AR051966A1 - Derivados de acido fenoxiacetico utiles para el tratamiento de enfermedades respiratorias - Google Patents

Derivados de acido fenoxiacetico utiles para el tratamiento de enfermedades respiratorias

Info

Publication number
AR051966A1
AR051966A1 ARP050104896A ARP050104896A AR051966A1 AR 051966 A1 AR051966 A1 AR 051966A1 AR P050104896 A ARP050104896 A AR P050104896A AR P050104896 A ARP050104896 A AR P050104896A AR 051966 A1 AR051966 A1 AR 051966A1
Authority
AR
Argentina
Prior art keywords
halogen
alkyl
optionally substituted
independently selected
substituents independently
Prior art date
Application number
ARP050104896A
Other languages
English (en)
Inventor
Roger Victor Bonnert
Rukhsana Tasmneem Mohammed
Anthony Ronald Cokk
Stephen Thom
Timothy Jon Luker
Lilian Alcaraz
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0425673A external-priority patent/GB0425673D0/en
Priority claimed from GB0508923A external-priority patent/GB0508923D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR051966A1 publication Critical patent/AR051966A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C07D213/34—Sulfur atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Composiciones farmacéuticas que los contienen, y procesos para su preparacion. Reivindicacion 1: Un compuesto caracterizado porque responde a la formula (1) o su sal aceptable para uso farmacéutico del mismo, en donde: R1 y R2 representan en forma independiente un átomo de hidrogeno, halogeno, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-7 o un grupo alquilo C1-6, donde los ultimos cuatro grupos están opcionalmente sustituidos con uno o más sustituyentes independientemente seleccionados entre halogeno, cicloalquilo C3-7, NR9R10, OR8, S(O)nR7 (donde n es 0, 1 o 2); o R1 y R2 juntos pueden formar un anillo de entre 3 y 8 miembros que contiene opcionalmente uno o más átomos seleccionados entre O, S, NR11 y que a su vez está sustituido con uno o más alquilo C1-3 o halogeno; W es halogeno, ciano, nitro, SO2R7, SO2NR9R10, OR8, o alquilo C1-6 donde el ultimo está opcionalmente sustituido con uno o más sustituyentes independientemente seleccionados entre halogeno, OR8 y NR7R8, S(O)nR5 donde n es 0, 1 o 2; R3 es uno o más sustituyentes independientemente seleccionados entre hidrogeno, halogeno CN, nitro, SO2R7, OR8, SR7, SOR7, SO2NR9R10, CONR9R10, NR9R1O, NR11SO2R7, NR11CO2R7, NR11COR7 o alquilo C1-6, donde el ultimo está opcionalmente sustituido con uno o más sustituyentes independientemente seleccionados entre halogeno, OR8 y NR9R10, S(O)nR7 donde n es 0, 1 o 2; X representa un enlace, o alquilo C1-6, opcionalmente sustituido con uno o más sustituyentes independientemente seleccionados entre halogeno, alquilo C1-6 donde el ultimo está opcionalmente sustituido con uno o más sustituyentes independientemente seleccionados entre halogeno, OR6 y NR7R8, S(O)nR5 donde n es 0, 1 o 2; Y representa una diamina del tipo de formula (2), donde R4 y R5 representan en forma independiente hidrogeno, SO2R7, C(O)R7, CO2R7 y alquilo C1-8, donde el ultimo está opcionalmente sustituido con uno o más sustituyentes independientemente seleccionados entre arilo, heteroarilo, halogeno, OR8 y NR9R10, S(O)nR7 donde n es 0, 1 o 2; R4 y R5 están unidos o uno de R4 y R5 está unido a P o Q para formar un anillo heterocíclico saturado de entre 3 y 10 miembros