JP6575950B2 - Bruton型チロシンキナーゼ(Btk)阻害剤に対する耐性を伴う変異 - Google Patents
Bruton型チロシンキナーゼ(Btk)阻害剤に対する耐性を伴う変異 Download PDFInfo
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- JP6575950B2 JP6575950B2 JP2015524400A JP2015524400A JP6575950B2 JP 6575950 B2 JP6575950 B2 JP 6575950B2 JP 2015524400 A JP2015524400 A JP 2015524400A JP 2015524400 A JP2015524400 A JP 2015524400A JP 6575950 B2 JP6575950 B2 JP 6575950B2
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- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- C12Y207/10—Protein-tyrosine kinases (2.7.10)
- C12Y207/10002—Non-specific protein-tyrosine kinase (2.7.10.2), i.e. spleen tyrosine kinase
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261675303P | 2012-07-24 | 2012-07-24 | |
| US61/675,303 | 2012-07-24 | ||
| US201261682688P | 2012-08-13 | 2012-08-13 | |
| US61/682,688 | 2012-08-13 | ||
| US201361780652P | 2013-03-13 | 2013-03-13 | |
| US61/780,652 | 2013-03-13 | ||
| PCT/US2013/051741 WO2014018567A1 (en) | 2012-07-24 | 2013-07-23 | Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019147993A Division JP2020000239A (ja) | 2012-07-24 | 2019-08-09 | Bruton型チロシンキナーゼ(Btk)阻害剤に対する耐性を伴う変異 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015530080A JP2015530080A (ja) | 2015-10-15 |
| JP2015530080A5 JP2015530080A5 (https=) | 2016-10-13 |
| JP6575950B2 true JP6575950B2 (ja) | 2019-09-18 |
Family
ID=48948511
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015524400A Active JP6575950B2 (ja) | 2012-07-24 | 2013-07-23 | Bruton型チロシンキナーゼ(Btk)阻害剤に対する耐性を伴う変異 |
| JP2019147993A Pending JP2020000239A (ja) | 2012-07-24 | 2019-08-09 | Bruton型チロシンキナーゼ(Btk)阻害剤に対する耐性を伴う変異 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019147993A Pending JP2020000239A (ja) | 2012-07-24 | 2019-08-09 | Bruton型チロシンキナーゼ(Btk)阻害剤に対する耐性を伴う変異 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10954567B2 (https=) |
| EP (2) | EP2877598A1 (https=) |
| JP (2) | JP6575950B2 (https=) |
| KR (2) | KR20150032340A (https=) |
| CN (1) | CN104704129A (https=) |
| AU (1) | AU2013293087B2 (https=) |
| BR (1) | BR112015001690A2 (https=) |
| CA (1) | CA2879570A1 (https=) |
| HK (1) | HK1206073A1 (https=) |
| MX (2) | MX2015001081A (https=) |
| WO (1) | WO2014018567A1 (https=) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2526933T3 (en) | 2006-09-22 | 2015-05-18 | Pharmacyclics Inc | Inhibitors of Bruton's tyrosine kinase |
| US20120101114A1 (en) | 2007-03-28 | 2012-04-26 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| MX2010007419A (es) | 2008-01-04 | 2010-11-12 | Intellikine Inc | Ciertas entidades quimicas, composiciones y metodos. |
| CA2730930C (en) | 2008-07-16 | 2015-01-13 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors |
| MY169791A (en) | 2008-10-22 | 2019-05-15 | Array Biopharma Inc | Substituted pyrazolo [1,5-a] pyrimidine compounds as trk kinase inhibitors |
| CA3007787C (en) | 2010-06-03 | 2020-03-10 | Pharmacyclics Llc | The use of inhibitors of bruton's tyrosine kinase (btk) |
| ES2637113T3 (es) | 2011-01-10 | 2017-10-10 | Infinity Pharmaceuticals, Inc. | Procedimientos para preparar isoquinolinonas y formas sólidas de isoquinolinonas |
| EP3812387A1 (en) | 2011-07-21 | 2021-04-28 | Sumitomo Dainippon Pharma Oncology, Inc. | Heterocyclic protein kinase inhibitors |
