AU617986B2 - Peptide derivatives - Google Patents

Peptide derivatives Download PDF

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Publication number
AU617986B2
AU617986B2 AU79564/87A AU7956487A AU617986B2 AU 617986 B2 AU617986 B2 AU 617986B2 AU 79564/87 A AU79564/87 A AU 79564/87A AU 7956487 A AU7956487 A AU 7956487A AU 617986 B2 AU617986 B2 AU 617986B2
Authority
AU
Australia
Prior art keywords
hydrogen
formula
residue
acid
atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU79564/87A
Other languages
English (en)
Other versions
AU7956487A (en
Inventor
Rainer Albert
Wilfried Bauer
Francois Cardinaux
Monika Mergler
Janos Pless
Walter Prikoszovich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of AU7956487A publication Critical patent/AU7956487A/en
Application granted granted Critical
Publication of AU617986B2 publication Critical patent/AU617986B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AU79564/87A 1986-10-13 1987-10-12 Peptide derivatives Ceased AU617986B2 (en)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
DE3634825 1986-10-13
DE3634797 1986-10-13
DE3634826 1986-10-13
DE3634826 1986-10-13
DE3634797 1986-10-13
DE3634825 1986-10-13
DE3712626 1987-04-14
DE3712626 1987-04-14
CH315387 1987-08-17
CH3153/87 1987-08-17

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU80150/91A Division AU634664B2 (en) 1986-10-13 1991-07-03 Solid phase synthesis of peptide alcohols

Publications (2)

Publication Number Publication Date
AU7956487A AU7956487A (en) 1988-04-14
AU617986B2 true AU617986B2 (en) 1991-12-12

Family

ID=27509117

Family Applications (2)

Application Number Title Priority Date Filing Date
AU79564/87A Ceased AU617986B2 (en) 1986-10-13 1987-10-12 Peptide derivatives
AU80150/91A Expired AU634664B2 (en) 1986-10-13 1991-07-03 Solid phase synthesis of peptide alcohols

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU80150/91A Expired AU634664B2 (en) 1986-10-13 1991-07-03 Solid phase synthesis of peptide alcohols

Country Status (23)

Country Link
US (1) US5656721A (esLanguage)
JP (2) JPH0645639B2 (esLanguage)
KR (1) KR960016861B1 (esLanguage)
AU (2) AU617986B2 (esLanguage)
BE (1) BE1003752A4 (esLanguage)
CA (1) CA1340985C (esLanguage)
CH (2) CH682632A5 (esLanguage)
DE (1) DE3790635T1 (esLanguage)
DK (1) DK174337B1 (esLanguage)
ES (1) ES2007418A6 (esLanguage)
FI (1) FI874495L (esLanguage)
FR (1) FR2609991A1 (esLanguage)
GB (2) GB2199829B (esLanguage)
GR (1) GR871567B (esLanguage)
HU (3) HU206890B (esLanguage)
IE (1) IE912442A1 (esLanguage)
LU (1) LU87014A1 (esLanguage)
NL (1) NL194729C (esLanguage)
NZ (1) NZ222133A (esLanguage)
PL (1) PL157156B1 (esLanguage)
PT (1) PT85904B (esLanguage)
SE (2) SE8703938L (esLanguage)
WO (1) WO1988002756A2 (esLanguage)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU623385B2 (en) * 1988-04-08 1992-05-14 Sandoz Ltd. Improvements in or relating to organic compounds

Families Citing this family (61)

