ATE504658T1 - Biochemische synthese von 1,4-butandiamin - Google Patents
Biochemische synthese von 1,4-butandiaminInfo
- Publication number
- ATE504658T1 ATE504658T1 AT05774363T AT05774363T ATE504658T1 AT E504658 T1 ATE504658 T1 AT E504658T1 AT 05774363 T AT05774363 T AT 05774363T AT 05774363 T AT05774363 T AT 05774363T AT E504658 T1 ATE504658 T1 AT E504658T1
- Authority
- AT
- Austria
- Prior art keywords
- encoding gene
- activity
- increased
- butanediamine
- ornithine decarboxylase
- Prior art date
Links
- KIDHWZJUCRJVML-UHFFFAOYSA-N putrescine Chemical compound NCCCCN KIDHWZJUCRJVML-UHFFFAOYSA-N 0.000 title abstract 6
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 230000000694 effects Effects 0.000 abstract 7
- 102000052812 Ornithine decarboxylases Human genes 0.000 abstract 3
- 108700005126 Ornithine decarboxylases Proteins 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102100032252 Antizyme inhibitor 2 Human genes 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 101000652415 Homo sapiens Agmatinase, mitochondrial Proteins 0.000 abstract 2
- 101000798222 Homo sapiens Antizyme inhibitor 2 Proteins 0.000 abstract 2
- YANFYYGANIYHGI-UHFFFAOYSA-N N-carbamoylputrescine Chemical compound NCCCCNC(N)=O YANFYYGANIYHGI-UHFFFAOYSA-N 0.000 abstract 2
- 102100021079 Ornithine decarboxylase Human genes 0.000 abstract 2
- 101000711499 Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) N(1)-aminopropylagmatine ureohydrolase Proteins 0.000 abstract 2
- 102000011229 agmatinase Human genes 0.000 abstract 2
- 238000000855 fermentation Methods 0.000 abstract 2
- 230000004151 fermentation Effects 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 2
- 230000002018 overexpression Effects 0.000 abstract 2
- 101150101115 speB gene Proteins 0.000 abstract 2
- 108700024157 Agmatine deiminases Proteins 0.000 abstract 1
- 102000004092 Amidohydrolases Human genes 0.000 abstract 1
- 108090000531 Amidohydrolases Proteins 0.000 abstract 1
- 241001415395 Spea Species 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
- 101150047781 ptcA gene Proteins 0.000 abstract 1
- 230000002103 transcriptional effect Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
- C12Y305/01053—N-carbamoylputrescine amidase (3.5.1.53)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/03—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amidines (3.5.3)
- C12Y305/03011—Agmatinase (3.5.3.11)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/03—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amidines (3.5.3)
- C12Y305/03012—Agmatine deiminase (3.5.3.12)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/01—Carboxy-lyases (4.1.1)
- C12Y401/01017—Ornithine decarboxylase (4.1.1.17)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04077047 | 2004-07-15 | ||
| PCT/EP2005/007608 WO2006005604A1 (en) | 2004-07-15 | 2005-07-11 | Biochemical synthesis of 1,4-butanediamine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE504658T1 true ATE504658T1 (de) | 2011-04-15 |
Family
