|
US3547119A
(en)
|
1967-12-08 |
1970-12-15 |
Baxter Laboratories Inc |
Catheter assembly
|
|
US4360019A
(en)
|
1979-02-28 |
1982-11-23 |
Andros Incorporated |
Implantable infusion device
|
|
US4692147A
(en)
|
1980-04-02 |
1987-09-08 |
Medtronic, Inc. |
Drug administration device
|
|
US4311137A
(en)
|
1980-04-30 |
1982-01-19 |
Sherwood Medical Industries Inc. |
Infusion device
|
|
JPS57106673A
(en)
|
1980-12-24 |
1982-07-02 |
Chugai Pharmaceut Co Ltd |
Dibenzo(b,f)(1,4)oxazepin derivative
|
|
US4487603A
(en)
|
1982-11-26 |
1984-12-11 |
Cordis Corporation |
Implantable microinfusion pump system
|
|
US4531937A
(en)
|
1983-01-24 |
1985-07-30 |
Pacesetter Systems, Inc. |
Introducer catheter apparatus and method of use
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
US4725852A
(en)
|
1985-05-09 |
1988-02-16 |
Burlington Industries, Inc. |
Random artificially perturbed liquid apparatus and method
|
|
US4755173A
(en)
|
1986-02-25 |
1988-07-05 |
Pacesetter Infusion, Ltd. |
Soft cannula subcutaneous injection set
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
US4843155A
(en)
|
1987-11-19 |
1989-06-27 |
Piotr Chomczynski |
Product and process for isolating RNA
|
|
US5052558A
(en)
|
1987-12-23 |
1991-10-01 |
Entravision, Inc. |
Packaged pharmaceutical product
|
|
US5033252A
(en)
|
1987-12-23 |
1991-07-23 |
Entravision, Inc. |
Method of packaging and sterilizing a pharmaceutical product
|
|
JPH01167840A
(ja)
|
1987-12-24 |
1989-07-03 |
Konica Corp |
新規な写真用シアンカプラー
|
|
US5744101A
(en)
|
1989-06-07 |
1998-04-28 |
Affymax Technologies N.V. |
Photolabile nucleoside protecting groups
|
|
US5143854A
(en)
|
1989-06-07 |
1992-09-01 |
Affymax Technologies N.V. |
Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
|
|
US6040138A
(en)
|
1995-09-15 |
2000-03-21 |
Affymetrix, Inc. |
Expression monitoring by hybridization to high density oligonucleotide arrays
|
|
US5800992A
(en)
|
1989-06-07 |
1998-09-01 |
Fodor; Stephen P.A. |
Method of detecting nucleic acids
|
|
JP2001524926A
(ja)
|
1991-09-18 |
2001-12-04 |
アフィマックス テクノロジーズ ナームロゼ フェンノートシャップ |
オリゴマーの雑多ライブラリーの集合体を合成する方法
|
|
US5384261A
(en)
|
1991-11-22 |
1995-01-24 |
Affymax Technologies N.V. |
Very large scale immobilized polymer synthesis using mechanically directed flow paths
|
|
DE69233501T2
(de)
|
1991-11-22 |
2006-02-23 |
Affymetrix, Inc. (n.d.Ges.d.Staates Delaware), Santa Clara |
Kombinatorische Strategien für die Polymersynthese
|
|
US5323907A
(en)
|
1992-06-23 |
1994-06-28 |
Multi-Comp, Inc. |
Child resistant package assembly for dispensing pharmaceutical medications
|
|
GB9226855D0
(en)
|
1992-12-23 |
1993-02-17 |
Erba Carlo Spa |
Vinylene-azaindole derivatives and process for their preparation
|
|
EP1302468B1
(en)
|
1992-12-29 |
2008-12-17 |
Abbott Laboratories |
Processes and intermediates for manufacturing retroviral protease inhibiting compounds
|
|
US5545143A
(en)
|
1993-01-21 |
1996-08-13 |
T. S. I. Medical |
Device for subcutaneous medication delivery
|
|
AU690131B2
(en)
|
1993-07-26 |
1998-04-23 |
Variagenics, Inc. |
Inhibitors of alternative alleles of genes as a basis for cancer therapeutic agents
|
|
US6326469B1
(en)
|
1994-04-22 |
2001-12-04 |
Sugen, Inc. |
Megakaryocytic protein tyrosine kinases
|
|
US6207646B1
(en)
|
1994-07-15 |
2001-03-27 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
US5556752A
(en)
|
1994-10-24 |
1996-09-17 |
Affymetrix, Inc. |
Surface-bound, unimolecular, double-stranded DNA
|
|
US5530012A
(en)
|
1994-12-22 |
1996-06-25 |
Bristol-Myers Squibb Co. |
3-alkoxybenzylpiperidine derivatives as melatonergic agents
|
|
US5643207A
(en)
|
1995-04-28 |
1997-07-01 |
Medtronic, Inc. |
Implantable techniques for infusing a therapeutic agent with endogenous bodily fluid
|
|
US5593997A
(en)
|
1995-05-23 |
1997-01-14 |
Pfizer Inc. |
4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors
|
|
US6113898A
(en)
|
1995-06-07 |
2000-09-05 |
Idec Pharmaceuticals Corporation |
Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies
|
|
US5545531A
(en)
|
1995-06-07 |
1996-08-13 |
Affymax Technologies N.V. |
Methods for making a device for concurrently processing multiple biological chip assays
|
|
US5994348A
(en)
|
1995-06-07 |
1999-11-30 |
Sanofi |
Pharmaceutical compositions containing irbesartan
|
|
US5856174A
(en)
|
1995-06-29 |
1999-01-05 |
Affymetrix, Inc. |
Integrated nucleic acid diagnostic device
|
|
US5854033A
(en)
|
1995-11-21 |
1998-12-29 |
Yale University |
Rolling circle replication reporter systems
|
|
JP3416147B2
(ja)
|
1996-01-23 |
2003-06-16 |
アイ・シー・エヌ・フアーマシユーテイカルズ・インコーポレイテツド |
活性化tリンパ球におけるリバビリン及びリバビリン類似体によるth1型/th2型サイトカインの発現の調節
|
|
EP0880598A4
(en)
|
1996-01-23 |
2005-02-23 |
Affymetrix Inc |
RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM
|
|
CH690773A5
(de)
|
1996-02-01 |
2001-01-15 |
Novartis Ag |
Pyrrolo(2,3-d)pyrimide und ihre Verwendung.