con 1 o 2 átomos de nitrogeno endocíclicos; P y Q representan en forma independiente, alquilo C1-6 opcionalmente sustituido con uno o más sustituyentes independientemente seleccionados entre (=O), halogeno, OR8 y NR9R10, S(O)nR7 (donde n es 0, 1 o 2), alquilo C1-6, cicloalquilo C3-6, arilo o heteroarilo (donde los ultimos dos están opcionalmente sustituidos con uno o más sustituyentes independientemente seleccionados entre halogeno, -OR8 y NR9R10, CONR9R10, S(O)nR7 donde n es 0, 1 o 2); representa un enlace, (CR12)n-C(O), (CR12)n-S(O)n, C(O)(CR12)n, o S(O)2(CR12)n, S(O)2N(CR12)n, donde = 0, 1 o 2; HET representa arilo o heteroarilo; R6 representa uno o más sustituyentes independientemente seleccionados entre hidrogeno, halogeno, CN, nitro, COR7, CO2R8, SO2R7, OR8, SR8, SOR8, SO2NR9R10, CONR9R10, NR9R1O, NR8SO2R7, NR8CO2R8, NR8COR7, NR8CONR9R10, NR8SO2NR9R10, arilo, heteroarilo, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-7 o alquilo C1-6, donde los ultimos cuatro grupos están opcionalmente sustituidos con uno o más sustituyentes independientemente seleccionados entre halogeno, cicloalquilo C3-7, CN, OR8, NR9R10, S(O)nR7 (donde n es 0, 1 o 2), CONR9R10, NR8COR7, SO2NR9R10 y NR8SO2R7; R7 representa un grupo alquilo C1-6, arilo o heteroarilo donde todos pueden estar opcionalmente sustituidos con átomos de halogeno, OR8, NR14R15; R8 representa hidrogeno, alquilo C1-6, un grupo arilo o heteroarilo donde todos pueden estar opcionalmente sustituidos con átomos de halogeno, OR8, NR14R15; R9 y R10 representan en forma independiente hidrogeno, cicloalquilo C3-7 o alquilo C1-6, donde los dos ultimos grupos están opcionalmente sustituidos con uno o más sustituyentes independientemente seleccionados entre halogeno, cicloalquilo C3-7, OR6 y NR14R15, S(O)nR6 (donde n = 0, 1 o 2), CONR7R8, NR6CO2R7, SO2NR7R8 y NR6SO2R5; o R9 y R10 junto con el átomo de nitrogeno al cual están unidos pueden formar un anillo heterocíclico saturado de entre 3 y 8 miembros que contiene opcionalmente uno o más átomos seleccionados entre O, S(O)n (donde n = 0, 1 o 2), NR13, y a su vez está opcionalmente sustituido con halogeno o alquilo C1-3; R11 representa un átomo de hidrogeno, C(O)R9, alquilo C1-6, un grupo arilo o heteroarilo (los ultimos tres pueden estar opcionalmente sustituidos halogeno); R12 representa uno o más hidrogeno, o un grupo alquilo C1-6, donde el ultimo está opcionalmente sustituido con uno o más sustituyentes independientemente seleccionados entre halogeno, cicloalquilo C3-7, NR14R15, OR8, S(O)nR7 donde (n es 0, 1 o 2); R13 representa hidrogeno, C1-4 alquilo, -COalquiloC1-4, COYalquiloC1-4, donde Y es O o NR7; y R14 y R15 representan en forma independientemente hidrogeno, alquilo C1-4; o R14 y R15 junto con el átomo de nitrogeno al cual están unidos pueden formar un anillo heterocíclico saturado de entre 3 y 8 miembros que contiene opcionalmente uno o más átomos seleccionados entre O, S(O)n, (donde n = 0, 1 o 2), y que a su vez está opcionalmente sustituido con halogeno o alquilo C1-3.
ARP050104896A 2004-11-23 2005-11-22 Derivados de acido fenoxiacetico utiles para el tratamiento de enfermedades respiratorias AR051966A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0425673A GB0425673D0 (en) 2004-11-23 2004-11-23 Novel compounds
GB0508923A GB0508923D0 (en) 2005-04-30 2005-04-30 Novel compounds

