HUP9802666A2 - Eljárás L-lizin termelésére - Google Patents

Eljárás L-lizin termelésére

Info

Publication number
HUP9802666A2
HUP9802666A2 HU9802666A HUP9802666A HUP9802666A2 HU P9802666 A2 HUP9802666 A2 HU P9802666A2 HU 9802666 A HU9802666 A HU 9802666A HU P9802666 A HUP9802666 A HU P9802666A HU P9802666 A2 HUP9802666 A2 HU P9802666A2
Authority
HU
Hungary
Prior art keywords
lysine
production
producing
kraine
fermentation
Prior art date
Application number
HU9802666A
Other languages
English (en)
Inventor
Atsushi Hayakawa
Masako Izui
Masaki Kobayashi
Tsuyoshi Nakamatsu
Eiichi Nakano
Seiko Otsuna
Masakazu Sugimoto
Yasuhiko Yoshihara
Original Assignee
Ajinomoto Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co., Inc. filed Critical Ajinomoto Co., Inc.
Publication of HUP9802666A2 publication Critical patent/HUP9802666A2/hu
Publication of HUP9802666A3 publication Critical patent/HUP9802666A3/hu
Publication of HU222503B1 publication Critical patent/HU222503B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0016—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A találmány tárgya eljárás L-lizin előállítására aminősav vagy hasőnlóanyagők fermentációs útőn történő termelésére használt kőrinefőrmbektériűmők géntechnőlógiai módszerekkel történt módősításávalelőállítőtt mikrőőrganizműsők alkalmazásával. A találmány szerinti eljárás alkalmas L-lizin ipari méretekben történőelőállítására. ŕ
HU9802666A 1995-06-07 1996-06-05 Eljárás L-lizin termelésére HU222503B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP14061495 1995-06-07
PCT/JP1996/001511 WO1996040934A1 (fr) 1995-06-07 1996-06-05 Procede de production de l-lysine

Publications (3)

Publication Number Publication Date
HUP9802666A2 true HUP9802666A2 (hu) 1999-02-01
HUP9802666A3 HUP9802666A3 (en) 2001-08-28
HU222503B1 HU222503B1 (hu) 2003-07-28

Family

ID=15272810

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9802666A HU222503B1 (hu) 1995-06-07 1996-06-05 Eljárás L-lizin termelésére

Country Status (17)