|
|
US6054472A
(en)
|
1996-04-23 |
2000-04-25 |
Vertex Pharmaceuticals, Incorporated |
Inhibitors of IMPDH enzyme
|
|
US5807876A
(en)
|
1996-04-23 |
1998-09-15 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of IMPDH enzyme
|
|
CA2252465C
(en)
|
1996-04-23 |
2007-07-03 |
Vertex Pharmaceuticals Incorporated |
Urea derivatives as inhibitors of impdh enzyme
|
|
US5820589A
(en)
|
1996-04-30 |
1998-10-13 |
Medtronic, Inc. |
Implantable non-invasive rate-adjustable pump
|
|
AU3176297A
(en)
|
1996-06-25 |
1998-01-14 |
Novartis Ag |
Substituted 7-amino-pyrrolo{3,2-d}pyrimidines and the use thereof
|
|
EP1254911A1
(en)
|
1996-10-16 |
2002-11-06 |
ICN Pharmaceuticals, Inc. |
Monocyclic L-nucleosides, analogs and uses thereof
|
|
US6756289B1
(en)
|
1996-12-27 |
2004-06-29 |
Canon Kabushiki Kaisha |
Method of producing semiconductor member and method of producing solar cell
|
|
DE69738307T2
(de)
|
1996-12-27 |
2008-10-02 |
Canon K.K. |
Herstellungsverfahren eines Halbleiter-Bauelements und Herstellungsverfahren einer Solarzelle
|
|
DK0966465T3
(da)
|
1997-03-14 |
2003-10-20 |
Vertex Pharma |
Inhibitorer af IMPDH-enzymer
|
|
DK0970084T3
(da)
|
1997-03-19 |
2003-09-29 |
Abbott Gmbh & Co Kg |
Pyrrolo[2,3-d]pyrimidiner og deres anvendelse som inhibitorer for tyrosinkinase
|
|
EP1027456B1
(en)
|
1997-10-31 |
2005-03-16 |
Affymetrix, Inc. (a Delaware Corporation) |
Expression profiles in adult and fetal organs
|
|
GB2332325A
(en)
|
1997-12-10 |
1999-06-16 |
Snell & Wilcox Ltd |
Video signal spatial interpolation for de-interlacing processing
|
|
US7390619B1
(en)
|
1998-02-11 |
2008-06-24 |
Maxygen, Inc. |
Optimization of immunomodulatory properties of genetic vaccines
|
|
US6200754B1
(en)
|
1998-03-19 |
2001-03-13 |
Variagenics, Inc. |
Inhibitors of alternative alleles of genes encoding products that mediate cell response to environmental changes
|
|
US6020135A
(en)
|
1998-03-27 |
2000-02-01 |
Affymetrix, Inc. |
P53-regulated genes
|
|
EP1071658B1
(en)
|
1998-04-17 |
2004-06-16 |
Parker Hughes Institute |
Btk inhibitors and methods for their identification and use
|
|
US6303652B1
(en)
|
1998-08-21 |
2001-10-16 |
Hughes Institute |
BTK inhibitors and methods for their identification and use
|
|
SE9801799D0
(sv)
|
1998-05-20 |
1998-05-20 |
Sten Eric Lindquist |
Färgämnessensiterad nanostrukturerad fotovoltaisk tandemcell
|
|
US6538194B1
(en)
|
1998-05-29 |
2003-03-25 |
Catalysts & Chemicals Industries Co., Ltd. |
Photoelectric cell and process for producing metal oxide semiconductor film for use in photoelectric cell
|
|
US20050287596A9
(en)
|
1998-06-26 |
2005-12-29 |
Braisted Andrew C |
Novel ligands and libraries of ligands
|
|
US6998233B2
(en)
|
1998-06-26 |
2006-02-14 |
Sunesis Pharmaceuticals, Inc. |
Methods for ligand discovery
|
|
US6335155B1
(en)
|
1998-06-26 |
2002-01-01 |
Sunesis Pharmaceuticals, Inc. |
Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules
|
|
US7087236B1
(en)
|
1998-09-01 |
2006-08-08 |
Merrion Research I Limited |
Method for inducing a cell-mediated immune response and improved parenteral vaccine formulations thereof
|
|
CA2345722A1
(en)
|
1998-09-28 |
2000-04-06 |
Albert Edge |
Determining resistance to treatment for hepatitis c virus
|
|
US6824768B2
(en)
|
1998-12-18 |
2004-11-30 |
Schering Corporation |
Ribavirin-pegylated interferon alfa induction HCV combination therapy
|
|
US6198966B1
(en)
|
1999-02-26 |
2001-03-06 |
Medtronic, Inc. |
Recirculating implantable drug delivery system
|
|
US6306897B1
(en)
|
1999-03-19 |
2001-10-23 |
Parker Hughes Institute |
Calanolides for inhibiting BTK
|
|
CA2367017C
(en)
|
1999-03-19 |
2009-05-26 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of impdh enzyme
|
|
AU4463300A
(en)
|
1999-04-19 |
2000-11-02 |
Schering Corporation |
Hcv combination therapy, containing ribavirin in association with antioxidants
|
|
CA2385747A1
(en)
|
1999-09-17 |
2001-03-22 |
Gavin C. Hirst |
Pyrazolopyrimidines as therapeutic agents
|
|
US6921763B2
(en)
|
1999-09-17 |
2005-07-26 |
Abbott Laboratories |
Pyrazolopyrimidines as therapeutic agents
|
|
EP1222187B1
(en)
|
1999-10-06 |
2004-09-22 |
Boehringer Ingelheim Pharmaceuticals Inc. |
Heterocyclic compounds useful as inhibitors of tyrosine kinases
|
|
US6506769B2
(en)
|
1999-10-06 |
2003-01-14 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Heterocyclic compounds useful as inhibitors of tyrosine kinases
|
|
CA2386270A1
(en)
|
1999-10-15 |
2001-04-26 |
University Of Massachusetts |
Rna interference pathway genes as tools for targeted genetic interference
|
|
WO2001032210A2
(en)
|
1999-10-29 |
2001-05-10 |
Pharmacyclics, Inc. |
Compositions for treating atheroma and neoplastic tissue
|
|
EP1235567A2
(en)
|
1999-11-30 |
2002-09-04 |
Parker Hughes Institute |
Inhibitors of collagen-induced platelet aggregation
|
|
AU2439701A
(en)
|
1999-12-17 |
2001-06-25 |
Ariad Pharmaceuticals, Inc. |
Novel heterocycles
|
|
US6602767B2
(en)
|
2000-01-27 |
2003-08-05 |
Canon Kabushiki Kaisha |
Method for transferring porous layer, method for making semiconductor devices, and method for making solar battery
|
|
US7835970B1
(en)
|
2000-02-02 |
2010-11-16 |
Cmvt, Llc |
Method and system for automated auction and tender of complex multi-variable commodities
|
|
GB0005345D0
(en)
|
2000-03-06 |
2000-04-26 |
Mathilda & Terence Kennedy Ins |
Methods of treating sepsis septic shock and inflammation
|
|
WO2001066132A2
(en)
|
2000-03-09 |
2001-09-13 |
Schering Corporation |
Hiv immune adjuvant therapy
|
|
AU2001250572A1
(en)
|
2000-04-07 |
2001-10-23 |
Epigenomics Ag |
Detection of single nucleotide polymorphisms (snp's) and cytosine-methylations
|
|
EP2567811A1
(en)
|
2000-05-19 |
2013-03-13 |
TDK Corporation |
Functional film having functional layer and article provided with the functional layer
|
|
AU8322401A
(en)
|
2000-08-09 |
2002-02-18 |
Univ California |
Indole compounds useful for the treatment of cancer
|
|
EP1326594A2
(en)
|
2000-10-18 |
2003-07-16 |
Schering Corporation |
Ribavirin-pegylated interferon alfa hcv combination therapy
|
|
HUP0303656A3
(en)
|
2000-10-23 |
2006-03-28 |
Bristol Myers Squibb Co |
Modulators of bruton's tyrosine kinase, their identification and use
|
|
US20020094545A1
(en)
|
2000-11-30 |
2002-07-18 |
Harris Paul E. |
Growth of human dendritic cells for cancer immunotherapy in closed system using microcarrier beads
|
|
WO2002045684A2
(en)
|
2000-12-06 |
2002-06-13 |
Pharmacia Corporation |
Rapidly dispersing pharmaceutical composition comprising effervescent agents
|
|
PT1355919E
(pt)
|
2000-12-12 |
2011-03-02 |
Medimmune Llc |
Moléculas com semivida longa, composições que as contêm e suas utilizações
|
|
MXPA03008560A
(es)
|
2001-03-22 |
2004-06-30 |
Abbot Gmbh & Co Kg |
Pirazolopirimidinas como agentes terapeuticos.
|
|
AR036993A1
(es)
|
2001-04-02 |
2004-10-20 |
Wyeth Corp |
Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas
|
|
US8306897B2
(en)
|
2001-05-04 |
2012-11-06 |
Stockshield, Inc. |
Method and system for insuring against investment loss
|
|
US20030103938A1
(en)
|
2001-05-09 |
2003-06-05 |
Alk-Abello A/S |
Pharmaceutical compositions for preventing or treating Th1 and Th2 cell related diseases by modulating the Th1/Th2 ratio
|
|
AU2002315389A1
(en)
|
2001-06-21 |
2003-01-08 |
Ariad Pharmaceuticals, Inc. |
Novel pyrazolo-and pyrrolo-pyrimidines and uses thereof
|
|
GB0116249D0
(en)
|
2001-07-05 |
2001-08-29 |
Imp College Innovations Ltd |
Methods
|
|
US20030124028A1
(en)
|
2001-08-10 |
2003-07-03 |
Carlson Eric D. |
Apparatuses and methods for creating and testing pre-formulations and systems for same
|
|
CA2450777C
(en)
|
2001-08-10 |
2013-04-09 |
Novartis Ag |
Use of c-src inhibitors alone or in combination with sti571 for the treatment of leukaemia
|
|
WO2003016338A1
(en)
|
2001-08-15 |
2003-02-27 |
Parker Hughes Institute |
Crystal structure of the btk kinase domain
|
|
US7622260B2
(en)
|
2001-09-05 |
2009-11-24 |
The Brigham And Women's Hospital, Inc. |
Diagnostic and prognostic tests
|
|
CA2464094C
(en)
|
2001-11-21 |
2013-07-02 |
Sunesis Pharmaceuticals, Inc. |
Methods for ligand discovery
|
|
US20030175761A1
(en)
|
2001-12-07 |
2003-09-18 |
Sabath Daniel E. |
Identification of genes whose expression patterns distinguish benign lymphoid tissue and mantle cell, follicular, and small lymphocytic lymphoma
|
|
US20050084905A1
(en)
|
2002-03-21 |
2005-04-21 |
Prescott John C. |
Identification of kinase inhibitors
|
|
WO2003081210A2
(en)
|
2002-03-21 |
2003-10-02 |
Sunesis Pharmaceuticals, Inc. |
Identification of kinase inhibitors
|
|
JP2006503264A
(ja)
|
2002-04-08 |
2006-01-26 |
サネシス ファーマシューティカルズ, インコーポレイテッド |
アロステリック部位を同定するための方法
|
|
JP3764402B2
(ja)
|
2002-05-02 |
2006-04-05 |
パイロットインキ株式会社 |
移動玩具セット
|
|
GB2388594A
(en)
|
2002-05-16 |
2003-11-19 |
Bayer Ag |
Imidazo-triazine PDE 4 inhibitors
|
|
CN1688340A
(zh)
|
2002-07-15 |
2005-10-26 |
韦思公司 |
调节t辅助(th)细胞发育和功能的方法和组合物
|
|
WO2004014905A1
(en)
|
2002-08-08 |
2004-02-19 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Substituted benzimidazole compounds
|
|
AU2003300184B8
(en)
|
2002-12-30 |
2009-12-03 |
3M Innovative Properties Company |
Immunostimulatory combinations
|
|
GB0303910D0
(en)
|
2003-02-20 |
2003-03-26 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
EP1463073A1
(en)
|
2003-03-24 |
2004-09-29 |
Sony International (Europe) GmbH |
Porous film having a gradient of light scattering strength
|
|
US7687506B2
(en)
|
2003-04-11 |
2010-03-30 |
The Regents Of The University Of California |
Selective serine/threonine kinase inhibitors
|
|
WO2004100868A2
(en)
|
2003-04-23 |
2004-11-25 |
Abbott Laboratories |
Method of treating transplant rejection
|
|
EP1473039A1
(en)
|
2003-05-02 |
2004-11-03 |
Centre National De La Recherche Scientifique (Cnrs) |
Use of inhibitors and antisense oligonucleotides of BTK for the treatment of proliferative mastocytosis
|
|
WO2004110245A2
(en)
|
2003-05-16 |
2004-12-23 |
Intermune, Inc. |
Combination therapy for cancer treatment
|
|
US7405295B2
(en)
|
2003-06-04 |
2008-07-29 |
Cgi Pharmaceuticals, Inc. |
Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
|
|
US7393848B2
(en)
|
2003-06-30 |
2008-07-01 |
Cgi Pharmaceuticals, Inc. |
Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of Bruton's tyrosine kinase by such compounds
|
|
US8131475B2
(en)
|
2003-09-03 |
2012-03-06 |
The United States Of America As Represented By The Secretary, Department Of Health And Human Services |
Methods for identifying, diagnosing, and predicting survival of lymphomas
|
|
JP2005089352A
(ja)
|
2003-09-16 |
2005-04-07 |
Kissei Pharmaceut Co Ltd |
新規なイミダゾ[1,5−a]ピラジン誘導体、それを含有する医薬組成物およびそれらの用途
|
|
EP1670503A4
(en)
|
2003-09-30 |
2008-09-24 |
Telethon Inst For Child Health |
IMMUNOTHERAPY METHOD
|
|
CN1897950A
(zh)
|
2003-10-14 |
2007-01-17 |
惠氏公司 |
稠合芳基和杂芳基衍生物及其使用方法
|
|
KR100872204B1
(ko)
|
2003-10-15 |
2008-12-09 |
오에스아이 파마슈티컬스, 인코포레이티드 |
이미다조피라진 티로신 키나제 억제제
|
|
US20050288295A1
(en)
|
2003-11-11 |
2005-12-29 |
Currie Kevin S |
Certain imidazo[1,2-a]pyrazin-8-ylamines, method of making, and method of use thereof
|
|
WO2005060956A1
(en)
|
2003-12-12 |
2005-07-07 |
University Of Maryland, Baltimore |
IMMUNOMODULATORY COMPOUNDS THAT TARGET AND INHIBIT THE pY+3 BINDING SITE OF TYROSENE KINASE p56 LCK SH2 DOMAIN
|
|
US20050153990A1
(en)
|
2003-12-22 |
2005-07-14 |
Watkins William J. |
Phosphonate substituted kinase inhibitors
|
|
US20070281907A1
(en)
|
2003-12-22 |
2007-12-06 |
Watkins William J |
Kinase Inhibitor Phosphonate Conjugates
|
|
JP2007517879A
(ja)
|
2004-01-08 |
2007-07-05 |
ワイス |
Cci−779経口投与用の直接圧縮可能な医薬組成物
|
|
NZ546058A
(en)
|
2004-01-12 |
2010-09-30 |
Ym Biosciences Australia Pty |
Benzimidazole and other fused ring derivatives as selective janus kinase inhibitors
|
|
US7855214B2
(en)
|
2004-01-26 |
2010-12-21 |
Vertex Pharmaceuticals Incorporated |
Fused cyclic systems useful as inhibitors of TEC family protein kinases
|
|
JP2007520559A
(ja)
|
2004-02-03 |
2007-07-26 |
アボット・ラボラトリーズ |
治療薬としてのアミノベンゾオキサゾール類
|
|
EP2298291A3
(en)
|
2004-06-18 |
2011-08-03 |
Agennix USA Inc. |
Kinase inhibitors for treating cancers
|
|
ITMI20041314A1
(it)
|
2004-06-30 |
2004-09-30 |
Nuvera Fuel Cells Europ Srl |
Dispositivo di raffreddamento per celle a combustibili a membrana
|
|
TW200613306A
(en)
|
2004-07-20 |
2006-05-01 |
Osi Pharm Inc |
Imidazotriazines as protein kinase inhibitors
|
|
EP1805676A1
(en)
|
2004-09-22 |
2007-07-11 |
Tripath Imaging, Inc. |
Methods and computer program products for analysis and optimization of marker candidates for cancer prognosis
|
|
WO2006036941A2
(en)
|
2004-09-27 |
2006-04-06 |
Kosan Biosciences Incorporated |
Specific kinase inhibitors
|
|
US20060069123A1
(en)
|
2004-09-28 |
2006-03-30 |
Mingde Xia |
Substituted dipiperidine CCR2 antagonists
|
|
WO2006039644A2
(en)
|
2004-10-01 |
2006-04-13 |
Medarex, Inc. |
Methods of treating cd30 positive lymphomas
|
|
CA2587192A1
(en)
|
2004-11-10 |
2006-05-18 |
Cgi Pharmaceuticals, Inc. |
Imidazo[1 , 2-a] pyrazin-8-ylamines useful as modulators of kinase activity
|
|
GB0425035D0
(en)
|
2004-11-12 |
2004-12-15 |
Novartis Ag |
Organic compounds
|
|
CA2591413A1
(en)
|
2004-12-16 |
2006-06-22 |
Vertex Pharmaceuticals Incorporated |
Pyrid-2-ones useful as inhibitors of tec family protein kinases for the treatment of inflammatory, proliferative and immunologically-mediated diseases
|
|
KR100735639B1
(ko)
|
2004-12-29 |
2007-07-04 |
한미약품 주식회사 |
암세포 성장 억제 효과를 갖는 퀴나졸린 유도체 및 이의제조방법
|
|
ES2364495T3
(es)
|
2005-02-03 |
2011-09-05 |
The General Hospital Corporation |
Método para tratar cáncer resistente a gefitinib.
