AU2013240280A1 - Improved harvest operations for recombinant proteins - Google Patents

Improved harvest operations for recombinant proteins Download PDF

Info

Publication number
AU2013240280A1
AU2013240280A1 AU2013240280A AU2013240280A AU2013240280A1 AU 2013240280 A1 AU2013240280 A1 AU 2013240280A1 AU 2013240280 A AU2013240280 A AU 2013240280A AU 2013240280 A AU2013240280 A AU 2013240280A AU 2013240280 A1 AU2013240280 A1 AU 2013240280A1
Authority
AU
Australia
Prior art keywords
recombinant protein
host cell
prokaryotic host
antibodies
maintained
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2013240280A
Other languages
English (en)
Inventor
Rachel Adams
Jane V. GUNSON
Kim KALEAS
Michael W. Laird
Deepa NADARAJAH
Bradley R. Snedecor
Richard St. John
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AU2013240280A1 publication Critical patent/AU2013240280A1/en
Priority to AU2017202484A priority Critical patent/AU2017202484B2/en
Priority to AU2019226192A priority patent/AU2019226192A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/42Means for regulation, monitoring, measurement or control, e.g. flow regulation of agitation speed
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Sustainable Development (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2013240280A 2012-03-27 2013-03-14 Improved harvest operations for recombinant proteins Abandoned AU2013240280A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2017202484A AU2017202484B2 (en) 2012-03-27 2017-04-13 Improved harvest operations for recombinant proteins
AU2019226192A AU2019226192A1 (en) 2012-03-27 2019-09-05 Improved harvest operations for recombinant proteins

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261616297P 2012-03-27 2012-03-27
US61/616,297 2012-03-27
PCT/US2013/031383 WO2013148249A1 (en) 2012-03-27 2013-03-14 Improved harvest operations for recombinant proteins

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017202484A Division AU2017202484B2 (en) 2012-03-27 2017-04-13 Improved harvest operations for recombinant proteins

Publications (1)

Publication Number Publication Date
AU2013240280A1 true AU2013240280A1 (en) 2014-10-16

Family

ID=48040433

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2013240280A Abandoned AU2013240280A1 (en) 2012-03-27 2013-03-14 Improved harvest operations for recombinant proteins
AU2017202484A Active AU2017202484B2 (en) 2012-03-27 2017-04-13 Improved harvest operations for recombinant proteins
AU2019226192A Abandoned AU2019226192A1 (en) 2012-03-27 2019-09-05 Improved harvest operations for recombinant proteins

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2017202484A Active AU2017202484B2 (en) 2012-03-27 2017-04-13 Improved harvest operations for recombinant proteins
AU2019226192A Abandoned AU2019226192A1 (en) 2012-03-27 2019-09-05 Improved harvest operations for recombinant proteins

Country Status (20)

Country Link
US (9) US20140080180A1 (enExample)
EP (1) EP2831261B1 (enExample)
JP (4) JP6225162B2 (enExample)
KR (2) KR102096678B1 (enExample)
CN (2) CN109880867A (enExample)
AR (2) AR090340A1 (enExample)
AU (3) AU2013240280A1 (enExample)
BR (1) BR112014023176B1 (enExample)
CA (2) CA3086730A1 (enExample)
ES (1) ES2654424T3 (enExample)
HR (1) HRP20171966T1 (enExample)
IL (1) IL234377B (enExample)
MX (3) MX365947B (enExample)
MY (1) MY171729A (enExample)
PL (1) PL2831261T3 (enExample)
RU (2) RU2017139267A (enExample)
SG (4) SG11201406112TA (enExample)
SI (1) SI2831261T1 (enExample)
WO (1) WO2013148249A1 (enExample)
ZA (1) ZA201406434B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6201037B1 (en) 1986-01-28 2001-03-13 Ophthalmic Research Group International, Inc. Plastic lens composition and method for the production thereof
JP2019517272A (ja) * 2016-06-10 2019-06-24 ロンザ リミテッドLonza Limited タンパク質の安定化方法
KR102595048B1 (ko) * 2016-11-07 2023-10-26 씨젠 인크. 조작된-시스테인 캡의 분포
US20210024873A1 (en) * 2018-03-27 2021-01-28 Bristol-Myers Squibb Company Real-time monitoring of protein concentration using ultraviolet signal
FI3857237T3 (fi) * 2019-01-16 2023-05-03 Regeneron Pharma Disulfidisidosten luonnehtimismenetelmiä
CN109725088B (zh) * 2019-03-16 2021-05-18 丁立平 一种测定豆芽中2-萘甲酸及其衍生物的气相色谱-质谱联用法
CN110305903B (zh) * 2019-07-31 2021-10-01 江苏璟泽生物医药有限公司 重组人促卵泡激素及其制备方法
CN113155776A (zh) * 2021-04-29 2021-07-23 华东交通大学 一种柑桔最佳采收期预测方法
FR3146146A1 (fr) 2023-02-24 2024-08-30 Bgene Genetics Production d’acide 1-4-dihydroxy-2-naphtoïque par Escherichia coli