Publications (1)

Publication Number Publication Date
AR051966A1 true AR051966A1 (es) 2007-02-21

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ID=35589515

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050104896A AR051966A1 (es) 2004-11-23 2005-11-22 Derivados de acido fenoxiacetico utiles para el tratamiento de enfermedades respiratorias

Country Status (14)

Country Link
US (1) US8524715B2 (es)
EP (1) EP1817282B1 (es)
JP (2) JP5208510B2 (es)
AR (1) AR051966A1 (es)
AT (1) ATE517085T1 (es)
CY (1) CY1112115T1 (es)
DK (1) DK1817282T3 (es)
PL (1) PL1817282T3 (es)
PT (1) PT1817282E (es)
SA (1) SA05260362B1 (es)
SI (1) SI1817282T1 (es)
TW (1) TW200630336A (es)
UY (1) UY29223A1 (es)
WO (1) WO2006056752A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0301009D0 (sv) * 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
SE0301010D0 (sv) * 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
SA04250253B1 (ar) 2003-08-21 2009-11-10 استرازينيكا ايه بي احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن
GB0415320D0 (en) * 2004-07-08 2004-08-11 Astrazeneca Ab Novel compounds
GB0418830D0 (en) 2004-08-24 2004-09-22 Astrazeneca Ab Novel compounds
GB0422057D0 (en) * 2004-10-05 2004-11-03 Astrazeneca Ab Novel compounds
WO2006056752A1 (en) 2004-11-23 2006-06-01 Astrazeneca Ab Phenoxyacetic acid derivatives useful for treating respiratory diseases
CA2621310C (en) * 2005-09-27 2014-08-12 Shionogi & Co., Ltd. Sulfonamide derivative having pgd2 receptor antagonistic activity
EA015358B1 (ru) * 2005-09-30 2011-06-30 Пульмаджен Терапьютикс (Эсме) Лимитед Хинолины и их терапевтическое применение
JP5155171B2 (ja) 2005-10-06 2013-02-27 アストラゼネカ・アクチエボラーグ 新規化合物
TW200745003A (en) 2005-10-06 2007-12-16 Astrazeneca Ab Novel compounds
JP2009514935A (ja) * 2005-11-05 2009-04-09 アストラゼネカ・アクチエボラーグ 新規化合物
ES2380683T3 (es) * 2005-12-15 2012-05-17 Astrazeneca Ab Difenil-éteres, -amidas, -sulfuros y - metanos sustituidos para el tratamiento de la enfermedad respiratoria
UA100983C2 (ru) * 2007-07-05 2013-02-25 Астразенека Аб Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты
DK2229358T3 (da) 2007-12-14 2011-07-04 Pulmagen Therapeutics Asthma Ltd Indoler og deres terapeutiske anvendelse
CN102395557A (zh) * 2008-12-09 2012-03-28 佛罗里达大学研究基金会公司 激酶抑制剂化合物
BRPI1006841A2 (pt) 2009-01-14 2017-05-30 Dow Agrosciences Llc composições fungicidas incluindo derivados de hidrazona e cobre
RU2013104506A (ru) 2010-07-05 2014-08-10 Актелион Фармасьютиклз Лтд 1-фенилзамещенные производные гетероциклила и их применение в качестве модуляторов рецептора простагландина d2
EP2457900A1 (en) 2010-11-25 2012-05-30 Almirall, S.A. New pyrazole derivatives having CRTh2 antagonistic behaviour
US20140328861A1 (en) 2011-12-16 2014-11-06 Atopix Therapeutics Limited Combination of CRTH2 Antagonist and a Proton Pump Inhibitor for the Treatment of Eosinophilic Esophagitis
KR20140107550A (ko) 2011-12-21 2014-09-04 액테리온 파마슈티칼 리미티드 헤테로시클릴 유도체 및 프로스타글란딘 ｄ2 수용체 조절제로서의 그의 용도
CA2876808A1 (en) * 2012-07-05 2014-01-09 Actelion Pharmaceuticals Ltd 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators
CN107531655B (zh) 2015-04-28 2021-03-12 荷兰联合利华有限公司 N-芳烷基羰基-哌嗪和n-芳烷基羰基-高哌嗪化合物以及包含它们的个人护理组合物
MX368097B (es) 2015-04-28 2019-09-19 Unilever Nv Compuestos de n-aralquilcarbonildiamina y composiciones para el cuidado personal que comprende los mismos.
WO2017209272A1 (ja) * 2016-06-03 2017-12-07 国立大学法人東京大学 がん転移阻害剤

