DK0841395T3 - Fremgangsmåde til at fremstille L-lysin - Google Patents

Fremgangsmåde til at fremstille L-lysin

Info

Publication number
DK0841395T3
DK0841395T3 DK96916305.4T DK96916305T DK0841395T3 DK 0841395 T3 DK0841395 T3 DK 0841395T3 DK 96916305 T DK96916305 T DK 96916305T DK 0841395 T3 DK0841395 T3 DK 0841395T3
Authority
DK
Denmark
Prior art keywords
lysine
preparing
Prior art date
Application number
DK96916305.4T
Other languages
English (en)
Inventor
Seiko Otsuna
Masakazu Sugimoto
Masako Izui
Atsushi Hayakawa
Eiichi Nakano
Masaki Kobayashi
Yasuhiko Yoshihara
Tsuyoshi Nakamatsu
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Application granted granted Critical
Publication of DK0841395T3 publication Critical patent/DK0841395T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0016—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK96916305.4T 1995-06-07 1996-06-05 Fremgangsmåde til at fremstille L-lysin DK0841395T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP14061495 1995-06-07
PCT/JP1996/001511 WO1996040934A1 (fr) 1995-06-07 1996-06-05 Procede de production de l-lysine

Publications (1)

Publication Number Publication Date
DK0841395T3 true DK0841395T3 (da) 2012-01-09

Family

ID=15272810

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96916305.4T DK0841395T3 (da) 1995-06-07 1996-06-05 Fremgangsmåde til at fremstille L-lysin

Country Status (17)

Country Link
US (3) US20020086370A1 (da)
EP (1) EP0841395B1 (da)
JP (1) JP3106501B2 (da)
KR (1) KR100268324B1 (da)
CN (1) CN1165619C (da)
AU (1) AU705550B2 (da)
BR (1) BR9606379A (da)
CA (1) CA2224058C (da)
CZ (1) CZ293268B6 (da)
DK (1) DK0841395T3 (da)
ES (1) ES2373863T3 (da)
HU (1) HU222503B1 (da)
MX (1) MX9709923A (da)
RU (1) RU2197528C2 (da)
SK (1) SK285013B6 (da)
WO (1) WO1996040934A1 (da)
ZA (1) ZA964665B (da)

Families Citing this family (59)

