ATE283362T1 - Verfahren zur erhöhung der produktion von clavam- antibiotika - Google Patents
Verfahren zur erhöhung der produktion von clavam- antibiotikaInfo
- Publication number
- ATE283362T1 ATE283362T1 AT96921954T AT96921954T ATE283362T1 AT E283362 T1 ATE283362 T1 AT E283362T1 AT 96921954 T AT96921954 T AT 96921954T AT 96921954 T AT96921954 T AT 96921954T AT E283362 T1 ATE283362 T1 AT E283362T1
- Authority
- AT
- Austria
- Prior art keywords
- clavam
- antibiotics
- increase production
- pathway
- plasmids
- Prior art date
Links
- WSHJJCPTKWSMRR-RXMQYKEDSA-N penam Chemical compound S1CCN2C(=O)C[C@H]21 WSHJJCPTKWSMRR-RXMQYKEDSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 229940088710 antibiotic agent Drugs 0.000 title 1
- 230000037361 pathway Effects 0.000 abstract 3
- 229930186147 Cephalosporin Natural products 0.000 abstract 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 2
- 101000586205 Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) Ornithine aminotransferase Proteins 0.000 abstract 2
- 229940124587 cephalosporin Drugs 0.000 abstract 2
- 150000001780 cephalosporins Chemical class 0.000 abstract 2
- 239000013612 plasmid Substances 0.000 abstract 2
- OYIFNHCXNCRBQI-BYPYZUCNSA-N L-2-aminoadipic acid Chemical compound OC(=O)[C@@H](N)CCCC(O)=O OYIFNHCXNCRBQI-BYPYZUCNSA-N 0.000 abstract 1
- 235000019766 L-Lysine Nutrition 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000002950 deficient Effects 0.000 abstract 1
- 230000002452 interceptive effect Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Catalysts (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9511679.4A GB9511679D0 (en) | 1995-06-09 | 1995-06-09 | Novel process |
| PCT/EP1996/002497 WO1996041886A1 (en) | 1995-06-09 | 1996-06-06 | Process to increase the production of clavam antibiotics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE283362T1 true ATE283362T1 (de) | 2004-12-15 |
Family
ID=10775768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96921954T ATE283362T1 (de) | 1995-06-09 | 1996-06-06 | Verfahren zur erhöhung der produktion von clavam- antibiotika |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6171814B1 (de) |
| EP (1) | EP0832247B1 (de) |
| JP (2) | JP3996640B2 (de) |
| KR (2) | KR100439081B1 (de) |
| AT (1) | ATE283362T1 (de) |
| AU (1) | AU6301796A (de) |
| CA (1) | CA2221518C (de) |
| DE (1) | DE69633921T2 (de) |
| ES (1) | ES2233969T3 (de) |
| GB (1) | GB9511679D0 (de) |
| HK (1) | HK1010087A1 (de) |
| WO (1) | WO1996041886A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1228218A2 (de) * | 1999-10-22 | 2002-08-07 | Smithkline Beecham Plc | 5r-clavam-produzierende mikroorganismen die deletierte lat- und cvm-gene enthalten |
| GB0402799D0 (en) * | 2004-02-09 | 2004-03-10 | Sandoz Ag | Pharmaceutical composition |
| CN100355895C (zh) * | 2004-12-17 | 2007-12-19 | 天津科技大学 | 棒状链霉菌lat基因缺失的质粒、衍生物及其构建方法 |
| EP2589663A1 (de) | 2011-11-04 | 2013-05-08 | LEK Pharmaceuticals d.d. | Verfahren zur Herstellung von Clavulansäure |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8813055D0 (en) * | 1988-06-02 | 1988-07-06 | Beecham Group Plc | Novel substance |
| EP0467049A1 (de) * | 1990-07-16 | 1992-01-22 | American Cyanamid Company | DNS-Sequenzen und Aminosäuresequenzen von Klasse B Beta-Lactamase Enzymen aus Bakteroides fragilis |
| GB9302041D0 (en) * | 1993-02-02 | 1993-03-17 | Smithkline Peecham P L C | Novel compounds |
| US5474912A (en) * | 1994-03-03 | 1995-12-12 | Sherman; David H. | Method for increasing production of microbial metabolites by genetic engineering |
| CA2182951A1 (en) * | 1994-03-03 | 1995-09-08 | Juan F. Martin | A method of transformation of nocardia |
-
1995
- 1995-06-09 GB GBGB9511679.4A patent/GB9511679D0/en active Pending
