AU2017324939B2 - 2'-substituted-N6-substituted purine nucleotides for RNA virus treatment - Google Patents

2'-substituted-N6-substituted purine nucleotides for RNA virus treatment Download PDF

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Publication number
AU2017324939B2
AU2017324939B2 AU2017324939A AU2017324939A AU2017324939B2 AU 2017324939 B2 AU2017324939 B2 AU 2017324939B2 AU 2017324939 A AU2017324939 A AU 2017324939A AU 2017324939 A AU2017324939 A AU 2017324939A AU 2017324939 B2 AU2017324939 B2 AU 2017324939B2
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formula
hydrogen
compound
virus
methyl
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AU2017324939A1 (en
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Adel Moussa
Jean-Pierre Sommadossi
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Atea Pharmaceuticals Inc
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Atea Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AU2017324939A 2016-09-07 2017-09-06 2'-substituted-N6-substituted purine nucleotides for RNA virus treatment Active AU2017324939B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2020220216A AU2020220216B2 (en) 2016-09-07 2020-08-21 2'-substituted-N6-substituted purine nucleotides for RNA virus treatment
AU2022215185A AU2022215185A1 (en) 2016-09-07 2022-08-09 2'-substituted-N6-substituted purine nucleotides for RNA virus treatment

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662384664P 2016-09-07 2016-09-07
US62/384,664 2016-09-07
PCT/US2017/050323 WO2018048937A1 (en) 2016-09-07 2017-09-06 2'-substituted-n6-substituted purine nucleotides for rna virus treatment

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020220216A Division AU2020220216B2 (en) 2016-09-07 2020-08-21 2'-substituted-N6-substituted purine nucleotides for RNA virus treatment

Publications (2)

Publication Number Publication Date
AU2017324939A1 AU2017324939A1 (en) 2019-03-21
AU2017324939B2 true AU2017324939B2 (en) 2021-10-14

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AU2017324939A Active AU2017324939B2 (en) 2016-09-07 2017-09-06 2'-substituted-N6-substituted purine nucleotides for RNA virus treatment
AU2020220216A Active AU2020220216B2 (en) 2016-09-07 2020-08-21 2'-substituted-N6-substituted purine nucleotides for RNA virus treatment
AU2022215185A Abandoned AU2022215185A1 (en) 2016-09-07 2022-08-09 2'-substituted-N6-substituted purine nucleotides for RNA virus treatment

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AU2020220216A Active AU2020220216B2 (en) 2016-09-07 2020-08-21 2'-substituted-N6-substituted purine nucleotides for RNA virus treatment
AU2022215185A Abandoned AU2022215185A1 (en) 2016-09-07 2022-08-09 2'-substituted-N6-substituted purine nucleotides for RNA virus treatment

Country Status (24)

Country Link
US (3) US10946033B2 (enExample)
EP (3) EP3865136A1 (enExample)
JP (4) JP2019526596A (enExample)
KR (3) KR102456417B1 (enExample)
CN (2) CN109689672B (enExample)
AU (3) AU2017324939B2 (enExample)
BR (1) BR112019004297A2 (enExample)
CA (2) CA3034648C (enExample)
CY (1) CY1125163T1 (enExample)
DK (1) DK3512863T3 (enExample)
EA (2) EA202190602A3 (enExample)
ES (1) ES2907874T3 (enExample)
HR (1) HRP20220278T1 (enExample)
HU (1) HUE057743T2 (enExample)
LT (1) LT3512863T (enExample)
MY (1) MY197236A (enExample)
PL (1) PL3512863T3 (enExample)
PT (1) PT3512863T (enExample)
RS (1) RS62943B1 (enExample)
SG (1) SG11201901457TA (enExample)
SI (1) SI3512863T1 (enExample)
SM (1) SMT202200072T1 (enExample)
WO (1) WO2018048937A1 (enExample)
ZA (2) ZA201901061B (enExample)

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SG11201906163TA (en) 2017-02-01 2019-08-27 Atea Pharmaceuticals Inc Nucleotide hemi-sulfate salt for the treatment of hepatitis c virus
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CN111087421B (zh) * 2019-12-24 2022-10-18 南京正大天晴制药有限公司 一种用于手性药物合成的磷酰胺化合物的制备方法
WO2021173713A1 (en) 2020-02-27 2021-09-02 Atea Pharmaceuticals, Inc. Highly active compounds against covid-19
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19
WO2021253376A1 (zh) * 2020-06-19 2021-12-23 南京正大天晴制药有限公司 一种用于手性药物合成的磷酰胺化合物的制备方法
AU2021327241A1 (en) * 2020-08-19 2023-04-20 Atea Pharmaceuticals, Inc. Stereoselective manufacture of selected purine phosphoramidates
CA3173701A1 (en) * 2020-10-09 2022-04-14 Jean-Pierre Sommadossi Niran interfering drugs for sars-cov-2 mutant therapy
US12274700B1 (en) 2020-10-30 2025-04-15 Accencio LLC Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors
AU2022213335A1 (en) 2021-01-26 2023-07-27 Atea Pharmaceuticals, Inc. Advantageous morphic form of at-527 hemi-sulfate salt
JP2024525164A (ja) 2021-06-17 2024-07-10 アテア ファーマシューティカルズ， インコーポレイテッド 有利な抗ｈｃｖ併用療法
WO2023034617A1 (en) * 2021-09-03 2023-03-09 Atea Pharmaceuticals, Inc. 2'-chloro-2'-fluoro-n2-amino-n6-methylamino purine nucleotides for flavivirus treatment
AU2022339679A1 (en) * 2021-09-03 2024-03-07 Atea Pharmaceuticals, Inc. 2'-chloro-2'-fluoro-n2-amino-n6-methylamino purine nucleotides for flavivirus treatment
CN115232165A (zh) * 2022-08-09 2022-10-25 安徽一灵药业有限公司 索非布韦中间体的合成方法
WO2025014360A1 (en) 2023-07-07 2025-01-16 Erasmus University Medical Center Rotterdam Guanosine nucleotide analogs for use in preventing and/or treating hepatitis e virus infection

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