AU2009274076C1 - Modified bovine G-CSF polypeptides and their uses - Google Patents

Modified bovine G-CSF polypeptides and their uses Download PDF

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Publication number
AU2009274076C1
AU2009274076C1 AU2009274076A AU2009274076A AU2009274076C1 AU 2009274076 C1 AU2009274076 C1 AU 2009274076C1 AU 2009274076 A AU2009274076 A AU 2009274076A AU 2009274076 A AU2009274076 A AU 2009274076A AU 2009274076 C1 AU2009274076 C1 AU 2009274076C1
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AU
Australia
Prior art keywords
csf
polypeptide
amino acid
substituted
alkylene
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AU2009274076A1 (en
AU2009274076B2 (en
Inventor
Peter C. Canning
Anna-Maria A. Hays Putnam
Lillian Ho
Nick Knudsen
Alan Koder
Vadim Kraynov
Thea Norman
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Ambrx Inc
Elanco US Inc
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Ambrx Inc
Elanco US Inc
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Priority to AU2013202836A priority Critical patent/AU2013202836B8/en
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Publication of AU2009274076B2 publication Critical patent/AU2009274076B2/en
Publication of AU2009274076C1 publication Critical patent/AU2009274076C1/en
Assigned to ELANCO US INC., AMBRX, INC. reassignment ELANCO US INC. Request for Assignment Assignors: AMBRX, INC., ELI LILLY AND COMPANY
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/53Colony-stimulating factor [CSF]
    • C07K14/535Granulocyte CSF; Granulocyte-macrophage CSF
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/16Central respiratory analeptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/193Colony stimulating factors [CSF]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyamides (AREA)
AU2009274076A 2008-07-23 2009-07-22 Modified bovine G-CSF polypeptides and their uses Active AU2009274076C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2013202836A AU2013202836B8 (en) 2008-07-23 2013-04-08 Modified bovine G-CSF polypeptides and their uses

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8313208P 2008-07-23 2008-07-23
US61/083,132 2008-07-23
PCT/US2009/051388 WO2010011735A2 (en) 2008-07-23 2009-07-22 Modified bovine g-csf polypeptides and their uses

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2013202836A Division AU2013202836B8 (en) 2008-07-23 2013-04-08 Modified bovine G-CSF polypeptides and their uses

Publications (3)

Publication Number Publication Date
AU2009274076A1 AU2009274076A1 (en) 2010-01-28
AU2009274076B2 AU2009274076B2 (en) 2014-01-09
AU2009274076C1 true AU2009274076C1 (en) 2014-04-17

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AU2009274076A Active AU2009274076C1 (en) 2008-07-23 2009-07-22 Modified bovine G-CSF polypeptides and their uses

Country Status (23)

Country Link
US (3) US10138283B2 (enExample)
EP (2) EP3225248B1 (enExample)
JP (2) JP5680534B2 (enExample)
KR (1) KR101726884B1 (enExample)
CN (2) CN106928339A (enExample)
AR (1) AR072967A1 (enExample)
AU (1) AU2009274076C1 (enExample)
BR (1) BRPI0916515B8 (enExample)
CA (1) CA2729851C (enExample)
CL (1) CL2011000013A1 (enExample)
CO (1) CO6351745A2 (enExample)
EA (1) EA019968B1 (enExample)
ES (2) ES2654387T3 (enExample)
IL (1) IL210265A (enExample)
MX (1) MX2011000859A (enExample)
NZ (2) NZ600382A (enExample)
PA (1) PA8836801A1 (enExample)
PE (1) PE20110426A1 (enExample)
PL (2) PL3225248T3 (enExample)
PT (1) PT2318029T (enExample)
UA (2) UA103774C2 (enExample)
WO (1) WO2010011735A2 (enExample)
ZA (1) ZA201101166B (enExample)

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US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides
ES2742296T3 (es) 2010-08-17 2020-02-13 Ambrx Inc Polipéptidos de relaxina modificados y sus usos
CN102380090A (zh) * 2010-08-31 2012-03-21 健能隆医药技术(上海)有限公司 G-csf二聚体在治疗嗜中性粒细胞减少症中的应用
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WO2013022328A1 (en) * 2011-08-09 2013-02-14 Uab Profarma Derivatives of recombinant proteins, homo-multimers of granulocyte colony-stimulating factor and method of preparation thereof
CN104245720A (zh) * 2012-02-29 2014-12-24 Ambrx公司 白细胞介素-3多肽结合物和其用途
CN103479574A (zh) * 2013-09-12 2014-01-01 华南农业大学 一种用于防治干奶期奶牛乳房炎的乳房注入剂及其制备方法
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CN109689079A (zh) 2016-08-22 2019-04-26 伊兰科美国公司 牛成纤维细胞生长因子21和乳畜中的酮病
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
KR102670432B1 (ko) 2017-02-08 2024-05-28 브리스톨-마이어스 스큅 컴퍼니 약동학적 인핸서를 포함하는 변형된 렐락신 폴리펩티드 및 그의 용도
AR113756A1 (es) 2017-10-11 2020-06-10 Ambrx Inc Variantes porcinas de g-csf y sus usos
HUE068337T2 (hu) 2018-03-29 2024-12-28 Ambrx Inc Humanizált, prosztataspecifikus membránantigén (PSMA) elleni ellenanyag-hatóanyag konjugátumok
JP7724061B2 (ja) 2018-04-11 2025-08-15 インヒブルクス バイオサイエンシズ インコーポレイテッド 制約されたcd3結合を有する多重特異性ポリペプチド構築物ならびに関連する方法および使用
SG11202010439VA (en) 2018-05-01 2020-11-27 Ambrx Inc A method for optimizing antibody expression
US11562806B2 (en) * 2018-05-09 2023-01-24 Shenzhen Jingtai Technology Co., Ltd. Drug crystal structure landscape analysis system and landscape analysis method thereof
SG11202107201YA (en) * 2018-12-28 2021-07-29 Coherus Biosciences Inc Process for producing, isolating, and purifying modified recombinant proteins
CN110320296A (zh) * 2019-07-04 2019-10-11 公安部物证鉴定中心 一种3,4-亚甲二氧基乙卡西酮的检测方法
CA3221173A1 (en) * 2021-06-02 2022-12-08 Joanna CAIN Methods of inhibiting bovine mastitis during the dry period
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CN120344270A (zh) 2022-10-07 2025-07-18 Ambrx 公司 药物接头及其抗体缀合物
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