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB690816A (en) 1950-01-02 1953-04-29 British Drug Houses Ltd Improvements in or relating to the manufacture of substituted phenoxy acetic acids
US3278524A (en) 1962-03-13 1966-10-11 Beecham Group Ltd Penicillins and their production
CH432119A (de) 1963-02-22 1967-03-15 Geigy Ag J R Verwendung von Halogen-o-hydroxy-diphenyläthern als antimikrobielle Mittel
BE790679A (fr) 1971-11-03 1973-04-27 Ici Ltd Derives de l'indole
DD113545A5 (es) 1973-03-30 1975-06-12
JPS5239888B2 (es) 1973-05-28 1977-10-07
ES431425A1 (es) 1973-10-29 1977-01-16 Eisai Co Ltd Un procedimiento para la preparacion de derivados del acido 2-(m-fenoxifenil)-propionico.
CH582476A5 (es) 1973-10-29 1976-12-15 Ciba Geigy Ag
GB1585963A (en) 1976-10-14 1981-03-11 Lilly Industries Ltd Aryl sulphur compounds
US4248618A (en) 1977-05-06 1981-02-03 Ici Australia Limited Derivatives of (pyrimidyloxy)phenoxy-alkanecarboxylic acid and herbicidal compositions thereof
FR2428629A1 (fr) 1978-06-14 1980-01-11 Hexachimie Nouveaux composes bis(aryloxycarboxyliques), leur preparation et leur utilisation en therapeutique
JPS5951943B2 (ja) 1978-08-21 1984-12-17 キツセイ薬品工業株式会社 新規なイミダゾ−ル誘導体
GB2041363B (en) 1979-01-19 1982-10-06 Pfizer Ltd N-benzyl-imidazoles
US4670566A (en) 1979-07-12 1987-06-02 A. H. Robins Company, Incorporated 3-methyl-hio-4-(5-, 6-, or 7-)phenylindolindolin-2-ones
US4486593A (en) 1983-01-19 1984-12-04 The Upjohn Company 2-,3-, or 4-Pyridinylmethylamino arylic acids as thromboxane A2 synthetase and 5-lipoxygenase inhibitors
US5006542A (en) 1988-10-31 1991-04-09 E. R. Squibb & Sons, Inc. Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same and method of use
US5145790A (en) 1990-05-04 1992-09-08 Abbott Laboratories Reagents and method for detecting polychlorinated biphenyls
EP0540165A1 (en) 1991-10-03 1993-05-05 Zeneca Limited Alkanoic acid derivatives
WO1993012086A1 (en) * 1991-12-11 1993-06-24 Ss Pharmaceutical Co., Ltd. Arylamide derivative
CA2090283A1 (en) 1992-02-28 1993-08-29 Nobuyuki Hamanaka Phenoxyacetic acid derivatives
ES2156120T3 (es) * 1992-12-08 2001-06-16 Ss Pharmaceutical Co Derivados arilamidicos.
JP2825755B2 (ja) * 1993-04-07 1998-11-18 大塚製薬株式会社 ピペリジン誘導体を有効成分とする末梢血管拡張剤および新規ピペリジン誘導体
JPH06313995A (ja) 1993-04-28 1994-11-08 Hodogaya Chem Co Ltd 静電荷像現像用トナー
EP0622816B1 (en) 1993-04-30 1998-07-22 Kabushiki Kaisha Meidensha Electrode and process for forming an electrode material
JPH07140725A (ja) 1993-06-25 1995-06-02 Hodogaya Chem Co Ltd 負帯電性トナー用摩擦帯電付与部材
US5612353A (en) * 1995-06-07 1997-03-18 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted (sulfinic acid, sulfonic acid, sulfonylamino or sulfinylamino) N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds
WO1997008126A1 (en) 1995-08-28 1997-03-06 American Home Products Corporation Phenoxy acetic acids as aldose reductase inhibitors and antihyperglycemic agents
AU714687B2 (en) 1996-07-22 2000-01-06 Monsanto Company Thiol sulfone metalloprotease inhibitors
EP0839808A1 (en) 1996-10-29 1998-05-06 Novartis AG Pyrazole derivatives, processes for their preparation, and their use as herbicides
FR2763588B1 (fr) 1997-05-23 1999-07-09 Cird Galderma Composes triaromatiques, compositions les contenant et utilisations
CO4960662A1 (es) 1997-08-28 2000-09-25 Novartis Ag Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados
US5942532A (en) 1997-09-05 1999-08-24 Ortho Pharmaceutical Corporation 2-substituted phenyl-benzimidazole antibacterial agents
EP1012142B1 (en) 1997-09-12 2004-08-11 Merck Frosst Canada & Co. 2,3,5-trisubstituted pyridines as inhibitors of cyclooxygenase-2
WO1999019291A1 (fr) 1997-10-14 1999-04-22 Asahi Kasei Kogyo Kabushiki Kaisha Derives de biphenyl-5-acide alcanoique et leurs applications
JP3486408B2 (ja) 1999-08-23 2004-01-13 株式会社ビー・エム・エル 物質のヒトプロスタグランジンｄ２受容体に対する性質の同定方法
SE9902987D0 (sv) * 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
CA2382966A1 (en) 1999-08-27 2001-03-08 Eli Lilly And Company Biaryl-oxa(thia)zole derivatives and their use as ppars modulators
AU784722B2 (en) 2000-02-18 2006-06-01 Merck & Co., Inc. Aryloxyacetic acids for diabetes and lipid disorders
WO2001081312A2 (en) 2000-04-24 2001-11-01 Merck Frosst Canada & Co. Method of treatment using phenyl and biaryl derivatives as prostaglandin e inhibitors and compounds useful therefore
JP2003535078A (ja) 2000-05-31 2003-11-25 アストラゼネカ アクチボラグ 血管損傷活性のあるインドール誘導体
MXPA02012795A (es) * 2000-06-28 2004-07-30 Teva Pharma Carvedilol.
US6878522B2 (en) 2000-07-07 2005-04-12 Baiyong Li Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2
US20040097555A1 (en) 2000-12-26 2004-05-20 Shinegori Ohkawa Concomitant drugs
CA2450167A1 (en) * 2001-06-12 2002-12-19 Elan Pharmaceuticals, Inc. Macrocycles useful in the treatment of alzheimer's disease
JP4209332B2 (ja) 2002-02-01 2009-01-14 エフ．ホフマン−ラ ロシュ アーゲー α−１アゴニストとしての置換インドール
SE0200411D0 (sv) 2002-02-05 2002-02-05 Astrazeneca Ab Novel use
WO2003068744A1 (fr) 2002-02-18 2003-08-21 Ishihara Sangyo Kaisha, Ltd. Derives de la pyridine ou leurs sels, et inhibiteurs de production de citokine renfermant ces derives
CN101172983A (zh) 2002-03-20 2008-05-07 麦它波莱克斯股份有限公司 取代的苯乙酸
AU2003231509A1 (en) 2002-05-16 2003-12-02 Shionogi And Co., Ltd. Compound exhibiting pgd 2 receptor antagonism
AU2003231513A1 (en) 2002-05-16 2003-12-02 Shionogi And Co., Ltd. Pgd2 receptor antagonist
SE0201635D0 (sv) 2002-05-30 2002-05-30 Astrazeneca Ab Novel compounds