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2036891B (en) 1978-12-05 1983-05-05 Windsor Smith C Change speed gear
US4515893A (en) 1979-04-26 1985-05-07 Ortho Pharmaceutical Corporation Hybrid cell line for producing complement-fixing monoclonal antibody to human T cells
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5672347A (en) 1984-07-05 1997-09-30 Genentech, Inc. Tumor necrosis factor antagonists and their use
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
WO1987002671A1 (en) 1985-11-01 1987-05-07 International Genetic Engineering, Inc. Modular assembly of antibody genes, antibodies prepared thereby and use
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
US5091313A (en) 1988-08-05 1992-02-25 Tanox Biosystems, Inc. Antigenic epitopes of IgE present on B cell but not basophil surface
US5720937A (en) 1988-01-12 1998-02-24 Genentech, Inc. In vivo tumor detection assay
WO1989012463A1 (en) 1988-06-21 1989-12-28 Genentech, Inc. Method and therapeutic compositions for the treatment of myocardial infarction
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
ES2193136T3 (es) 1991-08-14 2003-11-01 Genentech Inc Variantes de inmunoglubina para receptores especificos de fc epsilon.
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
US5288931A (en) 1991-12-06 1994-02-22 Genentech, Inc. Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
ATE149570T1 (de) 1992-08-17 1997-03-15 Genentech Inc Bispezifische immunoadhesine
EP0656789B1 (en) 1992-08-21 1997-12-17 Genentech, Inc. Method for treating a lfa-1-mediated disorder
US5736137A (en) 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
US5714338A (en) 1993-12-10 1998-02-03 Genentech, Inc. Methods for diagnosis of allergy
EP0739214B1 (en) 1994-01-18 1998-03-18 Genentech, Inc. A METHOD OF TREATMENT OF PARASITIC INFECTION USING IgE ANTAGONISTS
EP0749488A1 (en) 1994-03-03 1996-12-27 Genentech, Inc. Anti-il-8 monoclonal antibodies for treatment of inflammatory disorders
US5639635A (en) 1994-11-03 1997-06-17 Genentech, Inc. Process for bacterial production of polypeptides
IL117645A (en) 1995-03-30 2005-08-31 Genentech Inc Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
AU6267896A (en) 1995-06-07 1996-12-30 Imclone Systems Incorporated Antibody and antibody fragments for inhibiting the growth oftumors
EP1297847A3 (en) 1996-01-23 2003-05-07 Genentech, Inc. Anti-CD18 antibodies in stroke
US7147851B1 (en) 1996-08-15 2006-12-12 Millennium Pharmaceuticals, Inc. Humanized immunoglobulin reactive with α4β7 integrin
KR100532178B1 (ko) 1996-11-27 2005-12-01 제넨테크, 인크. 인간화 항-CD11a 항체
ES2236634T3 (es) 1997-04-07 2005-07-16 Genentech, Inc. Anticuerpos anti-vegf.
ES2293682T5 (es) 1997-05-15 2011-11-17 Genentech, Inc. Anticuerpo anti-apo2.
US6946129B1 (en) 1999-06-08 2005-09-20 Seattle Genetics, Inc. Recombinant anti-CD40 antibody and uses thereof
DK1226177T3 (da) 1999-10-29 2008-10-06 Genentech Inc Antistofsammensætninger mod anti-prostata stamcelle-antigen (PSCA) og anvendelser deraf
US6946271B2 (en) * 2000-09-20 2005-09-20 Degussa Ag Nucleotide sequences which code for the menE gene
US6979556B2 (en) 2000-12-14 2005-12-27 Genentech, Inc. Separate-cistron contructs for secretion of aglycosylated antibodies from prokaryotes
PT1572744E (pt) 2002-12-16 2010-09-07 Genentech Inc Variantes de imunoglobulina e utilizações destas
KR101003344B1 (ko) * 2003-03-26 2010-12-23 메이지 데어리스 코포레이션 1,4-디히드록시-2-나프토산의 안정화 방법
US7785830B2 (en) * 2003-08-13 2010-08-31 Sandoz Ag Expression vectors, transformed host cells and fermentation process for the production of recombinant polypeptides
WO2005078115A1 (en) * 2004-02-04 2005-08-25 Merck & Co., Inc. Process for large scale production of plasmid dna by e. coli fermentation
US7361764B2 (en) * 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
CN101115832A (zh) * 2004-11-26 2008-01-30 协和发酵工业株式会社 工业上有用的微生物
JP5383481B2 (ja) * 2006-05-05 2014-01-08 ガンガゲン インコーポレーテッド ファージに由来する抗微生物活性
JP5305615B2 (ja) * 2006-06-05 2013-10-02 株式会社Adeka メナキノンの新規生合成経路に関与するタンパク質の遺伝子群を利用したメナキノンの製造方法
WO2008008975A2 (en) * 2006-07-14 2008-01-17 Genentech, Inc. Refolding of recombinant proteins
WO2009009523A2 (en) * 2007-07-09 2009-01-15 Genentech, Inc. Prevention of disulfide bond reduction during recombinant production of polypeptides
CN101665798B (zh) * 2008-09-06 2012-11-21 浙江我武生物科技股份有限公司 一种制备重组人血清白蛋白与干扰素α融合蛋白的方法
CN101503470A (zh) * 2008-09-27 2009-08-12 上海交通大学 rhDSL重组蛋白及其制备方法
JP2010088387A (ja) * 2008-10-10 2010-04-22 Waseda Univ 放線菌内で目的タンパク質を誘導発現可能なプロモーター