|
|
CA2601628C
(en)
|
2005-03-10 |
2014-05-13 |
Cgi Pharmaceuticals, Inc. |
Certain substituted amides, method of making, and method of use thereof
|
|
KR20070104673A
(ko)
|
2005-03-23 |
2007-10-26 |
화이자 프로덕츠 인코포레이티드 |
암의 치료를 위한 항-ctla4 항체와 인돌리논병용요법
|
|
KR20080025039A
(ko)
|
2005-05-13 |
2008-03-19 |
아이알엠 엘엘씨 |
단백질 키나제 억제제로서의 화합물 및 조성물
|
|
AU2006272951A1
(en)
|
2005-05-17 |
2007-02-01 |
Plexxikon, Inc. |
Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
|
|
CN102206216B
(zh)
|
2005-06-22 |
2014-11-12 |
普莱希科公司 |
作为蛋白质激酶抑制剂的吡咯并[2,3-b]吡啶衍生物
|
|
CN104356236B
(zh)
|
2005-07-01 |
2020-07-03 |
E.R.施贵宝&圣斯有限责任公司 |
抗程序性死亡配体1(pd-l1)的人单克隆抗体
|
|
WO2007027594A1
(en)
|
2005-08-29 |
2007-03-08 |
Vertex Pharmaceuticals Incorporated |
3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases
|
|
US20070065449A1
(en)
|
2005-09-16 |
2007-03-22 |
Claire Verschraegen |
Method of treating cancer, especially soft tissue sarcoma utilizing gemcitabine in combination with docetaxel and anti-VEGF therapy (bevacizumab)
|
|
WO2007052059A2
(en)
|
2005-11-04 |
2007-05-10 |
Novartis Vaccines And Diagnostics Srl |
Changing th1/th2 balance in split influenza vaccines with adjuvants
|
|
WO2007058832A2
(en)
|
2005-11-12 |
2007-05-24 |
Boehringer Ingelheim International Gmbh |
Pyrrolo (2, 3-b) pyridine derivatives useful as tec kinase inhibitors
|
|
WO2007059329A2
(en)
|
2005-11-16 |
2007-05-24 |
Pharmacyclics, Inc. |
Methods and compositions for treating cancer
|
|
KR20080098490A
(ko)
|
2006-01-13 |
2008-11-10 |
파마시클릭스, 인코포레이티드 |
티로신 키나제 억제제 및 이의 용도
|
|
EP1984030B1
(en)
|
2006-01-30 |
2013-05-08 |
The Scripps Research Institute |
Methods for detection of circulating tumor cells and methods of diagnosis of cancer in a mammalian subject
|
|
US7908091B2
(en)
|
2006-03-17 |
2011-03-15 |
Prometheus Laboratories Inc. |
Methods of predicting and monitoring tyrosine kinase inhibitor therapy
|
|
GB0605521D0
(en)
|
2006-03-18 |
2006-04-26 |
Isis Innovation |
Adjuvant
|
|
WO2007114926A2
(en)
|
2006-04-04 |
2007-10-11 |
The Regents Of The University Of California |
Kinase antagonists
|
|
CA2645633A1
(en)
|
2006-04-05 |
2007-11-01 |
Novartis Ag |
Combinations of therapeutic agents for treating cancer
|
|
CN101415426A
(zh)
|
2006-04-07 |
2009-04-22 |
诺瓦提斯公司 |
c-Src抑制剂与嘧啶基氨基苯甲酰胺类化合物的组合治疗白血病的用途
|
|
MX2008014450A
(es)
|
2006-05-18 |
2009-03-09 |
Mannkind Corp |
Inhibidores de cinasa intracelular.
|
|
US20080131398A1
(en)
|
2006-08-21 |
2008-06-05 |
United Therapeutics Corporation |
Combination therapy for treatment of viral infections
|
|
WO2008033858A2
(en)
|
2006-09-11 |
2008-03-20 |
Cgi Pharmaceuticals, Inc. |
Kinase inhibitors, and methods of using and identifying kinase inhibitors
|
|
AR063946A1
(es)
|
2006-09-11 |
2009-03-04 |
Cgi Pharmaceuticals Inc |
Determinadas pirimidinas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmaceuticas que las comprenden.
|
|
AR063707A1
(es)
|
2006-09-11 |
2009-02-11 |
Cgi Pharmaceuticals Inc |
Determinadas amidas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmacéuticas que las comprenden.
|
|
BRPI0622054B8
(pt)
|
2006-09-22 |
2021-05-25 |
Oxford Amherst Llc |
composto e composição farmacêutica
|
|
EP2862579B1
(en)
|
2006-10-04 |
2017-05-17 |
Dana-Farber Cancer Institute, Inc. |
Tumor immunity
|
|
NZ598071A
(en)
|
2006-10-27 |
2013-08-30 |
Signal Pharm Llc |
Uses of and pharmaceutical compositions comprising 4-[9-(tetrahydro-furan-3-yl)-8-(2,4,6-trifluoro-phenylamino)-9h-purin-2-ylamino]-cyclohexan-1-ol compounds
|
|
US20100248225A1
(en)
|
2006-11-06 |
2010-09-30 |
Bankaitis-Davis Danute M |
Gene expression profiling for identification, monitoring and treatment of melanoma
|
|
RU2446796C2
(ru)
|
2006-12-26 |
2012-04-10 |
Фармасайкликс, Инк. |
Способ использования ингибиторов гистондеацетилазы и мониторинга биомаркеров в комбинированной терапии
|
|
US8846704B2
(en)
|
2007-01-31 |
2014-09-30 |
YM Biosciences Austraila Pty Ltd |
Thiopyrimidine-based compounds and uses thereof
|
|
BRPI0807812A2
(pt)
|
2007-02-15 |
2020-06-23 |
Novartis Ag |
Combinações de lbh589 com outros agentes terapêuticos para tratar câncer
|
|
NL2000640C2
(nl)
|
2007-03-05 |
2008-09-08 |
Stichting Wetsus Ct Of Excelle |
Werkwijze en systeem voor het zuiveren van een vloeistof.