| KR20210033067A (ko) | 2012-06-04 | 2021-03-25 | 파마싸이클릭스 엘엘씨 | 브루톤 타이로신 키나아제 저해제의 결정 형태 |
| US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| CN104704129A (zh) | 2012-07-24 | 2015-06-10 | 药品循环公司 | 与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变 |
| AU2013337717B2 (en) | 2012-11-01 | 2018-10-25 | Infinity Pharmaceuticals, Inc. | Treatment of cancers using PI3 kinase isoform modulators |
| EA201590855A1 (ru) | 2012-11-15 | 2015-11-30 | Фармасайкликс, Инк. | Соединения пирролопиримидина как ингибиторы киназ |
| MX394360B (es) | 2013-03-14 | 2025-03-24 | Sumitomo Pharma Oncology Inc | Inhibidores de jak2 y alk2 y metodos para su uso. |
| UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| CA2914284A1 (en) * | 2013-05-30 | 2014-12-04 | Infinity Pharmaceuticals, Inc. | Treatment of cancers using pi3 kinase isoform modulators |
| US9415050B2 (en) | 2013-08-12 | 2016-08-16 | Pharmacyclics Llc | Methods for the treatment of HER2 amplified cancer |
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| WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
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| US20160032404A1 (en) * | 2014-08-01 | 2016-02-04 | Pharmacyclics Llc | Biomarkers for predicting response of dlbcl to treatment with a btk inhibitor |
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| KR20170033358A (ko) | 2014-08-07 | 2017-03-24 | 파마싸이클릭스 엘엘씨 | 브루톤 티로신 키나아제 저해제의 신규한 제제 |
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| KR101776238B1 (ko) * | 2015-06-12 | 2017-09-12 | 사회복지법인 삼성생명공익재단 | 교모세포종 환자에서 이브루티닙 감수성과 관련된 유전자 및 그 용도 |
| US10227657B2 (en) | 2015-07-01 | 2019-03-12 | Neogenomics Laboratories, Inc. | Method for high sensitivity detection of MYD88 mutations |
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| EP3368039A1 (en) * | 2015-10-26 | 2018-09-05 | The Regents of The University of Colorado, A Body Corporate | Point mutations in trk inhibitor-resistant cancer and methods relating to the same |
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| FI3439662T3 (fi) | 2016-04-04 | 2024-09-04 | Loxo Oncology Inc | (s)-n-(5-((r)-2-(2,5-difluorifenyyli)pyrrolidin-1-yyli)pyratsolo[1,5-a]pyrimidin-3-yyli)-3-hydroksipyrrolidiini-1-karboksamidin nesteformulaatioita |
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| US11118233B2 (en) * | 2016-05-18 | 2021-09-14 | The University Of Chicago | BTK mutation and ibrutinib resistance |
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| EP2877598A1 (en) | 2015-06-03 |
| WO2014018567A1 (en) | 2014-01-30 |
| JP2020000239A (ja) | 2020-01-09 |
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| CN104704129A (zh) | 2015-06-10 |
| EP3550031A1 (en) | 2019-10-09 |
| AU2013293087B2 (en) | 2017-08-31 |
| US10954567B2 (en) | 2021-03-23 |
| US20150184249A1 (en) | 2015-07-02 |
| JP2015530080A (ja) | 2015-10-15 |
| CA2879570A1 (en) | 2014-01-30 |
| AU2013293087A1 (en) | 2015-03-05 |
| MX2020006151A (es) | 2020-08-13 |
| MX2015001081A (es) | 2015-10-14 |
| KR20150032340A (ko) | 2015-03-25 |
| HK1206073A1 (en) | 2015-12-31 |
| BR112015001690A2 (pt) | 2017-11-07 |
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