Also Published As

Publication number Publication date
AR090340A1 (es) 2014-11-05
KR20200037425A (ko) 2020-04-08
HK1207120A1 (en) 2016-01-22
US20200199639A1 (en) 2020-06-25
SI2831261T1 (en) 2018-01-31
EP2831261B1 (en) 2017-10-18
RU2014137554A (ru) 2016-05-20
RU2017139267A (ru) 2019-02-12
SG10201912877SA (en) 2020-02-27
JP2020202849A (ja) 2020-12-24
MX365947B (es) 2019-06-19
CA2866753A1 (en) 2013-10-03
US20240158825A1 (en) 2024-05-16
BR112014023176A2 (pt) 2017-06-20
CA2866753C (en) 2020-09-22
KR102096678B1 (ko) 2020-04-02
AU2017202484B2 (en) 2019-06-13
US20180291411A1 (en) 2018-10-11
RU2636353C2 (ru) 2017-11-22
JP2018046825A (ja) 2018-03-29
SG11201406112TA (en) 2014-10-30
JP2015512259A (ja) 2015-04-27
MX2019007032A (es) 2019-08-16
MX2014011558A (es) 2014-11-14
ZA201406434B (en) 2017-08-30
US9765379B2 (en) 2017-09-19
MX2018007677A (es) 2020-11-12
SG10202007206WA (en) 2020-08-28
CN104350156A (zh) 2015-02-11
BR112014023176B1 (pt) 2021-09-28
EP2831261A1 (en) 2015-02-04
CN109880867A (zh) 2019-06-14
US20150225760A1 (en) 2015-08-13
JP6225162B2 (ja) 2017-11-01
WO2013148249A1 (en) 2013-10-03
AR116615A2 (es) 2021-05-26
MY171729A (en) 2019-10-25
AU2019226192A1 (en) 2019-09-26
US20140080180A1 (en) 2014-03-20
JP2019141049A (ja) 2019-08-29
IL234377B (en) 2021-01-31
PL2831261T3 (pl) 2018-04-30
HRP20171966T1 (hr) 2018-02-09
CA3086730A1 (en) 2013-10-03
AU2017202484A1 (en) 2017-05-04
KR20140148392A (ko) 2014-12-31
SG10201508420VA (en) 2015-11-27
US20250137027A1 (en) 2025-05-01
US20230069966A1 (en) 2023-03-09
CN104350156B (zh) 2019-04-02
ES2654424T3 (es) 2018-02-13
US20160130624A1 (en) 2016-05-12
US20210171997A1 (en) 2021-06-10

Similar Documents

Publication Publication Date Title
US20250137027A1 (en) Harvest operations for recombinant proteins
EP1581644B1 (en) Purification of polypeptides
JP7323272B2 (ja) ポリペプチド生成のための細胞培養組成物及び方法
HK1207120B (zh) 用於重组蛋白质的改进的收获操作
HK40008573A (en) Improved harvest operations for recombinant proteins

Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted