
WO2008120629A1 (ja) 水素製造方法及び装置並びにそれに用いる微生物固定化担体
TW200716744A (en) Genetically modified microorganism and process for production of macrolide compound using the microorganism
BRPI0113540B8 (pt) meio e processo para detectar campylobacter em uma amostra
Vanotti et al. Removal and recovery of ammonia from liquid manure using gas-permeable membranes
BR0004000A (pt) Processo para a preparação fermentativa de ácido d-pantotênico usando bactéria corineforme
EA200800711A1 (ru) Способ культивирования микроорганизмов
ATE412062T1 (de) Verfahren und mittel zur detektion enzymatischer spalt- und verknüpfungsreaktionen
DK1238057T3 (da) Fremgangsmåde til produktion af vedhæftende dyreceller
Johnson Microbial Composition and Functional Diversity in Waste Environments
WO2002064811A3 (fr) Procede pour produire des proteines recombinantes, marquees par au moins un isotope