ID=34928371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05774363T ATE504658T1 (de) | 2004-07-15 | 2005-07-11 | Biochemische synthese von 1,4-butandiamin |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US9523083B2 (de) |
| EP (2) | EP1781799B1 (de) |
| JP (2) | JP5010470B2 (de) |
| CN (1) | CN101006183B (de) |
| AT (1) | ATE504658T1 (de) |
| AU (1) | AU2005261862B2 (de) |
| BR (1) | BRPI0513362A (de) |
| CA (1) | CA2571531C (de) |
| DE (1) | DE602005027356D1 (de) |
| EA (1) | EA011232B1 (de) |
| MX (1) | MX2007000565A (de) |
| MY (1) | MY148119A (de) |
| NZ (1) | NZ552628A (de) |
| PL (2) | PL1781799T3 (de) |
| TW (1) | TWI354026B (de) |
| UA (1) | UA91686C2 (de) |
| WO (1) | WO2006005604A1 (de) |
| ZA (1) | ZA200700072B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9523083B2 (en) * | 2004-07-15 | 2016-12-20 | Dsm Ip Assets B.V. | Biochemical synthesis of 1,4-butanediamine |
| ES2589378T3 (es) * | 2008-04-10 | 2016-11-14 | Korea Advanced Institute Of Science And Technology | Microorganismo mutante con capacidad elevada para producir putrescina, y preparación de putrescina usando el mismo |
| DK2427544T3 (da) * | 2009-05-07 | 2019-10-07 | Genomatica Inc | Mikroorganismer og fremgangsmåder til biosyntese af adipat, hexamethylendiamin og 6-aminokapronsyre |
| KR101694572B1 (ko) * | 2009-07-24 | 2017-01-09 | 디에스엠 아이피 어셋츠 비.브이. | Ｎ-아실 또는 ｎ-구아니딜 보호된 1,4-뷰테인다이아민 전구체를 통한 1,4-뷰테인다이아민의 제조 방법 |
| WO2013191651A1 (en) * | 2012-06-19 | 2013-12-27 | Nanyang Technological University | An expression construct for sensing cell density and substrate availability and its use in conversion of hydroxycinnamic acids |
| CN103451123B (zh) * | 2013-06-08 | 2015-10-21 | 江苏省农业科学院 | 溶酪大球菌及其制备方法和应用 |
| JP2017158434A (ja) * | 2014-07-22 | 2017-09-14 | 協同乳業株式会社 | バクテリア混合培養によるプトレッシン製造方法 |
| CN104152478A (zh) * | 2014-07-31 | 2014-11-19 | 洛阳华荣生物技术有限公司 | 一种生物转化联产d-精氨酸和胍基丁胺的方法 |
| KR102246288B1 (ko) | 2020-08-13 | 2021-04-29 | 씨제이제일제당 주식회사 | 퓨트레신 생산 미생물 및 이를 이용한 퓨트레신 생산방법 |
| CN112522171A (zh) * | 2020-12-18 | 2021-03-19 | 浙江中山化工集团股份有限公司 | 一种工程菌、含鸟氨酸溶液的处理方法及试剂盒 |
| CN113061562B (zh) * | 2021-03-22 | 2022-09-27 | 江南大学 | 一种利用钝齿棒杆菌发酵生产1,4-丁二胺的方法 |
| US20250382643A1 (en) * | 2022-02-15 | 2025-12-18 | Toray Industries, Inc. | GENETICALLY MODIFIED MICROORGANISM FOR PRODUCING 3-HYDROXYADIPIC ACID AND/OR Alpha-HYDROXYADIPIC ACID, AND METHOD FOR PRODUCING CHEMICAL PRODUCT |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2130948A (en) | 1937-04-09 | 1938-09-20 | Du Pont | Synthetic fiber |
| FR2729775B1 (fr) | 1995-01-23 | 1997-02-21 | France Telecom | Terminal a lecteur de carte et procede de traitement multi-applicatif d'un tel terminal |
| ES2088826B1 (es) * | 1995-02-10 | 1997-06-01 | Taguidell Sociedad Limitada | Procedimiento de obtencion de las diaminas putrescina y cadaverina a partir de productos naturales tratados, su uso como aditivo en abonos, y abono correspondiente. |
| FI980551A7 (fi) * | 1998-03-11 | 1999-09-12 | Valtion Teknillinen | Transformoidut mikro-organismit, joilla on parannettuja ominaisuuksia |
| WO2001011062A2 (en) * | 1999-08-10 | 2001-02-15 | John Innes Centre | Polyamine accumulation in plants |