Country Link
US (3) US20020086370A1 (hu)
EP (1) EP0841395B1 (hu)
JP (1) JP3106501B2 (hu)
KR (1) KR100268324B1 (hu)
CN (1) CN1165619C (hu)
AU (1) AU705550B2 (hu)
BR (1) BR9606379A (hu)
CA (1) CA2224058C (hu)
CZ (1) CZ293268B6 (hu)
DK (1) DK0841395T3 (hu)
ES (1) ES2373863T3 (hu)
HU (1) HU222503B1 (hu)
MX (1) MX9709923A (hu)
RU (1) RU2197528C2 (hu)
SK (1) SK285013B6 (hu)
WO (1) WO1996040934A1 (hu)
ZA (1) ZA964665B (hu)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100268324B1 (ko) 1995-06-07 2000-10-16 에가시라 구니오 L-리신의 제조 방법
JP4035855B2 (ja) * 1996-06-05 2008-01-23 味の素株式会社 Ｌ−リジンの製造法
SK285201B6 (sk) * 1996-12-05 2006-08-03 Ajinomoto Co., Inc. Rekombinantná DNA, autonómne reprodukovaná v bunkách koryneformnej baktérie, koryneformná baktéria a spôsob výroby L-lyzínu, vektor pVK7
JP4075087B2 (ja) * 1996-12-05 2008-04-16 味の素株式会社 Ｌ−リジンの製造法
US6114145A (en) * 1997-12-05 2000-09-05 Human Genome Sciences, Inc. Synferon, a synthetic interferon
JP3965821B2 (ja) * 1999-03-09 2007-08-29 味の素株式会社 Ｌ−リジンの製造法
JP2003135066A (ja) * 1999-03-19 2003-05-13 Ajinomoto Co Inc Ｌ−リジンの製造法
AU3194300A (en) * 1999-03-19 2000-10-09 Ajinomoto Co., Inc. Process for producing l-amino acid
DE19912384A1 (de) * 1999-03-19 2000-09-21 Degussa Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien
JP2003144161A (ja) * 1999-07-02 2003-05-20 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2003144160A (ja) * 1999-07-02 2003-05-20 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2003180355A (ja) * 1999-07-02 2003-07-02 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2003169674A (ja) * 1999-07-02 2003-06-17 Ajinomoto Co Inc Ｌ−リジンの製造法
JP2003180348A (ja) * 1999-07-02 2003-07-02 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
DE19931314A1 (de) * 1999-07-07 2001-01-11 Degussa L-Lysin produzierende coryneforme Bakterien und Verfahren zur Herstellung von Lysin
JP2001046067A (ja) 1999-08-04 2001-02-20 Ajinomoto Co Inc 好熱性バチルス属細菌由来のｌ−リジン生合成系遺伝子
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BRPI0516261A (pt) 2004-10-07 2008-08-26 Ajinomoto Kk método para produzir uma substãncia básica por fermentação, e, caldo de fermentação ou produto de fermentação contendo uma substáncia básica
JP2009089603A (ja) * 2006-02-02 2009-04-30 Ajinomoto Co Inc メタノール資化性細菌を用いたｌ−リジンの製造法
CN101389765B (zh) * 2006-03-30 2012-08-22 巴斯夫欧洲公司 生产尸胺的方法
JP2010041920A (ja) 2006-12-19 2010-02-25 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2010088301A (ja) 2007-02-01 2010-04-22 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2011067095A (ja) 2008-01-10 2011-04-07 Ajinomoto Co Inc 発酵法による目的物質の製造法
EP2248906A4 (en) 2008-01-23 2012-07-11 Ajinomoto Kk PROCESS FOR THE PREPARATION OF L-AMINO ACID
CA2712427A1 (en) * 2008-02-04 2009-08-13 Basf Se Method for the production of dipicolinate
PL2262894T3 (pl) 2008-03-03 2015-02-27 Global Bio Chem Tech Group Company Limited Rekombinowany mikroorganizm i sposób wytwarzania l-lizyny
JP2012029565A (ja) 2008-11-27 2012-02-16 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2010142200A (ja) 2008-12-22 2010-07-01 Ajinomoto Co Inc Ｌ−リジンの製造法
EP2460883A4 (en) 2009-07-29 2013-01-16 Ajinomoto Kk PROCESS FOR THE PREPARATION OF L-AMINO ACID
JP2012196144A (ja) 2009-08-03 2012-10-18 Ajinomoto Co Inc ビブリオ属細菌を用いたｌ−リジンの製造法
JP2012223091A (ja) 2009-08-25 2012-11-15 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
KR101226384B1 (ko) * 2010-03-05 2013-01-25 씨제이제일제당 (주) 개량된 프로모터 및 이를 이용한 ｌ-라이신의 생산 방법
EP2374873A1 (en) * 2010-04-08 2011-10-12 Technische Universität Hamburg-Harburg Modified aspartate kinase from corynebacterium and its application for amino acid production
RU2011134436A (ru) 2011-08-18 2013-10-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") Способ получения l-аминокислоты с использованием бактерии семейства enterobacteriaceae, обладающей повышенной экспрессией генов каскада образования флагелл и клеточной подвижности
ES2696173T3 (es) * 2011-12-21 2019-01-14 Cj Cheiljedang Corp Método para producir L-lisina usando microorganismos que tienen capacidad de producir L-lisina
CN103667165B (zh) * 2012-09-12 2017-05-31 中国科学院上海生命科学研究院 高产l‑赖氨酸的生产菌株及其应用
JP2016192903A (ja) 2013-09-17 2016-11-17 味の素株式会社 海藻由来バイオマスからのｌ−アミノ酸の製造方法
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KR101518860B1 (ko) * 2013-10-11 2015-05-12 씨제이제일제당 (주) L-아미노산의 생산 방법
CN105821090B (zh) * 2015-01-08 2019-12-13 中国科学院天津工业生物技术研究所 嗜热共生杆菌meso-二氨基庚二酸脱氢酶突变体应用
EP3415622A1 (en) 2017-06-14 2018-12-19 Evonik Degussa GmbH Method for production of fine chemicals using a corynebacterium secreting modified alpha-1,6-glucosidases
EP3456833A1 (en) 2017-09-18 2019-03-20 Evonik Degussa GmbH Method for the fermentative production of l-amino acids
EP3467099A1 (en) 2017-10-05 2019-04-10 Evonik Degussa GmbH Method for the fermentative production of l-amino acids
EP3498853A1 (en) 2017-12-14 2019-06-19 Evonik Degussa GmbH Method for the fermentative production of l-lysine
EP3594355A1 (en) 2018-07-12 2020-01-15 Evonik Operations GmbH Method for the fermentative production of l-lysine
EP3599282B1 (en) 2018-07-24 2021-03-17 Evonik Operations GmbH Method for the fermentative production of l-lysine
RU2019128538A (ru) 2018-09-26 2021-03-11 Эвоник Оперейшенс ГмбХ Способ ферментативного получения l-лизина
EP3660158A1 (en) 2018-11-29 2020-06-03 Evonik Operations GmbH Method for the fermentative production of l-lysine
EP3670525A1 (en) 2018-12-18 2020-06-24 Evonik Operations GmbH Method for the fermentative production of l-lysine using c. glutamicum strains with a mutated kup transporter
US10829746B2 (en) 2019-01-23 2020-11-10 Evonik Operations Gmbh Method for the fermentative production of L-lysine
WO2023041425A1 (en) 2021-09-20 2023-03-23 Evonik Operations Gmbh Method for the fermentative production of l-lysine using c. glutamicum strains expressing modified gluconate repressor proteins gntr1 and gntr2
WO2023222510A1 (en) 2022-05-18 2023-11-23 Evonik Operations Gmbh Biotechnological production of desferrioxamines and analogs thereof
WO2023222515A1 (en) 2022-05-18 2023-11-23 Evonik Operations Gmbh Biotechnological production of bisucaberins, desferrioxamines and analogs thereof
WO2023222505A1 (en) 2022-05-18 2023-11-23 Evonik Operations Gmbh Biotechnological production of monomers of bisucaberins, desferrioxamines and analogs thereof