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AU705550B2 (en) 1995-06-07 1999-05-27 Ajinomoto Co., Inc. Method of producing L-lysine
JP4035855B2 (ja) * 1996-06-05 2008-01-23 味の素株式会社 Ｌ−リジンの製造法
SK285201B6 (sk) * 1996-12-05 2006-08-03 Ajinomoto Co., Inc. Rekombinantná DNA, autonómne reprodukovaná v bunkách koryneformnej baktérie, koryneformná baktéria a spôsob výroby L-lyzínu, vektor pVK7
JP4075087B2 (ja) * 1996-12-05 2008-04-16 味の素株式会社 Ｌ−リジンの製造法
WO1999029862A1 (en) 1997-12-05 1999-06-17 Human Genome Sciences, Inc. Synferon, a synthetic type i interferon
JP3965821B2 (ja) * 1999-03-09 2007-08-29 味の素株式会社 Ｌ−リジンの製造法
DE19912384A1 (de) * 1999-03-19 2000-09-21 Degussa Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien
WO2000056859A1 (fr) * 1999-03-19 2000-09-28 Ajinomoto Co., Inc. Procede de production des l-aminoacides
JP2003135066A (ja) * 1999-03-19 2003-05-13 Ajinomoto Co Inc Ｌ−リジンの製造法
JP2003180348A (ja) * 1999-07-02 2003-07-02 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2003144161A (ja) * 1999-07-02 2003-05-20 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2003144160A (ja) * 1999-07-02 2003-05-20 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2003180355A (ja) * 1999-07-02 2003-07-02 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2003169674A (ja) * 1999-07-02 2003-06-17 Ajinomoto Co Inc Ｌ−リジンの製造法
DE19931314A1 (de) * 1999-07-07 2001-01-11 Degussa L-Lysin produzierende coryneforme Bakterien und Verfahren zur Herstellung von Lysin
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US6927046B1 (en) 1999-12-30 2005-08-09 Archer-Daniels-Midland Company Increased lysine production by gene amplification using coryneform bacteria
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WO2003014330A2 (en) * 2001-08-06 2003-02-20 Degussa Ag Coryneform bacteria which produce chemical compounds ii
EP1424397B1 (en) 2002-11-26 2011-01-19 Ajinomoto Co., Inc. Method for producing L-glutamine and L-glutamine producing bacterium
JP4655539B2 (ja) * 2004-08-06 2011-03-23 味の素株式会社 アシラーゼを用いたβアミノ酸の製造方法
EP2818556B1 (en) 2004-10-07 2023-05-10 Ajinomoto Co., Inc. Method for producing a basic substance
JP2009089603A (ja) 2006-02-02 2009-04-30 Ajinomoto Co Inc メタノール資化性細菌を用いたｌ−リジンの製造法
ES2592887T3 (es) 2006-03-30 2016-12-02 Basf Se Procedimiento la producción de cadaverina
JP2010041920A (ja) 2006-12-19 2010-02-25 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2010088301A (ja) 2007-02-01 2010-04-22 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2011067095A (ja) 2008-01-10 2011-04-07 Ajinomoto Co Inc 発酵法による目的物質の製造法
BRPI0906795A2 (pt) 2008-01-23 2015-08-18 Ajinomoto Kk Método para produzir um l-aminoácido
CA2712427A1 (en) * 2008-02-04 2009-08-13 Basf Se Method for the production of dipicolinate
JP2011512823A (ja) 2008-03-03 2011-04-28 グローバル バイオ−ケム テクノロジー グループ カンパニー リミテッド Ｌ−リシン製造のためのリコンビナント微生物および方法
JP2012029565A (ja) 2008-11-27 2012-02-16 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2010142200A (ja) 2008-12-22 2010-07-01 Ajinomoto Co Inc Ｌ−リジンの製造法
EP2460883A4 (en) 2009-07-29 2013-01-16 Ajinomoto Kk PROCESS FOR THE PREPARATION OF L-AMINO ACID
JP2012196144A (ja) 2009-08-03 2012-10-18 Ajinomoto Co Inc ビブリオ属細菌を用いたｌ−リジンの製造法
JP2012223091A (ja) 2009-08-25 2012-11-15 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
KR101226384B1 (ko) * 2010-03-05 2013-01-25 씨제이제일제당 (주) 개량된 프로모터 및 이를 이용한 ｌ-라이신의 생산 방법
EP2374873A1 (en) * 2010-04-08 2011-10-12 Technische Universität Hamburg-Harburg Modified aspartate kinase from corynebacterium and its application for amino acid production
RU2011134436A (ru) 2011-08-18 2013-10-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") Способ получения l-аминокислоты с использованием бактерии семейства enterobacteriaceae, обладающей повышенной экспрессией генов каскада образования флагелл и клеточной подвижности
CN105483145B (zh) * 2011-12-21 2021-04-06 Cj第一制糖株式会社 利用具有产生l-赖氨酸能力的微生物产生l-赖氨酸的方法
CN103667165B (zh) * 2012-09-12 2017-05-31 中国科学院上海生命科学研究院 高产l‑赖氨酸的生产菌株及其应用
JP2016192903A (ja) 2013-09-17 2016-11-17 味の素株式会社 海藻由来バイオマスからのｌ−アミノ酸の製造方法
WO2015050234A1 (ja) 2013-10-02 2015-04-09 味の素株式会社 アンモニア制御装置およびアンモニア制御方法
KR101518860B1 (ko) * 2013-10-11 2015-05-12 씨제이제일제당 (주) L-아미노산의 생산 방법
CN105821090B (zh) * 2015-01-08 2019-12-13 中国科学院天津工业生物技术研究所 嗜热共生杆菌meso-二氨基庚二酸脱氢酶突变体应用
EP3415622A1 (en) 2017-06-14 2018-12-19 Evonik Degussa GmbH Method for production of fine chemicals using a corynebacterium secreting modified alpha-1,6-glucosidases
EP3456833A1 (en) * 2017-09-18 2019-03-20 Evonik Degussa GmbH Method for the fermentative production of l-amino acids
EP3467099A1 (en) 2017-10-05 2019-04-10 Evonik Degussa GmbH Method for the fermentative production of l-amino acids
EP3498853A1 (en) 2017-12-14 2019-06-19 Evonik Degussa GmbH Method for the fermentative production of l-lysine
EP3594355A1 (en) 2018-07-12 2020-01-15 Evonik Operations GmbH Method for the fermentative production of l-lysine
EP3599282B1 (en) 2018-07-24 2021-03-17 Evonik Operations GmbH Method for the fermentative production of l-lysine
RU2019128538A (ru) 2018-09-26 2021-03-11 Эвоник Оперейшенс ГмбХ Способ ферментативного получения l-лизина
EP3660158A1 (en) 2018-11-29 2020-06-03 Evonik Operations GmbH Method for the fermentative production of l-lysine
EP3670525A1 (en) 2018-12-18 2020-06-24 Evonik Operations GmbH Method for the fermentative production of l-lysine using c. glutamicum strains with a mutated kup transporter
US10829746B2 (en) 2019-01-23 2020-11-10 Evonik Operations Gmbh Method for the fermentative production of L-lysine
US20240271169A1 (en) 2021-09-20 2024-08-15 Evonik Operations Gmbh Method for the fermentative production of l-lysine using c. glutamicum strains expressing modified gluconate repressor proteins gntr1 and gntr2
WO2023222510A1 (en) 2022-05-18 2023-11-23 Evonik Operations Gmbh Biotechnological production of desferrioxamines and analogs thereof
WO2023222505A1 (en) 2022-05-18 2023-11-23 Evonik Operations Gmbh Biotechnological production of monomers of bisucaberins, desferrioxamines and analogs thereof
WO2023222515A1 (en) 2022-05-18 2023-11-23 Evonik Operations Gmbh Biotechnological production of bisucaberins, desferrioxamines and analogs thereof

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JP4035855B2 (ja) * 1996-06-05 2008-01-23 味の素株式会社 Ｌ−リジンの製造法
SK285201B6 (sk) * 1996-12-05 2006-08-03 Ajinomoto Co., Inc. Rekombinantná DNA, autonómne reprodukovaná v bunkách koryneformnej baktérie, koryneformná baktéria a spôsob výroby L-lyzínu, vektor pVK7
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PL341895A1 (en) 1999-08-12 2001-02-26 Ajinomoto Kk Plasmide autonomously replicable in corynebacter bacteria
JP4306169B2 (ja) 1999-12-24 2009-07-29 味の素株式会社 Ｌ−アミノ酸の製造法及び新規遺伝子
JP4655539B2 (ja) 2004-08-06 2011-03-23 味の素株式会社 アシラーゼを用いたβアミノ酸の製造方法
DE602007005880D1 (de) 2006-07-26 2010-05-27 Ajinomoto Kk N-Acetyl-(R,S)-B-Aminosäuren-Acylase-Gene

Also Published As

Publication number Publication date
US7846698B2 (en) 2010-12-07
HUP9802666A2 (hu) 1999-02-01
EP0841395B1 (en) 2011-11-02
ZA964665B (en) 1997-01-07
RU2197528C2 (ru) 2003-01-27
AU5910796A (en) 1996-12-30
CA2224058A1 (en) 1996-12-19
CA2224058C (en) 2011-09-13
BR9606379A (pt) 1997-08-12
US8183017B2 (en) 2012-05-22
ES2373863T3 (es) 2012-02-09
HU222503B1 (hu) 2003-07-28
SK164097A3 (en) 1998-07-08
US20020086370A1 (en) 2002-07-04
JP3106501B2 (ja) 2000-11-06
CN1192242A (zh) 1998-09-02
CZ293268B6 (cs) 2004-03-17
EP0841395A4 (en) 2005-07-27
AU705550B2 (en) 1999-05-27
US20110065153A1 (en) 2011-03-17
CZ390397A3 (cs) 1998-06-17
CN1165619C (zh) 2004-09-08
MX9709923A (es) 1998-03-31
US20030054506A1 (en) 2003-03-20
KR19990022521A (ko) 1999-03-25
HUP9802666A3 (en) 2001-08-28
SK285013B6 (sk) 2006-04-06
KR100268324B1 (ko) 2000-10-16
EP0841395A1 (en) 1998-05-13
WO1996040934A1 (fr) 1996-12-19

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