|
|
JP5832721B2
(ja)
|
2007-03-14 |
2015-12-16 |
バイオンシル・エス.アール.エル.Bionsil S.R.L. |
上皮腫瘍細胞における薬剤耐性のモジュレータ化合物
|
|
IL295053A
(en)
|
2007-03-28 |
2022-09-01 |
Pharmacyclics Llc |
Broton tyrosine kinase inhibitors
|
|
US20120065201A1
(en)
|
2007-03-28 |
2012-03-15 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
|
US20120101114A1
(en)
|
2007-03-28 |
2012-04-26 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
|
AU2008236634A1
(en)
|
2007-04-05 |
2008-10-16 |
Aureon Laboratories, Inc. |
Systems and methods for treating, diagnosing and predicting the occurrence of a medical condition
|
|
US20090010911A1
(en)
|
2007-04-06 |
2009-01-08 |
Iowa State University Research Foundation, Inc. |
Methods and compositions for affecting cyclophilin a regulation of kinases in modulating cellular activities
|
|
WO2008127659A2
(en)
|
2007-04-13 |
2008-10-23 |
University Of Texas Southwestern Medical Center |
Combination therapy for cancer
|
|
DK2142529T3
(da)
|
2007-04-27 |
2014-02-10 |
Purdue Pharma Lp |
Trpv1-antagonister og anvendelser deraf
|
|
WO2008138578A2
(en)
|
2007-05-11 |
2008-11-20 |
Medical Prognosis Institute |
Methods, kits, and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy
|
|
WO2009021137A2
(en)
|
2007-08-07 |
2009-02-12 |
Purdue Research Foundation |
Kinase inhibitors and uses thereof
|
|
JP5376780B2
(ja)
|
2007-08-08 |
2013-12-25 |
株式会社東芝 |
圧電モータおよびカメラ装置
|
|
WO2009048307A2
(en)
|
2007-10-12 |
2009-04-16 |
Electronics And Telecommunications Research Institute |
Mobile rfid reader and rfid communication method using shared system clock
|
|
CN105367503A
(zh)
|
2007-10-19 |
2016-03-02 |
阿维拉制药公司 |
杂芳基化合物和其用途
|
|
US7989465B2
(en)
|
2007-10-19 |
2011-08-02 |
Avila Therapeutics, Inc. |
4,6-disubstituted pyrimidines useful as kinase inhibitors
|
|
WO2009053269A1
(en)
|
2007-10-23 |
2009-04-30 |
F. Hoffmann-La Roche Ag |
Novel kinase inhibitors
|
|
NZ585500A
(en)
|
2007-11-12 |
2012-06-29 |
Theraclone Sciences Inc |
Antibodies which bind to an epitope in the extracellular domain of the matrix 2 ectodomain polypeptide of an influenza virus
|
|
US8426441B2
(en)
|
2007-12-14 |
2013-04-23 |
Roche Palo Alto Llc |
Inhibitors of bruton's tyrosine kinase
|
|
US20150152115A1
(en)
|
2007-12-27 |
2015-06-04 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
|
CN101475632B
(zh)
|
2008-01-03 |
2012-01-04 |
张喜田 |
具有抗肿瘤作用的重组灵芝免疫调节蛋白及其药物制剂
|
|
WO2009089399A2
(en)
|
2008-01-10 |
2009-07-16 |
Bausch & Lomb Incorporated |
Compositions comprising toll-like receptor or coreceptor antagonists and methods for ocular neuroprotection
|
|
GB0805356D0
(en)
|
2008-03-25 |
2008-04-30 |
Isis Innovation |
Vaccine adjuvant composition
|
|
AU2009228616B2
(en)
|
2008-03-25 |
2014-07-24 |
Roche Glycart Ag |
Use of a type II anti-CD20 antibody with increased antibody dependent cellular cytotoxicity (ADCC) in combination with cyclophosphamide, vincristine and doxorubicine for treating non-Hodgkin' s lymphomas
|
|
US8426424B2
(en)
|
2008-05-06 |
2013-04-23 |
Cgi Pharmaceuticals, Inc. |
Certain substituted amides, method of making, and method of use thereof
|
|
PE20091846A1
(es)
|
2008-05-19 |
2009-12-16 |
Plexxikon Inc |
DERIVADOS DE PIRROLO[2,3-d]-PIRIMIDINA COMO MODULADORES DE CINASAS
|
|
CN102036658A
(zh)
|
2008-05-23 |
2011-04-27 |
香港大学 |
治疗流感的联合疗法
|
|
US20110218512A1
(en)
|
2008-06-03 |
2011-09-08 |
Aethlon Medical, Inc. |
Enhanced antiviral therapy methods and devices
|
|
ES2383246T3
(es)
|
2008-06-05 |
2012-06-19 |
Glaxo Group Limited |
4-amino-indazoles
|
|
ES2552320T3
(es)
|
2008-06-24 |
2015-11-27 |
F. Hoffmann-La Roche Ag |
Nuevas piridín-2-onas y piridazín-3-onas sustituidas
|
|
TWI546290B
(zh)
|
2008-06-27 |
2016-08-21 |
賽基艾維洛米斯研究股份有限公司 |
雜芳基化合物及其用途
|
|
ES2660418T3
(es)
|
2008-07-16 |
2018-03-22 |
Pharmacyclics Llc |
Inhibidores de la tirosina quinasa de Bruton para el tratamiento de tumores sólidos
|
|
ES2620442T3
(es)
|
2008-07-29 |
2017-06-28 |
Frontier Scientific, Inc. |
Uso de derivados de tetraquis(N-alquilpiridinio)-porfirina para la destrucción de microbios o la prevención de su crecimiento
|
|
JP2012501654A
(ja)
|
2008-09-05 |
2012-01-26 |
アビラ セラピューティクス, インコーポレイテッド |
不可逆的インヒビターの設計のためのアルゴリズム
|
|
JP2012503619A
(ja)
|
2008-09-26 |
2012-02-09 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
Hcv感染に対する抗ウイルス治療のための標的としての宿主細胞キナーゼ
|
|
WO2010056875A1
(en)
|
2008-11-12 |
2010-05-20 |
Cgi Pharmaceuticals, Inc. |
Pyridazinones and their use as btk inhibitors
|
|
CN102271683B
(zh)
|
2008-11-13 |
2014-07-09 |
吉里德卡利斯托加公司 |
恶性血液病的治疗
|
|
UA108193C2
(uk)
|
2008-12-04 |
2015-04-10 |
|
Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань
|
|
US20100160322A1
(en)
|
2008-12-04 |
2010-06-24 |
Abbott Laboratories |
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
|
|
US8426428B2
(en)
|
2008-12-05 |
2013-04-23 |
Principia Biopharma, Inc. |
EGFR kinase knockdown via electrophilically enhanced inhibitors
|
|
AU2009333580B2
(en)
|
2008-12-09 |
2016-07-07 |
Genentech, Inc. |
Anti-PD-L1 antibodies and their use to enhance T-cell function
|
|
ES2467108T3
(es)
|
2008-12-09 |
2014-06-11 |
Gilead Sciences, Inc. |
Moduladores de receptores tipo toll
|
|
WO2010068806A1
(en)
|
2008-12-10 |
2010-06-17 |
Cgi Pharmaceuticals, Inc. |
Amide derivatives as btk inhibitors in the treatment of allergic, autoimmune and inflammatory disorders as well as cancer
|
|
WO2010068788A1
(en)
|
2008-12-10 |
2010-06-17 |
Cgi Pharmaceuticals, Inc. |
Heterocyclic amides as btk inhibitors
|
|
WO2010068810A2
(en)
|
2008-12-10 |
2010-06-17 |
Cgi Pharmaceuticals, Inc. |
Certain substituted amides, method of making, and method of use thereof
|
|
JP2012512157A
(ja)
|
2008-12-15 |