-
1996
- 1996-06-06 JP JP50260797A patent/JP3996640B2/ja not_active Expired - Lifetime
- 1996-06-06 US US08/981,072 patent/US6171814B1/en not_active Expired - Lifetime
- 1996-06-06 AT AT96921954T patent/ATE283362T1/de not_active IP Right Cessation
- 1996-06-06 CA CA002221518A patent/CA2221518C/en not_active Expired - Lifetime
- 1996-06-06 KR KR1019970709202A patent/KR100439081B1/ko not_active IP Right Cessation
- 1996-06-06 DE DE69633921T patent/DE69633921T2/de not_active Expired - Lifetime
- 1996-06-06 EP EP96921954A patent/EP0832247B1/de not_active Expired - Lifetime
- 1996-06-06 KR KR10-2004-7000216A patent/KR100468932B1/ko not_active IP Right Cessation
- 1996-06-06 WO PCT/EP1996/002497 patent/WO1996041886A1/en active IP Right Grant
- 1996-06-06 ES ES96921954T patent/ES2233969T3/es not_active Expired - Lifetime
- 1996-06-06 AU AU63017/96A patent/AU6301796A/en not_active Abandoned
-
1998
- 1998-09-24 HK HK98110939A patent/HK1010087A1/xx not_active IP Right Cessation
-
2007
- 2007-05-28 JP JP2007140125A patent/JP2007289193A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US6171814B1 (en) | 2001-01-09 |
| KR20040010848A (ko) | 2004-01-31 |
| AU6301796A (en) | 1997-01-09 |
| CA2221518C (en) | 2009-01-06 |
| KR100439081B1 (ko) | 2004-07-16 |
| GB9511679D0 (en) | 1995-08-02 |
| EP0832247B1 (de) | 2004-11-24 |
| WO1996041886A1 (en) | 1996-12-27 |
| HK1010087A1 (en) | 1999-06-11 |
| ES2233969T3 (es) | 2005-06-16 |
| JP3996640B2 (ja) | 2007-10-24 |
| KR19990022760A (ko) | 1999-03-25 |
| KR100468932B1 (ko) | 2005-02-02 |
| JP2007289193A (ja) | 2007-11-08 |
| JPH11507546A (ja) | 1999-07-06 |
| EP0832247A1 (de) | 1998-04-01 |
| DE69633921T2 (de) | 2005-11-10 |
| DE69633921D1 (de) | 2004-12-30 |
| CA2221518A1 (en) | 1996-12-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP9802666A2 (hu) | Eljárás L-lizin termelésére | |
| DE69530242D1 (de) | Verfahren zur Herstellung von Glutaminsäure durch Fermentation | |
| DE59409542D1 (de) | Neue Mikroorganismen, deren Verwendung und Verfahren zur Herstellung von L-Alpha-Aminosäuren | |
| DE68906904D1 (de) | Verfahren zur herstellung von optisch aktiven 2-arylalkansaeuren. | |
| DE3875953D1 (de) | Verfahren zur herstellung von organischen chemischen verbindungen. | |
| AU5375290A (en) | An improved process for the production of a-21978c derivatives | |
| ATE283362T1 (de) | Verfahren zur erhöhung der produktion von clavam- antibiotika | |
| DE3581994D1 (de) | Verfahren zur herstellung der stereoisomeren von 1-amino-alkylphosphonsaeuren oder 1-amino-alkylphosphinsaeuren. | |
| DE3575743D1 (de) | Verfahren zur gewinnung von phenylalanin-dehydrogenase enthaltenden mikroorganismen und deren verwendung zur herstellung von l-alpha-aminosaeuren. | |
| ATE145670T1 (de) | Verfahren zur fermentativen herstellung von 2- hydroxyphenylessigsäure | |
| DE59305557D1 (de) | Verfahren zur Herstellung von L-Lysin durch Fermentation von coryneformen Bakterien | |
| ATE279527T1 (de) | Verfahren zur herstellung von l-2- aminoadipinsäure | |
| ATE191508T1 (de) | Mikrobiologisches verfahren zur herstellung von 1-ungesättigten, 17-beta-carboxysubstituierten 3- oxo-4-azaandrostan-3-onen | |
| AU1161488A (en) | Novel microorganisms and a method for production of glutamic acid using the same | |
| ATE144285T1 (de) | Mikrobiologisches verfahren zur herstellung von 5-hydroxy-2-pyrazincarbonsäure | |
| DE69526992D1 (de) | Fermentationsprozess für die Herstellung von Phenylessigsäure mit Phenylalanin als Ausgangskomponente | |
| IT1136580B (it) | Processo per la produzione di l-aminoacidi usando microorganismi immobilizzati | |
| WO1995011297A3 (en) | Phenylalanine dehydrogenase production |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |