KR102096678B1 - 재조합 단백질을 위한 개선된 수확 작업 - Google Patents

재조합 단백질을 위한 개선된 수확 작업 Download PDF

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KR102096678B1
KR102096678B1 KR1020147026772A KR20147026772A KR102096678B1 KR 102096678 B1 KR102096678 B1 KR 102096678B1 KR 1020147026772 A KR1020147026772 A KR 1020147026772A KR 20147026772 A KR20147026772 A KR 20147026772A KR 102096678 B1 KR102096678 B1 KR 102096678B1
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recombinant protein
delete delete
antibodies
antibody
recombinant
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KR20140148392A (ko
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마이클 더블유. 레이드
리차드 에스티. 존
제인 브이. 건슨
킴 칼레아스
디파 나다라자
레이첼 아담스
브래들리 알. 스네데코어
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제넨테크, 인크.
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/42Means for regulation, monitoring, measurement or control, e.g. flow regulation of agitation speed
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli

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  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
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  • Molecular Biology (AREA)
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  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Sustainable Development (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020147026772A 2012-03-27 2013-03-14 재조합 단백질을 위한 개선된 수확 작업 Active KR102096678B1 (ko)

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US201261616297P 2012-03-27 2012-03-27
US61/616,297 2012-03-27
PCT/US2013/031383 WO2013148249A1 (en) 2012-03-27 2013-03-14 Improved harvest operations for recombinant proteins

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KR1020207008828A Division KR20200037425A (ko) 2012-03-27 2013-03-14 재조합 단백질을 위한 개선된 수확 작업

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KR20140148392A KR20140148392A (ko) 2014-12-31
KR102096678B1 true KR102096678B1 (ko) 2020-04-02

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KR1020207008828A Ceased KR20200037425A (ko) 2012-03-27 2013-03-14 재조합 단백질을 위한 개선된 수확 작업

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US (9) US20140080180A1 (enExample)
EP (1) EP2831261B1 (enExample)
JP (4) JP6225162B2 (enExample)
KR (2) KR102096678B1 (enExample)
CN (2) CN109880867A (enExample)
AR (2) AR090340A1 (enExample)
AU (3) AU2013240280A1 (enExample)
BR (1) BR112014023176B1 (enExample)
CA (2) CA3086730A1 (enExample)
ES (1) ES2654424T3 (enExample)
HR (1) HRP20171966T1 (enExample)
IL (1) IL234377B (enExample)
MX (3) MX365947B (enExample)
MY (1) MY171729A (enExample)
PL (1) PL2831261T3 (enExample)
RU (2) RU2017139267A (enExample)
SG (4) SG11201406112TA (enExample)
SI (1) SI2831261T1 (enExample)
WO (1) WO2013148249A1 (enExample)
ZA (1) ZA201406434B (enExample)

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JP2019517272A (ja) * 2016-06-10 2019-06-24 ロンザ リミテッドLonza Limited タンパク質の安定化方法
KR102595048B1 (ko) * 2016-11-07 2023-10-26 씨젠 인크. 조작된-시스테인 캡의 분포
US20210024873A1 (en) * 2018-03-27 2021-01-28 Bristol-Myers Squibb Company Real-time monitoring of protein concentration using ultraviolet signal
FI3857237T3 (fi) * 2019-01-16 2023-05-03 Regeneron Pharma Disulfidisidosten luonnehtimismenetelmiä
CN109725088B (zh) * 2019-03-16 2021-05-18 丁立平 一种测定豆芽中2-萘甲酸及其衍生物的气相色谱-质谱联用法
CN110305903B (zh) * 2019-07-31 2021-10-01 江苏璟泽生物医药有限公司 重组人促卵泡激素及其制备方法
CN113155776A (zh) * 2021-04-29 2021-07-23 华东交通大学 一种柑桔最佳采收期预测方法
FR3146146A1 (fr) 2023-02-24 2024-08-30 Bgene Genetics Production d’acide 1-4-dihydroxy-2-naphtoïque par Escherichia coli

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AR090340A1 (es) 2014-11-05
KR20200037425A (ko) 2020-04-08
HK1207120A1 (en) 2016-01-22
US20200199639A1 (en) 2020-06-25
SI2831261T1 (en) 2018-01-31
EP2831261B1 (en) 2017-10-18
RU2014137554A (ru) 2016-05-20
RU2017139267A (ru) 2019-02-12
SG10201912877SA (en) 2020-02-27
JP2020202849A (ja) 2020-12-24
MX365947B (es) 2019-06-19
CA2866753A1 (en) 2013-10-03
US20240158825A1 (en) 2024-05-16
BR112014023176A2 (pt) 2017-06-20
CA2866753C (en) 2020-09-22
AU2017202484B2 (en) 2019-06-13
US20180291411A1 (en) 2018-10-11
RU2636353C2 (ru) 2017-11-22
JP2018046825A (ja) 2018-03-29
SG11201406112TA (en) 2014-10-30
JP2015512259A (ja) 2015-04-27
MX2019007032A (es) 2019-08-16
MX2014011558A (es) 2014-11-14
ZA201406434B (en) 2017-08-30
US9765379B2 (en) 2017-09-19
MX2018007677A (es) 2020-11-12
SG10202007206WA (en) 2020-08-28
CN104350156A (zh) 2015-02-11
BR112014023176B1 (pt) 2021-09-28
AU2013240280A1 (en) 2014-10-16
EP2831261A1 (en) 2015-02-04
CN109880867A (zh) 2019-06-14
US20150225760A1 (en) 2015-08-13
JP6225162B2 (ja) 2017-11-01
WO2013148249A1 (en) 2013-10-03
AR116615A2 (es) 2021-05-26
MY171729A (en) 2019-10-25
AU2019226192A1 (en) 2019-09-26
US20140080180A1 (en) 2014-03-20
JP2019141049A (ja) 2019-08-29
IL234377B (en) 2021-01-31
PL2831261T3 (pl) 2018-04-30
HRP20171966T1 (hr) 2018-02-09
CA3086730A1 (en) 2013-10-03
AU2017202484A1 (en) 2017-05-04
KR20140148392A (ko) 2014-12-31
SG10201508420VA (en) 2015-11-27
US20250137027A1 (en) 2025-05-01
US20230069966A1 (en) 2023-03-09
CN104350156B (zh) 2019-04-02
ES2654424T3 (es) 2018-02-13
US20160130624A1 (en) 2016-05-12
US20210171997A1 (en) 2021-06-10

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