BRPI0513362A - sìntese bioquìmica de 1,4-butanodiamina - Google Patents

sìntese bioquìmica de 1,4-butanodiamina

Info

Publication number
BRPI0513362A
BRPI0513362A BRPI0513362-9A BRPI0513362A BRPI0513362A BR PI0513362 A BRPI0513362 A BR PI0513362A BR PI0513362 A BRPI0513362 A BR PI0513362A BR PI0513362 A BRPI0513362 A BR PI0513362A
Authority
BR
Brazil
Prior art keywords
encoding gene
activity
increased
butanediamine
ornithine decarboxylase
Prior art date
Application number
BRPI0513362-9A
Other languages
English (en)
Inventor
Katrin Eppelmann
Petrus Martins Matheus Nossin
Susanne Maria Kremer
Marcel Gerhardus Wubbolts
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of BRPI0513362A publication Critical patent/BRPI0513362A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01053—N-carbamoylputrescine amidase (3.5.1.53)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/03—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amidines (3.5.3)
    • C12Y305/03011—Agmatinase (3.5.3.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/03—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amidines (3.5.3)
    • C12Y305/03012—Agmatine deiminase (3.5.3.12)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01017—Ornithine decarboxylase (4.1.1.17)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SìNTESE BIOQUìMICA DE 1,4-BUTANODIAMINA. A invenção é relacionada a um processo de síntese bioquímica de 1,4-butanodiamina em um microrganismo que apresenta um elevado nível de atividade de ornitina decarboxilase (atividade ODC aumentada) quando comparada aos níveis nativos de atividade ornitina decarboxilase, onde a atividade aumentada de ODC é obtida através da super expressão de um gene codificante para ornitina decarboxilase com eficiência de transcrição e/ou tradução aumentadas e onde a 1,4-butanodiamina produzida no microrganismo é excretada num caldo de fermentação, e é envolto do mesmo. Em incorporações preferidas também um aumento na atividade enzimática é obtida pela super expressão de tanto (i) um gene speA codificante para arginina decarboxilase e um gene speB codificante para agmatinase; ou (ii)um gene speA codificante para arginina decarboxilase e um gene águA codificante para agmatina iminohidrolase, e um gene aguB codificante para N-carbamilputrescina amidohidrolase, e opcionalmente também um gene speB codificante para agmatinase. A invenção também se relaciona aos vetores, plasmídeos e hospedeiros que carreiam, níveis de atividade aumentados de um ou mais atividades enzimáticas mencionadas.
BRPI0513362-9A 2004-07-15 2005-07-11 sìntese bioquìmica de 1,4-butanodiamina BRPI0513362A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04077047 2004-07-15
PCT/EP2005/007608 WO2006005604A1 (en) 2004-07-15 2005-07-11 Biochemical synthesis of 1,4-butanediamine

Publications (1)

Publication Number Publication Date
BRPI0513362A true BRPI0513362A (pt) 2008-05-06

Family

ID=34928371

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0513362-9A BRPI0513362A (pt) 2004-07-15 2005-07-11 sìntese bioquìmica de 1,4-butanodiamina

Country Status (18)