2012-05-31 |
イーライ リリー アンド カンパニー |
癌を治療するためのエンザスタウリン
|
|
CA2745284A1
(en)
|
2008-12-18 |
2010-06-24 |
F. Hoffmann-La Roche Ag |
Biomarkers for hcv treatment response
|
|
JP5487214B2
(ja)
|
2008-12-19 |
2014-05-07 |
ブリストル−マイヤーズ スクイブ カンパニー |
キナーゼ阻害剤として有用なカルバゾールカルボキシアミド化合物
|
|
WO2010093843A2
(en)
|
2009-02-12 |
2010-08-19 |
Vertex Pharmaceuticals Incorporated |
Hcv combination therapies
|
|
US8299077B2
(en)
|
2009-03-02 |
2012-10-30 |
Roche Palo Alto Llc |
Inhibitors of Bruton's tyrosine kinase
|
|
WO2010123891A1
(en)
|
2009-04-20 |
2010-10-28 |
Genentech, Inc. |
Adjuvant cancer therapy
|
|
EP2424368B1
(en)
|
2009-04-29 |
2014-12-31 |
Locus Pharmaceuticals, Inc. |
Pyrrolotriazine compounds
|
|
NZ595708A
(en)
|
2009-05-26 |
2014-03-28 |
Abbvie Bahamas Ltd |
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
|
|
EP2440204B1
(en)
|
2009-06-12 |
2013-12-18 |
Bristol-Myers Squibb Company |
Nicotinamide compounds useful as kinase modulators
|
|
LU91583B1
(en)
|
2009-07-03 |
2011-01-04 |
Wurth Paul Sa |
Sealing valve arrangement for a shaft furnace charging installation
|
|
PT2473049T
(pt)
|
2009-09-04 |
2019-03-04 |
Sunesis Pharmaceuticals Inc |
Inibidores de tirosina quinase de bruton
|
|
NZ620174A
(en)
|
2009-09-16 |
2016-08-26 |
Celgene Avilomics Res Inc |
Protein kinase conjugates and inhibitors
|
|
GB2474748B
(en)
|
2009-10-01 |
2011-10-12 |
Amira Pharmaceuticals Inc |
Polycyclic compounds as lysophosphatidic acid receptor antagonists
|
|
US7718662B1
(en)
|
2009-10-12 |
2010-05-18 |
Pharmacyclics, Inc. |
Pyrazolo-pyrimidine inhibitors of bruton's tyrosine kinase
|
|
US8859776B2
(en)
|
2009-10-14 |
2014-10-14 |
Merck Sharp & Dohme Corp. |
Substituted piperidines that increase p53 activity and the uses thereof
|
|
US8299070B2
(en)
|
2009-11-25 |
2012-10-30 |
Japan Tobacco Inc. |
Indole compounds and pharmaceutical use thereof
|
|
CN102762208A
(zh)
|
2009-12-04 |
2012-10-31 |
赛林药物股份有限公司 |
作为ck2抑制剂的吡唑嘧啶和相关杂环
|
|
WO2011133609A2
(en)
*
|
2010-04-19 |
2011-10-27 |
The Translational Genomics Research Institute |
Methods and kits to predict therapeutic outcome of btk inhibitors
|
|
KR101862327B1
(ko)
|
2010-05-07 |
2018-05-29 |
질레드 코네티컷 인코포레이티드 |
피리돈 및 아자-피리돈 화합물 및 사용 방법
|
|
JP5960688B2
(ja)
|
2010-05-17 |
2016-08-02 |
インコゼン セラピューティクス プライベート リミテッド |
プロテインキナーゼ調節物質としての新規3,5−二置換−3h−[1,2,3]トリアゾロ[4,5−b]ピリジン化合物
|
|
EP2571530A4
(en)
|
2010-05-20 |
2014-03-05 |
Univ Rochester |
METHOD AND COMPOSITIONS FOR AUTOPHAGIA MODULATION
|
|
BR112012030711B1
(pt)
|
2010-05-31 |
2020-10-13 |
Ono Pharmaceutical Co. Ltd |
derivado de purinona
|
|
US20120071497A1
(en)
|
2010-06-03 |
2012-03-22 |
Pharmacyclics, Inc. |
Methods of treating abc-dlbcl using inhibitors of bruton's tyrosine kinase
|
|
CN107898791A
(zh)
|
2010-06-03 |
2018-04-13 |
药品循环有限责任公司 |
布鲁顿酪氨酸激酶(btk)抑制剂的应用
|
|
US20130102477A1
(en)
|
2010-06-23 |
2013-04-25 |
Ryan D. Morin |
Biomarkers for non-hodgkin lymphomas and uses thereof
|
|
PT2585470T
(pt)
|
2010-06-23 |
2017-03-06 |
Hanmi Science Co Ltd |
Novos derivados fundidos de pirimidina para inibição da actividade da tirosina cinase
|
|
GB2481611A
(en)
|
2010-06-30 |
2012-01-04 |
Statoil Asa |
Test cell for well fluid assessment
|
|
CN105566229A
(zh)
|
2010-08-10 |
2016-05-11 |
西建阿维拉米斯研究公司 |
Btk抑制剂的苯磺酸盐及其用途和制备方法
|
|
AR082590A1
(es)
|
2010-08-12 |
2012-12-19 |
Hoffmann La Roche |
Inhibidores de la tirosina-quinasa de bruton
|
|
WO2012025186A1
(en)
|
2010-08-27 |
2012-03-01 |
Merck Patent Gmbh |
Triazolopyrazine derivatives
|
|
CA2809836C
(en)
|
2010-09-01 |
2019-01-15 |
Gilead Connecticut, Inc. |
Pyridinones/pyrazinones, method of making, and method of use thereof for the treatment of disorders mediated by bruton's tyrosine kinase
|
|
BR112013007499A2
(pt)
|
2010-09-01 |
2016-07-12 |
Genentech Inc |
piridazinonas - métodos de criação e usos
|
|
TWI620736B
(zh)
|
2010-11-23 |
2018-04-11 |
艾伯維巴哈馬有限公司 |
使用選擇性bcl-2抑制劑之治療方法
|
|
WO2012118632A1
(en)
|
2011-02-28 |
2012-09-07 |
Ning Xi |
Substituted quinoline compounds and methods of use
|
|
EP2694486B1
(en)
|
2011-04-01 |
2018-01-10 |
University of Utah Research Foundation |
Substituted n-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase btk inhibitors
|
|
US20140107151A1
(en)
|
2011-05-17 |
2014-04-17 |
Principia Biophama Inc. |
Tyrosine kinase inhibitors
|
|
CN103582637B
(zh)
|
2011-05-17 |
2015-08-12 |
弗·哈夫曼-拉罗切有限公司 |
酪氨酸激酶抑制剂
|
|
US9376438B2
(en)
|
2011-05-17 |
2016-06-28 |
Principia Biopharma, Inc. |
Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
|
|
CA2836417A1
(en)
|
2011-05-17 |
2012-11-22 |
Principia Biopharma Inc. |
Azaindole derivatives as tyrosine kinase inhibitors
|
|
EA025496B1
(ru)
|
2011-05-17 |
2016-12-30 |
Принсипиа Биофарма Инк. |
Ингибиторы тирозинкиназы
|
|
ES2585244T3
(es)
|
2011-06-07 |
2016-10-04 |
Clevexel Pharma |
Composiciones y métodos para modular una cinasa
|
|
AU2012275841A1
(en)
|
2011-06-27 |
2014-01-16 |
The Jackson Laboratory |
Methods and compositions for treatment of cancer and autoimmune disease
|
|
KR20140058543A
(ko)
|
2011-07-08 |
2014-05-14 |
노파르티스 아게 |
신규 피롤로 피리미딘 유도체
|
|
EP2548877A1
(en)
|
2011-07-19 |
2013-01-23 |
MSD Oss B.V. |
4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors
|
|
JP2014522860A
(ja)
|
2011-07-19 |
2014-09-08 |
メルク・シャープ・アンド・ドーム・ベー・フェー |
Btk阻害剤としての4−イミダゾピリダジン−1−イル−ベンズアミドおよび4−イミダゾトリアジン−1−イル−ベンズアミド
|
|
BR112014001255B1
(pt)
|
2011-07-19 |
2019-07-02 |
Merck Sharp & Dohme B.V. |
Composto, uso de um composto, combinação, composição farmacêutica, e, sal farmaceuticamente aceitável de um composto
|
|
MX2014000648A
(es)
|
2011-07-19 |
2014-09-25 |
Infinity Pharmaceuticals Inc |
Compuestos heterociclicos y sus usos.
