ATE531803T1 - Fermentierungsverfahren mittels veränderter bakterien mit einer erhöhten aufnahme von nebenprodukten - Google Patents
Fermentierungsverfahren mittels veränderter bakterien mit einer erhöhten aufnahme von nebenproduktenInfo
- Publication number
- ATE531803T1 ATE531803T1 AT04013158T AT04013158T ATE531803T1 AT E531803 T1 ATE531803 T1 AT E531803T1 AT 04013158 T AT04013158 T AT 04013158T AT 04013158 T AT04013158 T AT 04013158T AT E531803 T1 ATE531803 T1 AT E531803T1
- Authority
- AT
- Austria
- Prior art keywords
- target substance
- products
- fermentation process
- medium
- increased absorption
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- C12N15/69—Increasing the copy number of the vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
- C12P13/222—Phenylalanine
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003161181 | 2003-06-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE531803T1 true ATE531803T1 (de) | 2011-11-15 |
Family
ID=33157205
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04013158T ATE531803T1 (de) | 2003-06-05 | 2004-06-03 | Fermentierungsverfahren mittels veränderter bakterien mit einer erhöhten aufnahme von nebenprodukten |
Country Status (7)
Country | Link |
---|---|
US (1) | US7335496B2 (de) |
EP (1) | EP1484410B1 (de) |
JP (1) | JP5287904B2 (de) |
KR (1) | KR101110580B1 (de) |
CN (1) | CN100564516C (de) |
AT (1) | ATE531803T1 (de) |
BR (1) | BRPI0401918B1 (de) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0304860A (pt) * | 2002-11-11 | 2004-08-31 | Ajinomoto Kk | Método para produzir uma substância alvo pela utilização de uma-bactéria pertencente ao gênero escherichia |
JP4380305B2 (ja) * | 2003-11-21 | 2009-12-09 | 味の素株式会社 | 発酵法によるl−アミノ酸の製造法 |
US7344874B2 (en) * | 2004-03-04 | 2008-03-18 | Ajinomoto Co., Inc. | L-glutamic acid-producing microorganism and a method for producing L-glutamic acid |
US7482140B2 (en) * | 2004-06-15 | 2009-01-27 | Ajinomoto Co., Inc. | L-tyrosine-producing bacterium and a method for producing L-tyrosine |
US7205132B2 (en) * | 2004-09-10 | 2007-04-17 | Ajinomoto Co., Inc. | L-glutamic acid-producing microorganism and a method for producing L-glutamic acid |
EP2368905A3 (de) * | 2004-12-17 | 2012-08-29 | Metanomics GmbH | Verfahren zur Steuerung der Herstellung von Feinchemikalien |
US7794989B2 (en) | 2004-12-28 | 2010-09-14 | Ajinomoto Co., Inc. | L-glutamic acid-producing microorganism and a method for producing L-glutamic acid |
US7547531B2 (en) | 2005-01-18 | 2009-06-16 | Ajinomoto Co., Inc. | L-amino acid producing microorganism which has been modified to inactive the fimH gene, and a method for producing I-amino acid |
US20070004014A1 (en) * | 2005-06-29 | 2007-01-04 | Yuichiro Tsuji | Method for producing l-threonine |
JP2008283863A (ja) | 2005-08-26 | 2008-11-27 | Ajinomoto Co Inc | L−アミノ酸生産菌及びl−アミノ酸の製造方法 |
JP2010017082A (ja) | 2006-10-10 | 2010-01-28 | Ajinomoto Co Inc | L−アミノ酸の製造法 |
JP2010110216A (ja) | 2007-02-20 | 2010-05-20 | Ajinomoto Co Inc | L−アミノ酸または核酸の製造方法 |
JP2011067095A (ja) | 2008-01-10 | 2011-04-07 | Ajinomoto Co Inc | 発酵法による目的物質の製造法 |
JP5526785B2 (ja) | 2008-01-23 | 2014-06-18 | 味の素株式会社 | L−アミノ酸の製造法 |
WO2010137130A1 (ja) | 2009-05-27 | 2010-12-02 | 味の素株式会社 | 有機酸の製造方法 |
EP2460883A4 (de) | 2009-07-29 | 2013-01-16 | Ajinomoto Kk | Verfahren zur herstellung von l-aminosäure |
JP2012223092A (ja) | 2009-08-28 | 2012-11-15 | Ajinomoto Co Inc | L−アミノ酸の製造法 |
JP2013013329A (ja) | 2009-11-06 | 2013-01-24 | Ajinomoto Co Inc | L−アミノ酸の製造法 |
BR112015007916B1 (pt) | 2013-05-13 | 2023-04-04 | Ajinomoto Co., Inc | Método para produzir l-aminoácido |
EP3053999B1 (de) | 2013-10-02 | 2019-11-20 | Ajinomoto Co., Inc. | Vorrichtung und verfahren zur ammoniakkontrolle |