* Cited by examiner, † Cited by third party
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HU206890B (en) * 1986-10-13 1993-01-28 Sandoz Ag Process for producing sugar-modified somatostatin peptide derivatives and pharmaceutical compositions containing them as active components
DE3822557C2 (de) * 1987-07-10 1998-07-02 Ciba Geigy Ag Arzneimittel, enthaltend Somatostatine
EP0329295A1 (en) * 1988-02-01 1989-08-23 The Upjohn Company Renin inhibiting peptides with polar end groups
DE3910667A1 (de) * 1988-04-11 1989-10-19 Sandoz Ag Peptidderivate
GB8813339D0 (en) * 1988-06-06 1988-07-13 Sandoz Ltd Improvements in/relating to organic compounds
FR2638968B1 (fr) * 1988-11-11 1994-10-07 Sandoz Sa Nouvelle utilisation therapeutique de la somatostatine et de ses analogues et derives
US5776894A (en) * 1988-12-05 1998-07-07 Novartis Ag Chelated somatostatin peptides and complexes thereof, pharmaceutical compositions containing them and their use in treating tumors
US5753627A (en) * 1988-12-05 1998-05-19 Novartis Ag Use of certain complexed somatostatin peptides for the invivo imaging of somatostatin receptor-positive tumors and metastasis
MY106120A (en) * 1988-12-05 1995-03-31 Novartis Ag Peptide derivatives.
IT1229514B (it) * 1989-01-30 1991-09-03 Farmhispania S A A Montme Glicoconiugati anfifilici sintetici per impiego neurologico.
DK111489D0 (da) * 1989-03-08 1989-03-08 Novo Nordisk As Peptider
DE4206858A1 (de) * 1992-03-05 1993-09-09 Behringwerke Ag Glycopeptid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
IT1260156B (it) * 1992-08-03 1996-03-28 Fidia Spa Derivati dell'acido neuraminico
TW263437B (esLanguage) * 1992-09-24 1995-11-21 Takeda Pharm Industry Co Ltd
US5710244A (en) * 1992-12-31 1998-01-20 Labroo; Virender M. Derivatized calcitonins
US5508387A (en) * 1993-08-04 1996-04-16 Glycomed Incorporated Selectin binding glycopeptides
SI0788509T1 (en) * 1993-08-09 2003-10-31 Societe De Conseils De Recherches Therapeutic peptide derivatives
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
JP3896430B2 (ja) * 1996-07-15 2007-03-22 アークレイ株式会社 糖化アミノ化合物の製造方法
IL119029A0 (en) * 1996-08-07 1996-11-14 Yeda Res & Dev Long-acting drugs and pharamaceutical compositions comprising them
EP0981364B1 (en) 1997-05-13 2006-03-01 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Method and compositions for treating hyperlipidemia
EP0981363B1 (en) 1997-05-13 2003-07-30 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Somatostatin agonists for decreasing body weight
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
DE69943039D1 (de) * 1998-02-13 2011-01-27 Amylin Pharmaceuticals Inc Neue verbindungen mit gemischter amylin aktivität
US5968903A (en) * 1998-05-07 1999-10-19 Biomeasure, Incorporated Inhibition of H. pylori proliferation
US20050037490A1 (en) * 1999-10-29 2005-02-17 Lawrence Rosenberg Medium for preparing dedifferentiated cells
AU2002254691B8 (en) * 2001-04-23 2008-02-14 Mallinckrodt Inc. Tc and Re labeler radioactive glycosylated octreotide derivatives
DK2062914T3 (da) 2001-06-08 2014-07-14 Ipsen Pharma Somatostatin-dopamin-chimære analoger
PT1480998E (pt) * 2002-02-27 2007-02-28 Ferring Bv Intermediários e métodos para fazer heptapeptídeos análogos de oxitocina.
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