|
|
CN103748088A
(zh)
|
2011-08-17 |
2014-04-23 |
弗·哈夫曼-拉罗切有限公司 |
酪氨酸激酶抑制剂
|
|
WO2013036994A1
(en)
|
2011-09-16 |
2013-03-21 |
Biota Scientific Management Pty Ltd |
Compounds for the treatment of hcv
|
|
WO2013059738A2
(en)
|
2011-10-19 |
2013-04-25 |
Pharmacyclics, Inc. |
Use of inhibitors of bruton's tyrosine kinase (btk)
|
|
CN103073508B
(zh)
|
2011-10-25 |
2016-06-01 |
北京大学深圳研究生院 |
激酶抑制剂及治疗相关疾病的方法
|
|
CA2853138A1
(en)
|
2011-12-05 |
2013-06-13 |
Immunomedics, Inc. |
Therapeutic use of anti-cd22 antibodies for inducing trogocytosis
|
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
|
CN104582705A
(zh)
|
2012-01-10 |
2015-04-29 |
林伯士艾瑞斯公司 |
白介素-1受体相关激酶(irak)抑制剂和其用途
|
|
US8501724B1
(en)
|
2012-01-31 |
2013-08-06 |
Pharmacyclics, Inc. |
Purinone compounds as kinase inhibitors
|
|
US20150072988A1
(en)
|
2012-03-30 |
2015-03-12 |
The Johns Hopkins University |
Use of n-(4-((3-(2-amino-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamine in combination with histone deacetylase inhibitors for treatment of cancer
|
|
GB201207305D0
(en)
|
2012-04-26 |
2012-06-13 |
E Therapeutics Plc |
Therapy
|
|
JP5514256B2
(ja)
|
2012-05-18 |
2014-06-04 |
株式会社東芝 |
磁気記憶素子及びその製造方法
|
|
JO3754B1
(ar)
|
2012-06-04 |
2021-01-31 |
Pharmacyclics Llc |
أشكال كريستالين لمثبط أنزيم كيناز تيروسين بروتون
|
|
JP6280546B2
(ja)
|
2012-06-26 |
2018-02-14 |
デル マー ファーマシューティカルズ |
ジアンヒドロガラクチトール、ジアセチルジアンヒドロガラクチトール、ジブロモズルシトール、又はこれらの類似体若しくは誘導体を用いた、遺伝子多型又はahi1の調節不全若しくは変異を有する患者におけるチロシンキナーゼインヒビター抵抗性悪性腫瘍を処置するための方法
|
|
WO2014004707A1
(en)
|
2012-06-29 |
2014-01-03 |
Principia Biopharma Inc. |
Formulations comprising ibrutinib
|
|
CA3135005A1
(en)
|
2012-07-10 |
2014-01-16 |
The Regents Of The University Of California |
Methods of inducing anesthesia
|
|
US8684552B2
(en)
|
2012-07-11 |
2014-04-01 |
Agio International Company, Ltd |
Lighted furniture assembly
|
|
CN104704129A
(zh)
|
2012-07-24 |
2015-06-10 |
药品循环公司 |
与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变
|
|
CN104768581A
(zh)
|
2012-09-07 |
2015-07-08 |
吉宁特有限公司 |
II型抗CD20抗体与选择性Bcl-2抑制剂的组合治疗
|
|
WO2014071205A1
(en)
|
2012-11-02 |
2014-05-08 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for diagnosis, prognosis and treatment of hematological malignancies
|
|
SG11201503459SA
(en)
|
2012-11-02 |
2015-06-29 |
Pharmacyclics Inc |
Tec family kinase inhibitor adjuvant therapy
|
|
EA201590855A1
(ru)
|
2012-11-15 |
2015-11-30 |
Фармасайкликс, Инк. |
Соединения пирролопиримидина как ингибиторы киназ
|
|
JP2016505012A
(ja)
|
2013-01-10 |
2016-02-18 |
ニンバス アイリス, インコーポレイテッド |
Irak阻害剤およびその使用
|
|
WO2014114185A1
(en)
|
2013-01-23 |
2014-07-31 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
|
CA2895284A1
(en)
|
2013-02-07 |
2014-08-14 |
Immunomedics, Inc. |
Pro-drug form (p2pdox) of the highly potent 2-pyrrolinodoxorubicin conjugated to antibodies for targeted therapy of cancer
|
|
FR3002733B1
(fr)
|
2013-03-04 |
2015-08-14 |
Servier Lab |
Nouveau sel de l'abexinostat, forme cristalline associee,leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
ES2662598T3
(es)
|
2013-03-08 |
2018-04-09 |
F. Hoffmann-La Roche Ag |
Análisis de sangre para la detección de mutaciones de EGFR
|
|
JP2016512549A
(ja)
|
2013-03-14 |
2016-04-28 |
ファーマサイクリックス エルエルシー |
ブルトン型チロシンキナーゼ阻害剤及びcyp3a4阻害剤の組み合わせ
|
|
HK1215374A1
(zh)
|
2013-04-08 |
2016-08-26 |
Pharmacyclics Llc |
依鲁替尼联合疗法
|
|
SG11201509842SA
(en)
|
2013-05-30 |
2015-12-30 |
Infinity Pharmaceuticals Inc |
Treatment of cancers using pi3 kinase isoform modulators
|
|
WO2014195888A1
(en)
|
2013-06-07 |
2014-12-11 |
Rhizen Pharmaceuticals Sa |
Dual selective pi3 delta and gamma kinase inhibitors
|
|
CN105764501A
(zh)
|
2013-07-26 |
2016-07-13 |
现代化制药公司 |
改善比生群治疗效益的组合物
|
|
CA2919996A1
(en)
|
2013-08-02 |
2015-02-05 |
Pharmacyclics Llc |
Methods for the treatment of solid tumors
|
|
WO2015018522A1
(en)
|
2013-08-06 |
2015-02-12 |
Oncoethix Sa |
Bet-bromodomain inhibitor shows synergism with several anti-cancer agents in pre-clinical models of diffuse large b-cell lymphoma (dlbcl)
|
|
US9415050B2
(en)
|
2013-08-12 |
2016-08-16 |
Pharmacyclics Llc |
Methods for the treatment of HER2 amplified cancer
|
|
CA2925124A1
(en)
|
2013-09-30 |
2015-04-02 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
|
EP3054954A4
(en)
|
2013-10-10 |
2017-12-13 |
Acetylon Pharmaceuticals, Inc. |
Hdac inhibitors, alone or in combination with btk inhibitors, for treating non-hodgkin's lymphoma
|
|
US9795604B2
(en)
|
2013-10-25 |
2017-10-24 |