BR112015005215B1 (pt) | 2013-10-21 | 2022-12-13 | Ajinomoto Co., Inc | Métodos para a produção de um l-aminoácido e para a produção de l-lisina |
JP6519476B2 (ja) | 2013-10-23 | 2019-05-29 | 味の素株式会社 | 目的物質の製造法 |
JP6494738B2 (ja) * | 2015-02-23 | 2019-04-03 | 国立大学法人静岡大学 | 2−アザ−8オキソヒポキサンチンの製造方法 |
RU2015114955A (ru) | 2015-04-22 | 2016-11-10 | Аджиномото Ко., Инк. | Способ получения L-изолейцина с использованием бактерии семейства Enterobacteriaceae, в которой сверхэкспрессирован ген cycA |
JP7066977B2 (ja) | 2017-04-03 | 2022-05-16 | 味の素株式会社 | L-アミノ酸の製造法 |
WO2020071538A1 (en) | 2018-10-05 | 2020-04-09 | Ajinomoto Co., Inc. | Method for producing target substance by bacterial fermentation |
CN114540261B (zh) * | 2020-11-24 | 2024-02-02 | 北京化工大学 | 一种产氨基己二酸的基因工程菌 |
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JPH06506105A (ja) * | 1990-08-29 | 1994-07-14 | ファーミング ビーブイ | 哺乳動物細胞における相同性組換え |
WO1993019660A1 (en) * | 1992-04-03 | 1993-10-14 | Baylor College Of Medicine | Gene therapy using the intestine |
US5792751A (en) * | 1992-04-13 | 1998-08-11 | Baylor College Of Medicine | Tranformation of cells associated with fluid spaces |
US5645986A (en) * | 1992-05-13 | 1997-07-08 | Board Of Reagents, The University Of Texas System | Therapy and diagnosis of conditions related to telomere length and/or telomerase activity |
US5645829A (en) * | 1993-06-18 | 1997-07-08 | Beth Israel Hospital Association | Mesothelial cell gene therapy |
CZ288247B6 (en) | 1993-10-08 | 2001-05-16 | Lonza Ag | DNA fragment, vector a microorganism containing genes for metabolic transformation of butyrobetaine/crotonobetaine-L-carnitine and process for preparing L-carnitine |
US5665350A (en) * | 1994-11-23 | 1997-09-09 | University Of Massachusetts Medical Center | Cell cycle dependent transplantation and ex vivo gene therapy |
US5780296A (en) * | 1995-01-17 | 1998-07-14 | Thomas Jefferson University | Compositions and methods to promote homologous recombination in eukaryotic cells and organisms |
US5824655A (en) * | 1995-02-15 | 1998-10-20 | The University Of Utah | Anti-transforming growth factor-β gene therapy |
US5656638A (en) * | 1995-04-18 | 1997-08-12 | Geron Corporation | Telomerase inhibitors |
US5760062A (en) * | 1995-04-18 | 1998-06-02 | Geron Corporation | Telomerase inhibitors |
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US5756283A (en) * | 1995-06-05 | 1998-05-26 | The Trustees Of The University Of Pennsylvania | Method for improved production of recombinant adeno-associated viruses for gene therapy |
US5776744A (en) * | 1995-06-07 | 1998-07-07 | Yale University | Methods and compositions for effecting homologous recombination |
DE19523279A1 (de) * | 1995-06-27 | 1997-01-09 | Forschungszentrum Juelich Gmbh | Verfahren zur mikrobiellen Herstellung von Aminosäuren mittels rekombinanter Mikroorganismen mit erhöhter Sekretionsrate |
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DE19548222A1 (de) | 1995-12-22 | 1997-06-26 | Forschungszentrum Juelich Gmbh | Verfahren zur mikrobiellen Herstellung von Aminosäuren durch gesteigerte Aktivität von Exportcarriern |
US5874304A (en) * | 1996-01-18 | 1999-02-23 | University Of Florida Research Foundation, Inc. | Humanized green fluorescent protein genes and methods |
DE19644566A1 (de) * | 1996-10-26 | 1998-04-30 | Forschungszentrum Juelich Gmbh | Mikrobielle Herstellung von Substanzen aus dem aromatischen Stoffwechsel / I |
DE19644567A1 (de) | 1996-10-26 | 1998-04-30 | Forschungszentrum Juelich Gmbh | Mikrobielle Herstellung von Substanzen aus dem aromatischen Stoffwechsel / II |
EP0839909A1 (de) * | 1996-10-29 | 1998-05-06 | Rijksuniversiteit te Groningen | Nukleinsäuresequenzen die für Citrat-Transporterproteine Kodieren |
US5925544A (en) * | 1996-11-18 | 1999-07-20 | Novo Nordisk A/S | Method of homologous recombination followed by in vivo selection of DNA amplification |
US5830698A (en) * | 1997-03-14 | 1998-11-03 | Idec Pharmaceuticals Corporation | Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same |
US5948653A (en) * | 1997-03-21 | 1999-09-07 | Pati; Sushma | Sequence alterations using homologous recombination |
EP1004663B1 (de) | 1997-07-18 | 2007-02-07 | Ajinomoto Co., Inc. | Verfahren und mikroorganism zur herstellung von purin-nukleosiden durch fermentation |
DE69942022D1 (de) * | 1998-04-13 | 2010-04-01 | Univ Georgia | Pyruvate carboxylase überexpression zur verstärkten produktion von oxalacetat abgeleiteten verbindungen in mikrobiellen zellen |
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RU2144564C1 (ru) * | 1998-10-13 | 2000-01-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | ФРАГМЕНТ ДНК rhtB, КОДИРУЮЩИЙ СИНТЕЗ БЕЛКА RhtB, ПРИДАЮЩЕГО УСТОЙЧИВОСТЬ К L-ГОМОСЕРИНУ БАКТЕРИЯМ ESCHERICHIA COLI, И СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ |
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RU2148642C1 (ru) * | 1998-12-23 | 2000-05-10 | ЗАО "Научно-исследовательский институт АДЖИНОМОТО-Генетика" (ЗАО "АГРИ") | Фрагмент днк rhtc, кодирующий синтез белка rhtc, придающего повышенную устойчивость к l-треонину бактериям escherichia coli, и способ получения l-аминокислоты |
JP4061769B2 (ja) | 1999-03-25 | 2008-03-19 | 味の素株式会社 | L−グルタミン酸の製造法 |
CN1298854C (zh) | 1999-07-02 | 2007-02-07 | 味之素株式会社 | 编码蔗糖pts酶ⅱ的dna |
JP2003159065A (ja) | 1999-07-19 | 2003-06-03 | Ajinomoto Co Inc | 発酵法による目的物質の製造法 |
WO2001048146A1 (fr) * | 1999-12-24 | 2001-07-05 | Ajinomoto Co., Inc. | Procede de production d'acide l-amine et nouveau gene |
RU2212447C2 (ru) * | 2000-04-26 | 2003-09-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Штамм escherichia coli - продуцент аминокислоты (варианты) и способ получения аминокислот (варианты) |
JP4380029B2 (ja) * | 2000-07-05 | 2009-12-09 | 味の素株式会社 | 微生物を利用した物質の製造法 |
BR0113034B1 (pt) * | 2000-08-04 | 2014-09-16 | Genencor Int | Método para aumento da produção biossintética de ácido 2-ceto-L-gulônico (2-KLG) de uma célula hospedeira |
CN1245215C (zh) * | 2001-02-28 | 2006-03-15 | 四川省生物工程研究中心 | 重组高效复合干扰素用作乙型肝炎表面抗原和e抗原抑制剂 |
JP2002330763A (ja) * | 2001-05-02 | 2002-11-19 | Ajinomoto Co Inc | 発酵法による目的物質の製造法 |
DE60233573D1 (de) | 2001-07-18 | 2009-10-15 | Evonik Degussa Gmbh | Verfahren zur herstellung von l-aminosäuren durch enterobakteriaceae-stämmen mit verstärkter exprimierung des rsea-gens |
-
2004
- 2004-06-03 US US10/859,210 patent/US7335496B2/en active Active
- 2004-06-03 AT AT04013158T patent/ATE531803T1/de active
- 2004-06-03 EP EP04013158A patent/EP1484410B1/de active Active
- 2004-06-04 CN CNB2004100631895A patent/CN100564516C/zh active Active
- 2004-06-04 BR BRPI0401918-0A patent/BRPI0401918B1/pt active IP Right Grant
- 2004-06-04 KR KR1020040040950A patent/KR101110580B1/ko active IP Right Grant
-
2011
- 2011-02-28 JP JP2011042797A patent/JP5287904B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
BRPI0401918B1 (pt) | 2014-12-09 |
CN100564516C (zh) | 2009-12-02 |
BRPI0401918A (pt) | 2005-06-28 |
EP1484410B1 (de) | 2011-11-02 |
US7335496B2 (en) | 2008-02-26 |
KR20040105568A (ko) | 2004-12-16 |
JP5287904B2 (ja) | 2013-09-11 |
KR101110580B1 (ko) | 2012-02-15 |
US20050170474A1 (en) | 2005-08-04 |
CN1572868A (zh) | 2005-02-02 |
EP1484410A1 (de) | 2004-12-08 |
JP2011103899A (ja) | 2011-06-02 |
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