ATE458491T1 (de) 2005-08-26 2010-03-15 Univ Leland Stanford Junior Verfahren zur behandlung von kopfschmerzen durch verabreichung von oxytocin
ATE549011T1 (de) 2005-11-10 2012-03-15 Chemi Spa Formulierungen mit verzögerter freisetzung, die somatostatin-analoge wachstumshormoninhibitoren enthalten
WO2008011168A2 (en) * 2006-07-21 2008-01-24 Amgen Inc. Glycosylated peptide antagonists of the bradykinin b1 receptor
WO2008095063A1 (en) 2007-01-31 2008-08-07 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
EP2508531B1 (en) 2007-03-28 2016-10-19 President and Fellows of Harvard College Stitched polypeptides
US8785594B2 (en) 2007-09-25 2014-07-22 Glycom A/S Glycoproteins and glycosylated cells and a method for the preparation of the same
JP5660898B2 (ja) * 2007-11-09 2015-01-28 ユニバーシティ オブ テネシー リサーチ ファウンデーション 経口投与用の抗炎症性キナ酸誘導体
BRPI0915888E2 (pt) 2008-06-12 2020-09-01 Syntaxin Ltd polipetídeo, seu método de ativação, sequência de ácido nucléico codificando o mesmo e seu uso
ES2732205T3 (es) 2008-06-12 2019-11-21 Ipsen Bioinnovation Ltd Proteínas de fusión para uso en el tratamiento del cáncer
WO2010089757A2 (en) * 2008-11-07 2010-08-12 Usv Limited An improved process for synthesis of cyclic octapeptide
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
CN103282510A (zh) 2010-08-13 2013-09-04 爱勒让治疗公司 拟肽大环化合物
RU2627184C2 (ru) 2011-09-04 2017-08-03 Глитек, Инк. Гликозилированные полипептиды и лекарственные композиции, содержащие данные полипептиды
BR112014004784A2 (pt) 2011-09-04 2017-03-21 Glytech Inc polipeptídeo glicosilado e composição de drogas contendo referido polipeptídeo
KR20140100937A (ko) 2011-10-18 2014-08-18 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
WO2013123266A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
JP6450192B2 (ja) 2012-02-15 2019-01-09 エイルロン セラピューティクス，インコーポレイテッド トリアゾール架橋した、およびチオエーテル架橋したペプチドミメティック大環状化合物
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
ES2862125T3 (es) 2013-06-13 2021-10-07 Antisense Therapeutics Ltd Terapia combinada para acromegalia
SG11201702223UA (en) 2014-09-24 2017-04-27 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
US11389473B2 (en) 2015-01-07 2022-07-19 Tonix Pharmaceuticals Holding Corp. Magnesium-containing oxytocin formulations and methods of use
US10253067B2 (en) 2015-03-20 2019-04-09 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
SMT202500100T1 (it) 2016-04-12 2025-05-12 Tonix Pharma Ltd Formulazioni di ossitocina contenenti magnesio e metodi d'uso
US20200353419A1 (en) 2017-11-22 2020-11-12 Dauntless 1, Inc. Membrane emulsification device for microsphere creation
US20200281857A1 (en) 2017-11-22 2020-09-10 Dauntless 1, Inc. Therapeutic compound formulations
WO2020005842A1 (en) 2018-06-25 2020-01-02 Dauntless 2, Inc. Membrane emulsification device with impeller for microsphere creation
EP3956343A1 (en) 2019-04-16 2022-02-23 Bachem Holding AG Manufacture of disulfide bonded peptides
CA3180317A1 (en) 2020-04-17 2021-10-21 The Trustees Of Indiana University Small molecule antiviral drug treatment for human papillomavirus infections
US20230399373A1 (en) * 2020-10-22 2023-12-14 The Trustees Of Indiana University Molecular designs of glucose-responsive and glucose-cleavable insulin analogues
WO2025229200A1 (en) 2024-05-03 2025-11-06 Bachem Holding Ag Manufacture of disulfide bonded peptides