SE0202241D0 (sv) 2002-07-17 2002-07-17 Astrazeneca Ab Novel Compounds
US7119200B2 (en) * 2002-09-04 2006-10-10 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
AR042206A1 (es) 2002-11-26 2005-06-15 Novartis Ag Acidos fenilaceticos y derivados
WO2004052862A1 (ja) * 2002-12-10 2004-06-24 Ono Pharmaceutical Co., Ltd. 含窒素複素環化合物およびその医薬用途
JP4457017B2 (ja) 2002-12-20 2010-04-28 アムジエン・インコーポレーテツド 喘息及びアレルギー性炎症モジュレーター
JP2006521382A (ja) 2003-03-28 2006-09-21 イーライ リリー アンド カンパニー Ａｋｔ（プロテインキナーゼｂ）阻害剤
JP2004315511A (ja) * 2003-03-31 2004-11-11 Taisho Pharmaceut Co Ltd Ｍｃｈ受容体アンタゴニスト
SE0301009D0 (sv) 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
SE0301010D0 (sv) 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
EP1471057B1 (en) 2003-04-25 2006-01-18 Actimis Pharmaceuticals, Inc. Pyrimidinylacetic acid derivatives useful for the treatment of diseases mediated by CRTH2
SA04250253B1 (ar) 2003-08-21 2009-11-10 استرازينيكا ايه بي احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن
GB0324763D0 (en) 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy
US7166738B2 (en) 2004-04-23 2007-01-23 Roche Palo Alto Llc Non-nucleoside reverse transcriptase inhibitors
GB0409921D0 (en) 2004-05-04 2004-06-09 Novartis Ag Organic compounds
WO2005115382A1 (en) * 2004-05-29 2005-12-08 7Tm Pharma A/S Crth2 receptor ligands for medicinal uses
GB0415320D0 (en) 2004-07-08 2004-08-11 Astrazeneca Ab Novel compounds
GB0418830D0 (en) 2004-08-24 2004-09-22 Astrazeneca Ab Novel compounds
GB0422057D0 (en) 2004-10-05 2004-11-03 Astrazeneca Ab Novel compounds
WO2006056752A1 (en) 2004-11-23 2006-06-01 Astrazeneca Ab Phenoxyacetic acid derivatives useful for treating respiratory diseases
GB0510584D0 (en) 2005-05-24 2005-06-29 Novartis Ag Organic compounds
TW200745003A (en) 2005-10-06 2007-12-16 Astrazeneca Ab Novel compounds
JP5155171B2 (ja) 2005-10-06 2013-02-27 アストラゼネカ・アクチエボラーグ 新規化合物
JP2009514935A (ja) 2005-11-05 2009-04-09 アストラゼネカ・アクチエボラーグ 新規化合物
ES2380683T3 (es) 2005-12-15 2012-05-17 Astrazeneca Ab Difenil-éteres, -amidas, -sulfuros y - metanos sustituidos para el tratamiento de la enfermedad respiratoria
UA100983C2 (ru) 2007-07-05 2013-02-25 Астразенека Аб Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты

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EP1817282A1 (en) 2007-08-15
SA05260362B1 (ar) 2009-04-18
PL1817282T3 (pl) 2011-11-30
WO2006056752A1 (en) 2006-06-01
PT1817282E (pt) 2011-09-19
US8524715B2 (en) 2013-09-03
UY29223A1 (es) 2006-06-30
EP1817282B1 (en) 2011-07-20
SI1817282T1 (sl) 2011-10-28
JP2008520637A (ja) 2008-06-19
US20090149448A1 (en) 2009-06-11
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ATE517085T1 (de) 2011-08-15

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