Country Link
US (2) US9523083B2 (pt)
EP (2) EP2236613B1 (pt)
JP (2) JP5010470B2 (pt)
CN (1) CN101006183B (pt)
AT (1) ATE504658T1 (pt)
AU (1) AU2005261862B2 (pt)
BR (1) BRPI0513362A (pt)
CA (1) CA2571531C (pt)
DE (1) DE602005027356D1 (pt)
EA (1) EA011232B1 (pt)
MX (1) MX2007000565A (pt)
MY (1) MY148119A (pt)
NZ (1) NZ552628A (pt)
PL (2) PL2236613T3 (pt)
TW (1) TWI354026B (pt)
UA (1) UA91686C2 (pt)
WO (1) WO2006005604A1 (pt)
ZA (1) ZA200700072B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2236613T3 (pl) * 2004-07-15 2015-11-30 Dsm Ip Assets Bv Biochemiczna synteza 1,4-butanodiaminy
WO2009125924A2 (ko) 2008-04-10 2009-10-15 한국과학기술원 퓨트레신 고생성능을 가지는 변이 미생물 및 이를 이용한 퓨트레신의 제조방법
EP2427544B1 (en) * 2009-05-07 2019-07-17 Genomatica, Inc. Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid
CA2768614A1 (en) * 2009-07-24 2011-01-27 Dsm Ip Assets B.V. Process for the preparation of 1,4-butanediamine via n-acyl or n-guanidyl protected 1,4-butanediamine precursors
US10683521B2 (en) * 2012-06-19 2020-06-16 Nanyang Technological University Expression construct for sensing cell density and substrate availability and its use in conversion of hydroxycinnamic acids
CN103451123B (zh) * 2013-06-08 2015-10-21 江苏省农业科学院 溶酪大球菌及其制备方法和应用
JP2017158434A (ja) * 2014-07-22 2017-09-14 協同乳業株式会社 バクテリア混合培養によるプトレッシン製造方法
CN104152478A (zh) * 2014-07-31 2014-11-19 洛阳华荣生物技术有限公司 一种生物转化联产d-精氨酸和胍基丁胺的方法
KR102246288B1 (ko) 2020-08-13 2021-04-29 씨제이제일제당 주식회사 퓨트레신 생산 미생물 및 이를 이용한 퓨트레신 생산방법
CN112522171A (zh) * 2020-12-18 2021-03-19 浙江中山化工集团股份有限公司 一种工程菌、含鸟氨酸溶液的处理方法及试剂盒
CN113061562B (zh) * 2021-03-22 2022-09-27 江南大学 一种利用钝齿棒杆菌发酵生产1,4-丁二胺的方法
WO2023157816A1 (ja) * 2022-02-15 2023-08-24 東レ株式会社 ３－ヒドロキシアジピン酸および／またはα－ヒドロムコン酸を生産するための遺伝子改変微生物および当該化学品の製造方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2130948A (en) 1937-04-09 1938-09-20 Du Pont Synthetic fiber
FR2729775B1 (fr) 1995-01-23 1997-02-21 France Telecom Terminal a lecteur de carte et procede de traitement multi-applicatif d'un tel terminal
ES2088826B1 (es) 1995-02-10 1997-06-01 Taguidell Sociedad Limitada Procedimiento de obtencion de las diaminas putrescina y cadaverina a partir de productos naturales tratados, su uso como aditivo en abonos, y abono correspondiente.
FI980551A (fi) * 1998-03-11 1999-09-12 Valtion Teknillinen Transformoidut mikro-organismit, joilla on parannettuja ominaisuuksia
WO2001011062A2 (en) * 1999-08-10 2001-02-15 John Innes Centre Polyamine accumulation in plants
DE10161412A1 (de) * 2001-12-13 2003-07-03 Aventis Pharma Gmbh Verfahren zur Bestimmung der Aktivität der Ornithin-Decarboxylase sowie zur Identifizierung von Effektoren der Ornithin-Decarboxylase-Aktivität
PL2236613T3 (pl) * 2004-07-15 2015-11-30 Dsm Ip Assets Bv Biochemiczna synteza 1,4-butanodiaminy

Also Published As

Publication number Publication date
EA011232B1 (ru) 2009-02-27
CN101006183A (zh) 2007-07-25
MY148119A (en) 2013-02-28
CA2571531C (en) 2016-02-16
ATE504658T1 (de) 2011-04-15
EP1781799A1 (en) 2007-05-09
JP2012130343A (ja) 2012-07-12
PL2236613T3 (pl) 2015-11-30
NZ552628A (en) 2009-09-25
AU2005261862B2 (en) 2010-08-26
US20160319311A1 (en) 2016-11-03
DE602005027356D1 (de) 2011-05-19
US20090275093A1 (en) 2009-11-05
ZA200700072B (en) 2008-05-28
CN101006183B (zh) 2011-07-27
CA2571531A1 (en) 2006-01-19
JP2008505652A (ja) 2008-02-28
EP2236613A1 (en) 2010-10-06
EP2236613B1 (en) 2015-05-27
EA200700330A1 (ru) 2007-06-29
MX2007000565A (es) 2007-04-02
AU2005261862A1 (en) 2006-01-19
UA91686C2 (en) 2010-08-25
TW200613558A (en) 2006-05-01
TWI354026B (en) 2011-12-11
WO2006005604A1 (en) 2006-01-19
JP5010470B2 (ja) 2012-08-29
PL1781799T3 (pl) 2011-07-29
EP1781799B1 (en) 2011-04-06
US9523083B2 (en) 2016-12-20

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]