AU2021392032A1 - Genetically engineered cells and uses thereof - Google Patents

Genetically engineered cells and uses thereof Download PDF

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Publication number
AU2021392032A1
AU2021392032A1 AU2021392032A AU2021392032A AU2021392032A1 AU 2021392032 A1 AU2021392032 A1 AU 2021392032A1 AU 2021392032 A AU2021392032 A AU 2021392032A AU 2021392032 A AU2021392032 A AU 2021392032A AU 2021392032 A1 AU2021392032 A1 AU 2021392032A1
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Australia
Prior art keywords
seq
cell
ipsc
amino acid
cells
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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AU2021392032A
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English (en)
Inventor
Luis Borges
Kenneth Brasel
Liam Campion
Jill Carton
Buddha GURUNG
Heidi Jessup
Barry Morse
Michael Naso
Hillary QUINN
Lucas THOMPSON
Mark WALLET
John Wheeler
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Century Therapeutics Inc
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Century Therapeutics Inc
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Publication date
Application filed by Century Therapeutics Inc filed Critical Century Therapeutics Inc
Publication of AU2021392032A1 publication Critical patent/AU2021392032A1/en
Pending legal-status Critical Current

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001111—Immunoglobulin superfamily
    • A61K39/001112—CD19 or B4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
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    • C12N5/0634—Cells from the blood or the immune system
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AU2021392032A 2020-12-03 2021-12-01 Genetically engineered cells and uses thereof Pending AU2021392032A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202063120980P 2020-12-03 2020-12-03
US202063120948P 2020-12-03 2020-12-03
US202063120799P 2020-12-03 2020-12-03
US63/120,980 2020-12-03
US63/120,799 2020-12-03
US63/120,948 2020-12-03
PCT/US2021/072646 WO2022120334A1 (en) 2020-12-03 2021-12-01 Genetically engineered cells and uses thereof

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AU2021392032A1 true AU2021392032A1 (en) 2023-06-22

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US (2) US12269888B2 (https=)
EP (1) EP4255922A1 (https=)
JP (1) JP2023553419A (https=)
KR (1) KR20230118887A (https=)
AU (1) AU2021392032A1 (https=)
CA (1) CA3201621A1 (https=)
IL (1) IL303269A (https=)
MX (1) MX2023006395A (https=)
TW (1) TW202237827A (https=)
WO (1) WO2022120334A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3210702A1 (en) * 2021-04-07 2022-10-13 Century Therapeutics, Inc. Gene transfer vectors and methods of engineering cells
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