JP6575950B2 - Bruton型チロシンキナーゼ(Btk)阻害剤に対する耐性を伴う変異 - Google Patents
Bruton型チロシンキナーゼ(Btk)阻害剤に対する耐性を伴う変異 Download PDFInfo
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- JP6575950B2 JP6575950B2 JP2015524400A JP2015524400A JP6575950B2 JP 6575950 B2 JP6575950 B2 JP 6575950B2 JP 2015524400 A JP2015524400 A JP 2015524400A JP 2015524400 A JP2015524400 A JP 2015524400A JP 6575950 B2 JP6575950 B2 JP 6575950B2
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- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- C12Y207/10—Protein-tyrosine kinases (2.7.10)
- C12Y207/10002—Non-specific protein-tyrosine kinase (2.7.10.2), i.e. spleen tyrosine kinase
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261675303P | 2012-07-24 | 2012-07-24 | |
| US61/675,303 | 2012-07-24 | ||
| US201261682688P | 2012-08-13 | 2012-08-13 | |
| US61/682,688 | 2012-08-13 | ||
| US201361780652P | 2013-03-13 | 2013-03-13 | |
| US61/780,652 | 2013-03-13 | ||
| PCT/US2013/051741 WO2014018567A1 (en) | 2012-07-24 | 2013-07-23 | Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019147993A Division JP2020000239A (ja) | 2012-07-24 | 2019-08-09 | Bruton型チロシンキナーゼ(Btk)阻害剤に対する耐性を伴う変異 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015530080A JP2015530080A (ja) | 2015-10-15 |
| JP2015530080A5 JP2015530080A5 (https=) | 2016-10-13 |
| JP6575950B2 true JP6575950B2 (ja) | 2019-09-18 |
Family
ID=48948511
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015524400A Active JP6575950B2 (ja) | 2012-07-24 | 2013-07-23 | Bruton型チロシンキナーゼ(Btk)阻害剤に対する耐性を伴う変異 |
| JP2019147993A Pending JP2020000239A (ja) | 2012-07-24 | 2019-08-09 | Bruton型チロシンキナーゼ(Btk)阻害剤に対する耐性を伴う変異 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019147993A Pending JP2020000239A (ja) | 2012-07-24 | 2019-08-09 | Bruton型チロシンキナーゼ(Btk)阻害剤に対する耐性を伴う変異 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10954567B2 (https=) |
| EP (2) | EP3550031A1 (https=) |
| JP (2) | JP6575950B2 (https=) |
| KR (2) | KR20180088926A (https=) |
| CN (1) | CN104704129A (https=) |
| AU (1) | AU2013293087B2 (https=) |
| BR (1) | BR112015001690A2 (https=) |
| CA (1) | CA2879570A1 (https=) |
| HK (1) | HK1206073A1 (https=) |
| MX (2) | MX2015001081A (https=) |
| WO (1) | WO2014018567A1 (https=) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
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| BRPI0622054B8 (pt) | 2006-09-22 | 2021-05-25 | Oxford Amherst Llc | composto e composição farmacêutica |
| US20120101114A1 (en) | 2007-03-28 | 2012-04-26 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| EP3613743B1 (en) | 2008-01-04 | 2022-03-16 | Intellikine, LLC | Processes for the preparation of 1h-pyrazolo[3,4-d]pyrimidin-4-amine derivatives |
| ES2660418T3 (es) | 2008-07-16 | 2018-03-22 | Pharmacyclics Llc | Inhibidores de la tirosina quinasa de Bruton para el tratamiento de tumores sólidos |
| AR074052A1 (es) | 2008-10-22 | 2010-12-22 | Array Biopharma Inc | Compuestos pirazolo{1,5-a}pirimidina sustituida como inhibidores de trk cinasa |
| CN107898791A (zh) | 2010-06-03 | 2018-04-13 | 药品循环有限责任公司 | 布鲁顿酪氨酸激酶(btk)抑制剂的应用 |
| TWI674262B (zh) | 2011-01-10 | 2019-10-11 | 美商英菲尼提製藥股份有限公司 | 製備異喹啉酮之方法及異喹啉酮之固體形式 |
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| US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| CN104704129A (zh) | 2012-07-24 | 2015-06-10 | 药品循环公司 | 与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变 |
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| EA201590855A1 (ru) | 2012-11-15 | 2015-11-30 | Фармасайкликс, Инк. | Соединения пирролопиримидина как ингибиторы киназ |
| MX394360B (es) | 2013-03-14 | 2025-03-24 | Sumitomo Pharma Oncology Inc | Inhibidores de jak2 y alk2 y metodos para su uso. |
| UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| SG11201509842SA (en) * | 2013-05-30 | 2015-12-30 | Infinity Pharmaceuticals Inc | Treatment of cancers using pi3 kinase isoform modulators |
| US9415050B2 (en) | 2013-08-12 | 2016-08-16 | Pharmacyclics Llc | Methods for the treatment of HER2 amplified cancer |
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| AU2015296215A1 (en) | 2014-08-01 | 2017-03-23 | Pharmacyclics Llc | Inhibitors of bruton's tyrosine kinase |
| MX2017001302A (es) * | 2014-08-01 | 2017-10-11 | Pharmacyclics Llc | Biomarcadores para predecir la respuesta del dlbcl al tratamiento con un inhibidor de la btk. |
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| HK1206073A1 (en) | 2015-12-31 |
| KR20180088926A (ko) | 2018-08-07 |
| BR112015001690A2 (pt) | 2017-11-07 |
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| AU2013293087A1 (en) | 2015-03-05 |
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| EP2877598A1 (en) | 2015-06-03 |
| WO2014018567A1 (en) | 2014-01-30 |
| AU2013293087B2 (en) | 2017-08-31 |
| CA2879570A1 (en) | 2014-01-30 |
| US20150184249A1 (en) | 2015-07-02 |
| JP2020000239A (ja) | 2020-01-09 |
| CN104704129A (zh) | 2015-06-10 |
| EP3550031A1 (en) | 2019-10-09 |
| KR20150032340A (ko) | 2015-03-25 |
| JP2015530080A (ja) | 2015-10-15 |
| US10954567B2 (en) | 2021-03-23 |
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