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5376886A (en) * 1985-02-20 1986-08-28 Ciba-Geigy Ag Acylated hexose derivatives and processes for the manufacture thereof
AU6778487A (en) * 1985-12-20 1987-07-15 Astra Lakemedel Aktiebolag New 8-substituted derivatives of an anhydrooctonic acid, methods for their preparation, pharmaceutical preparations containing these and intermediates
AU1840988A (en) * 1987-06-29 1989-01-05 Sandoz Ltd. Improvements in or relating to organic compounds

Family Cites Families (17)

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Publication number Priority date Publication date Assignee Title
US4254023A (en) * 1979-10-16 1981-03-03 Pennwalt Corporation Synthesis of peptide alcohols by the solid phase method
US4280953A (en) * 1979-11-08 1981-07-28 The Salk Institute For Biological Studies Glycosylated analogs of somatostatin
ATE2512T1 (de) * 1979-11-27 1983-03-15 Sandoz Ag Polypeptide, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen, die diese polypeptide enthalten, und ihre verwendung.
FR2522967B1 (fr) * 1982-03-15 1986-03-07 Anvar Conjugues d'haptenes et de muramyl-peptides, doues d'activite immunogene et compositions les contenant
US4483792A (en) * 1982-11-17 1984-11-20 Kim Wan S Glycosylated insulin derivatives
US4444683A (en) * 1982-11-17 1984-04-24 University Of Utah Glycosylated insulin derivatives
FR2546163B1 (fr) * 1983-05-16 1987-10-09 Centre Nat Rech Scient Nouveaux derives acyles hydrosolubles de peptides ou d'amino-acides, leur preparation et leur application
FR2548673B1 (fr) * 1983-07-05 1985-10-04 Essilor Int Polymeres supports de produits actifs relargables et leur procede de preparation
LU85269A1 (fr) * 1984-03-26 1985-10-14 Techland S A Composes nouveaux de somatostatine,procede pour leur synthese,preparation a usage veterinaire contenant lesdits composes et procede pour le traitement d'animaux
US4564998A (en) * 1984-10-19 1986-01-21 Westinghouse Electric Corp. Coil winding methods and apparatus
DE3439610A1 (de) * 1984-10-30 1986-04-30 Boehringer Mannheim Gmbh, 6800 Mannheim Immunogene, verfahren zu deren herstellung sowie damit gewonnene antikoerper gegen glykosiliertes haemoglobin
JPS61264260A (ja) * 1985-05-17 1986-11-22 Rikagaku Kenkyusho アルデヒド化多孔性高分子材料によるタンパク質の除去方法
CA1337041C (en) * 1985-10-09 1995-09-19 Brett Alan Evans Granular detergent compositions having improved solubility
JPS63165411A (ja) * 1986-09-11 1988-07-08 Tokyo Organ Chem Ind Ltd アルデヒド基を有する架橋共重合体の製法
JPS63165410A (ja) * 1986-09-11 1988-07-08 Tokyo Organ Chem Ind Ltd アルデヒド基を有する架橋共重合体の製造方法
HU206890B (en) * 1986-10-13 1993-01-28 Sandoz Ag Process for producing sugar-modified somatostatin peptide derivatives and pharmaceutical compositions containing them as active components
US4859736A (en) * 1987-03-30 1989-08-22 Ciba-Geigy Corporation Synthetic polystyrene resin and its use in solid phase peptide synthesis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5376886A (en) * 1985-02-20 1986-08-28 Ciba-Geigy Ag Acylated hexose derivatives and processes for the manufacture thereof
AU6778487A (en) * 1985-12-20 1987-07-15 Astra Lakemedel Aktiebolag New 8-substituted derivatives of an anhydrooctonic acid, methods for their preparation, pharmaceutical preparations containing these and intermediates
AU1840988A (en) * 1987-06-29 1989-01-05 Sandoz Ltd. Improvements in or relating to organic compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU623385B2 (en) * 1988-04-08 1992-05-14 Sandoz Ltd. Improvements in or relating to organic compounds

Also Published As

Publication number Publication date
GB8723737D0 (en) 1987-11-11
HU906340D0 (en) 1991-04-29
PL268173A1 (en) 1988-09-01
SE9301172L (esLanguage) 1900-01-01
FR2609991B1 (esLanguage) 1995-03-10
FI874495A0 (fi) 1987-10-12
SE8703938D0 (sv) 1987-10-12
US5656721A (en) 1997-08-12
KR960016861B1 (ko) 1996-12-23
SE8703938L (sv) 1988-04-14
IE912442L (en) 1988-04-13
GB8800537D0 (en) 1988-02-10
CH682632A5 (de) 1993-10-29
GR871567B (en) 1988-02-16
JPS63101399A (ja) 1988-05-06
GB2199829A (en) 1988-07-20
JPH0645639B2 (ja) 1994-06-15
DE3790635T1 (esLanguage) 1988-10-06
DK532787D0 (da) 1987-10-12
NL194729C (nl) 2003-01-07
HUT46710A (en) 1988-11-28
CA1340985C (en) 2000-05-09
HU906341D0 (en) 1991-04-29
NZ222133A (en) 1993-02-25
BE1003752A4 (fr) 1992-06-09
KR880005153A (ko) 1988-06-28
PL157156B1 (pl) 1992-05-29
HU206890B (en) 1993-01-28
JPH0314599A (ja) 1991-01-23
WO1988002756A2 (en) 1988-04-21
WO1988002756A3 (en) 1988-07-14
AU8015091A (en) 1991-10-31
FI874495A7 (fi) 1988-04-14
ES2007418A6 (es) 1989-06-16
PT85904B (pt) 1990-08-31
NL8702345A (nl) 1988-05-02
IE912442A1 (en) 1992-02-12
CH680512A5 (esLanguage) 1992-09-15
AU7956487A (en) 1988-04-14
JP2744910B2 (ja) 1998-04-28
FR2609991A1 (fr) 1988-07-29
SE9301172D0 (sv) 1993-04-07
GB2199831A (en) 1988-07-20
SE518630C2 (sv) 2002-11-05
LU87014A1 (fr) 1988-05-03
DK174337B1 (da) 2002-12-16
PT85904A (en) 1987-11-01
NL194729B (nl) 2002-09-02
GB2199831B (en) 1991-04-17
AU634664B2 (en) 1993-02-25
FI874495L (fi) 1988-04-14
DK532787A (da) 1988-04-14
GB2199829B (en) 1991-04-17

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