Pharmacyclics Llc |
Methods of treating and preventing graft versus host disease
|
|
JP6508785B2
(ja)
|
2013-10-25 |
2019-05-08 |
ファーマサイクリックス エルエルシー |
ブルトンチロシンキナーゼ阻害剤および免疫療法を使用する処置
|
|
CN105899232A
(zh)
|
2013-11-13 |
2016-08-24 |
诺华股份有限公司 |
用于增强免疫应答的mTOR抑制剂
|
|
WO2015084892A1
(en)
|
2013-12-02 |
2015-06-11 |
Cornell University |
Methods for treating b cell proliferative disorders
|
|
SG10201900002QA
(en)
|
2014-01-24 |
2019-02-27 |
Dana Farber Cancer Institue Inc |
Antibody molecules to pd-1 and uses thereof
|
|
CN103923084B
(zh)
|
2014-01-29 |
2016-08-17 |
苏州晶云药物科技有限公司 |
几种晶型及其制备方法
|
|
WO2015127234A1
(en)
|
2014-02-20 |
2015-08-27 |
Board Of Regents, The University Of Texas System |
Use of ibrutinib to treat egfr mutant cancer
|
|
WO2015127261A1
(en)
|
2014-02-21 |
2015-08-27 |
Pharmacyclics, Inc. |
Biomarkers for predicting response of dlbcl to treatment with ibrutinib
|
|
WO2015143400A1
(en)
|
2014-03-20 |
2015-09-24 |
Pharmacyclics, Inc. |
Phospholipase c gamma 2 and resistance associated mutations
|
|
NZ724796A
(en)
|
2014-04-04 |
2019-04-26 |
Bionomics Ltd |
Method for treating chronic lymphocytic leukemia
|
|
ES2738695T3
(es)
|
2014-05-28 |
2020-01-24 |
Novartis Ag |
Nuevos Derivados de Pirazolo Pirimidina y su uso como inhibidores de MALT1
|
|
WO2015192081A1
(en)
|
2014-06-13 |
2015-12-17 |
Byrd, John C. |
Biomarker for predicting response of cll to treatment with a btk inhibitor
|
|
US9580418B2
(en)
|
2014-07-14 |
2017-02-28 |
Incyte Corporation |
Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
|
|
WO2016014859A1
(en)
|
2014-07-25 |
2016-01-28 |
Pharmacyclics Llc |
Bet inhibitor and bruton's tyrosine kinase inhibitor combinations
|
|
MX2017001302A
(es)
|
2014-08-01 |
2017-10-11 |
Pharmacyclics Llc |
Biomarcadores para predecir la respuesta del dlbcl al tratamiento con un inhibidor de la btk.
|
|
SG11201700849XA
(en)
|
2014-08-07 |
2017-03-30 |
Pharmacyclics Llc |
Novel formulations of a bruton's tyrosine kinase inhibitor
|
|
CA2956550A1
(en)
|
2014-08-08 |
2016-02-11 |
Pharmacyclics Llc |
Bruton's tyrosine kinase inhibitor combinations and uses thereof
|
|
WO2016024227A1
(en)
|
2014-08-11 |
2016-02-18 |
Acerta Pharma B.V. |
Btk inhibitors to treat solid tumors through modulation of the tumor microenvironment
|
|
CA2960436C
(en)
|
2014-09-16 |
2021-01-05 |
Gilead Sciences, Inc. |
Solid forms of a toll-like receptor modulator
|
|
WO2016044774A1
(en)
|
2014-09-18 |
2016-03-24 |
Pharmacyclics Llc |
Dendritic cell based vaccine with bruton's tyrosine kinase inhibitor
|
|
AU2015327868A1
(en)
|
2014-10-03 |
2017-04-20 |
Novartis Ag |
Combination therapies
|
|
US20170298446A1
(en)
|
2014-10-03 |
2017-10-19 |
Ohio State Innovation Foundation |
Biomarkers of bruton tyrosine kinase inhibitor resistance
|
|
JP6991857B2
(ja)
|
2014-10-10 |
2022-01-13 |
イデラ ファーマシューティカルズ インコーポレイテッド |
Tlr9アゴニストをチェックポイント阻害剤と共に用いるがんの治療
|
|
TWI716362B
(zh)
|
2014-10-14 |
2021-01-21 |
瑞士商諾華公司 |
針對pd-l1之抗體分子及其用途
|
|
TW201628622A
(zh)
|
2014-11-17 |
2016-08-16 |
製藥公司 |
Tlr抑制劑與布魯頓氏(bruton's)酪胺酸激酶抑制劑之組合
|
|
TWI595006B
(zh)
|
2014-12-09 |
2017-08-11 |
禮納特神經系統科學公司 |
抗pd-1抗體類和使用彼等之方法
|
|
WO2016106381A1
(en)
|
2014-12-23 |
2016-06-30 |
Pharmacyclics Llc |
Btk inhibitor combinations and dosing regimen
|
|
WO2016123504A1
(en)
|
2015-01-30 |
2016-08-04 |
Pharmacyclics Llc |
Btk inhibitor combinations and multidrug-resistance
|
|
IL315294A
(en)
|
2015-03-03 |
2024-10-01 |
Pharmacyclics Llc |
Pharmaceutical formulations of bruton's tyrosine kinase inhibitor
|
|
WO2016141092A1
(en)
|
2015-03-04 |
2016-09-09 |
Gilead Sciences, Inc. |
Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds
|
|
WO2016161347A1
(en)
|
2015-04-03 |
2016-10-06 |
Pharmacyclics Llc |
Combinations for generating tumor-specific immunological memory
|
|
CN106336413B
(zh)
|
2015-07-09 |
2021-04-20 |
广东东阳光药业有限公司 |
作为jak抑制剂的化合物及其用途
|
|
WO2017011314A1
(en)
|
2015-07-10 |
2017-01-19 |
Paharmacyclics Llc |
Btk and hdac combinations
|
|
CN106474143A
(zh)
|
2015-08-26 |
2017-03-08 |
长春华普生物技术有限公司 |
Toll样受体TLR7和TLR9抑制性寡核苷酸在制备用于治疗B细胞淋巴瘤的药物方面的应用
|
|
AU2016317049A1
(en)
|
2015-08-31 |
2018-03-15 |
Pharmacyclics Llc |
BTK inhibitor combinations for treating multiple myeloma
|
|
US20170071962A1
(en)
|
2015-09-11 |
2017-03-16 |
Acerta Pharma B.V. |
Therapeutic Combinations of a Proteasome Inhibitor and a BTK Inhibitor
|
|
WO2017087947A2
(en)
|
2015-11-19 |
2017-05-26 |
Pharmacyclics Llc |
Method of treatment of follicular lymphoma with a btk inhibitor
|