AU2005212409C1 - Pyrazolopyrimidine-derivatives as cyclin dependent kinase inhibitors - Google Patents

Pyrazolopyrimidine-derivatives as cyclin dependent kinase inhibitors Download PDF

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Publication number
AU2005212409C1
AU2005212409C1 AU2005212409A AU2005212409A AU2005212409C1 AU 2005212409 C1 AU2005212409 C1 AU 2005212409C1 AU 2005212409 A AU2005212409 A AU 2005212409A AU 2005212409 A AU2005212409 A AU 2005212409A AU 2005212409 C1 AU2005212409 C1 AU 2005212409C1
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compound
pct
yield
mmol
lcms
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AU2005212409A
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AU2005212409B2 (en
AU2005212409A1 (en
Inventor
Carmen S. Alvarez
Tin-Yau Chan
Lawrence W. Dillard
Ronald J. Doll
Michael P. Dwyer
Thierry O. Fischmann
Viyyoor Moopil Girijavallabhan
Timothy J. Guzi
Zhen Min He
Douglas Walsh Hobbs
Ray Anthony James
Kartik M. Keertikar
Vincent Madison
Alan Mallams
Vidyadhar M. Paradkar
Haengsoon Park
Kamil Paruch
Jocelyn Rivera
Vinh D. Tran
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Merck Sharp and Dohme LLC
Pharmacopeia LLC
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Pharmacopeia Inc
Merck Sharp and Dohme LLC
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Application filed by Pharmacopeia Inc, Merck Sharp and Dohme LLC filed Critical Pharmacopeia Inc
Publication of AU2005212409A1 publication Critical patent/AU2005212409A1/en
Assigned to SCHERING CORPORATION, PHARMACOPEIA, INC. reassignment SCHERING CORPORATION Request for Assignment Assignors: PHARMACOPEIA DRUG DISCOVERY, INC., SCHERING CORPORATION
Publication of AU2005212409B2 publication Critical patent/AU2005212409B2/en
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Assigned to PHARMACOPEIA, INC., MERCK SHARP & DOHME CORP. reassignment PHARMACOPEIA, INC. Request to Amend Deed and Register Assignors: PHARMACOPEIA, INC., SCHERING CORPORATION
Assigned to PHARMACOPEIA, INC., MERCK SHARP & DOHME LLC reassignment PHARMACOPEIA, INC. Request to Amend Deed and Register Assignors: MERCK SHARP & DOHME CORP., PHARMACOPEIA, INC.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2005212409A 2004-02-11 2005-02-08 Pyrazolopyrimidine-derivatives as cyclin dependent kinase inhibitors Expired AU2005212409C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/776,988 2004-02-11
US10/776,988 US7119200B2 (en) 2002-09-04 2004-02-11 Pyrazolopyrimidines as cyclin dependent kinase inhibitors
PCT/US2005/003859 WO2005077954A2 (en) 2004-02-11 2005-02-08 Pyrazolopyrimidine-derivatives as cyclin dependent kinase inhibitors

Publications (3)

Publication Number Publication Date
AU2005212409A1 AU2005212409A1 (en) 2005-08-25
AU2005212409B2 AU2005212409B2 (en) 2011-12-01
AU2005212409C1 true AU2005212409C1 (en) 2012-07-19

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ID=34860861

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AU2005212409A Expired AU2005212409C1 (en) 2004-02-11 2005-02-08 Pyrazolopyrimidine-derivatives as cyclin dependent kinase inhibitors

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US (2) US7119200B2 (enExample)
EP (1) EP1720882B1 (enExample)
JP (2) JP4845743B2 (enExample)
KR (1) KR101196498B1 (enExample)
CN (1) CN1946725B (enExample)
AR (1) AR047543A1 (enExample)
AT (1) ATE494287T1 (enExample)
AU (1) AU2005212409C1 (enExample)
BR (1) BRPI0507644B8 (enExample)
CA (1) CA2555345C (enExample)
CY (1) CY1112400T1 (enExample)
DE (1) DE602005025733D1 (enExample)
DK (1) DK1720882T3 (enExample)
ES (1) ES2359410T3 (enExample)
HR (1) HRP20110245T1 (enExample)
IL (1) IL177283A (enExample)
MY (1) MY149044A (enExample)
NO (1) NO337520B1 (enExample)
NZ (1) NZ590480A (enExample)
PE (1) PE20050774A1 (enExample)
PL (1) PL1720882T3 (enExample)
RU (1) RU2414472C9 (enExample)
SI (1) SI1720882T1 (enExample)
TW (1) TWI393566B (enExample)
WO (1) WO2005077954A2 (enExample)
ZA (1) ZA200606573B (enExample)

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