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JP4655539B2 (ja) 2004-08-06 2011-03-23 味の素株式会社 アシラーゼを用いたβアミノ酸の製造方法
DE602007005880D1 (de) 2006-07-26 2010-05-27 Ajinomoto Kk N-Acetyl-(R,S)-B-Aminosäuren-Acylase-Gene

Also Published As

Publication number Publication date
WO1996040934A1 (fr) 1996-12-19
ES2373863T3 (es) 2012-02-09
DK0841395T3 (da) 2012-01-09
CN1192242A (zh) 1998-09-02
JP3106501B2 (ja) 2000-11-06
HUP9802666A3 (en) 2001-08-28
US20110065153A1 (en) 2011-03-17
CZ293268B6 (cs) 2004-03-17
EP0841395A1 (en) 1998-05-13
US7846698B2 (en) 2010-12-07
CA2224058A1 (en) 1996-12-19
HU222503B1 (hu) 2003-07-28
EP0841395A4 (en) 2005-07-27
US20030054506A1 (en) 2003-03-20
EP0841395B1 (en) 2011-11-02
AU5910796A (en) 1996-12-30
CA2224058C (en) 2011-09-13
US20020086370A1 (en) 2002-07-04
SK164097A3 (en) 1998-07-08
CN1165619C (zh) 2004-09-08
BR9606379A (pt) 1997-08-12
US8183017B2 (en) 2012-05-22
CZ390397A3 (cs) 1998-06-17
KR100268324B1 (ko) 2000-10-16
ZA964665B (en) 1997-01-07
SK285013B6 (sk) 2006-04-06
AU705550B2 (en) 1999-05-27
MX9709923A (es) 1998-03-31
KR19990022521A (ko) 1999-03-25
RU2197528C2 (ru) 2003-01-27

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