| DE10161412A1 (de) * | 2001-12-13 | 2003-07-03 | Aventis Pharma Gmbh | Verfahren zur Bestimmung der Aktivität der Ornithin-Decarboxylase sowie zur Identifizierung von Effektoren der Ornithin-Decarboxylase-Aktivität |
| US9523083B2 (en) * | 2004-07-15 | 2016-12-20 | Dsm Ip Assets B.V. | Biochemical synthesis of 1,4-butanediamine |
-
2005
- 2005-07-11 US US11/632,625 patent/US9523083B2/en not_active Expired - Fee Related
- 2005-07-11 EA EA200700330A patent/EA011232B1/ru not_active IP Right Cessation
- 2005-07-11 EP EP05774363A patent/EP1781799B1/de not_active Expired - Lifetime
- 2005-07-11 AU AU2005261862A patent/AU2005261862B2/en not_active Ceased
- 2005-07-11 PL PL05774363T patent/PL1781799T3/pl unknown
- 2005-07-11 CN CN2005800238076A patent/CN101006183B/zh not_active Expired - Fee Related
- 2005-07-11 AT AT05774363T patent/ATE504658T1/de not_active IP Right Cessation
- 2005-07-11 PL PL10164437T patent/PL2236613T3/pl unknown
- 2005-07-11 MX MX2007000565A patent/MX2007000565A/es active IP Right Grant
- 2005-07-11 DE DE602005027356T patent/DE602005027356D1/de not_active Expired - Lifetime
- 2005-07-11 WO PCT/EP2005/007608 patent/WO2006005604A1/en not_active Ceased
- 2005-07-11 JP JP2007520745A patent/JP5010470B2/ja not_active Expired - Fee Related
- 2005-07-11 BR BRPI0513362-9A patent/BRPI0513362A/pt not_active IP Right Cessation
- 2005-07-11 NZ NZ552628A patent/NZ552628A/en not_active IP Right Cessation
- 2005-07-11 CA CA2571531A patent/CA2571531C/en not_active Expired - Fee Related
- 2005-07-11 EP EP10164437.5A patent/EP2236613B1/de not_active Expired - Lifetime
- 2005-07-15 MY MYPI20053245A patent/MY148119A/en unknown
- 2005-07-15 TW TW094124158A patent/TWI354026B/zh not_active IP Right Cessation
- 2005-11-07 UA UAA200701586A patent/UA91686C2/ru unknown
-
2007
- 2007-01-02 ZA ZA200700072A patent/ZA200700072B/en unknown
-
2012
- 2012-01-20 JP JP2012010241A patent/JP2012130343A/ja active Pending
-
2016
- 2016-07-18 US US15/212,385 patent/US20160319311A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MX2007000565A (es) | 2007-04-02 |
| CA2571531C (en) | 2016-02-16 |
| DE602005027356D1 (de) | 2011-05-19 |
| TWI354026B (en) | 2011-12-11 |
| JP5010470B2 (ja) | 2012-08-29 |
| US9523083B2 (en) | 2016-12-20 |
| US20090275093A1 (en) | 2009-11-05 |
| UA91686C2 (en) | 2010-08-25 |
| PL2236613T3 (pl) | 2015-11-30 |
| US20160319311A1 (en) | 2016-11-03 |
| MY148119A (en) | 2013-02-28 |
| CN101006183B (zh) | 2011-07-27 |
| CA2571531A1 (en) | 2006-01-19 |
| EP1781799B1 (de) | 2011-04-06 |
| CN101006183A (zh) | 2007-07-25 |
| EA200700330A1 (ru) | 2007-06-29 |
| PL1781799T3 (pl) | 2011-07-29 |
| EP1781799A1 (de) | 2007-05-09 |
| EP2236613A1 (de) | 2010-10-06 |
| EA011232B1 (ru) | 2009-02-27 |
| WO2006005604A1 (en) | 2006-01-19 |
| JP2012130343A (ja) | 2012-07-12 |
| BRPI0513362A (pt) | 2008-05-06 |
| ZA200700072B (en) | 2008-05-28 |
| TW200613558A (en) | 2006-05-01 |
| AU2005261862B2 (en) | 2010-08-26 |
| NZ552628A (en) | 2009-09-25 |
| AU2005261862A1 (en) | 2006-01-19 |
| JP2008505652A (ja) | 2008-02-28 |
| EP2236613B1 (de) | 2015-05-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |